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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Agrikultura Jurnal Sains Materi Indonesia Urania Jurnal Ilmiah Daur Bahan Bakar Nuklir JFA (Jurnal Fisika dan Aplikasinya) IDJP (Indonesian Journal of Pharmaceutics) Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Material Kedokteran Gigi PROSIDING SEMINAR NASIONAL FISIKA (E-JOURNAL) Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Material dan Energi Indonesia Jurnal Ilmu dan Inovasi Fisika

I Made Joni

Department Of Physics, Faculty Of Mathematics And Natural Sciences, Universitas Padjadjaran, Sumedang 45363, Indonesia

Author-ID : 2793915

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Other

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Sintesis partikel zirkonia-alumina-silika (ZrO2-Al2O3-SiO2) dari pasir zirkon alam sebagai bahan pengisi komposit kedokteran gigiSynthesis of zirconia-alumina-silica particles (ZrO2-Al2O3-SiO2) from natural zircon sand as dental composite fillers Febrida, Renny; Joni, I Made; Susra, Silmina; Djustiana, Nina
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 29, No 1 (2017): April
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Pasir zirkon (ZrSiO4) merupakan mineral alam yang tersusun atas zirkonia (ZrO2) dan silika (SiO2) yang berikatan dengan stabil. Zirkonia adalah salah satu material keramik kedokteran gigi yang banyak digunakan karena memiliki sifat mekanis dan biokompatibilitas yang tinggi. Zirkonia dapat dikombinasikan dengan silika dan alumina untuk membentuk suatu bahan pengisi komposit dengan sifat mekanis dan estetis yang dapat disesuaikan dengan sifat gigi kodrat. Tujuan dari penelitian ini adalah untuk menghasilkan bahan bahan pengisi komposit alternatif di bidang kedokteran gigi yang berasal dari pasir zirkon alam untuk dijadikan bahan bahan pengisi komposit. Metode: Jenis penelitian yang dilakukan adalah eksperimental laboratoris untuk mensintesis dan mengkarakterisasi partikel ZrO2-Al2O3-SiO2 dari bahan baku alam berupa pasir zircon dengan reaksi geopolimerisasi dan proses pemanasan suhu tinggi. Aktivator yang digunakan adalah larutan NaOH 3 mol dengan temperatur pemanasan 1100Â° C pada lama pemanasan 4 jam, 6 jam, dan 8 jam. Â Hasil: Hasil analisis uji X-Ray Diffraction (XRD) menunjukkan jumlah zirkonia berstruktur tetragonal terbesar ada pada sampel pemanasan 8 jam, yaitu 24%. Hasil analisis uji Energy Dispersive Spectroscopy (EDS) menunjukkan rasio komposisi zirkonia-alumina-silika dengan nilai zirkonia tertinggi ada pada sampel pemanasan 8 jam, yaitu 55,7 : 23,6 : 20,6. Hasil analisis mikrograf Scanning Electron Microscope (SEM) menunjukkan morfologi permukaan dan partikel yang tidak beraturan dan beraglomerasi. Simpulan: Sintesis partikel zirkonia-alumina-silika (ZrO2-Al2O3-SiO2) dari pasir zirkon alam dengan pemanasan 8 jam ditinjau dari jumlah zirkonia berstruktur tetragonal memadai digunakan sebagai bahan pengisi komposit berdasarkan uji XRD danEDS, namun pada ujiSEM partikel berbentuk tidak beraturan dan beraglomerasi.Â ABSTRACTIntroduction: Zircon sand (ZrSiO4) is a natural mineral that is composed of zirconia (ZrO2) and silica (SiO2) which binds stable. Zirconia is a dental dentistry material that is widely used because it has high mechanical properties and biocompatibility. Zirconia can be combined with silica and alumina to form a composite filler with mechanical and aesthetic properties that can be adapted to the nature of natural teeth. The purpose of this study was to produce alternative composite fillers in the field of dentistry derived from natural zircon sand to be used as composite fillers. Methods: This type of research was experimental laboratory to synthesize and characterize ZrO2-Al2O3-SiO2 particles from natural raw materials in the form of zircon sand with geopolymerization reaction and high temperature heating process. The activator used is a 3 mol NaOH solution with a heating temperature of 1100 Â° C at a heating time of 4 hours, 6 hours, and 8 hours. Results: The results of the X-Ray Diffraction (XRD) test showed that the largest number of zirconia with a tetragonal structure was on an 8-hour heating sample, which was 24%. The results of the Energy Dispersive Spectroscopy (EDS) test analysis show the highest ratio of zirconia-alumina-silica composition with zirconia values in the 8 hour heating sample, which is 55.7: 23.6: 20.6. The results of the Scanning Electron Microscope (SEM) micrograph analysis showed that the surface morphology and particles were irregular and agglomerated. Conclusion: Synthesis of zirconia-alumina-silica particles (ZrO2-Al2O3-SiO2) from natural zircon sand with 8 hours heating in terms of sufficient tetragonal zirconia amount used as composite filler based on XRD and EDS test, but in SEM test irregularly shaped particles and agglomerated.Keywords:Â Zircon sand, zirconia-alumina-silica, geopolymerisation, composite filler materials

Efek Penambahan Suspensi Nanokitosan pada Edible Coating terhadap Aktivitas Antibakteri Emma Rochima; Elisah Fiyanih; Eddy Afrianto; I Made Joni; Ujang Subhan; Camellia Panatarani
Jurnal Pengolahan Hasil Perikanan Indonesia Vol 21 No 1 (2018): Jurnal Pengolahan Hasil Perikanan Indonesia 21(1)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Edible coating atau edible film didefinisikan sebagai lapisan tipis yang dapat dikonsumsi dan berfungsi melindungi makanan dari kerusakan akibat kelembaban, oksigen, dan perpindahan zat terlarut. Komponen penyusun edible coating dapat dibedakan menjadi tiga jenis yaitu hidrokoloid, lipid dan komposit. Penelitian ini bertujuan untuk mendapatkan edible coating berbasis karaginan-pati termodifikasi dengan penambahan suspensi nanokitosan hasil proses beads-milling sebagai bahan antibakteri dan aplikasinya pada buah strowberi. Suspensi edible dibuat dengan mengkombinasikan karaginan jenis kappa dengan pati termodifikasi dan penambahan larutan nanokitosan sebesar 0,5%, 1%, 1,5%, dan 2% (v/v). Pengujian antibakteri dilakukan dengan metode zona hambat dan efek dari penggunaan edible coating ditentukan melalui susut bobot buah strawberry. Karakteristik edible coating yaitu ketebalan dan tingkat transparansi diukur dengan cara mencetak edible pada plat plastik sehingga membentuk film. Penambahan suspensi nanokitosan 1% v/v pada larutan edible cukup efektif menghambat pertumbuhan Escherichia coli dan Staphylococcus aureus,hal ini terbukti setelah satu minggu, susut bobot buah strowberi yang dipapar dengan E.coli 6,13% lebih kecil jika dibandingkan dengan S.aureus sebesar 6,26%. Suspensi edible memilikiketebalan 0,065 mm dengan tingkat transparansi sebesar 82,56. sesuai standar Chroma Meter.

THE POTENTIAL OF INDONESIAN GRAPHITE AS RDE FUEL MATRIX Deni Mustika; Sudirman Sudirman; Adel Fisli; I Made Joni; Th. Rina M.
Jurnal Sains Materi Indonesia Vol 20, No 2: JANUARY 2019
Publisher : Center for Science & Technology of Advanced Materials - National Nuclear Energy Agency

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/jsmi.2019.20.2.5472

THE POTENTIAL OF INDONESIAN GRAPHITE AS RDE FUEL MATRIX. The development plan of Ex- perimental Power Reactor (RDE) in Indonesia is non-commercial and leads to the technology type of Pebble Bed Reactor (PBR) - High Temperature Gas Cooled Reactor (HTGR). The fuel used for PBR reactors is kernel dispersed in spherical fuel elements. The matrix used in PBR nuclear fuel is graphite which functions as a neutron moderator, fuel protective material and heat conductor. Domestication of the domestic fuel matrix needs to be conducted to improve national independence. Therefore, it is necessary to do research on the potential of local graphite to be used as RDE fuel matrix. This study focused on the identification and characterization of local and commercial graphite. The results are compared with the literature, how far it is fulfilling nuclear grade graphite for PBR fuel matrix. Characterization of graphite includes phase analysis with XRD, micro- structure with SEM, surface area/porosity, impurities determination with AAS, ICP-OES and NAA, equivalent boron content, carbon content, density, particle size distribution and ash content. The characterization results show that the carbon content obtained was 87.0 ± 4.2% for local graphite and 100% for commercial graphite. Meanwhile, for the purposes of nuclear graphite it requires a carbon content of >99%. The impurity content in local and commercial graphite still does not meet the RDE fuel matrix standard. The results of XRD analysis show that the local graphite phase is the same as the commercial graphite phase, namely the 2H graphite hexagonal crystal system with the lattice group of P 63/mmc. Particle size distribution and surface area of local graphite are higher compared to nuclear graphite literature. The ash content of commercial graphite was 0.236 ± 0.029 and local graphite was 9.587 ± 0.010%. The results of this study indicate that the local graphite from the flotation still requires a further refinement process to obtain local graphite that can be used as a fuel matrix for RDE.

PURIFICATION OF INDONESIAN NATURAL GRAPHITE AS CANDIDATE FOR NUCLEAR FUEL MATRIX BY ACID LEACHING METHOD: CHEMICAL CHARACTERIZATION Deni Mustika; Torowati Torowati; Arbi Dimyati; Sudirman Sudirman; Adel Fisli; I Made Joni; Ratih Langenati
Urania : Jurnal Ilmiah Daur Bahan Bakar Nuklir Vol 26, No 3 (2020): Oktober, 2020
Publisher : website

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17146/urania.2020.26.3.6059

PURIFICATION OF INDONESIAN NATURAL GRAPHITE AS CANDIDATE FOR NUCLEAR FUEL MATRIX BY ACID LEACHING METHOD: CHEMICAL CHARACTERIZATION. Graphite matrix in Pebble Bed Reactor (PBR) – High Temperature Gas Cooled Reactor (HTGR) has an important role as heat transfer medium, neutron moderator and structural material to protect fuel. Thus, graphite matrix must fulfill chemical and physical characteristics for PBR-HTGR fuel. Indonesia has graphite sources in several regions that can potentially be purified. This research aimed to purify Indonesian natural graphite by several variation of acids and to perform chemical characterizations. Natural graphite from flotation process was purified by several variations of acid, i. e., hydrofluoric acid (HF), sulphuric acid + nitric acid (H2SO4 + HNO3) and hydrofluoric acid + hydrochloric acid + sulphuric acid (HF + HCl + H2SO4) and subsequently followed by chemical characterizations such as purity level, ash content, and boron quivalent. The highest purity was obtained in the purification process by HF with carbon content up to 99.52%; this purity level fulfills the specification of nuclear graphite (>99%). Ash content analysis shows a value in compliance with the specification requirement, i.e., < 100 ppm, and boron equivalent value also fulfills the specification value of < 1 ppm. It can be concluded from this study that the graphite purified by acid leaching with HF can be used as fuel matrix candidate but is qualified as low quality. Futher research is required to produce high quality nuclear graphite, particularly research in the minimization of the impurity by evaporation at temperatures over 950 oC to by far lower the ash content.Keywords: Indonesian natural graphite, purification, nuclear fuel matrix, acid leaching, chemical characterization.

Efek Jenis Pelarut pada Sifat Optik, Morfologi Permukaan dan Koefisien Waveguide Loss dari Pandu Gelombang Planar Polimer Terkonjugasi MEH-PPV Ayi Bahtiar; Yeni Kurniawati; Fitrilawati Fitrilawati; Yayah Yuliah; I Made Joni
Jurnal Fisika dan Aplikasinya Vol 4, No 1 (2008)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat, LPPM-ITS

Dalam tulisan ini dilaporkan studi efek jenis pelarut pada sifat optik, morfologi permukaan dan koefisien waveguide loss gw dari pandu gelombang planar polimer MEH-PPV. Pandu gelombang planar dibuat dengan teknik spin-coating dari larutan polimer dengan pelarut toluen, kloroform dan THF. Hasil studi menunjukkan bahwa sifat optik dan morfologi permukaan film MEH-PPV dipengaruhi oleh jenis pelarut yang digunakan.Film dengan pelarut toluen dan kloroform mempunyai morfologi permukaan yang homogen, akibatnya nilai gw lebih kecil dari 1 dB/cm. Sedangkan pelarut THF membentuk tekstur di permukaan film MEH-PPV karena agregasi rantai polimer, sehingga nilai gw menjadi besar.

Nanoparticles Targeted Drug Delivery System via Epidermal Growth Factor Receptor: a Review Agus Rusdin; Nasrul Wathoni; Keiichi Motoyama; I Made Joni; Ronny Lesmana; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Overexpressing of epidermal growth factor receptor (EGFR) in specific organ implicates tumour aggression and proliferation. Therefore, EGFR becomes a primary consideration for targeted cancer therapy. Nanoparticle drug delivery system is a promising multifunctional technique to provide the targeted drug delivery system. This review was aimed to discuss the nanoparticles formulation for targeted drug delivery system via EGFR. The data were collected from published journals recorded in the Scopus database. Various types of nanoparticles were widely studied to provide an EGFR-targeted drug delivery system. The formulations using specific targeting mediators were conjugated on several technologies such as polymeric nanoparticles, nanometals, and miscellaneous nanoparticles. Most of nanoparticles formulation become an excellent delivery carrier for drugs or gene to site-specific targeted by in vitro and in vivo evaluations. EGFR-targeted drug delivery system could be a promising technique to provide high effectiveness of drugs in EGFR-positive cells cancers with lower side effects to non-tumour cells.Keywords : Epidermal growth factor receptor, Cancer, Nanoparticle, targeted drug

Sintesis partikel zirkonia-alumina-silika (ZrO2-Al2O3-SiO2) dari pasir zirkon alam sebagai bahan pengisi komposit kedokteran gigiSynthesis of zirconia-alumina-silica particles (ZrO2-Al2O3-SiO2) from natural zircon sand as dental composite fillers Silmina Susra; Nina Djustiana; Renny Febrida; I Made Joni
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 29, No 1 (2017): April
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Pendahuluan: Pasir zirkon (ZrSiO4) merupakan mineral alam yang tersusun atas zirkonia (ZrO2) dan silika (SiO2) yang berikatan dengan stabil. Zirkonia adalah salah satu material keramik kedokteran gigi yang banyak digunakan karena memiliki sifat mekanis dan biokompatibilitas yang tinggi. Zirkonia dapat dikombinasikan dengan silika dan alumina untuk membentuk suatu bahan pengisi komposit dengan sifat mekanis dan estetis yang dapat disesuaikan dengan sifat gigi kodrat. Tujuan dari penelitian ini adalah untuk menghasilkan bahan bahan pengisi komposit alternatif di bidang kedokteran gigi yang berasal dari pasir zirkon alam untuk dijadikan bahan bahan pengisi komposit. Metode: Jenis penelitian yang dilakukan adalah eksperimental laboratoris untuk mensintesis dan mengkarakterisasi partikel ZrO2-Al2O3-SiO2 dari bahan baku alam berupa pasir zircon dengan reaksi geopolimerisasi dan proses pemanasan suhu tinggi. Aktivator yang digunakan adalah larutan NaOH 3 mol dengan temperatur pemanasan 1100°C pada lama pemanasan 4 jam, 6 jam, dan 8 jam. Hasil: Hasil analisis uji X-Ray Diffraction (XRD) menunjukkan jumlah zirkonia berstruktur tetragonal terbesar ada pada sampel pemanasan 8 jam, yaitu 24%. Hasil analisis uji Energy Dispersive Spectroscopy (EDS) menunjukkan rasio komposisi zirkonia-alumina-silika dengan nilai zirkonia tertinggi ada pada sampel pemanasan 8 jam, yaitu 55,7; 23,6; 20,6. Hasil analisis mikrograf Scanning Electron Microscope (SEM) menunjukkan morfologi permukaan dan partikel yang tidak beraturan dan beraglomerasi. Simpulan: Sintesis partikel zirkonia-alumina-silika (ZrO2-Al2O3-SiO2) dari pasir zirkon alam dengan pemanasan 8 jam ditinjau dari jumlah zirkonia berstruktur tetragonal memadai digunakan sebagai bahan pengisi komposit berdasarkan uji XRD dan EDS, namun pada uji SEM partikel berbentuk tidak beraturan dan beraglomerasi.Kata kunci: Pasir zirkon, zirkonia-alumina-silika, geopolimerisasi, bahan pengisi komposit ABSTRACTIntroduction: Zircon sand (ZrSiO4) is natural mineral sand which is composed of zirconia (ZrO2) and silica (SiO2) that bind in a stable condition. Zirconia is one of a ceramic that is widely used in dentistry because of its high biocompatibility and good mechanical properties. Zirconia can be combined with silica and alumina to form a bahan pengisi composite material with its esthetics and mechanical properties that can be adjusted to real tooth properties. Methods: This study focuses on a synthesis of zirconia-alumina-silica (ZrO2-Al2O3-SiO2) from natural zircon sand using a geopolymerization method and a heat treatment in high temperature. Activator used in this method is 3 mol NaOH solutions. A temperature that is used to heat is 1100° C for 4 hours, 6 hours, and 8 hours. Results: Analysis result of X-ray Diffraction (XRD) indicates that a sample with 8 hours heating time has a greatest amount of tetragonal zirconia: 24%. An analysis result of Energy Dispersive Spectroscopy (EDS) indicates that a composition ratio of zirconia-alumina-silica with a highest score in zirconia is present in a sample with 8 hours heating time, with a ratio 55,7 : 23,6 : 20,6. Analysis result of Scanning Electron Microscope (SEM) show irregularities in particles and surface morphology, and agglomerated particles. Conclusion: The study concludes that a synthesis of zirconia-alumina-silica (ZrO2-Al2O3-SiO2) particles from natural zircon sand based on the amount of tetragonal structure that is present in zirconia is suitable to be used as composite bahan pengisi materials based on XRD and EDS characterization tests. But in a SEM test, the particles show irregularities and agglomerations.Keywords: Zircon sand, zirconia-alumina-silica, composite bahan pengisi

Analisis Mikrostruktur Partikel Zirkoniakalsia-silika (ZrO 2 -CaO-SiO ) Dari Pasir Zirkon Alam Indonesia Menggunakan Metode Spray Pyrolysis Elin Karlina; Nina Djustiana; I Made Joni; Renny Febrida; Camellia Panatarani; Akhyar Dyni Zakyah
Jurnal Material Kedokteran Gigi Vol 6 No 1 (2017): JMKG Vol 6 No 1 Maret 2017
Publisher : Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI)

Indonesian Natural Sand, Zircon, is an Indonesia’s natural resource that contains zirconia, silica, titania and alumina. In Dentistry, zirconia as one of the content in natural zircon sand, have the potential to be the material for filler composites. The purpose of this research was to analyze the Zirconia-Calcium-Silicate Particle (ZrO2CaO-SiO2) synthesized from Indonesia natural sand, zircon, in microstructural way. Methods: By synthesizing ZirconiaCalcium-Silicate particle (ZrO2-CaO-SiO2) from Indonesia natural zircon sand, using spray pyrolysis method. A precursor solution that is used consists of zirconil nitrate (Zr (NO3) 2), sodium silicate (Na2SiO3), and calcium hydroxide (Ca (OH) 2). Variations in the temperature of the reactor that are used were 4000C, 4500C, and 5000C with a feed rate of 6 L / min and a piezoelectric frequency of 1.7 MHz. Result showed that the better content in zirconia-calcium-silicate is the one that was synthesized at a temperature of 4500C, based on the results of EDS, SEM and XRD. The composition that is obtained in the zirconia-calcium-silicate particle has a ratio of 1: 14: 4 with the size of 500-1000nm, and has a tetragonal crystal zirconium silicate structure and dicalcium monoclinic silicate. From this research it can be concluded that the result that was synthesized at a temperature of 4500C is adequate to use as a filler based on the characterization result of SEM and XRD.

PEMODELAN DAN SIMULASI TOPOLOGI SINGLE ENDED PRIMARY INDUCTOR CONVERTER (SEPIC) UNTUK MINI 3 PLUS WIND TURBINE Ryan Prasetiyo; Dwindra Wilham Maulana; Camellia Panatarani; I Made Joni
PROSIDING SEMINAR NASIONAL FISIKA (E-JOURNAL) Vol 5 (2016): PROSIDING SEMINAR NASIONAL FISIKA (E-JOURNAL) SNF2016
Publisher : Program Studi Pendidikan Fisika dan Program Studi Fisika Universitas Negeri Jakarta, LPPM Universitas Negeri Jakarta, HFI Jakarta, HFI

In order to have a DC-DC buck boost converter with performances as desired specifications, the design process was performed by developing a model and simulation. The purpose of this research was to design a converter applied for a MINI 3 plus Wind Turbine. The converter topology was designed with Single Ended Primary Inductor Converter (SEPIC) using a Continuous Conduction Mode (CCM). The output specifications of converter are input voltage 60 V, input current 7,5 A, output voltage 25 V, output current 4,17 A, and frequency 25kHz. The average state space method was used to obtain its transfer function. The transfer function represented the characteristics of an average state of SEPIC converter system. The characteristics and designed quality of SEPIC converter determined by system performance analysis. The results showed that as designed SEPIC converter achieved excellent performances and stability based on their overshoot, rise time, settling time, frequency, and location of pole-zeros. Incontrast, the designed SEPIC converter showed that converter increased the input voltage (boost mode) with duty cycle more than 50% and reduced voltage (buck mode) with duty cycle less than 50%. It was concluded that the designed converter system achieved excellent and stable performances. Keywords: SEPIC converter, state space analysis, transfer function, DC-DC converter.

[REVIEW] USAHA PENINGKATAN KELARUTAN DAN LAJU DISOLUSI ZAT AKTIF FARMASI SUKAR LARUT AIR Revika - Rachmaniar; Taofik - Rusdiana; Camellia - Panatarani; I Made Joni
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 6, No 2 (2017)
Publisher : Sekolah Tinggi Farmasi Indonesia

AbstrakKelarutan dan laju disolusi obat pada saluran gastrointestinal merupakan parameter dalam mengendalikan absorpsi dan bioavaibilitas obat. Obat yang sulit larut air dan disolusi rendah dalam cairan gastrointestinal akan menghasilkan bioavaibilitas oral rendah sehingga peningkatan kelarutan dan laju disolusi menjadi tantangan. Salah satu upaya mengatasinya adalah dengan menurunkan ukuran partikel, tapi partikel kecil yang terbentuk berpotensi membentuk aglomerasi dan agregasi. Karya tulis ini merupakan kajian pustaka bertujuan untuk mengetahui teknologi rekayasa partikel dalam rangka mengatasi permasalahan kelarutan dan laju disolusi yang rendah. Upaya meningkatkan kelarutan dan laju disolusi, yaitu modifikasi ukuran partikel, kristalinitas, modifikasi permukaan, dan teknologi preparasi partikel. Penurunan ukuran partikel obat dapat meningkatkan luas permukaan kontak obat dan media disolusi sehingga laju absorpsi meningkat. Namun, semakin kecil ukuran partikel dikhawatirkan terjadi aglomerasi dan agregasi karena efek elektrostatik. Oleh karena itu, untuk mencegah terjadinya aglomerasi dan agregasi perlu ditambahkan stabilizer. Gugus fungsi pada stabilizer berfungsi untuk membantu meningkatkan obat yang sulit larut air, seperti polimer dan surfaktan. Partikel yang memiliki kristalinitas rendah (amorf) dapat memperbaiki kelarutan dan laju disolusi dengan luas permukaannya yang lebih besar dibandingkan partikel yang memiliki kristalinitas tinggi. Salah satu teknologi yang sering digunakan untuk meningkatkan kelarutan dan disolusi obat yang sukar larut air adalah spray drying. Kata kunci: spray drying, kelarutan, disolusi AbstractSolubility and dissolution rate of drug in gastrointestinal tract is an important in controlling absorption and bioavailability. Water insoluble and low dissolution drug will result low oral bioavailability. An effort to solve it is by reducing particle size, but fine particles have potential to form aggregation. This paper is a review which is aimed to determine the particle engineering technology in order to solve problems of solubility and dissolution rate. Several efforts of modification to increase solubility and dissolution rate, which is modification of particle size, crystallinity, surface, and preparation of particle technology. Decreasing size of drug particles can increas contact surface area of drug and dissolution medium so that the rate of drug absorption increases. However, agglomeration and aggregation occur in fine particle because of electrostatic effects. Therefore, stabilizer is needed to prevent aggregation. The functional groups on stabilizer has another function which improve the water insoluble drugs, such as polymers and surfactants. Particles which have a low crystallinity (amorphous) can improve the solubility and dissolution rate with a surface area larger than the particles which have high crystallinity. A technology which is often used in order to improve solubility and dissolution of water insoluble drugs is spray drying. Keywords: spray drying, solubility,dissolution

Co-Authors Adel Fisli Adel Fisli Agus Rusdin Akhyar Dyni Zakyah Arbi Dimyati Ayi Bahtiar Camellia Panatarani Deni Mustika Deni Mustika Desak Made Malini Dwindra Wilham Maulana Eddy Afrianto Elin Karlina Elisah Fiyanih Emma Rochima F FITRILAWATI Fitrilawati Fitrilawati Keiichi Motoyama Melanie Melanie, Melanie Mia Miranti Rustama Muchtaridi Muchtaridi Nasrul Wathoni Nina Djustiana Nina Djustiana Nina Djustiana Norman Syakir Norman Syakir, Norman Nur Khanifah RATIH LANGENATI Renny Febrida Renny Febrida Renny Febrida Revika - Rachmaniar Ronny Lesmana Ryan Prasetiyo Saajidah Fathinal Haq SALSA INDAH MAULIA THALLAH Silmina Susra Sudirman Sudirman Sudirman Sudirman Susra, Silmina Taofik Rusdiana TEGUH HUSODO Th. Rina M. Torowati Torowati Ujang Subhan Wawan Hermawan Yayah Yuliah Yeni Kurniawati

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