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All Journal Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Aisyah : Jurnal Ilmu Kesehatan Science Midwifery Journal of Health Sciences and Medicine Jurnal Ilmiah Medicamento Jurnal Farmasi Indonesia Usadha
Ketut Agus Adrianta
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Journal of Health Sciences and Medicine

 1 
EFFECTIVENESS OF LEAF EXTRACT REDUCE INFLAMMATION REACTION IN HYPERCHOLESTEROLEMIA RATS Puguh Santoso; Ni Nyoman Wahyu Udayani; I Nyoman Gede Tri Sutrisna; Ketut Agus Adrianta
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.677 KB) | DOI: 10.24843/JHSM.2017.v01.i01.p04

Abstract

Abstract High blood cholesterol is often called hypercholesterolemia is a risk factor for the emergence of pathological conditions such as heart and blood vessel disease. Hypercholesterolemia has an important role in the occurrence of damage to the endothelial cells is mainly caused by oxidized LDL. Oxidation of LDL triggers the formation of TNF - ?. Leaves messengers that allegedly contains flavonoids can improve the situation of hypercholesterolemia through the barriers specifically the expression of TNF - ? increased due to hypercholesterolemia. Plants messengers known to contain alkaloids, flavonoids, tannins, saponins, polyphenols, calcium oxalate, fats, and essential oil. Flavonoids which has the ability to bind the atom to form free radicals not to excess free radicals, thereby inhibiting the oxidative modification of LDL become ox-LDL so it will not be formed atherosclerosis. This study uses the Randomize pattern Pre and Post Test Control Group Design, using white rats (Rattusnovergicus) with Wistar strain aged 3-4 months, weighing 175-200 grams. Divided into four groups: Group I as a control with placebo, Group II treatment using extracts of ethanol leaves a messenger at a concentration of 10%, Group III treatments using extracts of ethanol leaves a messenger at a concentration of 20%, Group IV is to use the extract ethanol leaves errand at a concentration of 30%. It can be concluded at 4 dose group 30% messengers leaf extract significantly different, p <0.05, so it can be said that the provision of effective messengers extract at a dose of 30%.
Co-Authors Agung Ari Chandra Wibawa Bagus Komang Satriyasa Debby Juliadi Desak Made Wihandani Dewa Ayu Ika Pramitha Fitria Megawati Gamaliel Agripa Gunawan, I Wayan Suardi Adi Herleeyana Meriyani I Gede Made Suradnyana I Gusti Agung Ayu Kusuma Wardani I Gusti Agung Ayu Kusuma Wardani I Made Jawi I Nyoman Gede Tri Sutrisna I Putu Windra Gunawan IGAA Kusuma Wardani Meriyani, Herleeyana Ni Nyoman Wahyu Udayani Ni Putu Siska Sugiantari Ni Putu Udayana Antari Puguh Santoso Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Suena, Ni Made Dharma Shantini Veryanti, Putu Rika Wardani, I Gusti Agung Ayu Kusuma Yeni Cendana