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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 10 Documents
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Search results for , issue "Vol 3 No 2 (2017)" : 10 Documents clear
The Effect of Purple Sweet Potato Extract on The Circulating Endothelial Cell (CEC) levels in Rat Model of Diabetes Emilia Puspita Sari; Edi Junaidi; Heni Fatmawati
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5070

Abstract

Diabetes mellitus is a metabolic disease with impaired metabolism of carbohydrates, fats and proteins are characterized by hiperglycemia caused by insufficiency of insulin secretion and insulin resistance. Diabetes mellitus is the leading cause of death in Indonesia, especially in developing countries. Most (90%) classified as type 2 diabetes mellitus and 10% of type 1 diabetes mellitus. In DM, increased oxidative stres. DM oxidative stres due to the increase of free radicals in the body. Oxidative stres can lead to irreversible endothelial injury that would lead to the loss of endothelial cells characterized by the expression of CD 146. Ipomoea batatas L. anthocyanin-containing compound is an antioxidant that can reduce free radicals and reduce oxidative cell damage caused by free radicals. From the analysis of the data obtained Ipomoea batatas L. mempuyai influence on the content of the CEC of 42.5%.
Effectiveness Test of Basil Leaf (Ocimum basilicum) Extract As Bioinsecticide In Mosquito Coil to Mosquito Aedes aegypti Death Indri Ramayanti; Kamalia Layal; Putri Utami Pratiwi
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5063

Abstract

Aedes aegypti is the vector of Dengue Haemorhagic fever. One of the method to prevent the spread of dengue fever is vector control. Principal activity to control this vector might decrease their population as transmitter of disease. One way of controlling mosquitoes vectors is using a bioinsecticide from basil leaf. Basil leaf extract has bioinsecticide effect to Aedes aegypti because basil leaf has some active compounds, such as Flavonoid, Saponin, Tannin and essential oils. These compound are toxic to mosquitoes. The purpose of this study was to determine the effectiveness of basil leaf (Ocimum basilicum L.) extract as mosquito coil against Aedes aegypti. The design of this study is xperimental study with 450 subjects of Aedes aegypti. Subjects were divided into six groups. They were 0% (negative control), 25%, 50%. 70%, 90% extract and Transfluthrin 0,03% (positive control). Each group contained 25 mosquitoes. Observation were carried out for 60 minutes with 10 minutes intervals and three times of repetition. The Data were analyzed by probit to calculate the value of Lethal consentration. The result of Probit Analyze showed that LC50 was at a concentration of 41,81% and LC90 was at concentration of 101.66%. The results showed that the extract of basil leaf (Ocimum basilicum L.) effective as Aedes aegypti bioinsecticide in mosquito coil.
Humoral Response to Anopheles maculatus and Anopheles sundaicus Salivary Gland Proteins Yunita Armiyanti; Widodo widodo; Loeki Enggar Fitri; Teguh Wahju Sardjono
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5071

Abstract

The salivary gland of female Anopheles mosquito has important role in malaria transmission by salivary proteins that enhancing Plasmodium transmission. The mosquito saliva contains vasomodulatory and immunomodulatory components that inhibit the physiological response of the host. Therefore, the pathogen infects the host without any resistance. The salivary proteins also induce the production of antibody IgG in the host after exposed by the Anopheles mosquito bites repeatedly. This study aims to measured the antibody response of inhabitants living in malaria endemic areas (Kalirejo viilages, Kokap, Kulonprogo) to salivary gland proteins of An. maculatus and An.sundaicus. The level of antibody response was measured by ELISA and analyzed with T test or Anova test for normal distribution of data and Mann Whitney test or Kruskal Wallis test for the data were not normally distributed. The result showed that the level of anti-salivary gland homogenate IgG from sera of people living in malaria endemic area was significantly higher than people living in non-malaria endemic area and negative control (p<0.05). Sera from inhabitants living in Kalirejo village showed that the level of antibody response to both salivary gland homogenate of An.sundaicus and An.maculatus were not significantly different (p<0.05). It was concluded that exposure to An.maculatus and An.sundaicus bites repeatedly could trigger the production of anti-salivary gland proteins IgG antibodies that recognized antigenic proteins from the salivary glands.
Effects of Herbal Forte Rice as Replacement of Carbohydrate to Insulin Resistance in Patients with Type 2 Diabetes in Sumbersari Health Center Jember Dina Faizatur Rahmah; Ancah Caesarina Novi Marchianti; Rini Riyanti
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5064

Abstract

The population of type 2 diabetes mellitus sufferer continuously increases due to the increase of insulin resistance characterised by the rise of the secretion insulin. Insulin resistance is affected by several factors such as the lack of physical activity, obesity, and unhealthy diet. One of the characteristics of the unhealthy diet is the high consumption of carbohydrates.Whereas Indonesian prefers to have carbohydrate sources from food which has high glycemic index such as rice so thatit makes the glucose in the blood increased rapidly. This condition causes more and faster insulin secretion and can affect insulin resistance. The purpose of this study is to know the effectiveness of herbal forte rice as a substitute of the main carbohydrate in the state of hyperinsulinemia suffered by 15 patients of type 2 diabetes mellitus in Puskesmas (community health center) Sumbersari Jember. This study is a clinical trial with a quasi experimental method and crossover design. In this study, the sample is interviewed by characteristics (age, gender) and the early consumption patterns using 24-hour food recall three times at different times. Samples acted as a control group once the experimental group. The control group did not receive any treatment, while the experimental group received the herbal forte rice as much as 100 grams for 7 consecutive days in the morning (at 06.30 am). After washing out period for 9 days, experimental group switched into control group. At the end of the period (7 days), data of fasting blood glucose and fasting insulin were collected then counted by HOMA-IR formula. The result of the study based on the paired t test p=0.001 in comparison to the state of the control and experimental group. The conclusion of this study is there is a changing state of insulin resistance with the replacement of food based on glycemic index.
The Difference in Lemuru Fish Oil Duration of Administration on Connective Tissue Fibroblast Cell Count in Rheumatoid Arthritis Rat Model Asyirah Mujahidah Fillah; Rena Normasari; Dwita Aryadina Rachmawati
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5062

Abstract

Rheumatoid arthritis is a joint chronic inflammation process leadingto progressive distruction.Cytokinessecreted from chronic inflammation increases fibroblast cell number that synthesize matrix metalloproteinase. Non steroidal anti inflammation drugs administrated to lighten inflammation symptoms had several side effects that increase the urge to discover an alternative antiinflammation with lower side effect like lemuru fish oil. This true experimental study with randomized post test only control group design aimed to investigate the difference in lemuru fish oil duration of administration on connective tissue fibroblast cell count in rheumatoid arthritis rat model. The One Way Anovatestrevealed that there are at least two group means that are statistically significant different from each other with a p value of 0,004. Post Hoc LSD analysis result indicate a significant difference after21 days duration of administrationcompared to 7 days administration with significance value of 0,038.It can be concluded that there is a significant difference in lemuru fish oil administration after21 days duration.
Difference in The Incidence Severe Preeclampsia and Eclampsia between Maternal Age 20-34 Years and >34 Years in dr. Soebandi Hospital Jember Muhammad Fakhri Ali; Yonas Hadisubroto; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5065

Abstract

Maternal Mortality Rate (MMR) in Indonesia is still high. The maternal mortality rate continues to rise due to hypertension, one of which is caused by pre-eclampsia and eclampsia. Many factors cause preeclampsia, including advanced maternal age. The purpose of this study was to determine the effect of advanced maternal age during pregnancy with severe preeclampsia and eclampsia in RSD dr. Soebandi Jember. This study used cross sectional approach using 264 samples were divided into two groups, there are pregnant women aged 20-34 years and >34 years. The results of data analysis using Chi Square for severe preeclampsia and obtained p = 0.015 and OR = 2.494, which means there is a significant difference in comparison severe preeclampsia between gestational age of 20-34 years and >34 years. At the age of 20-34 years from 216 samples found 28 people suffering from severe preeclampsia (12.9%). Whereas at the age of mother> 34 years of 48 people found 13 people (27.1%) suffered severe preeclampsia Results of data analysis obtained eclampsia using Fisher and p = 0.554, which means there are no significant differences in comparison eclampsia between gestational age of 20-34 years and >34 years. At the age of 20-34 years from 216 samples found 3 people suffering from eclampsia (1.38%). While at mother age> 34 years from 48 people found 1 person (2.08%) suffered eclampsia.
The Effect Of Folic On Different Dosage Level Against Retina Destruction Level Of Mice With Peroral Methanol 50% I Gusti Ngurah Agung Darma Putra; Al Munawir; Sugiyanta sugiyanta
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5066

Abstract

In recent years, there are many methanol poisoned cases. Methanol poisoned cause of blindness, CNS problem, and metabolic acidosis. Folic acid is the one of many medicinal treatment for methanol poisoned. Folic acid has important role on methanol metabolism in our body. The aim of the study was to known the effect of addition folic acid on retina damage level of methanol poisoned. The method is experimental laboratories (true experiment design) with post test only control group design. The study included 5 separate test. The subject were mice which in 2 - 3 months age and had weight about 25 - 35 gr. There were 5 groups subject in the study. There were control group which given usual meals for mice and aquadest, negative control group which given methanol 7gr/ kgBW, treatment group 1,2, and 3 were given methanol 7gr/kgBW and folic acid 1 mg/kg BW, 3mg/kgBW, and 5 mg/kgBW. The treatment was given about 24 hours, then the eyes of the mice were taken to made blood smear. Damage of eyes were evaluated based score determined before. It can be concluded that addition folic acid can reduce retina damage level of metanol poisoned.
The effect of Kefir on The Immune Response of Healthy Volunteers In Vitro Desie Dwi Wisudanti
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5067

Abstract

Kefir is a functional foodstuff of probiotics, made from fermented milk with kefir grains containing various types of beneficial bacteria and yeast. There have been many studies on the effects of oral kefir on the immune system, but few studies have shown the effect of bioactive components from kefir (peptides and exopolysaccharides/ kefiran), on immune responses. The purpose of this study was to prove the effect of kefir supernatant from milk goat on healthy immune volunteer response in vitro. The study was conducted on 15 healthy volunteers, then isolated PBMC from whole blood, then divided into 5 groups (K-, P1, P2, P3 and P4) before culture was done for 4 days. The harvested cells from culture were examined for the percentage of CD4+ T cells, CD8+ T cells, IFN-γ, IL-4 using flowsitometry and IL-2 levels, IL-10 using the ELISA method. The results obtained that kefir do not affect the percentage of CD4+ T cells and CD8+ T cells. The higher the concentration of kefir given, the higher levels of secreted IFN- γ and IL-4, but a decrease in IL-2 levels. Significant enhancement occurred at levels of IL-10 culture PBMC given kefir with various concentrations (p <0.01), especially at concentrations of 1%. These results also show the important effects of kefir bioactive components on immune responses. The conclusion of this study is that kefir can improve the immune response, through stimulation of IL-10 secretion in vitro.
Effect of Leg Length Discrepancy to the Hip Function on Post Hemiarthroplasty Patients in Jember Yosalfa Adhista Kurniawan; Muhammad Hasan; Rena Normasari
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5068

Abstract

Hip fractures in elderly patient are often treated with hemiarthroplasty. Hemiarthroplasty can cause various complications, one of which is leg legth descrepancy (LLD). The function of the hip joint is reduced due to these complications. Previous studies have shown contradictive results regarding the relationship of LLD to the function of the hip joint in post-arthroplasty patient's. This type of research is observational with retrospective study. The population in this study came from 2 hospitals in Jember was 53 patients and the sample was 30 people. LLD is measured by true leg length and apparent leg length, whereas hip joint function is measured by Oxford Hip Score (OHS). The data were tested by using Spearman correlation test. In conclusion, there was a moderate relationship between LLD true leg length to the function of the hip joint. This study does not support the implications of the LLD to the hip function because of weak relationship between LLD true leg to the hip function and moderate relasionship between LLD apparent leg length to the hip function.
Immunoblotting Detection of Immunoglobulin G Post Subcutaneous Immunization Of Protein Hemaglutinin Pili Klebsiella pneumoniae 12,8 kDa on Mice BALB / C Dini Agustina
Journal of Agromedicine and Medical Sciences Vol 3 No 2 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i2.5069

Abstract

Klebsiella pneumoniae is the second most common cause of community infection and nosocomial infections due to Gram-negative bacteria. These bacteria are able to induce the onset of immune response, especially humoral immune response.Humoral immunity acts through the activation of B cells that produce antibodies. Antibodies, especially IgG, will cause encapsulated bacteria such as Klebsiella pneumoniae to be better phagocytosed. The purpose of this study was to determine the IgG response to hemagglutinin protein pili K. pneumoniae 12.8 kDa. The method used in this research is Immunoblotting method with western blot and dot blot. The primary antibodies used for the western blot and dot blot tests were isolated from BALB / C mice serum induced with the subcutaneous pili K. pneumoniae 12.8 kDa protein. To get the standard in assessing the results of dot blot were used Corel Photo-paint X6. The semi-quantitative result of dot blot was obtained with the strongest reaction of the antibody dilution at 1/100 while the antigen dilution titer at 1 / 10.000. Results from western blotting showed a positive reaction of the pili protein subunit with a molecular weight of 128.1 kDa, 114.4 kDa, 64.9 kDa, 31.1 kDa, 27.7 kDa, 24.8 kDa, 20.9 kDa, 12.8 kDa, and 10 kDa. The conclusion of this study is the immunization of hemagglutinin pili K. pneumoniae 12.8 kDa subcutaneously capable of inducing the formationof Immunoglobulin G in BALB / C mice.

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