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MNJ (Malang Neurology Journal)

MNJ
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Published by Universitas Brawijaya

ISSN : 24076724 EISSN : 24425001 DOI : -

Core Subject : Science,

Neuroscience

Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.

Arjuna Subject : -

Articles 194 Documents

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INTRACELLULAR Ca2+ HOMEOSTASIS Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Ca2+ signaling functions to regulate many cellular processes. Dynamics of Ca2+ signaling or homeostasis is regulated by the interaction between ON and OFF reactions that control Ca2+ flux in both the plasma membrane and internal organelles such as the endoplasmic reticulum (ER) and mitochondria. External stimuli activate the ON reactions, which include Ca2+ into the cytoplasm either through channels in the plasma membrane or from internal storage like in ER. Most of the cells utilize both channels/sources, but there area few cells using an external or internal source to control certain processes. Most of the Ca entering the cytoplasm adsorbed to the buffer, while a smaller part activate effect or to stimulate cellular processes. Reaction OFF is pumping of cytoplasmic Ca2+ using a combination mechanism of mitochondrial and others. Changes in Ca2+ signal has been detected in various tissues isolated from animals induced into diabetes as well as patients with diabetes. Ca2+ signal interference is also found in sensory neurons of experimental animals with diabetes. Ca2+ signaling is one of the main signaling systems in the cell.

THE INFECTION EFFECT OF STRAIN H37Rv MYCOBACTERIUM TUBERCULOSIS ON APOPTOSIS OF MICEâ€™S NEURON CELL BRAIN (MUS MUSCULUS) Kaspia, Rima Nor; Hidayati, Dwi Yuni Nur; Widayati, Aris
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Background. Ischemia on the cells and the lack of supply of glucose, will trigger a Ca2 + influx into the cell and increased expression of glutamate. Result in mitochondrial Ca2 + Influx be "overloaded". Glucose metabolism then switched to the anaerobic process that makes ATP increasingly depleted and there acidosis. This situation makes the neuron cell apoptosis triggered to occur. Apoptosis is programmed cell death. Neuron cell apoptosis is thought to have a strong connection to the tuberculosis infection in the brain.Objective. To determine the number of cells undergoing apoptosis neurons in brain tissue of mice.Methods. This study is a semiquantitative by comparing the number of cells undergoing apoptosis neurons in the three groups of samples. Observations apoptosis of neuronal cells in the brain tissue of mice was conducted using TUNEL staining technique (terminal deoxynucleotidyl transferase dUTP nick end labeling) are seen in a microscope with a magnification of 1000x.Results. The results showed that neuronal cells undergo apoptosis in brain tissue infected with M.tb for 8 and 16 weeks were marked with brown color in the cell nucleus. Neuron cell apoptosis were observed at M.tb-infected brain tissue for 16 weeks.Conclusion. The longer the M.tb infection can affect the increase in the number of neuronal cell apoptosis.

RELATIONSHIP BETWEEN THE RANDOM BLOOD GLUCOSE LEVELS DURING ADMISSION AT EMERGENCY ROOM WITH CLINICAL OUTPUT IN ACUTE ISCHEMIC STROKE PATIENTS Munir, Badrul; Rasyid, Harun Al; Rosita, Rizky
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. High blood glucose level occurs on 20-50% acute ischemic stroke patients. Hyperglycemia can worsen neurology disorder of patients.Objective. To find out the relationship between random blood glucose level and clinical outcome on patients with acute ischemic stroke measured with NIHSS.Methods. Observational using stroke registry of acute ischemic stroke patients. There are 38 patients involved in this research.Results. Using Spearman shows an insignificant correlation between random blood glucose level and NIHSS output (p=0.548). However, random blood glucose level and NIHSS input shows a significant correlation (p=0.011). The result of Chi-Square test on correlation between random blood glucose level and NIHSS output shows an insignificant correlation (p=1), in contrast, random blood glucose level and NIHSS input and improvement shows a significant correlation (p=0.024 and p=0.047).Conclusion. There is no correlation between random blood glucose level at initial care and clinical outcome on patients suffering acute ischemic stroke. However, normal random blood glucose level shows had better improvement and they had tendency to get better outcome.

CORRELATION BETWEEN BLOOD PRESSURE AT ADMITTED EMERGENCY ROOM AND CLINICALLY OUTCOME IN ACUTE THROMBOTIC STROKE PATIENTS Rianawati, Sri Budhi; Aurora, Habiba; Nugrahanitya, Yulia
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. High blood pressure is the first risk factor in stroke, but it is possible that low blood pressure causes stroke, although it is a few incident. Objective. To know the relation between blood pressure on arrival time in stroke unit and the clinical outcome of acute thrombolytic stroke patients using NIHSS score. Methods. Using cohort retrospective study, 38 samples were selected by consecutive method. The variable measured in this research is systolic blood pressure (SBP), diastolic blood pressure (DBP), and Mean Arterial Pressure (MAP) at the first time in stroke unit to NIHSS patients in the last day nursing (10-14 days). Results. Based from Spearman correlation test, SBP (p = 0,136; r = 0,246), DBP (p = 0,586; r = 0,091), and MAP (p = 0,171; r = 0,227) indicate that have not significant correlation with NIHSS and indicate that very weak correlation. Conclusion. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and Mean Arterial Pressure (MAP) have not significant correlation with NIHSS and indicate that very weak correlation. Study is needed to understand the relation without any treatment influence and confounding factor.

CORRELATION OF SEVERE HEAD INJURY EPIDURAL HEMATOMA TREPANATION RESPOND TIME WITH OUTCOME Santoso, Mochamad Istiadjid Eddy; Rahayu, Masruroh; Balafif, Fachriy
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Epidural hematoma is intracranial hemorrhage, due to skull fracture caused by head injury which there is a blood accumulation between the layers of duramater and the skull. Objective. To determine the corellation of epidural hematoma trepanation respond time with outcome. Methods. A retrospective observational analytic study (cross sectional) with 30 samples taken in Saiful Anwar Hospital Malang from June to August 2012. The independent variable in this study is trepanation respond time that divided into trepanation respond time less than 6 hours, between 6-12 hours, between 12-18 hours, between 18-24 hours, and more than 24 hours while the dependent variable in this study is the outcome of the patient. Secondary data were taken using medical records. The data were analyzed using independent T-test, spearman correlation test, kruskall walis test, and ROC test with confidence level 95% (Î±=0.005). Results. The analysis shows a significant corelation between severe head injury epidural hematoma trepanation respond time with the outcome.Conclusion. Faster trepanation respond time will have better outcome.

THE CLINICIAN'S APPROACH TO THE MANAGEMENT OF HEADACHE Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Headache is one of the most common complaints presenting to primary care physicians, as well as neurologists. Although the vast majority of headache syndromes are benign, clinicians are faced with the crucial task of differentiating benign headache disorders from potentially life threatening headache. Given the broad range of disorders that present with headache, a focused and systematic approach is necessary to facilitate the prompt diagnosis and treatment of various kinds of head pain.

MANIFESTATIONS OF HIV AIDS IN CASE NEUROLOGY: EPIDEMIOLOGY STUDY AT SAIFUL ANWAR HOSPITAL YEAR 2013-2014 Munir, Badrul; Candradikusuma, Didi
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Background. Complications of HIV-AIDS cases neurological disorders are quite high and also very highÂ mortality, but so far the data on disease epidemiology in Indonesia is still very limited.Objective.Â To determine the pattern of HIV-AIDS disease involving the nervous system in patients admittedÂ to Saiful Anwar hospital.Methods. This prospective cohort study with a record of all patients with HIV-AIDS didagnosis manifestÂ neurological disorders treated in an isolation room for HIV-AIDS Saiful Anwar Hospital for 1 year (September 2013- August 2014).Results. During 12 months acquired HIV-AIDS with neurological disorders as many as 23 patients (38.3% ofÂ all patients with an infection of the nervous system) with an average age of 48 years. Male genderÂ 47.83%) and 52.17% of women. Number of CD4+ average of 24 / microliter, while the average number ofÂ leucocytes 9675/uL, while the most common sequence of disease; 39.1% of cerebral toxoplasmosis,Â tuberculosis meningoencephalitis 21.7%, 17.4% viral encephalitis, bacterial meningoencephalitis 13%,Â 4.3% dementia, cerebral abscess 4.3%. The mortality rate is still high, ranging from 57.6%.Conclusion. Manifestations of HIV AIDS in the field of neurology are very high, cerebral toxoplasmosis is theÂ most common diagnosis, and correlated with the levels of CD4+. The mortality rate of HIV-AIDS cases manifesting high neurology.

DETERMINANTS AFFECTING THE DEPRESSION OF INFARCTION POST STROKE PATIENTS IN (SAIFUL ANWAR HOSPITAL MALANG) Munir, Badrul; Nasution, Arief Alamsyah; Purnamasari, Yeni
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Background. Stroke is a functional disorder of the brain that occurs suddenly with signs and symptoms ofÂ both focal and global clinical lasting more than 24 hours, or can lead to death due to circulatory disorders of the brain. Stroke ranks third leading cause of death in Indonesia. Someone with stroke will leading mood disruption that would cause a depression. Objective. To determine the effect on depression of stroke infarction.Methods. The study used descriptive analytic cross-sectional study. 42 samples was selected by consecutive method. The distribution of the sample are 18 males and 24 females, 23 samples below 60 years and 19 samples over 60 years, 13 samples had duration of suffering a stroke less than 6 months and 29 samples above 6 months. The independent variables in this study were age, sex, and duration of suffering a stroke, while the depression is the dependent variable. Depression was assessed using the Hamilton Depression Rating Scale (HDRS). Results. The results used logistic regression test obtained value of (p = 0.021) is significant in age.Conclusion. The age is the determinant affecting the quality of life after stroke infarction.

ANTI ATHEROSCLEROTIC EFFECT OF ADIPONECTIN Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Atherosclerosis is a chronic, inflammatory disease of the arterial wall. Atherosclerosis underlies many ofÂ the common causes of cardiovascular morbidity and mortality, including myocardial infarction (MI),Â peripheral vascular disease, and cerebrovascular. Cardiovascular disease (CVD) has become the mostÂ frequent cause of death globally and then stroke is the second leading cause of death worldwide and aÂ major cause of long-term disability.Recent study shows that adiponectin exhibits potent antiatherosclerotic effects. Adiponectin is a proteinÂ secreted specifically from adipose tissue. Adiponectin has a potential inhibitory effect on all molecularÂ mechanisms of atherosclerosis.

GERIATRIC PATIENT WITH DELIRIUM PROFILE IN SAIFUL ANWAR GENERAL HOSPITAL MALANG FROM JANUARY 2005 UNTIL JUNE 2010 Sunarti, Sri; Rahayu, Masruroh; Desetyaputra, Dimas Ryan
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. Delirium is a serious health problem and the most frequent complaints in geriatric patients. Objective. This research aims to analyzes the patient profile and the underlying disease of delirum by using descriptive study and survey methods. Methods. Subjects were geriatric patients with age >60 years old diagnosed with delirium.Results. Patients with delirium syndrome was male sex 58.3% and female sex 41,7%, the highest age group between 60-65 years was 31.7% and 66-70 years was 30%, education is the senior high school level of 41.7% and junior high school level of 35%. Temperature delirium patients that >37.5oC (61.7%) patients and GCS due to moderate state was 100% patients. Hb and PCV were below normal at 71.7% and 70%. Conditions out of the hospital patients delirum syndrome is to live for 71.7%. The most underlying disease delirium syndrome were CVA 56.7%, Diabetes Melitus type II 23,3% and Sepsis 8,3%. Conclusion. The factors underlying the occurrence of delirium syndrome are male sex, aged 60-65 years old, low education, temperatures above normal, decreased consciousness, low PCV, anemia and most diseases that cause delirium syndrome is CVA, Diabetes Melitus type II and Sepsis.

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