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Rinawati, Fajar
Institut Ilmu Kesehatan STRADA Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Acta Biochimica Indonesiana

 1 
Inhibition of cancer cells using target-specific 2A3 antibody-conjugated gold nanoclusters Jui-Chi Kuo; Tsung-Rong Kuo; Fajar Rinawati; Erna Susilowati; Sucipto; Dyah Ika Krisnawati
Acta Biochimica Indonesiana Vol. 4 No. 2 (2021): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.69

Abstract

Background: Metal nanoclusters (NCs) with outstanding structural and optical properties have been intensively validated for applications in nanomedicine and nanotechnology. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is overexpressed in many cancer cells. Objective: The gold nanoclusters conjugated with a single domain antibody targeting CEACAM6 of 2A3 (2A3-AuNCs) were synthesized for the inhibition of cancer cells. Methods: 2A3-AuNCs were prepared via a facile hydrothermal approach. The cell viability was measured by resazurin dye reduction assay. The cell death was analyzed by fluorescence imaging. Results: Structural and optical characterizations demonstrated the successful synthesis of 2A3-AuNCs with a roughly spherical shape and a size of 2.35 nm. The 2A3-AuNCs revealed a maximum fluorescence intensity at 350 nm with a fluorescence quantum yield of 4.0%. The cell viability assay indicated that 2A3-AuNCs could inhibit the growths of cancer cells with overexpressed CEACAM6, including breast cancer MDA-MB-231 and MDA-MB-468 cells. The fluorescence imaging results also demonstrated that 2A3-AuNCs could inhibit the growth of cancer cells with MDA-MB-231 and MDA-MB-468 cells. Conclusion: Combination with the results of cell viability assay and fluorescence imaging, the surface ligand of 2A3 antibody on 2A3-AuNCs exhibited promising inhibition of CEACAM6 overexpressed cancer cells. Our work provides a potential application of AuNCs in cancer therapy.
Co-Authors A.A. Ketut Agung Cahyawan W Ali Djamhuri Alimansur, Moh Anak Agung Istri Sri Wiadnyani Angga Pradityo christianto nugroho Didik Atmojo Didik Susetiyanto Atmojo Didik Susetiyanto Atmojo Dwi Rahayu Dwi Rahayu Dwi rahayu Dwi Rahayu Dwi Rahayu Rahayu Dyah Ika Krisnawati Dyah Ika Krisnawati Elfi Quyumi Rahmawati Elfi Quyumi Rahmawati Erna Susilowati Erna Susilowati Erwin Yektiningsih Irawan, Hengky Jui-Chi Kuo Kristanto, Heny livana ph Mohammad Fatkhul Mubin Nirmala Kusumaningrum Sunaryo Novita Setyowati Novita Setyowati Puguh Santoso Sucipto Sucipto Sucipto Sucipto Sucipto Sucipto Sucipto Sucipto Tsung-Rong Kuo Wiseno, Bambang Yunarsih Yunarsih Yunarsih Yunarsih Yunarsih