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INDONESIA
Indonesian Journal of Cancer
Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)
ISSN : 19783744     EISSN : 23556811     DOI : -
Core Subject : Health,
Health Professions
The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.
Arjuna Subject : -
Articles 448 Documents
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The Effect of Electroacupunture on the Percentage of Lymphocyte Count on the Peripheral Blood Smear of C3H Mice Breast Adenocarcinoma Model Kamalia, Rizki; Mihardja, Hasan; Srilestari, Adiningsih; Barasila, Atikah C; Thamrin Akib, Husniah Rubiana
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (726.552 KB) | DOI: 10.33371/ijoc.v12i1.551

Abstract

Background: Breast cancer patients often experience decreased the immune system such as a decreased of lymphocytes, which can increase mortality. Acupuncture is expected to be a therapeutic option to increase lymphocyte because current pharmacological therapy is very expensive with the risk of adverse event. This study aims to prove the action of Electroacupuncture (EA) as an immunomodulator for cellular immunity by increasing the percentage of lymphocytes of Peripheral Blood Smear (PBS) in C3H mice of breast adenocarcinoma model. Methods:Laboratory experimental study with post test only controls group design involving twenty PBS preparations taken from 20 C3H mice of breast adenocarcinoma models divided into 4 groups. Group K with no EA treatment, group P1 was given 1 time EA treatment, group P2 was given 2 times EA treatment and P3 was given 3 times EA treatments (with seven days interval). EA stimulation was performed at ST36 Zusanli, BL18 Ganshu, BL20 Pishu with frequency of 2 Hz for 15 minutes. Result:The mean weight of mice was 23.90 ± 3.03 gr in control group, 25.40 ± 1.54 gr in P1 group, 27.00 ± 3.87 gr in P2 group and 25.90 ± 5.83 gr in P3 group, with most of them were female mice. The mean volume tumor in mice of control group was 14.49 ± 2.75 mm3, 16.72 ± 6,40 mm3 in P1 group, 20.18 ± 5.94 mm3 in P2 group and 22.07 ± 6.51 mm3 in P3 group. The mean percentage of lymphocyte was 44.20 ± 15.72 in control group, 43.00 ± 11.70 in P1 group, 49.60 ± 7.02 in P2 group and 43.20 ± 13.10 in P3 group. The correlation between the number of electro­acupuncture treatments on the number of lymphocytes in the treatment group were compared to the control group with p = 0.811. Conclusions: Research acupuncture on cancer management has been done and provided good result. Acupuncture in particular EA has benefits in improving immunity by affecting lymphocyte enhancement. Acupuncture can be considered as adjuvant therapy in cancer patients breast. ABSTRAKLatar Belakang: Pada pasien kanker payudara sering terjadi penurunan sistemimun antara lain menurunnya limfosit, yang dapatm eningkatkan angka kematian. Akupunktur diharapkan dapat menjadi pilihan terapi untuk meningkatkan limfosit karena terapi farmakologi saat ini harganya sangat mahal dengan resiko efek samping. Penelitian ini bertujuan untuk membuktikan bahwa tindakan elektroakupunktur (EA) dapat berefek sebagaii mmunomodulator terhadap imunitas seluler dengan meningkatkan persentase limfosit sediaan apus darah tepi (SADT) pada mencit C3H model adenokarsinoma payudara. Metode: Penelitian eksperimental ini dilakukan dengan post test only control group design terhadap dua puluh sediaan apus darah tepi yang diambil dari 20 mencit C3H model adenokarsinoma payudara. Kelompok studi dibagi menjadi 4 kelompok yaitu Kelompok K tidak diberi perlakuan EA, kelompok P1 dilakukan EA 1 kali, kelompok P2 dilakukan EA 2 kali dan P3 dilakukan EA 3 kali. Tindakan EA dilakukan pada titik ST36 Zusanli, BL18 Ganshu, BL20 Pishu dengan frekuensi 2 Hz selama 15 menit. The
Identifikasi Isolat Antikanker Spons Hyrtios Erecta SWANTARA, I MADE DIRA; RITA, WIWIK SUSANAH; HERNINDYA, ANISA
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTIsolation, anticancer activity test, and identification of the toxic isolate from ethanol extract of the sponge Hyrtios erecta taken from Pari Island beach (Jakarta) has conducted. Extraction of the sponges was carried out by 70% ethanol at room temperature. Partition and purification of the compounds were done by column chromatography with the stationary phase of silica gel and the mobile phase of n-hexane-chloroform (2:8). Toxicity screening test was done based on Bhrine Shrimp Lethality Test (BSLT). In vitro anticancer activity test of the isolate was carried out using HeLa cell line. Identification of the compounds was performed by Gas chromatography-mass spectroscopy (GC-MS). Based on the results, it was found that the toxic isolate of H. erecta sponges has anticancer activity with IC50 of 30,497 ppm. Four compounds was detected from the anticancer isolate i.e: 4-nonylphenol; dibutyl phthalate; hexanedioic acid bis(2- ethylhexyl) ester; and cholesterol.ABSTRAKTelah dilakukan isolasi, uji aktivitas antikanker, dan identifikasi isolat toksik yang berasal dari ekstrak etanol spons Hyrtios erecta yang diambil dari perairan Pulau Pari (Jakarta). Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70% pada temperatur kamar. Pemisahan dan pemurnian komponen menggunakan kromatografi kolom denganfase diam silikagel dan fase gerak n-heksana-kloroform (2:8). Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat toksik tersebut menggunakan sel HeLa. Senyawanya diidentifikasi menggunakan Gas chromatography-mass spectroscopy (GC-MS). Berdasarkan hasil penelitian ini diperoleh bahwa isolat toksik spons H. erecta bersifat antikanker dengan IC50 sebesar 30,497 ppm. Pada isolat antikanker tersebut terdeteksi empat senyawa, yaitu 4-nonylphenol; dibutil phtalat; ester heksadioat bis(2-etilheksil); dankolesterol.
Mixed Adeno and Neuroendocrine Carcinoma of The Ovary: Case Report MANNA, JOHANA SENSY LENI; SASPRIYANA, KADE YUDI; MAHENDRA, I NYOMAN BAYU; SUWIYOGA, KETUT; MAKER, LUH PUTU IIN INDRAYANI
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : Indonesian Journal of Cancer

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Abstract

Reporting two cases of mixed adenocarcinoma and neuroendocrine carcinoma of the ovary. A case report two cases of an ovarian cyst suspect malignancy after complete surgical staging in woman aged 39 year old and 72 year old. By this case report, we want to know prognosis of the malignancy. Mixed adenocarcinoma and neuroendocrine carcinoma of the ovary of the first case arised from mature cystic teratoma, and second case as metastatic process from gastrointestinal tract. Mixed adenocarcinoma and neuroendocrine carcinoma is rare hystologic type of ovarian cancer. Need further exploration to know the survival of this hystologic type.ABSTRAKArtikel ini melaporkan dua kasus, yaitu mixed adenocarcinoma dan neuroendocrine carcinoma ovarium, dua kasus kista ovarium curiga ganas pada pasien berusia 39 tahun dan 72 tahun. Terhadap kedua pasien dilakukan komplit surgical staging. Melalui laporan kasus ini, diharapkan bisa diketahui prognosis kasus. Mixed adenocarcinoma dan neuroendocrine carcinoma ovarium pada kasus pertama timbul dari teratoma matur kistik, sedangkan kasus kedua merupakan penyebaran dari traktus digestivus. Mixed adenocarcinoma dan neuroendocrine carcinoma merupakan tipe histologi kanker ovarium yang jarang. Ia membutuhkan eksplorasi lebih lanjut untuk mengetahui survival dari tipe histologi ini.
Deteksi Dini Karsinoma Sel Basal TAN, SUKMAWATI TANSIL; GHAZNAWIE, MAHMUD; REGINATA, GABRIELA
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTBasal Cell Carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells that originate in the basal layer of the epidermis, which is locally invasive, aggressive, destructive, and rarely metastasize. BCC is more common in the elderly. Etiopathogenesis associated with BCC is genetic, environmental, and most often is exposure to ultraviolet light. Clinically, there are five types of BCC, which are nodular, superficial, morpheaform, pigmented, and fibroepitelioma Pinkus. Early detection of skin cancer can be done with self skin examination. Definitive diagnosis of malignancy is determined by anatomical pathology examination. However, for very early BCC lesion, it’s difficult to determine with hematoxylin eosin staining. Therefore, it is uses Ber-EP4 staining which is specific and highly sensitive for early BCC growing as budding in basal layer of the epidermis and follicles. This finding is particularly significant in the development of molecular pathology and clinical management of BCC lesions or suspected BCC. ABSTRAKKarsinoma Sel Basal (KSB) merupakan neoplasma ganas dari sel yang tidak mengalami keratinisasi pada lapisan basal epidermis, bersifat invasif lokal, agresif, destruktif, dan jarang bermetastasis. KSB lebih sering terjadi pada usia lanjut. Etiopatogenesis yang berkaitan dengan KSB adalah genetik, lingkungan, dan yang paling sering adalah paparan sinar ultraviolet. Secara klinis, terdapat lima tipe KSB, yaitu nodular, superfisial, morpheaform, pigmented, dan fibroepitelioma Pinkus. Deteksi dini kanker kulit dapat dilakukan dengan pemeriksaan kulit sendiri (SAKURI). Diagnosis pasti keganasan ditentukan dengan pemeriksaan patologi anatomi. Namun, untuk lesi sangat dini KSB sulit ditentukan dengan pewarnaan hematoksilin eosin. Oleh karena itu, digunakanlah pewarnaan Ber-EP4 yang bersifat spesifik dan sangat sensitif untuk KSB dini yang tumbuh sebagai tunas di lapisan basal epidermis dan folikel. Temuan ini sangat berarti dalam pengembangan patologi molekuler dan penanganan klinis lesi KSB atau yang dicurigai KSB.
Identifikasi Isolat Antikanker Spons Hyrtios Erecta SWANTARA, I MADE DIRA; RITA, WIWIK SUSANAH; HERNINDYA, ANISA
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.135 KB)

Abstract

ABSTRACTIsolation, anticancer activity test, and identification of the toxic isolate from ethanol extract of the sponge Hyrtios erecta taken from Pari Island beach (Jakarta) has conducted. Extraction of the sponges was carried out by 70% ethanol at room temperature. Partition and purification of the compounds were done by column chromatography with the stationary phase of silica gel and the mobile phase of n-hexane-chloroform (2:8). Toxicity screening test was done based on BhrineShrimp Lethality Test (BSLT). In vitro anticancer activity test of the isolate was carried out using HeLa cell line. Identification of the compounds was performed by Gas chromatography-mass spectroscopy (GC-MS). Based on theresults, it was found that the toxic isolate of H. erecta sponges has anticancer activity with IC50 of 30,497 ppm. Four compounds was detected from the anticancer isolate i.e: 4-nonylphenol; dibutyl phthalate; hexanedioic acid bis(2-ethylhexyl) ester; and cholesterol. ABSTRAKTelah dilakukan isolasi, uji aktivitas antikanker, dan identifikasi isolat toksik yang berasal dari ekstrak etanol spons Hyrtios erecta yang diambil dari perairan Pulau Pari (Jakarta). Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70% pada temperatur kamar. Pemisahan dan pemurnian komponen menggunakan kromatografi kolom dengan fase diam silikagel dan fase gerak n-heksana-kloroform (2:8). Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat toksik tersebut menggunakan sel HeLa. Senyawanya diidentifikasi menggunakan Gas chromatography-mass spectroscopy (GC-MS). Berdasarkan hasil penelitian ini diperoleh bahwa isolat toksik spons H. erecta bersifat antikanker dengan IC50 sebesar 30,497 ppm. Pada isolat antikankertersebut terdeteksi empat senyawa, yaitu 4-nonylphenol; dibutil phtalat; ester heksadioat bis(2-etilheksil); dan kolesterol.
Uji Diagnosis Ultrasonografi Strain Ratio Elastography Dihubungkan dengan Histopatologi pada Palpable Mass Payudara di RSUP Dr. Hasan Sadikin, Bandung SOEKERSI, HARI; MAHADIAN, FERDI
Indonesian Journal of Cancer Vol 11, No 2 (2017): April - June
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACT Strain ratio elastography ultrasound of palpable mass of the breast is one of ultrasound examination based on semiquantitative analysis, is currently widely used to assess tissue stiffness that vary. Strain ratio elastography ultrasound is expected to be able to establish a quick and proper diagnosis to get the right therapy resulting in lower morbidity and mortality in breast carcinoma. Strain ratio elastography ultrasound have been more useful on the morphology of lesions such as suspicious atypical benign (BIRADS 3), suspected malignant (BIRADS 4), suggestive of malignancy (BIRADS 5). The aim of this study to determine the results of the diagnostic tests strain ratio elastography ultrasound associated with histopathology in palpable breast mass in Dr. Hasan Sadikin General Hospital. This research is an analytic observational study and a diagnostic test of strain ratioelastographyultrasound associated with histopathology in palpable breast mass with a model to assess the validity of cross sectional. Sampling was conducted prospectively and performed in the Department of Radiology Dr. Hasan Sadikin General Hospital Bandung from November 2016 to January 2017. Data analysis using univariate analysis and bivariate analysis and Chi Square test. Results, the subject of study are 32 female patients, the youngest are 21 years old and the oldest are 72 years old. The results of diagnostic tests strain ratio elastography ultrasound in differentiating palpable breast mass after being confirmed by histopathology in Dr. Hasan Sadikin General Hospital Bandung with a sensitivity 81.5%, specificity 80.0%, accuracy of 81.3%, PPV 95.7% and NPV 44.4%. Conclusion: strain ratio elastography ultrasound has value of sensitivity and specificity that is high enough in differentiating palpable breast mass after being confirmed by histopathology in Dr. Hasan Sadikin General Hospital Bandung.ABSTRAK Ultrasonografi (USG) strain ratio elastography pada palpable mass payudara yang merupakan salah satu turunan dari pemeriksaan USG berdasarkan analisis semikuantitatif, saat ini banyak digunakan untuk menilai kekakuan jaringan yang bervariasi. Dengan USG strain ratio elastography diharapkan dapat mendiagnosis dengan tepat dan cepat untuk mendapatkan terapi yang tepat sehingga menurunkan angka morbiditas serta mortalitas pada karsinoma payudara. USG strain ratio elastography lebih bermanfaat pada morfologi lesi-lesi atipikal seperti curiga jinak (BIRADS 3), curiga ganas (BIRADS 4), atau sugestif keganasan (BIRADS 5). Histopatologi merupakan baku emas untuk mendiagnosis palpable mass dan non palpable mass payudara. Penelitian ini bertujuan mengetahui hasil uji diagnosis USG strain ratio elastography dihubungkan dengan histopatologi pada palpable mass payudara di RSUP Dr. Hasan Sadikin, Bandung. Penelitian ini merupakan studi observasional analitik dan merupakan suatu uji diagnosis dari USG strain ratio elastography dihubungkan dengan histopatologi pada palpable mass payudara dengan model cross sectional untuk menilai validitas. Pengambilan sampel dilakukan secara prospektif dan dilakukan di Departemen Radiologi/ RSUP Dr. Hasan Sadikin, Bandung, dari November 2016 sampai Januari 2017. Data dianalisis menggunakan analisis univariabel dan bivariabel menggunakan uji Chi square. Hasil penelitian menunjukkan subjek penelitian sebanyak 32 penderita wanita, usia termuda 21 tahun, dan usia tertua 72 tahun. Hasil uji diagnosis USG strain ratio elastography dalam membedakan palpable mass payudara setelah dikonfirmasi dengan histopatologi di RSUP Dr. Hasan Sadikin, Bandung, menunjukkan sensitivitas 81,5%; spesifisitas 80,0%; akurasi 81,3%; PPV 95,7%; dan NPV 44,4%. Penelitian ini menyimpulkan bahwa USG strain ratio elastography memiliki nilai sensitivitas dan spesifisitas yang cukup tinggi dalam membedakan palpable mass payudara setelah dikonfirmasi dengan histopatologi di RSUP Dr. Hasan Sadikin, Bandung.
Sebaran Kanker di Indonesia, Riset Kesehatan Dasar 2007 DEWI, MAKASSARI
Indonesian Journal of Cancer Vol 11, No 1 (2017): Jan-Mar
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTCancer is one of the leading causes of death in the world. It takes an evidence-based strategy to address the increasing incidence of cancer in the world. To control the increase of cancer in Indonesia required control strategies of the key riskfactors associated with the incidence of cancer. Currently the data on the distribution of cancer in Indonesia is still limited. Key risk factors for cancer can be known from the existing types of cancer. By knowing the distribution of cancerthat is expected to become a factor in the prevention of cancer in Indonesia. The purpose of this paper is to describe the distribution of cancer in Indonesia by the community in 2007. The data used is data survey of basic health research(Riskesdas) 2007. Design this study was a descriptive cross-sectional. The analysis showed that from 768 635 respondents there were 4647 (0.6%) respondents who had cancer. Central Java province was the province with the highest number of cancer patients (23.6%). Cervical and ovarian cancer as well as breast cancer were the most commonly found as many as 927 (20%) of respondents to cervical and ovarian cancer, and as many as 746 (16%) of respondents had breast cancer. Cervical and ovarian cancer were most commonly found in adults, with the status ofmarried, live in urban areas and have low education status. Breast cancer was most common in women aged adult, married status, living in urban, low educational status and low economic status.ABSTRAKKanker merupakan salah satu penyebab kematian utama di dunia. Dibutuhkan strategi berbasis bukti untuk mengatasi meningkatnya kejadian kanker di dunia. Untuk mengontrol peningkatan kanker di Indonesia diperlukan strategipengendalian faktor risiko kunci yang berhubungan dengan kejadian kanker. Saat ini, data tentang sebaran kanker di Indonesia masih terbatas. Faktor risiko kunci kanker dapat diketahui dari jenis kanker yang ada. Dengan mengetahuisebaran kanker yang ada diharapkan dapat menjadi salah satu acuan dalam penanggulangan kanker di Indonesia. Tujuan dari tulisan ini adalah untuk menggambarkan sebaran kanker di Indonesia berdasarkan komunitas pada tahun2007. Data yang digunakan adalah data surveI Riset Kesehatan Dasar (Riskesdas) 2007. Desain studi ini adalah deskriptif cross-sectional. Hasil analisis menunjukkan bahwa dari 768.635 responden, 4.647 (0,6%) responden di antaranya menderita kanker. Jawa Tengah merupakan provinsi dengan jumlah penderita kanker tertinggi (23,6%). Kanker serviks uteri dan ovarium serta kanker payudara merupakan jenis kanker yang paling banyak ditemukan, yaitu 927 (20%) responden untuk kanker serviks uteri dan ovarium serta 746 (16%) responden kanker payudara. Kanker serviks uteri dan ovarium paling banyak ditemukan pada usia dewasa, dengan status menikah, hidup di perkotaan, dan memiliki status pendidikan rendah. Kanker payudara paling banyak ditemukan pada wanita usia dewasa, status menikah, tinggal di perkotaan, status pendidikan rendah, dan status ekonomi rendah.
Peran Terapi Akupunktur pada Kondisi Leukopenia Kanker Payudara Pasien Kemoterapi NARESWARI, I; HARYOKO, N.R.; MIHARDJA, HASAN
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : Indonesian Journal of Cancer

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Abstract

Breast cancer is a malignant disease that has the highest against women. Management of breast cancer that is currently done is a combination of surgery and chemotherapy, because in addition to effective therapy, but also can extend the recurrence. Chemotherapy given a systemic therapy that has serious side effects, one of which the effects of myelosuppression. Leukopenia is a condition that requires proper treatment and immediately, because it can cause dose reductions and delays in chemotherapy. Medication is given on the condition of chemotherapy-induced leukopenia one of which is the provision of Granulocyte Stimulating Factor (G-CSF), but these drugs have side effects, and requires a high cost. Based on several studies, acupuncture is effective in treating conditions due to the effects of chemotherapy leukopenia, and give excellent results. Acupuncture can stimulate the formation of CSF thereby increasing the number of leukocytes in the blood and improve the function of hematopoiesis in bone marrow.ABSTRAK Kanker payudara merupakan penyakit keganasan yang menyerang wanita dan menduduki peringkat tertinggi. Tatalaksana kanker payudara yang saat ini banyak dilakukan adalah kombinasi pembedahan dan kemoterapi, karena terapi tersebut selain efektif, juga dapat memperpanjang masa kekambuhan. Kemoterapi yang diberikan merupakan terapi sistemik yang mempunyai efek samping cukup serius, salah satunya efek myelosupresi. Leukopenia merupakan kondisi yang memerlukan penanganan tepat dan segera, karena dapat menyebabkan penurunan dosis dan penundaan kemoterapi. Salah satu medikasi yang diberikan pada kondisi leukopeni akibat kemoterapi adalah pemberian Granulocyte Stimulating Factor (G-CSF). Namun, obat ini mempunyai efek samping dan membutuhkan biaya yang tinggi. Berdasarkan beberapa penelitian yang dilakukan, akupunktur efektif dalam mengatasi kondisi leukopenia akibat efek kemoterapi dan memberikan hasil yang sangat baik. Akupunktur dapat merangsang pembentukan CSF sehingga meningkatkan jumlah leukosit dalam darah dan memperbaiki fungsi hematopoiesis di sumsum tulang.
Hubungan antara Menyusui dengan Risiko Kanker Ovarium ADISASMITA, ASRI; MARYANI, DINI; DWIPOYONO, BAMBANG
Indonesian Journal of Cancer Vol 10, No 3 (2016): July - September 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTIncidence of Ovarian Cancer, which has a high mortality rate, has been reported to increase since 2008 in Indonesia. A number of protective factors have been identified, one of which is breastfeeding. Despite this, published literature on the association of breastfeeding and ovarian cancer in Indonesia has not been found. The aim of this study is to determine the effect of breastfeeding on ovarian cancer in general, as well as among pre and post menopause patients. This case control study was done at “Dharmais”Cancer Hospital, involving 71 patients with ovarian cancer as the cases, and 140 cervical cancer patients who served as the controls. Interviews were done during follow-up visits. Patients, with adouble primary cancer,were not included in the study. The study shows that lifetime breastfeeding contributes to a decrease in the risk of ovarian cancer by 55% (OR=0.45, 95%CI 0.23 – 0.91) among all cases; the decrease was 53% (OR=0.47, 95%CI 0.23 – 0.96) for those who had previously given birth. These results were adjusted for level of education and menopause status at the time of diagnosis. Women with a history of breastfeeding have a lower risk of having ovarian cancer. The longer the duration of breastfeeding, the lower the risk of having ovarian cancer. The reduced risk was more than 50% for those with a lifetime breastfeeding of 24 months or more. ABSTRAKInsiden kanker ovarium yang memiliki tingkat letalitas tinggi, terus mengalami peningkatan sejak 2008. Beberapa faktor protektifnya telah diidentifkasi, salah satunya adalah menyusui. Meskipun begitu, penelitian yang membahas mengenai faktor tersebut belum banyak dilakukan. Untuk itu, penelitian ini bertujuan untuk mengetahui hubungan antara menyusui dengan risiko kanker ovarium, baik secara umum maupun pada kelompok pre-menopause dan postmenopause. Studi kasus kontrol ini dilakukan di Rumah Sakit Kanker “Dharmais” dengan kasus pasien kanker ovarium (N=71) dan kontrol pasien kanker serviks (n=140). Interview dilakukan pada pasien yang melakukan follow up visit. Pasien dengan kanker primer lain selain kanker ovarium (double primary cancer case) tidak diikutsertakan dalam studi. Hasil penelitian menunjukkan total durasi menyusui seumur hidup (lifetime breastfeeding) berhubungan dengan penurunan risiko terjadinya kanker ovarium sebesar 55% (OR=0,45; 95%CI 0,23–0,91). Pada semua responden yang pernah melahirkan, penurunan risiko sebesar 53% (OR=0,47; 95%CI 0,23–0,96). Nilai tersebut telah dikontrol terhadap variabel pendidikan dan status menopause saat didiagnosis. Penelitian ini menyimpulkan bahwa wanita dengan riwayat menyusui memiliki risiko yang lebih rendah untuk menderita kanker ovarium. Semakin lama durasi menyusui, semakin besar penurunan risiko terjadinya kanker ovarium, yaitu sebesar lebih dari 50% bagi mereka yang menyusui lebih dari 24 bulan.
Korelasi Ekspresi ezrin dan CD44 dengan Respons Kemoterapi pada Pasien Osteosarkoma SULISTIO, CHRISTIAN BAMBANG; MUSTOKOWENI, SJAHJENNY; KURNIASARI, NILA
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : Indonesian Journal of Cancer

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Abstract

Osteosarcoma is the most common malignant bone tumor in children and young adults. The process of metastasis and recurrence involves several proteins, including ezrin, and CD44 that are shown to be involved in tumor growth,metastasis and recurrence. To analyse the corelation of ezrin and CD44 expression with chemotherapy responsse in osteosarcoma patient. Cross sectional method on paraffin block of Osteosarcoma in Anatomic Pathology Laboratory of RSUD dr Soetomo, (January 1, 2010 - December 31, 2015). There were 17 out of 26 cases of amputated osteosarcoma which are met the inclusion criteria were performed immunohistochemical staining with ezrin and CD44 antibodies. The corellation of ezrin and CD44 expression with chemotherapy responsse was analyzed using Spearman’s rho test. The coeficient correlation in this experiment p<0.05, there was no corellation of ezrin expression with chemotherapy responsse of osteosarcoma. There was no correlation of CD44 expression with chemotherapy responsse in osteosarcoma. There was no correlation of ezrin and CD44 expression with chemotherapy responsse of osteosarcoma. There was no corellation of ezrin and CD44 expression with chemotherapy responsse of osteosarcoma.ABSTRAKOsteosarkoma merupakan tumor ganas tulang, sering terjadi pada anak-anak dan dewasa muda. Proses metastasis dan rekurensi melibatkan beberapa protein, di antaranya ezrin dan CD44 yang terbukti ikut serta dalam pertumbuhan tumor, metastasis, dan rekurensi. Penelitian ini bertujuan menganalisis hubungan antara ekspresi ezrin dan CD44 dengan respons kemoterapi. Penelitian ini menggunakan metode cross sectional blok parafin osteosarkoma di Laboratorium Patologi Anatomi RSUD Dr. Soetomo (1 Januari 2010–31 Desember 2015). Sebanyak 17 kasus sesuai kriteria inklusi dari 26 kasus osteosarkoma yang telah diamputasi dilakukan seleksi serta pemeriksaan imunohistokimia dengan antibodi ezrin danCD44. Hubungan ekspresi antara ezrin dan CD44 dengan respons kemoterapi dianalisis menggunakan uji Spearman’srho. Pada penelitian ini, nilai koefisien korelasi p<0,05 sehingga tidak terdapat hubungan antara ekspresi ezrin denganrespons kemoterapi pada osteosarkoma, di mana nilai p=0,868 (p>0,05). Tidak terdapat hubungan antara ekspresi CD44 dengan respons kemoterapi pada osteosarkoma di mana nilai p = 0,740 (p> 0,05).Tidak terdapat korelasi antaraekspresi ezrin dengan CD44 dengan respons kemoterapi osteosarkoma, nilai p=0,113 (p>0,05). Tidak terdapat hubungan antara ekspresi ezrin dan CD44 dengan respons kemoterapi pada pasien osteosarkoma.

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