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MNJ (Malang Neurology Journal)

MNJ
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Published by Universitas Brawijaya

ISSN : 24076724 EISSN : 24425001 DOI : -

Core Subject : Science,

Neuroscience

Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.

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Articles 7 Documents

Search results for , issue "Vol 1, No 2 (2015): July" : 7 Documents clear

RELATIONSHIP BETWEEN THE RANDOM BLOOD GLUCOSE LEVELS DURING ADMISSION AT EMERGENCY ROOM WITH CLINICAL OUTPUT IN ACUTE ISCHEMIC STROKE PATIENTS Munir, Badrul; Rasyid, Harun Al; Rosita, Rizky
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. High blood glucose level occurs on 20-50% acute ischemic stroke patients. Hyperglycemia can worsen neurology disorder of patients.Objective. To find out the relationship between random blood glucose level and clinical outcome on patients with acute ischemic stroke measured with NIHSS.Methods. Observational using stroke registry of acute ischemic stroke patients. There are 38 patients involved in this research.Results. Using Spearman shows an insignificant correlation between random blood glucose level and NIHSS output (p=0.548). However, random blood glucose level and NIHSS input shows a significant correlation (p=0.011). The result of Chi-Square test on correlation between random blood glucose level and NIHSS output shows an insignificant correlation (p=1), in contrast, random blood glucose level and NIHSS input and improvement shows a significant correlation (p=0.024 and p=0.047).Conclusion. There is no correlation between random blood glucose level at initial care and clinical outcome on patients suffering acute ischemic stroke. However, normal random blood glucose level shows had better improvement and they had tendency to get better outcome.

CORRELATION BETWEEN BLOOD PRESSURE AT ADMITTED EMERGENCY ROOM AND CLINICALLY OUTCOME IN ACUTE THROMBOTIC STROKE PATIENTS Rianawati, Sri Budhi; Aurora, Habiba; Nugrahanitya, Yulia
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. High blood pressure is the first risk factor in stroke, but it is possible that low blood pressure causes stroke, although it is a few incident. Objective. To know the relation between blood pressure on arrival time in stroke unit and the clinical outcome of acute thrombolytic stroke patients using NIHSS score. Methods. Using cohort retrospective study, 38 samples were selected by consecutive method. The variable measured in this research is systolic blood pressure (SBP), diastolic blood pressure (DBP), and Mean Arterial Pressure (MAP) at the first time in stroke unit to NIHSS patients in the last day nursing (10-14 days). Results. Based from Spearman correlation test, SBP (p = 0,136; r = 0,246), DBP (p = 0,586; r = 0,091), and MAP (p = 0,171; r = 0,227) indicate that have not significant correlation with NIHSS and indicate that very weak correlation. Conclusion. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and Mean Arterial Pressure (MAP) have not significant correlation with NIHSS and indicate that very weak correlation. Study is needed to understand the relation without any treatment influence and confounding factor.

ANTI ATHEROSCLEROTIC EFFECT OF ADIPONECTIN Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Atherosclerosis is a chronic, inflammatory disease of the arterial wall. Atherosclerosis underlies many ofÂ the common causes of cardiovascular morbidity and mortality, including myocardial infarction (MI),Â peripheral vascular disease, and cerebrovascular. Cardiovascular disease (CVD) has become the mostÂ frequent cause of death globally and then stroke is the second leading cause of death worldwide and aÂ major cause of long-term disability.Recent study shows that adiponectin exhibits potent antiatherosclerotic effects. Adiponectin is a proteinÂ secreted specifically from adipose tissue. Adiponectin has a potential inhibitory effect on all molecularÂ mechanisms of atherosclerosis.

GERIATRIC PATIENT WITH DELIRIUM PROFILE IN SAIFUL ANWAR GENERAL HOSPITAL MALANG FROM JANUARY 2005 UNTIL JUNE 2010 Sunarti, Sri; Rahayu, Masruroh; Desetyaputra, Dimas Ryan
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. Delirium is a serious health problem and the most frequent complaints in geriatric patients. Objective. This research aims to analyzes the patient profile and the underlying disease of delirum by using descriptive study and survey methods. Methods. Subjects were geriatric patients with age >60 years old diagnosed with delirium.Results. Patients with delirium syndrome was male sex 58.3% and female sex 41,7%, the highest age group between 60-65 years was 31.7% and 66-70 years was 30%, education is the senior high school level of 41.7% and junior high school level of 35%. Temperature delirium patients that >37.5oC (61.7%) patients and GCS due to moderate state was 100% patients. Hb and PCV were below normal at 71.7% and 70%. Conditions out of the hospital patients delirum syndrome is to live for 71.7%. The most underlying disease delirium syndrome were CVA 56.7%, Diabetes Melitus type II 23,3% and Sepsis 8,3%. Conclusion. The factors underlying the occurrence of delirium syndrome are male sex, aged 60-65 years old, low education, temperatures above normal, decreased consciousness, low PCV, anemia and most diseases that cause delirium syndrome is CVA, Diabetes Melitus type II and Sepsis.

NEURONAL SIGNALING Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Intracellular processes in neurons begins when the extracellular chemical signals such as neurotransmitters, attached at specific receptors which then activates a cascade of intracellular reactions included herein are proteins GTP, second messengers, protein kinases, ion channels, and other effector proteins that will change the instantaneous state of the physiology of the cell the target. The intracellular signal will also change the long-term performance by interfering with the transcription of genes that will change the protein composition of the target cell. Many components are involved in intracellular signal that will control the neurons, so that the necessary coordination of electrical and chemical signals in the nervous system. Also discussed here regarding the conducting various signals in neurons, including signaling pathways, type receptors, G proteins and molecular targets, second messengers, the target of second messengers, NGF/TrkA, long-term depression (LTD), and tyrosine phosphorylation hidrosilase.Â

EFFECT OF THE RADIATION OF GAMMA RAYS ON CASPASE-3 EXPRESSION IN RATTUS NORVEGICUS WISTAR MALE VARIANT BRAIN CELL WITH IMMUNOHISTOCHEMISTRY METHOD Alam, Ahmad Bayhaqi Nasir; Rahayu, Masruroh; Islani, Ahmad Zaki Sukma
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Â Background. The brain is an organ that has an important function potentially exposed to bad influences of radiation, especially on the head neck tumors. Gamma rays interact with body molecules causing damage to DNA and subsequently apoptosis. Caspase-3 plays an important role in apoptosis as effector caspase. Objective. To prove that the radiation of cobalt-60 gamma rays in Rattus norvegicus Wistar male variant causes brain cell apoptosis by the number of apoptotic cells more than in the single-dose fractionation. Methods. This Experimental research using animals were randomly divided into 3 groups: control, single and fractionation.Results. An increase in apoptotic index in the irradiated brain cells in single dose and fractionation dose compared by control group were significant (ANOVA, p > 0.05 ). Sequentially, the highest apoptotic index in a single group, fractionation, and control.Conclusion. The provision of radiation Cobalt - 60 gamma rays cause brain cell apoptosis Rattus norvegicus Wistar male variant and a single dose to cause apoptosis of brain cells more than the dose fractionation.

CORRELATION BETWEEN LEUKOCYTE COUNT WHEN ADMITTED IN EMERGENCY ROOM (ER) WITH CLINICALLY ACUTE ISCHEMIC STROKE PATIENTS Husna, Machlusil; Kusworini, Kusworini; Wulansari, Dian Ayu
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. Stroke is a local or extensive disorder of brain function that occurs suddenly and rapidly, can cause death without another cause except vascular. Based on pathophysiology of acute ischemic stroke, leukocytes play an important role against deterioration and clinical manifestations in patients by releasing three inflammatory mediators, plugging mechanism in microcirculation, and vasoconstriction. Objective. To investigate the relationship between the clinical manifestations of acute ischemic stroke (incoming, outgoing, and improvement) as measured by the NIHSS score with the number of leukocytes . Methods. The study design was a retrospective cohort sampling. Samples were taken from 62 patients with acute ischemic stroke (31 patients who have normal leukocytes and 31 patients who showed leukocytosis) in Dr. Saiful Anwar (RSSA) Malang hospital that met the inclusion criteria of the study.Results. The results of the statistical test used is Kolmogorov-Smirnov test for incoming NIHSS (p = 0.999), and Chi-Square Test for outcoming NIHSS (p = 0.000) and improved patient (p = 0.001).Conclusion. Patients who have normal leukocyte count at the beginning of treatment is likely to have clinical manifestations by category of incoming NIHSS similar to patients who showed leukocytosis, and tend to have clinical manifestations by category of outcoming NIHSS and improvement or significantly better than patients which showed leukocytosis.

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