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Pengaruh Pemberian Gel Doksisiklin terhadap Jumlah Fibroblas pada Proses Penyembuhan Dermatitis Paederus akibat Racun Kumbang Tomcat (Paederus sp.) pada Mencit (The Effect of Doxycycline Gel on The Number of Fibroblast in Paederus Dermatitis Healing Silvi Ahmada Chasya; Al Munawir; Erma Sulistyaningsih
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Paederus dermatitis caused by rove beetle makes the tissue damage called dermonecrosis. The MMP on pederin toxins from the symbiosis of rove beetle (Paederus sp.) and Pseudomonas aeruginosa is supposed can delay the wound healing process. Doxycycline gel as a MMP inhibitor is believed can accelerate the healing process. The purpose of this study was to determine the effect of doxycycline gel on the healing process of Paederus dermatitis by observing the number of fibroblasts as an indicator. This study used 40 mice, were divided into four major groups, those were normal control group, the negative control, treatment groups with doxycycline gel 1% and 5%. Termination was performed on days 1, 3, 5, 7, and 15. Data was obtained by calculating the number of fibroblasts per field of view, then processed in ImageJ and tested statistically with comparation test of One Way Anova. The average number of fibroblasts per field of view in treatment groups was higher. The peak occurred on day 7 and decrease on day 15. It indicated that the topical administration of doxycycline gel on Paederus dermatitis can accelerate healing process, showed by the increasing in average number of fibroblasts per field of view. Keywords: doxycycline gel, fibroblast, paederus dermatitis
Efektivitas Chlorhexidine sebagai Inhibitor MMP-2 dan MMP-9 dalam Proses Dermonekrosis Akibat Racun Kumbang Tomcat (Paederus sp.) (The Effectiveness of Chlorhexidine as MMP-2 and MMP-9 inhibitor in Dermonecrotic Process due to Rove Beetles Toxin (Paederus sp.)) Putri Erlinda Kusumaningarum; Al Munawir
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Paederus dermatitis is dermonecrotic condition caused by Rove beetles (Paederus sp.). Paederin toxin come from endosymbiotic between rove beetles and Pseudomonas aeruginosa and can produces MMP-2 and MMP-9. Chlorhexidine is expected to be alternative therapy and prevention of dermatitis paederus due to it's MMP inhibitor and bacteriostatic effect. The study aimed to investigated the effectivity of chlorhexidine as MMP-2 and MMP-9 inhibitor in dermonecrotic process due to rove beetles toxin. Research groups consisted of negative control (paederin toxin), treatment 1 (paederin toxin + chlorhexidine 0,012%), treatment 2 (paederin toxin + chlorhexidine 0,06%), treatment 3 (paederin toxin + chlorhexidine 0,3%), and normal control (aquadest). As much as 9,3 µg paederin toxin and chlorhexidine are injected to the well of 8% acrylamide gel containing gelatin. Measuring of band density using ImageJ showed a decreasing of MMP-2 and MMP-9 band density. Negative control group was considered to have 1 of relative optical density. The result showed that chlorhexidine 0,06% can inhibits 21,6% MMP-2 activities and at 0,3% can inhibits 16,4% MMP-9 activities. One way ANOVA test show different significantly between negative control and treatment group (p<0,05). In conclusion chlorhexidine has potency as MMP-2 and MMP-9 inhibitor in dermonecrotic process due to Rove Beetles toxin. Keywords: Rove beetles(Paederus sp.), dermonrcrotic, MMP-2, MMP-9, chlorhexidine
Duration of Gadget Usage Affects Eye Fatigue in Students Aged 16-18 Years Bukhori, Saiful; Munawir, Al; Rahmat, Nafolion Nur
Health Notions Vol 1 No 4 (2017): October-December 2017
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Abstract

Gadget is one of the innovations generated by humans in order to simplify the work or for the benefit of everyday because with gadgets will easily get various kinds of information needed with a single press. Gadgets easily accessible by everyone one of them is a student or schoolchild so that it is possible for school children have complaints on the eyes if too concentrated on gadgets. Student should know Factors associated with vision complaints such as gender and length of use of gadgets in a day. The purpose of this study was to determine the effect of long use of gadgets against eye fatigue. This research is analytic observational with cross sectional method. The population in this study were all students in SMA Zainul Hasan Gengong Problinggo which used gadgets as many as 296 students. A large sample calculation using the formula Isaac and Michael, amount to 165 students. Sampling technique with simple random sampling and carried out in August 2017. To determine the effect of the long use of gadgets against eye fatigue is used chi-Square test. The results of this study as many as 58 respondents who long using gadgets and fatigue, 22 respondents used gadget for &lt; 2 hours, 3 respondents used gadget 2-3 hours, 5 respondents used gadgets for &gt;3-4 hours, 4 respondents used gadget for&nbsp; &gt; 4-6 hours, 23 respondents usedgadget for&nbsp; &gt;6-8 hours, and 1 respondents used gadget &gt; 8 hours. then. Respondents who long used gadget and&nbsp; did not experience some eye fatigue 107 respondents, 43 respondents used gadget for &lt; 2 hours, 30 respondents used gadget 2-3 hours, 20 respondents used gadget for &gt; 3-4 hours, 3 respondents used&nbsp; gadget for &gt; 4-6 hours, 9 respondents used gadget for &gt;6-8 hours, and 2 respondents used gadget &gt; 8 hours. Chi-Square result is taken data P value &lt; 0,00 with&nbsp; α significance 0,05 so it takes conlusion H1 received if P value &lt;0,05 it means there is an effect of long time usage of gadget against eye fatigue in SMA 1 Zainul Hasan Genggong Probolinggo. Technological innovation is made in the purpose in order to simplify all human affairs hence from the human unknowingly also exposed negative impact of the use of gadgets one of them is eyestrain.
The Effects of Junk Food Consumption on Incidence of Early Puberty in Adolescent Females Munawir, Al; Wahyuningtyias, Farida; Kustin, Kustin
Health Notions Vol 1 No 4 (2017): October-December 2017
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Abstract

The transition between childhood and adulthood is the period of puberty. An important event in puberty is rapid body growth, the appearance of secondary sex features, menarche, and psychic changes. Menarche is too early to be associated with risk factors for some malignant disease such as ovarian cancer, breast cancer, and myoma. Hyperplasia cholecystitis, incidence of uterine cancer and risk of Non Insulin Dependent Diabetes Mellitus (NIDDM / Type II) as adults. The consumption of junk food tends to increase from year to year. The habit of consuming junk food among modern teenage children will affect the improvement of nutrition. This is because the fat content, animal protein and trans fat contained in junk food will trigger the release of hormones that affect the occurrence of menarche and the emergence of secondary signs in children faster than normal age. The purpose of this study analyzed the effect of junk food consumption on early puberty incidence in junior high school girls in Jember district. This study was conducted in two stages, the first quantitative observational analytic study with cross sectional design and the second stage of the laboratory using pre experimental design with one shot case study approach for the most frequently consumed food samples. The sample of this research is 88 female teenagers of junior high shool. Data analysis was processed using logistic regression statistic test of significance level p&lt;0,05. Result showed that there was significant effect between junk food consumption pattern on early puberty statistically p = 0,002 &lt; 0,05. From the laboratory test results also showed that the fat content of junk food on average over 20%. The conclusion are consumption habits, consumption time and percentage of fat consumed from junk food affect the incidence of early puberty in female teenagers, while the frequency of consumption does not affect the incidence of early puberty. Keywords: early puberty, junk food, fat
Anti-Metastatic Effect of Boiled Garlic Extract on A549 Lung Cancer Cells Line by FAK Mechanism Munawir, AL
Jurnal Kedokteran Brawijaya Vol 28, No 4 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

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Abstract

According to epidemiological and animal study, the daily intake of garlic have important role in decreasing of cancer prevalence and tumor metastasis. However, mechanism of anti-metastatic of garlic is not fully understood. In the present study, we examined the anti metastatic effect of a brief exposure to boiled garlic extract (BGE) on A549 Lung cancer cells. Cytotoxicity BGE on A549 lung cancer cells was tested using MTT Assay. Migration and invasion scratching wound assay A549 lung cancer cells was tested usingscratching wound assay and agarose dropt explants assay.The growth of A549 lung cancer cell was measured using Colony forming assay. To explore the molecular mechanism and effect of BGE on migration and invasion, western blotting was used to analyze the FAK/Paxillin pathway. We found that BGE inhibits the growth, migration and invasion  of A549 lung cancer cells at 300 µg/mL. Interestingly, BGE inhibits migration and invasion of A549lung cancer cells by decreasing the total of FAK and P-Y397 expression at 6 hours after a brief exposure, but not influence of the paxillin expression. We think the present finding demonstrate a novel anti-metastatic effect of garlic and suggests a certain garlic-derived compounds, BGE may be potential agent for inhibiting migration and invasion through decreasing the total of FAK and P-Y397 expression in the cancer cell.  Keywords: A549 lung cancer cells, boiled garlic extract, FAK mechanism, migration cell
Food Intake and Food Security as Determinants of Stunting Children Under Five Years Munawir, Al; Ningtyias, Farida Wahyu; Laili, Ayik Nikmatul
Health Notions Vol 2 No 1 (2018): January, 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Abstract

Stunting is a linier growth failure caused by chronic malnutrition or chronic infectious disease. Stunting became nutritional problem that need attention because it can influence quality of human resources. Factors associated with stunting, such as nutrition intake, household food security, and parenting. Three work area health centers in Jember such as Sumberjambe, Kasiyan, and Sumberbaru which has highest rate of stunting children under five years in 2006. The purpose of this research was to analyze the determinant of stunting children under five years. This research was analytical observational with case control design. This research was conducted in three work area health centers such as Sumberjambe, Kasiyan, and Sumberbaru in September to October 2017. The sample of this research was 71 case respondents and 71 control respondents. Sampling technique used cluster random sampling. Logistic regression statistic test with significant level p &lt; 0.05 was used to analyze the data. The result of this research showed that nutrition intake and household food security could influence incidence of stunting children under five years (each p-value was 0.00). Conclusion of this research was there significant influence noted between nutrition intake and food security on incidence of stunting children under five years.&nbsp;
Implementation of Islamic Nursing Care in Improving Patient Satisfaction Zulkarnain, Elfian; Munawir, Al; Musviro, Musviro
Health Notions Vol 1 No 4 (2017): October-December 2017
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Abstract

Hospital must have a superiority in order to survive and compete with other hospitals which have patients satisfaction oriented. One of the factors that influence the patients’ satisfaction is nursing care. Nursing care must relevant with Islamic rule that it was basic for nurses in practicing nursing care plan. The purpose of this research was to analyze the influence of Islamic nursing care phases of orientation, working, and termination on patients’ satisfaction level in Lumajang Islamic hospital. The respondent 92 people were taken by proportionate stratified random sampling. The instrument used was check list of Islamic nursing care phases of orientation, working, termination, and questionnaire of patients’ satisfaction. The result of ordinal regression test showed that there were significant influence in all phases of Islamic nursing care of orientation, working, and termination on patients’ satisfaction level in Lumajang Islamic hospital where p&lt;0.05 and wald &gt; 3.84/df (in orientation p = 0.000 and wald 14. 274; working p = 0.000 and wald 12.230; termination p = 0.000 and wald 20.850). Islamic nursing care which most significant was termination phase. Islamic nursing care was significantly influence on patients’ satisfaction; therefore it could be used as guidelines for nurses on practicing nursing care plans.
Management of Immunization in Public Health Center Related to The Universal Child Immunization (UCI) in Arjowinangun Health Center, Malang Ummah, Wiqodatul; Munawir, Al; Ningtyias, Farida Wahyu
Health Notions Vol 2 No 1 (2018): January, 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Abstract

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Pengaruh Faktor Predisposing terhadap Perilaku Ketepatan Pengisian Kode Penyakit Rawat Inap Pada Klaim JKN (Di Era Vedika (Verifikasi Di Kantor) Rumah Sakit Daerah Lumajang Nanda Prima; Al Munawir; Dewi Rokhmah
Jurnal MID-Z (MIDWIFERI ZIGOT) Vol 4 No 1 (2021): MAY
Publisher : Universitas Islam Jember

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Abstract

Pengajuan klaim pembiayaan pelayanan kesehatan oleh fasilitas kesehatan kepada BPJS Kesehatan diberikan jangka waktu paling lambat 6 bulan sejak pelayanan kesehatan selesai diberikan dan terdapat pengecualian pada beberapa hal. Mengingat pentingnya peran koder dalam melakukan ketepatan pengisian koding penyakit pada e-klaim, maka peneliti bermaksud melakukan penelitian untuk menelusuri determinan perilaku ketepatan pengisian kode penyakit yang dihasilkan koder rawat inap serta melihat faktor predisposing yang mempengaruhinya.Penelitian menggunkan desain penelitian deskriptif dengan pendekatan kualitatif. Metode pengumpulan data yang dilakukan pada penelitian ini yaitu dengan wawancara mendalam, dokumentasi dan Observasi, dengan jumlah informan sebanyak 5 informan. Informan utama pada penelitian ini adalah Koder berjumlah 2 orang dan verifikator Internal yang berjumlah 3 orang. Hasil analisis Faktor Predisposing berdasarkan segi pengetahuan, dalam hal ini koder memahami tentang klaim pending dan tidak hanya sekedar tahu terhadap klaim pending, koder dapat menyebutkan penyebab terjadinya klaim pending secara detail. Berdasarkan segi sikap, lebih ke kurang setuju dalam hal menerima klaim pending karena petugas harus meluangkan waktunya untuk mengerjakan berkas pending tersebut kembali namun petugas tetap bertanggung jawab (responsible). Dalam mengisian kode pada apliksi e-klaim tentu perlu diperhatikannya tanda pada kode penyakit. Vedika merupakan sistem yang dikembangkan oleh BPJS Kesehatan untuk mempercepat proses verifikasi klaim. Koder memahami tentang baik dalam hal klaim pending, pemberian kode icd 10 sehingga mempermudah dalam diagnosa. Adanya kode kombinasi juga akan mempengaruhi entry tata letak diagnosa utama dan sekunder pada e-klaim. Kata kunci: Perilaku; Pengisian Kode Penyakit; VEDIKA; Faktor Predisposing
Individual Characteristics, Antibody, Work Environment and Sick Building Syndrome (SBS) Ma’rufi, Isa; Ikmala, Riskita; Munawir, Al
Health Notions Vol 2 No 5 (2018): May 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Abstract

Sick Building Syndrome (SBS) is a collection of complaints that a person feels being inside of a building or a room. SBS happens to many employees who work indoors. The purpose of this study is to analyze the influence of individual characteristics, IgE antibodies, and work environment against the incidence of SBS in the employees of Telkom Jember. The research design used was case control. The results showed that there was influence of age, duration of work, IgE antibody, room temperature and humidity to the incidence of SBS on Telkom Jember employees with sig &lt;0,05. The results also showed that smoking habits, nutritional status, ventilation conditions, lighting and room dust levels do not affect the occurrence of SBS. Improvements that can be done are improvements to the working environment, especially in controlling the temperature and humidity of the room and healthy living the for employees. Keywords: SBS, IgE, Work environment