Garuda - Garba Rujukan Digital

All

IDJP (Indonesian Journal of Pharmaceutics)

idjp
Website

Published by Universitas Padjadjaran

ISSN : - EISSN : 25978748 DOI : -

Core Subject :

The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.

Arjuna Subject : -

Articles 5 Documents

Search results for , issue "Vol 1, Issue 3, Sept - Dec 2019" : 5 Documents clear

Nanoparticles Targeted Drug Delivery System via Epidermal Growth Factor Receptor: a Review Agus Rusdin; Nasrul Wathoni; Keiichi Motoyama; I Made Joni; Ronny Lesmana; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Overexpressing of epidermal growth factor receptor (EGFR) in specific organ implicates tumour aggression and proliferation. Therefore, EGFR becomes a primary consideration for targeted cancer therapy. Nanoparticle drug delivery system is a promising multifunctional technique to provide the targeted drug delivery system. This review was aimed to discuss the nanoparticles formulation for targeted drug delivery system via EGFR. The data were collected from published journals recorded in the Scopus database. Various types of nanoparticles were widely studied to provide an EGFR-targeted drug delivery system. The formulations using specific targeting mediators were conjugated on several technologies such as polymeric nanoparticles, nanometals, and miscellaneous nanoparticles. Most of nanoparticles formulation become an excellent delivery carrier for drugs or gene to site-specific targeted by in vitro and in vivo evaluations. EGFR-targeted drug delivery system could be a promising technique to provide high effectiveness of drugs in EGFR-positive cells cancers with lower side effects to non-tumour cells.Keywords : Epidermal growth factor receptor, Cancer, Nanoparticle, targeted drug

Solvent Evaporation as an Efficient Microencapsulating Technique for Taste Masking in Fast Disintegrating Oral Tablets Nagina Gulab Belali; Anis Yohana Chaerunisaa
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Microencapsulation is an extensively used technology of present era, that has been applied to various fields like pharmaceutical industry, agriculture, cosmetics and food technology. With the help of which liquid or solid material can be encapsulated inside a polymeric coating film for various reasons such as taste masking, control release and enhancing stability and etc. Microencapsulation can be achieved with different approaches and methods but one of the popular and frequently used feasible method is Solvent evaporation. Solvent evaporation is based on emulsification, solvent evaporation and extraction of microspheres, recently many variations have been made in this technology to improve the yield and properties of microspheres. Solvent evaporation has been widely used in microencapsulating for different purposes one of which is taste masking of bitter drugs in fast disintegrating oral tablets, for pediatric and geriatric use. FDTs are center of attraction due to their merits and feasibility of use for people with problem of dysphagia at the same time, it can also improve bioavailability and time of action of drugs. The main focus of current review is use of solvent evaporation technique for taste masking of bitter drugs in production of fast disintegrating oral tablets. In this review, we will summarize uses, novelties and variations in Solvent Evaporation technique, preparation technique, materials used, merits and demerits of this method over other microencapsulation method in taste masking.Keywords: Microencapsulation, Solvent Evaporation, FDTs, extraction, microspheres

Formulation and Physical Stability Testing of Chitosan Gel from Vaname Shrimp Shell (Litopenaeus Vannamei) with Carbopol 940 Gelling Agent Norisca Aliza Putriana; Taofik Rusdiana; M. Abdul Aziz Prakoso
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Wound is defined as a disorder of normal anatomy and skin’s function that occurs as a result of tissue injury or patalogic process resulting in epithelium discontinuity, with or without lossing underlying connective tissue. The use of chitosan in medicine, especially in surgery, gives many advantages in terms of wound healing that stimulates hemostasis of cell. Chitosan gel is one of the alternative wound treatments that still needs improvement, especially in terms of the effectiveness of the formulation. In this study, the physical stability of chitosan gel formulations was tested in various concentration of carbopol 940 as a gelling agent i.e, 0,5%, 1% and 1,5%. The parameters observed during the physical stability testing of this gel research were pH, viscosity, spreadability, homogeneity, organoleptic and sineresis gel. The result of the physical stability testing of chitosan gel stored for 56 days showed that formula 1 has the best result according to all parameters. Formula 1 has pH 5,8-6,2 at 25oC and 40oC, the best organoleptic stability, viscosity shift 9% at 25oC and 13,8% at 40oC, spreadability shift 10,9% at 25oC and 14,4% at 40oC. The best chitosan gel formulation for physical stability testing is chitosan gel with carbopol 940 concentration of 0.5%Keywords: Wound, Chitosan gel, Physical Stability

Dissolution Behaviours of Acetaminophen and Ibuprofen Tablet Influenced By L–HPC 21, 22, and Sodium Starch Glycolate as Disintegrant Yoga Windhu Wardhana; Dradjad Priambodo
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

The dissolution of tablets is one of a drug absorption determinant. Disintegrant agent has play an important role on determining the dissolution of tablets. In this experiment, the dissolution behaviours of Acetaminophen and Ibuprofen Tablet was studied using various disintegrant agent such as Low substituted – Hydroxypropyl Cellulose (L–HPC) 21, L–HPC 22 and Sodium Starch Glycolate (SSG) as comparator. Those disintegrant agents were used at three concentration (6%, 7% and 8%) for every tablets formula. Tablets were made by wet granulation method and pressed using single punch 13 mm flat E. Korsch machine. Evaluation of each tablets quality were conducted include for uniformity of weight and size (diameter and thickness), hardness, friability, disintegration time and dissolution. Physically standards from tablets were in good condition, the standards of the weight and thickness uniformity, hardness and friability met the requirement. The dissolution profile on Acetaminophen Tablets showed that only tablet with 6 % L–HPC 21 did not meet the requirement of FI V (Q = 80%, 30 minutes), but on Ibuprofen Tablets where met the requirement of FI V (Q = 80%, 60 minutes) only tablet with 8% L– HPC 21, 7% and 8% SSG. The conclusion of the study was the L–HPC has more disintegrant character at hydrophilic active ingredients. Key words: Acetaminophen Tablet, Ibuprofen Tablet, SSG, L-HPC 21 and 22, Dissolution Profile

Formulation and Physical Evaluation of Cream Containing Neem Oil 5% Patihul Husni; Anggia Diani Amalia; Soraya Ratnawulan Mita; Norisca Aliza Putriana
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Permethrin Cream 5%, a topical scabicidal agent, is usually used for the treatment of infestation with Sarcoptes scabiei (scabies). Nowadays, neem oil, a vegetable oil pressed from the fruits and seeds of the neem (Azadirachta indica A.Juss), is reported having an antiscabies effect. The aim of the study was to formulate and evaluate the physical properties of cream containing neem oil 5%. Methods of the study were characterization of physicochemical properties of neem oil, preparation and physical stability study at room temperature (25 oC) and 40 oC for three months storage of the neem oil 5% cream. Physical evaluation involved organoleptic, homogeneity, pH, tipe of cream and viscosity. The study results showed that all of the physicochemical properties of neem oil met the requirement. The cream were white to yellowish white, characteristic neem oil odor, homogenous cream, pH ± 8, viscosity approximately 2000-8000 cps and o/w cream. Three months storage of the cream showed that the formula resulted a stable cream physically.Keywords: neem oil, permethrin, scabies, Azadirachta indica A.Juss

Page 1 of 1 | Total Record : 5

Filter by Year

2019 2019

Filter By Issues

All Issue Vol 4, Issue 3, Sep - November, 2022 Vol 4, Issue 2, May - August, 2022 Vol 4, Issue 1, Jan - April 2022 Vol 3, Issue 3, Sept - Dec 2021 Vol 3, Issue 2, May - August, 2021 Vol 3, Issue 1, Jan - April 2021 Vol 2, Issue 3, Sept - Dec 2020 Vol 2, Issue 2, May - August, 2020 Vol 2, Issue 1, Jan - April 2020 Vol 1, Issue 3, Sept - Dec 2019 Vol 1, Issue 2, May - August 2019 Vol 1, Issue 1, Jan - April 2019 More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota bandung,

Jawa barat

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kota bandung, Jawa barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota bandung,

Jawa barat

INDONESIA