Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
Website

Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 14 Documents

1 2

Search results for , issue "Vol 12, No 1 (2022): Pharmaciana" : 14 Documents clear

The antioxidant activity of Zingiber officinale, Hibiscus sabdariffa, and Caesalpinia sappan combination Ari Hasna Widyapuspa; Elizabeth Betty Elok Kristiani; Yohanes Martono
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Medicinal plants have been used in traditional treatment since a long time ago by local people in Indonesia. Nowadays, the trend in the consumption of medicinal plants, especially herbal drinks, is increasing. Zingiber officinale, Hibiscus sabdariffa, and Caesalpinia sappan are their main materials of medicinal plants. They were chosen because of their high antioxidant contents. Nevertheless, there is no scientific research on the antioxidant activity of the combination of the three extracts. Therefore, the purpose of this study was to determine the total flavonoid contents and antioxidant activity, as well as to compare the antioxidant enhancement pattern of the combination. Samples were extracted by successive maceration with hexane and ethyl acetate as solvents. Total flavonoids contents were determined through colorimetric analysis and antioxidant activity was determined based on the DPPH method with the IC50 value as a parameter. Total flavonoids of ethyl acetate extract from Z. officinale, H. sabdariffa, and C. sappan were 30.28Â±0.04; 24.81Â±0.03; and 24.01Â±0.04 mg QE/ gram extract, and the IC50 value were 51.36Â±0.05; 83.37Â±0.06; and 35Â±0.04 ppm. Total flavonoid contents of their combination were 22.48Â±0.05 (0:1:1); 23.88Â±0.05 (1:1:1); 23.68Â±0.05 (1:4:1); 22.81Â±0.05; 28.81Â±0.04 (4:1:1); 27.55Â±0.03 (1:1:0); 24.41Â±0.04 mg QE/ gram extract (1:0:1). Antioxidant activities obtained from the combination were 57.50Â±0.05 (0:1:1); 52.25Â±0.06 (1:1:1); 71.50Â±0.06 (1:4:1); 45.74Â±0.05 (1:1:4); 54.36Â±0.05 (4:1:1); 68.97Â±0.06 (1:1:0); 40.52Â±0.05 ppm (1:0:1). The strongest antioxidant activity was C. sappan.Â

Diffusion rate of quercetin from chitosan-TPP nanoparticles dispersion of onion (Allium cepa L.) ethanol extract in medium phosphate buffer pH 7.4 Anisa Amalia; Rahmah Elfiyani; Putri Ulan Sari
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Onion extract contains quercetin, which has anti-inflammatory properties. The absorption of quercetin in the extract can be improved by using the ionic gelation method to composition the extract into a nanoparticle system. Chitosan is a polymer that is used to make nanoparticles that impact medicinal drug absorption. Although many studies of nanoparticle coatings with chitosan have been performed, the effect of the chitosan concentration used remains an intriguing research issue, especially as a natural compound carrier.Â The goal of this study was to examine how varying chitosan polymer concentrations affected the rate of quercetin diffusion from onion (Allium cepa L.) ethanol extract nanoparticles. With 0.1% tripolyphosphate (TPP) as a crosslinker, the concentrations of chitosan used were 0.1% (F1), 0.2% (F2), 0.3% (F3), and 0.4% (F4). Organoleptic test, particle size measurement, zeta potential, polydisperse index, entrapment efficiency, density, and determination of quercetin diffusion rate using a phosphate buffer medium pH 7.4 were all used to analyze each composition. Transparent yellow nanoparticles with particle sizes ranging from 199.89 nm to 514.97 nm, a zeta potential of 47.73 mV to 51.36 mV, a polydispersity index of 0.57, an entrapment efficiency of 54.78 % to 59.06 %, and a density of 1.012 g/mL to 1.042 g/mL are the result of this system. In each composition, the rate of diffusion follows the Higuchi reaction kinetics. Increased chitosan concentration decreases the diffusion rate of onion ethanol extract nanoparticles (Allium cepa L). The fastest diffusion rate value with requirements-meeting physical properties was obtained in nanoparticle systems containing a 0.1 % chitosan solution.Â

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model Rahmad Abdillah; Fitra Fauziah; Putri Indah Lestari; Fitri Rachmaini
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Averrhoa bilimbi L. is used widely as spices and traditional medicine, which contained several chemical compounds such as alkaloid, flavonoid, saponin, and tannin. The aim of this study is to discover the best dose of ethyl acetate fraction from A.bilimbi leaves, which have pharmacology activity on total cholesterol and triglycerides in the hypercholesterolemic model. Thirty adult male white mice were divided into six groups; each group was containing five animals. Five groups were given high-fat diet foods and PTU induced the animals to obtain hypercholesterolemia with a frequency of 1 time a day orally for 14 days, while the normal group was given vehicle (Na CMC 5%) and standard feed. On the 15th day the normal group was given vehicle (Na CMC 5%), negative control group was given high-fat feed, positive control group was given atorvastatin dose 0.26 mg/kg BW, and another group was given ethyl acetate fraction of A.bilimbi leaves dose 200, 400, and 800 mg/kg BW orally. All animal were treated until the 28th day. On day 29, the bloods were taken to determine the total cholesterol and trygliceride levels using clinical photometer 5010 v5+. The data was statistically analyzed using a one-way ANOVA followed by the Duncan Multiple Range Test.. This study indicates that administration of ethyl acetate fraction from A.bilimbi leaves can affect the total cholesterol levels and triglycerides in hypercholesterolemic mice (P<0.05). Ethyl acetate fraction dose 200 mg/kg BW shows the best activity in decreasing total cholesterol levels and triglycerides on mice hypercholesterolemic model (P<0.05).

Anredera cordifolia leaves extract accelerates the wound healing of normal and hyperglycemic rats Gembira Arkemo Situmorang; Zulham Yamamoto; M. Ichwan; Bambang Prayugo
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Anredera cordifolia ((Madeira vein (English) or Binahong (Indonesia language)) leaves contain ingredients that promote wound healing. This study aims to determine the effect of Madeira vein leaves ethanolic extract (MLE) on normal and hyperglycemic rat wounds. This is an experimental study using male Wistar rats aged 2-3 months, body weight between 250-300 grams induced by a single injection of streptozotocin dose 60 mg/kg BW intraperitoneally. Rats were divided into 8 groups namely normal without MLE, normal with MLE 2.5% w/v, normal with MLE 5% w/v, normal with MLE 10% w/v, hyperglycemia without MLE, hyperglycemia with MLE 2.5% w/v, hyperglycemia with MLE 5% w/v and hyperglycemia with MLE 10% w/v. Punch biopsy was used to create wounds on the skin of rats with a diameter of 8 mm after the blood glucose level measurement was higher than 200 mg/dL. MLE is applied 3 times a day for 14 days on the wounds. Wound contractions occurred in line with the length of treatment days. In normal skin, the area of the wound had decreased by 22% within three days and to 76% at 14 days after wound creation. On the 14th day of treatment, the wound area of hyperglycemic rats decreased > 60%. The largest wound contraction was found when using MLE 10% w/v. Increasing the MLE dose stimulated better wound contraction/healing than control wounds. Wound healing involves many types and products of cells. Starting with hemostasis, wound healing is followed by inflammatory and proliferative phases to form new tissue, angiogenesis, and matrix formation. The MLE content is beneficial for wound healing in normal and hyperglycemic rats. MLE plays a role in accelerating wound healing in normal and hyperglycemic rats. The MLE dose of 10% w/v provides faster wound healing than the 2.5% and 5% w/v doses.

Inulin determination of yam bean tuber (Pacyrrhizus erosus l.) water extract from different altitude areas using TLC- Densitometry Yuni Retnaningtyas; Lestyo Wulandari; Mariska Wimala
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Inulin is a polysaccharide with a lot of potential in the field of food and pharmaceuticals. Inulin can be found in yam bean tuber. Chemical constituents of yam bean tuber are inulin, pachyrion, and rotenone. The levels of inulin could be influenced by differences in the altitude of the cultivation area. The objective of this study was to determine the inulin of yam bean tuber extract from several areas in East Java based on the altitude difference, they are low (Gresik), middle (Kediri), and high (Malang), using validated TLC Densitometry method. The samples were extracted by the infusion method. The samples were put to silica gel TLC plates and developed using ascending chromatography with a mobile phase of 0.5:7:2 glacial acetic acid: methanol: Â deionized water. Â Densitometry at 380 nm was used to assess the intensity of inulin spots dipped in Aniline: diphenylamine: phosphoric acid (5:5:1), and winCATS software version 1.3.0 was used to quantify the results. A standard curve Â meets the requirement of linearity (r=0.997; Vxo=3.847%), sensitivity (LOD=71.030 ng/spot, and LOQ=236.766 ng/spot), selectivity and specificity, Precision (RSDâ‰¤2.754 %), and accurate (% recovery Â± RSD = 100.161 Â± 1.839%). The results showed that the inulin content in yam tubers produced by areas with different altitudes had different inulin levels. The levels of inulin derived from the low altitude (Gresik) was 9.066 Â± 1.218 %, middle (Kediri) was 7.776 Â± 0.420 %, and high (Malang) was 6.796 Â± 2.045 %. One-Way ANOVA test showed the significant difference between the levels of inulin from different altitude areas (p < 0.01), the highest inulin level comes from yam bean tuber from low altitude.Â

Implementation of pharmacy delivery services in the era of digital and pandemic Covid-19 Dewi Gulyla Hari; Yasinda Oktariza; Ayu Rahmawati
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v12i1.20127

The Covid-19 pandemic has had a significant impact on changes in people's behavior which currently prefer online ordering in order to implement social distancing and physical distancing. This study aims to see the behavior of pharmacy customers in using delivery services during the pandemic and strategies that can be used to attract customers to return to using delivery service. This study is an observational analytic study conducted at CV. Apotek Keluarga in the period October-December 2020. A total of 149 respondents were involved in this study. Customer behavior was observed by collecting information from customers as well as profiles of requests for delivery services from January to August 2020. Analysis of strategies to attract customer interest in shopping again at the pharmacy was carried out by looking at the correlation of the factors that influence the intention to return through distributing questionnaires. The demand profile for delivery services shows an increase in demand during pandemic in March 2020 from 22.92% to 94.35%. The results of the bivariate analysis show that there is a significant correlation on each variable score for trust, checkout satisfaction, after-delivery satisfaction, and price perception on the intention to return. The results of the multivariate analysis show that the variables, independently correlated with intention to return were trust variables with a weak positive correlation coefficient (r = 0.210), after-delivery satisfaction with sufficient positive correlation coefficient (r = 0.306), and price perception with sufficient positive correlation coefficient (0.434). Based on the results of this study, it can be concluded that the application of delivery services at pharmacies has the opportunity to be applied during the Covid-19 pandemic period as well as after the pandemic. Pharmacies need to build trust, satisfaction, and good price perceptions for customers to attract customers to return to using home delivery at pharmacies.

Cost-effectiveness analysis of empiric antibiotics in hospitalized community-acquired Pneumonia Yeni Farida; Qisty Aulia Khoiry; Muchtar Hanafi; Maryani Maryani
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Community-Acquired Pneumonia (CAP) remains an important infectious disease due to its impact on patient outcomes. Â This study aimed to investigate the clinical outcome and especially costs of hospitalization for community-acquired pneumonia (CAP) concerning empirical antibiotics. This research was conducted to estimate the cost-effectiveness of levofloxacin, ceftriaxone, and a combination of ceftriaxone and azithromycin aiming to improve the clinical outcome of CAP. A retrospective observational study was conducted in secondary care, University Hospital in Surakarta, Central Java, Indonesia. The study enrolled all CAP patients hospitalized in the period January until December 2018, with agesâ‰¥ 18 years old, and at least used antibiotic for three days. We compared cost-effectiveness, as measured by total cost and proportion of patients successfully treated, of 3 empirical antibiotics for inpatient CAP, involving ceftriaxone, levofloxacin, or combination ceftriaxone + azithromycin. Our analyses were conducted based on a healthcare perspective. In all groups were analyzed based on severity classification (Pneumonia Severity Index score). The use of levofloxacin instead of ceftriaxone improved clinical response, but it is more expensive. Levofloxacin was the most cost-effective based on ACER value. Treatment using a combination of ceftriaxone + azithromycin was more expensive without added benefit. Based on this study, the use of levofloxacin as the first-line therapy for CAP could be maintained because it was more cost-effective than other alternatives. Since the limitations, a study on a broader population is needed to confirm these findings.

Chemical qualitative analysis and spf value stability of nutmeg seed oil in microemulsions with tween 80 and PEG 400 as surfactants and cosurfactants Ayu Shabrina; Erika Indah Safitri; Risha Fillah Fithria; Misbahul Munir; Sumantri Sumantri
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Nutmeg oil contains Î±-pinene, which can be used as sunscreen. The combination of Tween 80 and PEG 400 can maintain the stability of nutmeg oil microemulsion. This research was a follow-up study that aims to determine the stability of the SPF value and qualitative chemical content of nutmeg seed oil microemulsions (NSM). NSM was made with a nutmeg seed oil concentration of 6.4% and tween 80 and PEG 400 as surfactants and cosurfactants with variations in the ratio of F1 (5: 4), F2 (6: 4), and F3 (7: 4). Nutmeg seed oil and NSM content was analyzed using GC-MS. NSM formula were tested for in vitro SPF value stability by storing NSM in a climatic chamber at 30 Â°C Â± 2 Â°C with RH 65 % Â± 5 % for 4 weeks. The SPF values were calculated every week. GC-MS data were analyzed descriptively and data of SPF value stability were analyzed statistically using one way ANOVA. The GC-MS results of nutmeg seed oil showed 35 components, including significant compounds, namely Î±-pinene, sabinene, Î²-phellandrene and also Î±-terpinolene. GC-MS results of NSM showed those significant compounds were still detected after being formulated in microemulsion. The results of the sunscreen activity test of NSM before storage were 10.31 Â± 0.03 (F1); 10.47 Â± 0.07 (F2); 10.45 Â± 0.03 (F3) and did not show significant change after storage for 4 weeks (p > 0.05). The SPF values of NSM were categorized in maximum activity.Â

Antibacterial activity of mexican sunflower leaf Tithonia diversifolia (Hemsl.) A.Gray Aqueous extract against methicillin-resistant Staphylococcus aureus Misrahanum Misrahanum; Zahratul Safarah; Yulia Sari Ismail
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The research of antibacterial activity of Mexican sunflower leaf Tithonia diversifolia (Hemsl.) A.Gray aqueous extract against Methicillin-Resistant Staphylococcus aureus (MRSA) was carried out. The research aimed to observe the antibacterial activity of Mexican sunflower leaves aqueous extract to inhibit the growth of MRSA with concentrations of 10, 20, 30, 40, and 50%. The extracts were obtained by the maceration method, and the antibacterial activity was tested using the agar well diffusion method. Characterization of Mexican sunflower leaves simplicia were obtained with water level 9%, water-soluble level 21,6%, ethanol-soluble level 10,3%, and total ash level 14,36%. Characterization of Mexican sunflower leaves aqueous extracts were obtained with water level 26,36%, water-soluble level 53,13%, ethanol-soluble level 26,36%, and total ash level 19,98%. Phytochemical screening revealed that aqueous extract of Mexican sunflower leaves contained secondary metabolites of alkaloids, flavonoids, tannins, and saponins. The largest inhibitory zone was shown at a 50% extract concentration with a diameter of 12,40 mm. The aqueous extract of Mexican sunflower leaves was capable to form the inhibition zone on the MRSA growth.

Molecular docking study and molecular dynamics simulation of spice metabolites against main protease enzymes and NSP3 macrodomain SARS CoV-2 Purwaniati Purwaniati; Asep Roni
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

COVID-19 is still a global pandemic. The transmission is very fast and wide. Its prevalence continues to increase. There is no specific antiviral drug for SARS CoV 2 yet. This study aims to find lead compounds from compounds derived from spices that can work as multitarget SARS CoV-2 antivirals. The target of drug action chosen in this study is the main protease enzyme and non-structural protein 3 (NSP3) macrodomain. Antiviral compounds that work on both targets are expected to be more potent. This antivirus will work to inhibit virus replication through main protease inhibition and increase innate immunity through NSP3 macrodomain inhibition. Molecular docking and molecular dynamics simulation were chosen as the methods in this study. Based on the results of molecular docking, it was found that the compound of dauricine, tomentin A, daurisoline, xhantoangelol, rutin and myricetin gave good affinity to both targets. These compounds provide an inhibition constant below 10000 nM or 10 micromolar. Meanwhile, in the molecular dynamics simulation test, it was found that dauricine, rutin, myricetin, and xhantoangelol have good interaction stability with both targets. So from this study, it can be concluded that dauricine, rutin, myricetin and xhantoangelol are potential compounds as lead compounds for SARS CoV-2 antivirals that act on the main protease and the NSP3 macrodomain.

Page 1 of 2 | Total Record : 14

1 2

Filter by Year

2022 2022

Filter By Issues

All Issue Vol 14, No 1 (2024): Pharmaciana Vol 13, No 3 (2023): Pharmaciana Vol 13, No 2 (2023): Pharmaciana Vol 13, No 1 (2023): Pharmaciana Vol 12, No 3 (2022): Pharmaciana Vol 12, No 2 (2022): Pharmaciana Vol 12, No 1 (2022): Pharmaciana Vol 11, No 3 (2021): Pharmaciana Vol 11, No 2 (2021): Pharmaciana Vol 11, No 1 (2021): Pharmaciana Vol 10, No 3 (2020): Pharmaciana Vol 10, No 2 (2020): Pharmaciana Vol 10, No 1 (2020): Pharmaciana Vol 9, No 2 (2019): Pharmaciana Vol 9, No 1 (2019): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5 No 1, 2015 Vol 5, No 2 (2015): Pharmaciana Vol 5, No 2 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1: Mei 2013 Vol 3, No 1 (2013): Pharmaciana Vol 2, No 2 (2012): Pharmaciana Vol 2, No 2: November 2012 Vol 2, No 2 (2012): Pharmaciana Vol 2, No 1: Mei 2012 Vol 2, No 1 (2012): Pharmaciana Vol 2, No 1 (2012): Pharmaciana Vol 1, No 2: November 2011 Vol 1, No 2 (2011): Pharmaciana Vol 1, No 2 (2011): Pharmaciana Vol 1, No 1: Mei 2011 Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA