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All Journal Dentino: Jurnal Kedokteran Gigi Dentin
Firdaus, I Wayan Arya Krishnawan
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Dentistry

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UJI TOKSISITAS EKSTRAK DAUN KARAMUNTING (Rhodomyrtus tomentosa (Aiton) Hassk.) TERHADAP GINJAL TIKUS WISTAR (Berdasarkan Ureum dan Kreatinin) Wibowo, M. Ridhotama; Oktiani, Beta Widya; Budipramana, Melisa; Apriasari, Maharani Laillyza; Firdaus, I Wayan Arya Krishnawan
Dentin Vol 8, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v8i2.13113

Abstract

ABSTRACTBackground: Karamunting leaf have been used among community as traditional medication. Karamunting leaf have many properties because they contain secondary metabolite compounds such as flavonoids, triterpenoids, phenols, saponins and tannins. Administration as medicine is usually through oral. Oral administration of karamunting leaf in high dosage is considered to damage kidney microscopically. In vivo toxicity testing can be done to determine the toxicity effects of caramunting leaf extract at doses 600, 1200, 2400 mg/kg body weight before being tested on humans. Purpose: This study was conducted to determine whether karamunting leaf extract is toxic to the kidneys of Wistar rats subchronically with the parameters ureum and creatinine. Methods: The Rhodomyrtus Tomentosa (Aiton) Hassk. leaf were extracted using 96% ethanol and then given to male Wistar strain (Rattus norvegicus) with a 600, 1200, and 2400 mg/kg/body weight two times a day for 28 days. Rat blood was taken to check the levels of urea and creatinine. Result: The kidney ureum levels of Wistar rats in all treatment groups were still normal and did not exceed the normal range of ureum (10-50 mg/dL) while creatinine levels in all treatment groups were potentially toxic because they exceeded normal limits (0.578-1.128 mg/dL). Conclusion: The parameters of ureum and creatinine levels are not toxic because both can reduce the average value of both levels although some decrease significantly and some do not.Keywords : Creatinine, Excretion, Karamunting leaf, Kidney, Toxicity, Ureum ABSTRAKLatar Belakang: Daun karamunting telah digunakan oleh masyarakat sebagai obat tradisional. Daun karamunting banyak memiliki khasiat karena memiliki kandungan senyawa metabolit sekunder seperti flavonoid, triterpenoid, fenol, saponin dan tanin. Pemberiannya sebagai obat biasanya melalui oral. Pemberian daun ini secara oral dengan dosis tinggi diduga dapat merusak ginjal secara mikroskopis. Pengujian toksisitas secara in vivo dapat dilakukan untuk mengetahui efek toksisitas ekstrak daun karamunting pada dosis 600, 1200, 2400 mg/kg BB sebelum diujikan pada manusia. Tujuan: Penelitian ini dilakukan untuk mengetahui apakah ekstrak daun karamunting bersifat toksik terhadap ginjal tikus Wistar secara subkronik dengan parameter ureum dan kreatinin. Metode: Daun Rhodomyrtus Tomentosa (Aiton) Hassk. diekstraksi menggunakan etanol 96% dan kemudian diberikan pada tikus jantan galur Wistar (Rattus norvegicus) dengan dosis 600, 1200, dan 2400 mg/kg BB dua kali sehari selama 28 hari. Darah tikus diambil untuk memeriksa kadar urea dan kreatinin. Hasil: Kadar ureum ginjal tikus Wistar pada semua kelompok perlakuan masih normal dan tidak melebihi kisaran normal ureum (10-50 mg/dL), dan kadar kreatinin pada semua kelompok perlakuan juga normal karena tidak melebihi batas normal (0,578-1,128 mg/dL). Kesimpulan: Parameter kadar ureum dan kreatinin tidak toksik karena keduanya dapat menurunkan nilai rata-rata dari kedua kadar walaupun ada yang turun secara signifikan dan ada     yang tidak. Kata kunci: Ekskresi, Ekstrak Daun Karamunting, Ginjal, Kreatinin, Toksisitas, Ureum
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT BASED ON LIVER HISTOPATHOLOGY HYDROPIC DEGENERATION AND NECROSIS Azminida, Dhiya Salma; Firdaus, I Wayan Arya Krishnawan; Utami, Juliyatin Putri; Oktiani, Beta Widya; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20400

Abstract

Background: Ironwood bark extract contains antioxidant properties such as flavonoids, phenolics, and proanthocyanidins, which can stabilize ROS in the body and help accelerate wound healing. The liver plays a role in nutrient metabolism, detoxification, and ROS production. The lack of antioxidants to neutralize excess ROS makes the liver vulnerable to damage. Purpose: This study aimed to determine that there was no toxic effect of giving ironwood bark extract (Eusideroxylon zwageri) doses of 1.250 mg/kg, 2.750 mg/kg, and 4.750 mg/kg on the liver of Wistar rats based on histopathological features of hydropic degeneration and necrosis. Methods: Pure laboratory experimental quantitative (true experimental) with a post-test-only research design with control group design and One Way Anova statistical test. Treatment was given to 4 groups, namely group (K) was given aquadest control, group (T1) was given ironwood bark extract at a dose of 1.250 mg/kgBW, group (T2) was given ironwood bark extract at a dose of 2.750 mg/kgBW, and group (T3) given ironwood bark extract at a dose of 4.750 mg/kgBW. Results: The results showed no significant difference between the four treatment groups based on the average percentage of hydropic degeneration and necrosis. Conclusion: There was no toxic effect of giving ironwood bark extract doses of 1.250 mg/kgBW, 2.750 mg/kgBW, and 4.750 mg/kgBW on the liver of Wistar rats based on histopathological appearance of hydropic degeneration and necrosis for 14 days.
TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RAT KIDNEY (Rattus norvegicus) Robiyansyah, Hengki; Firdaus, I Wayan Arya Krishnawan; Tri Putri, Deby Kania; Sukmana, Bayu Indra; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20401

Abstract

Background: Excessive free radicals cause oxidative stress which is dangerous for the body. The number of free radicals in the body can be controlled with the presence of antioxidants. Kelakai leaves (Stenochlaena palustris.) are known to have activity as an antioxidant which has the potential to become an ingredient in herbal medicine. Purpose: To prove whether there is a toxic effect of administering kelakai leaf extract on the kidneys of Wistar rats based on analysis of blood urea and creatinine levels. Method: A pure experimental study with a posttest-only with control group design method, there were 4 groups consisting of 1 negative control group and 3 treatment groups who were given kelakai leaf extract orally for 28 days and then analyzed the blood urea and creatinine levels of the Wistar rats. Results: The average values of urea and creatinine levels in the three treatment groups were still within the normal range. There was a significant difference in the urea levels of all groups (p<0.05), and there was no significant difference in the creatinine levels of treatment groups 2 and 3 (p>0.05). Conclusion: Kelakai leaf extract given orally for 28 days did not cause toxic effects on the kidneys of Wistar rats based on analysis of blood urea and creatinine levels.
TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT ON KIDNEY HISTOPATHOLOGY GLOMERULAR HYPERTROPHY AND HYDROPIC DEGENERATION Nur Tsaniya, Gusti Erysa; Firdaus, I Wayan Arya Krishnawan; Dewi, Nurdiana; Utami, Juliyatin Putri; Setiawan, Bambang
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20403

Abstract

Background: Ironwood bark extract (Eusideroxylon zwageri) has antioxidant properties such as tannins, phenolics, flavonoids, saponins and alkonoids. Most compounds in the ironwood bark extract were phenolics (31.28 mg GAE/g), flavonoids (30.48 mg CE/g), and proanthocyanidins (183.30 mg PE/g). These can be used as alternative herbal medicines, but also has toxic effects, so a toxicity test is necessary. Toxicity tests can be seen through histopathological parameters based on glomerular hypertrophy and hydropic degeneration. Purpose: To determine the toxic effect of ironwood bark extract administration at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg orally on the kidneys of Wistar rats based on histopathological appearance of glomerular hypertrophy and hydropic degeneration. Methods: Pure experimental study with a posttest-only with control design, consisting of 4 groups with 3 treatment groups given ironwood bark extract at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg, and 1 control group was given distilled water 2x1 ml every 24 hours orally for 14 days. Results: In administration of ironwood bark extract at doses of 2,750 mg/kgBW and 4,750 mg/kgBW, glomerular diameter was found increased. The histopathological hydropic degeneration showed a score of 1 in all dose groups. The research data were analyzed using the One Way Anova and Kruskal Wallis tests. Both tests showed no significant differences between groups. Conclusion: There was no toxic effect of ironwood bark extract at doses of 1,250 mg/kg, 2,750 mg/kg, and 4,750 mg/kg on the kidneys of Wistar rats based on histopathological appearance of glomerular hypertrophy and hydropic degeneration.
COMPARISON OF FREEWAY SPACE DISTANCE OF WILLIS METHOD WITH DIGITAL PHOTO ANALYSIS METHOD IN BANJAR TRIBE Fachriani, Fachriani; Arifin, Rahmad; Puspitasari, Dewi; Wibowo, Diana; Firdaus, I Wayan Arya Krishnawan
Dentino: Jurnal Kedokteran Gigi Vol 9, No 2 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i2.20394

Abstract

Background: The face's vertical dimension or vertical height is the distance between two anatomical points, namely the points on the maxilla and mandible. In measuring the vertical dimension, vertical dimensions of rest (DVR) and vertical dimensions of occlusion (DVO) must be measured. The difference between the vertical dimension of rest (DVR) and the vertical dimension of occlusion (DVO) is called the freeway space (FWS) or interocclusal distance. Freeway space is a key requirement for optimal comfort and function of a partial or complete denture. Each individual's freeway space distance is the movement of muscle function, which can be measured by direct methods such as the Willis method using calipers and the digital photo analysis method using computer software. Two measurement methods can be used to measure freeway space distance direct and indirect. Purpose: To analyze the difference between freeway space distance measured by the Willis method and by digital photo analysis of Adobe Photoshop and Corel Draw graphic design software in the Banjar tribe (a review of students at the Faculty of Dentistry, Universitas Lambung Mangkurat Banjarmasin). Methods: This study is a quantitative study with an analytic observational method and a cross-sectional approach. This study was conducted by collecting data simultaneously at one time by comparing three different methods on the same sample without being given any treatment. Results: One Way ANOVA test is 0.296 (P>0.05) which means there is no significant difference. Conclusion: There is no significant difference between the results of measuring freeway space distance using the Willis method with a digital caliper and digital photo analysis with Adobe Photoshop and Corel Draw software.
Co-Authors Arifin, Rahmad Azminida, Dhiya Salma Bambang Setiawan Bayu Indra Sukmana Dewi Nurdiana Dewi Puspitasari Diana Wibowo Fachriani, Fachriani Maharani Laillyza Apriasari Melisa Budipramana, Melisa Nur Tsaniya, Gusti Erysa Oktiani, Beta Widya Robiyansyah, Hengki Tri Putri, Deby Kania Utami, Juliyatin Putri Wibowo, M. Ridhotama Wydiamala, Erida