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All Journal Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Aisyah : Jurnal Ilmu Kesehatan Science Midwifery Journal of Health Sciences and Medicine Jurnal Ilmiah Medicamento Jurnal Farmasi Indonesia Usadha
Ketut Agus Adrianta
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Journal : Majalah Obat Tradisional

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Utilization of Artocarpus heterophylla Lamk. As UV Protector In mice exposed to UV-B Ketut Agus Adrianta; I Made Agus Sunadi Putra
Majalah Obat Tradisional Vol 23, No 3 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.009 KB) | DOI: 10.22146/mot.37407

Abstract

In daily life, Artocarpus heterophylla Lamk., the leaves are rarely used even just as animal feed. In the bark of Artocarpus heterophylla Lamk there are new flavonoid compounds namely morusin, artokarpin, artonin E, cycloartobilosantone, and artonol B. This research is an experimental design with randomized posttest only with control group design. A total of 21 mice were divided into 3 groups, each consisting of 7 mice, group 1: negative control given oral placebo and exposed to UV-B rays, group 2:giving Vitamin C cream 4% mg and exposed to UV-B rays, group 3: giving cream of Artocarpus heterophylla Lamk leaf extract 4% and exposed to UV-B rays. The total of UV radiation dose of 600 mJ / cm² for 3 weeks, then performed a biopsy for examination of the amount of dermis collagen. The average number of collagen in the three groups after treatment was given significantly different (p <0.05). Mean and Significant level of collagen density of group 1 : 51,42 ± 5,16; group P2 ± 91,18 ± 1,13; and P3 group: 88,77 ± 1,10. Conclusion : Cream of 4% Artocarpus heterophylla Lamk leaf extract can increase the amount of collagen density in mice exposed to UV-B rays.
The Antioxidant Capacity of Peristrophe Bivalvis (L.) Merr. as Natural-Based Nephroprotection Ketut Agus Adrianta; Bagus Komang Satriyasa; Desak Made Wihandani; I Made Jawi
Majalah Obat Tradisional Vol 26, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.53861

Abstract

The kidneys as one of the important body organs have a very important role in maintaining a healthy body. The kidneys function to regulate fluid balance in the body the concentration of salt in the blood, acid-base balance in the blood, and excretion of waste materials such as urea and other nitrogenous waste in the blood. Magenta plants (Peristrophe bivalvis (L.) Merr.) contain secondary metabolites, namely alkaloids, saponins, triterpenoids, tannins, and flavonoids as antioxidants. The abundance of antioxidants sourced from natural sources for various diseases is often used as a complementary therapy and is one of the current therapeutic choices. However, the development of natural sources must also consider kidney function during an intervention. The incidence of kidney failure can be caused either by the occurrence of oxidative stress or exposure to drugs and other chemical compounds must also consider the physiological functions of important organs in the body such as the liver and kidneys. This study was conducted to determine the protective role of magenta leaves extract (Peristrophe bivalvis (L.) Merr.) on the kidneys after being given an acetaminophen hepatotoxic dose. In this study, the effectiveness of magenta leaves antioxidants and the safety of use was analyzed by looking at the kidney function in the experimental model of Wistar strain male white rats, using a Randomized Post Test Only Control Group Design. Four treatment groups showed that magenta leaves extract (Peristrophe bivalvis (L.) Merr.) at 125 and 250 mg/kg BW can protect the kidneys with average creatinine levels of 0.63 and 0.75 and with a normal range (0.7 - 1.2). It means that these two groups could protect the kidney function although in the histopathology test only the group administering extracts of 250 mg/Kg BW showed good results. It can be concluded that administration of the magenta leaves extracts at 250 mg/kg BW can protect renal function as seen from serum creatinine levels. Besides, histopathological features can provide a protective effect on the kidneys with the incidence of necrosis in the kidneys of less than 60% of the toxic dose of acetaminophen.
Co-Authors Agung Ari Chandra Wibawa Bagus Komang Satriyasa Debby Juliadi Desak Made Wihandani Dewa Ayu Ika Pramitha Fitria Megawati Gamaliel Agripa Gunawan, I Wayan Suardi Adi Herleeyana Meriyani I Gede Made Suradnyana I Gusti Agung Ayu Kusuma Wardani I Gusti Agung Ayu Kusuma Wardani I Made Jawi I Nyoman Gede Tri Sutrisna I Putu Windra Gunawan IGAA Kusuma Wardani Meriyani, Herleeyana Ni Nyoman Wahyu Udayani Ni Putu Siska Sugiantari Ni Putu Udayana Antari Puguh Santoso Puguh Santoso puguh santoso, puguh Putra, I Made Agus Sunadi Suena, Ni Made Dharma Shantini Veryanti, Putu Rika Wardani, I Gusti Agung Ayu Kusuma Yeni Cendana