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Indonesian Journal of Cancer

ijoc
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Published by Rumah Sakit Kanker Dharmais (Pusat Kanker Nasional)

ISSN : 19783744 EISSN : 23556811 DOI : -

Core Subject : Health,

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The Indonesian Journal of Cancer (official journal of the Dharmais Cancer Center Hospital) is a peer-reviewed, quarterly, open access journal. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. The journal publishes original research articles, case reports, systematic literature reviews, and letters to the editor under the following categories: Cancer prevention, diagnosis, surgery, systemic therapy, radiotherapy, paliative therapy, and molecular biology.

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Articles 448 Documents

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Karakteristik dan Faktor-faktor Prediktif pada Tumor Testis Dewasa di Jakarta Suprabawati, Tri Endah; Umbas, Rainy
Indonesian Journal of Cancer Vol 1, No 3 (2007): Jul - Sep 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v1i3.17

Penelitian ini bertujuan untuk mengetahui karakteristik dan faktor-faktor prediktif tumor testis dewasa di JakartaData dikumpulkan dari status khusus di departemen urologi RSCM dan RS kanker Dharmais. Data yang dikumpulkan adalah usia, tumor marker yaitu AFP, LDH, HCG, jenis operasi, jenis tumor, jenis terapi, dan stadium. Dilakukan analisa terhadap usia dengan stadium, Undescended Testicle (UDT) dengan stadium, tumor marker dengan stadium pada semua kasus, dan hubungan AFP dengan jenis nonseminoma dengan stadium menggunakan ANOVA pada SPSS 11,5 .Selama 10 tahun terdapat 149 kasus tumor testis, 129 kasus diantaranya adalah dewasa. Rentang usia yaitu 18-72 tahun, dengan usia rata-rata 33,03 tahun. Jenis tumor diantaranya seminoma 67 (51,9 %) pasien, nonseminoma 50 (38,8 %) pasien, non germinal 6 (4,7 %) pasien, tidak diketahui jenis tumornya 6 (4,7 %) pasien. Delapan puluh tujuh pasien (67,4 %) dilakukan orkhidektomi ligasi tinggi, 23 (17,8 %) pasien dilakukan orkhidektomi transscrotal. Insidens UDT terdapat pada 13 (10,1 %) pasien. Seminoma paling banyak ditemukan pada stadium 2c (36,9 %), dan non -seminoma pada stadium 3c (48,9 %). Kemoterapi dilakukan terhadap 51 (39,5 %) pasien, radioterapi pada 24 (18,6 %) pasien, dan 27 (20,9 %) pasien menolak dilakukan tindakan, dan 18 (14,0 %) pasien meninggal karena keadaan umum yang buruk. Pada penelitian ini tidak ditemukan hubungan bermakna antara usia dengan stadium. Tujuh puluh tujuh persen pasien dengan UDT ditemukan pada stadium lanjut, dibandingkan dengan 66,7 % pada pasien non-UDT, tetapi secara statistik tidak bermakna. Angka rata-rata LDH 1785,35 dan nilai LDH meningkat sesuai dengan stadium, tetapi tidak bermakna untuk memprediksi stadium. Angka rata-rata AFP pada pasien non-seminoma adalah 6421,13 dan mempunyai hubungan yang bermakna dengan stadium (p: 0,009).Jenis tumor yang paling banyak ditemukan di Jakarta adalah seminoma. Pada penelitian ini usia dan LDH tidak dapat memprediksi stadium tumor, tetapi AFP mempunyai hubungan yang bermakna dengan stadium pada penderita kanker testis non-seminoma.Kata kunci: tumor testis, undescended testicle, faktor prediktif ABSTRACTThe aim of this research is to determine characteristics and predictive factors in adult testicular tumor in JakartaAnalyzed the data were collected from urology departemen at Cipto Mangunkusumo hospital and Dharmais hospital medical records. The collected data were age, AFP, LDH, HCG, type of operation, type of tumor, type of therapy and staging and reviewed retrospectively. Data were analyzed by using ANOVA in SPSS 11.5 for correlation between age and stage, undescended testicle (UDT) and stage, serum marker in all cases as well as and stage, and correlation between AFP in non-seminomatous patients with stage.During 10 years, 149 testicular tumors patients were registered, among these cases, 129 cases are adult patients and the range of age was 18-72 years old with mean of age was 33.03 years old. Type of tumors were seminoma 67 (51,9 %) patients, non-seminoma 50 (38.8 %) patients, non germinal 6(4,7 %) patients, unidentified 6 (4,7 %) patients. Eighty seven patients (67,4 %) underwent high ligation orchidectomy ivhile 23 (17,8 %) patients underwent transcrotal orchidectomy. Incidence of UDT patients was 13 (10,1%) patients. Most of the seminoma patients were diagnosed as stage 2c (36,9 %), and in non-seminoma was 3c (48.9 %). Chemotherapy was performed in 51 (39,5 %) patients, radiotherapy 24 (18,6 %) patients and 27 (20,9 %) patients refused to be treated, and 18 (14,0 %) patients were died before treatment due to poor condition. In this study, there was no significant correlation between age and stage. Seventy seven percent patient with UDT had advance stage compare to 66,7 % in non-UDT patients, however this was not statistically significant. Mean for LDH was 1785,35, and the LDH

Squamous Cell Carcinoma of the Oral Tongue: A Single Institution Retrospective Cohort Study from Mansoura University Hospital Hamdy, Rasha; Halim, Amal
Indonesian Journal of Cancer Vol 12, No 4 (2018): October-December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Egyptian hospital–based statistics showed that head & neck carcinomas represent 18% of all cancers and mostly diagnosed at advanced stages. Our Clinical Oncology & Nuclear Medicine Department of Mansoura Faculty of Medicine serves a large rural area of the Delta region of Egypt. There is no previous study in our institution that focused on oral tongue carcinoma alone. This study aims in establishing the demographics, treatment outcome and prognostic factors of oral tongue squamous cell carcinoma (SCC).Methods: We retrospectively reviewed data of 50 cases with oral tongue SCC treated in our department from January 2014 to December 2016 to evaluate the demography, pathological characteristics, and therapeutic modalities. We estimated the survival rates during the entire follow-up period by the Kaplan–Meier method. The univariate and multivariate Cox proportional hazards analysis were performed for prognostic factors determination.Results: The median follow-up was 30 months (range: 4-45 months). The 3-year overall survival (OS) and disease-free survival (DFS) rates were 68% and 60% respectively. By univariate analysis, both advanced stages (III, IVA) and depth of invasion >0.5 cm were statistically significant as prognostic factors for 3-year DFS and OS rates. DFS rates were 34% vs. 98% for stage III and IVA vs. stage I and II respectively (p = 0.001); 52% vs. 78% for >0.5 cm vs. ≤0.5 cm depth of invasion (p = 0.003). OS rates were 36% vs. 99% for stage III and IVA vs. stage I and II respectively (p = 0.002); 52% vs. 80% for >0.5 cm vs. ≤0.5 cm depth of invasion (p = 0.001). Multivariate analysis of prognostic factors affecting 3-year DFS and OS rates confirmed the statistical significance of the same 2 factors.Conclusions: The majority of our patients were males below 60 years. Tumors were mainly found at stage III and were moderately differentiated. Vascular invasion and lymphatic permeation were uncommon. Staging and tumor invasion depth significantly affected the outcome. The 3-year OS and DFS were 68% and 60% respectively.

Aktifitas Caspase 3 sebagai Indikator Apoptosis pada Sel Kanker Ovarium Dwipoyono, Bambang
Indonesian Journal of Cancer Vol 1, No 2 (2007): Apr - Jun 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Kematian yang diakibatkan oleh kanker ovarium masih tetap tinggi meskipun sudah dengan penanganan yang agresif. Pemberian kemoterapi merupakan bagian penting selain tindakan operasi di dalam pengobatan kanker ovarium. Obat sitostatika yang digunakan bertujuan mempengaruhi DNA dan pada akhirnya memicu henti siklus sel dan apoptosis.Untuk mengetahui aktifitas caspase 3 sebagai indikator terjadinya apoptosis pada sel kanker ovarium setelah terpapar dengan sitostatika.Penelitian in vitro dengan memaparkan sel kanker ovarium primer yang berasal dari asi tes dan/atau "established" sel kanker ovarium dengan sitostatika dengan dosis dan waktu yang berbeda. Kemudian dilakukan perhitungan aktifitas caspase 3 dari kedua sel kanker ovarium tersebut.Penelitian ini dilakukan terhadap penderita kanker ovarium yang dilakukan operasi pada "Yale New Haven Hospital". Sel tumor yang berasal dari cairan asites menjalani isolasi dan kultur untuk mendapatkan kultur primer. Dilakukan pemaparan sel kanker ovarium primer dan "established" dengan carbo-platin dan docetaxel selama 24 dan 48 jam dengan dosis yang berbeda. Apoptosis yang terjadi diketahui dengan melihat aktifitas spesifik caspase 3 dari masing-masing kelompok sel kanker ovarium tersebut.Dari 11 pasien kanker ovarium stadium lanjut (III-IV, FIGO) dengan jenis epithelial didapatkan bahwa carboplatin dosis 100-400mg/ml dapat menginduksi aktifitas caspase 3 dari "established" sel kanker ovarium maupun sel kanker ovarium primer. Docetaxel dosis 5ng/ml dan 500ng/ ml juga dapat menginduksi aktifitas caspase 3 pada kedua kelompok sel kanker ovarium.Aktifitas caspase 3 dapat ditimbulkan dengan melakukan pemaparan sel kanker ovarium baik primer maupun "established" terhadap carboplatin dan docetaxel.Kata kunci: caspase 3, apoptosis, kanker ovarium.

Tata Laksana Farmakologis Nyeri Kanker Lukman, Gardian; Harjanto, Eddy
Indonesian Journal of Cancer Vol 1, No 3 (2007): Jul - Sep 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Diperkirakan akan ada 15 juta kasus kanker baru seperti yang diprediksi oleh Badan Kesehatan Dunia. Sayangnya tata laksana nyeri kanker masih di bawah standar. Hal yang terpenting dalam mengobati nyeri kanker adalah menentukan nyeri macam apa yang diderita oleh pasien. Setelah itu pengobatan dilakukan dengan penggunaan anak tangga nyeri. Opioid terutama morfin masih merupakan obat utama dalam tata laksana kanker.Kata kunci: nyeri kanker, opioid, anak tangga nyeri

Pengamatan Pengobatan Kanker Leher Rahim dengan Kombinasi Radiasi dan Khemoterapi serta Radiasi Saja Djuita, Fielda; -, Dewi; Ranuhardi, Doddy; Tadjudin, Hilman; Dwipoyono, Bambang; -, Sumannadi; -, Nasdaldy
Indonesian Journal of Cancer Vol 1, No 1 (2007): Jan - Mar 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v1i1.5

Several clinical trial reported that chemo radiation has significant and equivalent improvement in pelvic failure and overall survival for uterine cervical cancer copared with radiation alone. The best result is certainly achieved by careful attention to management, including the overall treatment time because prolongation overall treatment time will reduce survival. For that reasons lue have reviewed 52 patients ; 14 patients without chemotherapy, 14 patients with chemotherapy docetaxel, 14 patiens with chemotherapy cisplatin and 10 patiens with paclitaxel. 33 patient stage HB and 19 patient stage 1UB. All patients received external radiation in prone position with 50 Gy dose and brachytherapy 3 X 70 Gy at point A. All patients clinically complete respons except 2 patients partial respons from group radiation alone and docetaxel but the overall treatment times from groups cisplatine and paclitaxel longer than others.Key words; Radiation, Uterine Cervical Cancer, Sensitizer Chemotherapy.

Evaluasi Dosis Glandular dalam Pemeriksaan Mammografi Yubhar, Yulfiatry; Adi, Rachmat; -, Supriyanto; -, Pawiro; -, Kardinah
Indonesian Journal of Cancer Vol 1, No 3 (2007): Jul - Sep 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Telah dilakukan pengukuran Dosis Rata-rata Glandular (Mean glandular Dose) pada pemeriksaan mammografi dengan menggunakan Thermoluminiscense Dosimeter(7LD) terhadap 49 pasien. Dosis yang terbaca pada TLD adalah Entrance Surface Dose (ESD) dengan nilai rata-rata yang didapat 7.6 ('bl 3.9) mGy. Untuk konversi ke nilai Mean Glandular Dose, nilai ESD dikalikan dengan nilai Dgn (ESD dengan faktor konversi average glandular dose per unit exposure) yang terkonversi dengan memperhitungkan prosentase glandular terhadap adipose. Data Dgn diperoleh dari perhitungan John M Boone yang menggunakan metode Monte Carlo yang masih tergantung dari nilai HVL dan ketebalan payudara. Prosentase glandular terhadap adipose dihitung dengan menggunakan metoda analisa film Nooriah Djamal. Kemudian nilai Dgn 0% glandular untuk kontribusi adipose maupun Dgn 100% glandular untuk kontribusi glandular diperoleh dari Tabel Dgn Boone. Nilai MGD yang diperoleh adalah 1.818 ('bl 0.615) mGy. Nilai masih dibawah limit yang direkomendasikan FDA {Food and Drug Administration) yaitu < 3 mGy.Kata kunci : mean glandular dose (MGD), entrance surface dose (ESD), thermoluminiscense dosimeter (TLD)ABSTRACTMean glandular Dose (MGD) during mammography has been determined for 49 patients using TLD. MGD numbers has been derived from the measured ESD (Entrance Surface Dose) by multiplicating ESD with converted Dp, (ESD with average glandular dose per unit exposure conversion factor) incorporating the glandular percentage to adipose percentage. Dgn data were obtained from Boone's Monte Carlo calculation and generally is a function of HVL values and breast thickness. The glandular percentage to adipose were obtained using Nooriah Djamal's methods of mammography film analysis Both 0% glandular Dgn for adipose contribution and 100% glandular DSu for glandular contribution were then obtained from Boone's table. Average Entrance Surface Dose (ESD) for 49 patients were found to be 7.6 ('bl 3.9) mGy. The average MGD for 49 patients were found to be 1.818 (bl 0.615) mGy. These values were generally below the recommended FDA (Food and Drug Administration) limit of 3 mGy.Key Words : mean glandular dose (MGD), entrance surface dose (ESD), thermoluminiscense dosimeter (TLD)

Jejunal MALT (Mucosa Associated Lymphoid Tissue) Lymphoma: A Case Report Suparman, Alexandria Stephanie; Soeselo, Daniel Ardian; Harjanti, Dyonesia Arie
Indonesian Journal of Cancer Vol 12, No 4 (2018): October-December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: MALT (Mucosa Associated Lymphoid Tissue) Lymphoma is an uncommon condition. It is an involvement of extranodal site in hematologic malignancy, Non-Hodgkin Lymphoma.Case Presentation: Pondok Indah, Puri Indah Hospital Jakarta treated a 38-year-old female with acute abdomen due to jejunal MALT Lymphoma perforation, one meter from treitz ligament. Emergency laparotomy was performed, the patient had a resection and end to end anastomose. She was hospitalized in intensive care unit for 4 days after the surgery and died because of prolonged septic shock.Conclusions: MALT lymphoma is an uncommon condition which is often encountered in emergency conditions due to acute abdominal pain caused by intra-abdominal perforation of the hollow viscus. Late diagnosis and treatment may cause severe outcome such as perforation and hypovolemic shock. This case report is expected to provide insight and to increase the awareness of the incidence of jejunal MALT lymphoma in Indonesia.

Kolon Endometriosis Kastomo, Dukut Respati
Indonesian Journal of Cancer Vol 1, No 2 (2007): Apr - Jun 2007
Publisher : National Cancer Center - Dharmais Cancer Hospital

Pendahuluan: Endometriosis sering dihubungkan dengan genitalia interna wanita, terdapat pada 75 % wanita usia produktif. Pada keadaan tertentu diagnosis kelainan kolon berhubungan endometriosis karena 26 % endometriosis terdapat pada rektosigmoid dan 13 % menimbulkan komplikasi. Perubahan keganasan di kolon terjadi pada 0,7% -1 % kasus, di ovarium 78 %.Metoda : Data penderita keganasan kolon dari tahunl994 sampai 2006 yang di teliti secara retrospektif observasional dijumpai dua kasus endometriosis kolon. Dari kasus ini dibahas studi pustaka, diagnosis, tindakan operatif dan tindak lanjut terapi.Hasil: Dilaporkan dari 600 keganasan kolon yang dioperasi, dua penderita secara histopatologis didiagnosis endometriosis, pertama di kolon transversum, yang kedua di rektosigmoid beserta adenomiosis uterus.Bahasan: Endometriosis kolon terdiagnosis pasca bedah secara histopatologis setelah pra bedah didiagnosis keganasan kolon. Karena menimbulkan obstruksi dilakukan tindakan reseksi kolon.Kata kunci: Endometriosis kolon, keganasan kclon, reseksi kolon.

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