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Berkala Ilmu Kesehatan Kulit dan Kelamin

BIKK
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Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

Arjuna Subject : -

Articles 12 Documents

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Search results for , issue "Vol. 29 No. 3 (2017): DESEMBER" : 12 Documents clear

In Vitro Susceptibilty Test of Fluconazole to Candida spp in Patients with Oropharyngeal Candidiasis and HIV/AIDS with Vitek II Novianti Rizky Reza; Tantari SHW; Santosa Basuki
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Oral candidiasis (OC) was the most common opportunistic infection in HIV/AIDS. Widespread and inadequate use of fluconazole as a prophylaxis and therapy in OC resulted in decreasing susceptibility. Decreased susceptibility of fluconazole will show the increasing in vitro Minimum Inhibitory Concentration (MIC) was reported in some studies. Purpose: To determine in vitro susceptibilty of fluconazole to Candida spp in patients with Oropharyngeal Candidiasis and HIV/AIDS. Methods: The study design was descriptive, observational, cross sectional study for three months in Saiful Anwar Hospital Malang. Species identification and fluconazole susceptibility used Vitek II. Result: Thirty three subject with 36 Candida isolates. Candida albicans was the most common species identified in 86% isolates, C. krusei 8%, and C. glabrata 6%. C. albicans had MIC between ≤ 1 mg/l – 16 mg/l, C. glabrata 4mg/l, dan C. krusei 2 mg/l - 32 mg/l. Sensitivity of C. albicans to fluconazole was demonstrated in 83% isolates and resistance of non-albicans was found in 8% isolates. Conclution: Most common isolates found was C. albicans which show sensitivity to fluconazole, resistance was found in C. krusei isolates.

Comparison of May Grunwald Giemsa and Potassium Hydroxide Examination of Malassezia Folliculitis Patient Dermatologic Outpatient Clinic of Dr. Soetomo General Hospital Surabaya Pramita Ariyanti; Afif Nurul Hidayati; Sunarso Suyoso
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Malassezia folliculitis (MF) is a pilosebaceous follicle infection caused by Malassezia sp., in the form of papules, solid, diameter <1cm, follicular pustules, moderate itchy, in the upper body, and rarely on the face. Microscopic examination with potassium hydroxide (KOH) found spores. May Grunwald Giemsa (MGG) cytologic staining to diagnose MF spores may demonstrate a more detailed and sharper. Objective: Identification of MF with MGG compared KOH in Dermatology outpatient clinic Dr. Soetomo General Hospital. Methods: The study was observational analytic to identify MF using MGG compared KOH. Involving 52 new patients fulfield the criteria of the study from March to May 2016. Results: An examination of 52 patients with MF, 7 patients (13.5%) were negative with KOH examination, while the examination MGG negative in 2 patients (3.8%), but not statistically significant (p ≥ 0.5 ). PPV=90% ; NPV value=100% ; sensitivity=95,7% ; spesificity=28,5% Conclusion: KOH still a good investigation for diagnose of MF, but if clinically result positive MF whereas negative KOH, MGG examination should be performed as a diagnostic confirmation of MF

Metal Patch Testing with Nickel, Chromium, and Cobalt in Atopic Dermatitis Patients Yuri Widia; Evy Ervianti; Marsudi Hutomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a cutaneous inflammation characterized by skin hyperreactivity due to complex interplay between genetic susceptibility and environmental allergens. In AD, recurrences are frequent and cause problems. Although elevation of total immunoglobulin E (IgE) level; and positive specific IgE to environmental allergens and food are found in most cases, some AD patients with normal IgE level still recurred and raised the possibility of other factors as a trigger. Datas from some studies showed high frequency of positive results in metal patch testing and improvement in AD after allergen elimination and low metals diet. Based on these studies, metal is considered as a trigger of reccurrences in AD. Nickel, chromium and cobalt are the primary metals that gives high frequency of positive patch test results in patients with intrinsic AD. Purpose: To evaluate metal patch testing results with nickel, chromium and cobalt in atopic dermatitis patients at Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital Surabaya. Methods: This study was observational cross-sectional descriptive study of patch testing to nickel, chromium, and cobalt at 23 AD patients who met the inclusion and exclusion criteria. Results: Patch testing to nickel sulphate metal gave positive result in 17.39% patients, potassium dichromate 8.7%, and cobalt chloride 4.35%. Four people (17.39%) showed positive patch test results; 3 people (13.04%) showed the value of the normal serum total IgE and 1 (4.35%) showed an increasing total serum IgE level. Conclusions: Metal patch testing against AD can be considered in AD patients with normal IgE values.

Profile of Fungal and Bacterial Infections in Inguinal Erythrosquamous Dermatoses Irma Tarida Listiyawati; Sunarso Suyoso; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Erythrosquamous dermatoses are diseases of the skin, characterized with the erythematous changing accompanied with scales. Usually, the patients were treated with antifungal and antibiotic, but there were no data to support this therapy. Purpose: To describe the profile of fungal and bacterial infections in erythrosquamous dermatoses. Methods: This is a descriptive cross-sectional study in patient with inguinal erythrosquamous dermatoses in Dermatology and Venereology Outpatient Department, Dr. Soetomo General Hospital 2016. Subjects have been collected through consecutive sampling, and the amount of subject were determined as total sampling from May – August 2016 Results: The profile of fungal infections were tinea kruris (57.14%) and intertriginous candidiasis (9.52%). Fungal infections as a trigger were seborrheic dermatitis (14.29%) and erythema intertrigo (14.29%). Profile of bacterial infections were erythrasma (4.76%). Result of fungal culture were T. mentagrophytes (52.38%), C. parapsilosis (9.52%), S. ciferii (4.76%), C. albicans (4.76%), T. inkin (4.76%), Malaszesia spp (9.52%), and negative result (14.28%). Result of gram positive bacterial culture were S. aureus (38.10%), S. epidermidis (9.52%), S. lentus, S. haemolyticus, S. hominis 4.76%. Mixed gram positive bacteria were S. aureus-S. haemolyticus dan S. lentus-E. faecalis 4.76%. Gram positive and gram negative bacteria were S. aureus-A. baumanii, S. aureus-S. haemolyticus-A. baumanii 4.76% each. Gram negative bacteria were A. baumanii and K. pneumoniae 4.76% each and contamination 9.52%. Conclusion: The profile of fungal and bacterial infections in inguinal erythrosquamous dermatoses mostly were tinea cruris. The result of fungal culture mostly were T. mentagrophytes. The result of bacterial culture mostly were gram positive bacteria, consist of S. aureus, S. epidermidis, S. lentus, S. haemolyticus, S. hominis, E. faecalis.

The Role of Human Papillomavirus in Bowenoid Papulosis Yuli Wahyu Rahmawati; Dwi Murtiastutik; Sjahjenny Mustokoweni
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Human Papillomavirus (HPV) infection can be associated with a variety of cutaneous as well as mucosal manifestations. Some types of HPV are associated with increased risk of epithelial malignancies; these have been divided into low-risk and high-risk types based on their oncogenic potential. Bowenoid papulosis (BP) strongly associated with high risk type. Purpose: To provide information to health workers, in order to be more concern about BP.Review: The term BP refers to multifocal papular lesions on the genitalia with histological features similar to squamous cell carcinoma (SCC) in situ or Bowen’s Disease (BD). Its clinical manifestation is characterized by multiple brownish or erythematous papules located in the anogenital region, affecting mostly young adults with an active sex life. Clinically, it must be differentiated from seborrheic keratosis, and melanocytic nevus. Bowenoid papulosis is strongly associated with HPV 16.Conclusion: The natural course of BP is unpredictable, the lesions may increase, decrease, and even disappear spontaneously. Progression to an invasive SCC has been estimated in 2.6% of cases, HPV type 16 is the most frequent causative agent of BP.

Profile of Serum Interferon Gamma Induced Protein 10 in Borderline Leprosy Patients with and without Type 1 Leprosy Reaction Agustina Tri Pujiastuti; Indropo Agusni; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Leprosy reaction is an acute episode in leprosy characterized by acute inflammation sometimes accompanied with systemic symptoms. Leprosy type 1 reaction often occurs in borderline leprosy patients. Leprosy type 1 reaction can cause peripheral nerve damage through neuritis that can lead to disability. Interferon-γ induced protein 10 (IP10) is a chemokine with chemotaxis function to various immune cells such as macrophage, dendritic cells, Natural Killer cells, and activated T lymphocites. Several studies have found an increase of IP10 serum level when type 1 reaction occurred. Purpose: To evaluate the profile of IP10 serum levels in borderline patients with and without type 1 leprosy reaction. Methods: This is a descriptive cross-sectional study, with 34 borderline leprosy patients of which 17 had leprosy type 1 reaction and 17 without reaction that qualify inclusion and exclusion criteria. Results: Mean serum IP10 levels in leprosy type 1 reaction groups are 594,123 ± 327,628 pg/mL and 331,648 ± 101,819 pg/mL in groups without reaction. Conclusions: Serum IP10 levels in borderline leprosy patient with type 1 reaction is higher than patients without reaction, although confounding factors in borderline leprosy patients with type 1 reaction that can influence serum IP10 levels cannot be eliminated. Further studies are needed to reveal the role of IP`10 in type 1 leprosy reaction.

Successful Combination Therapy of Acne Keloidalis Nuchae Kartika Ruchiatan; Erfina Rohana Sormin; Reti Hindritiani; Asmaja Soedarwoto; Hendra Gunawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne keloidalis nuchae (AKN) is a chronic, inflammatory, idiopathic disorder of hair follicle, characterized by keloidal papules or plaques on the nape and occipital scalp. Various therapies have been reported to treat AKN with various results. Purpose: To observe the efficacy of combination therapy for AKN. Case report: A 19-year-old man presented with multiple pruritic papules, 0.1–0.3 cm in diameter on the nape and occipital area. The histopathological examination revealed neutrophil, eosinophil, and plasma cell infiltration in infundibulum, which was consistent with AKN pathological patterns. Discussion: Combination therapy consisted of 0.025% tretinoin cream, 0.1% mometasone furoate cream, intralesional triamcinolone acetonide 5 mg/ml, and doxycycline 2x100 mg. The improvement was initially observed on 2nd week of follow up, as the lesions had reduced in size and number, and the improvement became more significant on 4th week of follow up. Conclusion: Combination therapy of topical tretinoin, topical and intralesional steroid, and systemic doxycycline shows good result and can be considered in the management of AKN.

Profile of Melasma Patients: A Retrospective Study Alfrid Asditya; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Melasma is a common hypermelanotic condition that can be frustrating to patients, thus appropriate diagnosis and management of melasma is required. Purpose: To evaluate patient’s profile, diagnosis, and management of melasma. Methods: Retrospective study of new patient in Cosmetic Division, Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital, Surabaya from January 2011 until December 2013. Result: Total new patient of melasma in Cosmetic Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 2011 until December 2013 (3 years) is 869 patients. Conclusion: Appropriate diagnosis, treatment, and education is needed to manage melasma because of the chronicity and progressivity of this disease.

Anti-inflammatory Activity of Ointment in Water Soluble Base of Volatile Oil of Syzygium aromaticum with Variation Composition of Oleic acid and Propylene glycol as Enhancer Dewi Rahmawati; Nining Sugihartini; Tedjo Yuwono
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: The dosage form of ointment clove essential oil in water-soluble base has proven efficacious as anti-inflammatory with eugenol as active substance. Further research to increase the penetration of eugenol in penetrating the skin layer needs to be done with the addition of enhancer. Purpose: To determine the anti-inflammatory activity of ointment base water soluble of clove essential oil with composition variation of oleic acid and propylene glycol as enhancers. Methods: The ointment was made using fusion method. Addition of enhancer composition refers to the system Simplex Lattice Design for Formula 1, Formula 2 and Formula 3 successively used: 100% oleic acid; 50% oleic acid: 50% propylene glycol; and 100% propylene glycol. The evaluation of anti-inflammatory activity was based on the parameters epidermal thickness, the number of inflammatory cells, and the number of cells that expressed cyclooxygenase-2 (COX-2). The anti-inflammatory tests used male mice strain BALB/C which was induced by croton oil. Results: The enhancer composition of oleic acid and propylene glycol affect the activity of ointment clove essential oil in water-soluble base. Conclusion: The increasing composition of propylene glycol improved anti-inflammatory activity of ointment.

Tinea Capitis Favus-Like Appearance: Problem of Diagnosis Dwi Ratna Adisty; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Tinea capitis (TC) is an infection of scalp, hair follicles, and the surrounding skin, caused by dermatophyte fungi. Favus, a chronic inflammatory tinea capitis typically seen in Trichophyton schoenleinii infection. Favus is characterized by ‘scutula’. Favus may result in cicatricial alopecia. Purpose: To understand the clinical manifestation and management of tinea capitis. Case: A girl, 8 year-old, 18 kg, with thick crust located at the center of the head since 3 months, became spreading overtime. There were itchy sensation, no fever, no pain. There was history of an itchy red patch on her neck which diminished with topical antifungal. Dermatological examination revealed multiple thick brown-yellow crust sharply marginated, there were erosion and alopecia area beneath the crust. There were no sign of inflammation, no pustule, no enlargement of cervical and occipital lymphnodes on palpation. Discussion: Wood’s light examination showed no fluorescence and potassium hydroxide (KOH) showed no spores. Result of fungal culture was no colony growth. Patient was given griseofulvin 20 mg/kg body weight/day, wet dressing, and ketoconazole 2% shampoo twice weekly. Good clinical result shown after 10 weeks. Conclusion: Diagnosis of TC established based on history taking, clinical findings, Wood’s light examination, KOH preparation, fungal culture. A negative culture may arise because antifungal treatment had been used prior to collection of the specimen. Griseofulvin still became the drug of choice for tinea capitis even there are new generations of antifungal.

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