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Sel Induk Mesenchymal Secretome untuk Gangguan Permukaan Okular Mia Arifka; Nasrul Wathoni; Gofarana Wilar
Majalah Farmasetika Vol 7, No 2 (2022): Vol. 7, No. 2, Tahun 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v7i2.38337

Gangguan permukaan okular adalah sekelompok penyakit heterogen yang sangat umum dengan berbagai etiologi dan gejala serta merupakan faktor risiko dengan komplikasi serius pada mata. Obat-obatan saat ini termasuk obat tetes mata yang dijual bebas tidak mengobati gangguan permukaan okular atau telah dikaitkan dengan berbagai efek samping yang mengarah pada pengobatan alternatif menggunakan terapi sel induk. Sel induk mesenchymal (MSC) adalah sel induk multipoten yang berpartisipasi dalam perbaikan jaringan dan memiliki potensi imunomodulator yang cukup besar untuk mengatasi gangguan permukaan okular. MSC mensekresi secretome dengan aktivitas autokrin dan parakrin yang bekerja menghambatan fibrosis dan apoptosis, penekanan sistem kekebalan lokal, peningkatan angiogenesis, dan diferensiasi sel induk dengan melibatkan faktor-faktor terlarut seperti IL-10, TGF-β1, IL-6, TNF-α dan faktor pertumbuhan endotel vaskular (VEGF). Aplikasi MSC-secretome pada kornea tikus setelah cedera secara in vivo diketahui mencegah perkembangan neovaskularisasi kornea. Mekanisme immunomodulasi MSC-secretome dalam memediasi regulasi inflamasi, angiogenesis dan neovaskularisasi pada gangguan permukaan okular dibahas dalam ulasan ini.

EVALUASI INTERAKSI OBAT PADA RESEP PASIEN GERIATRI DI INSTALASI FARMASI RAWAT JALAN DI SALAH SATU RUMAH SAKIT DI SUKABUMI Aurizal Risandy Irawan; Gofarana Wilar
Farmaka Vol 20, No 1 (2022): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i1.33484

ABSTRAKKomplikasi penyakit biasanya terdapat pada pasien geriatri, yaitu berbagai gangguan penyakit kronis seperti hipertensi, diabetes melitus, gangguan jantung dan penyakit lainnya. Hal tersebut menyebabkan pasien geriatri akan mendapatkan resep dengan jumlah R/ lebih dari satu. Banyaknya jumlah obat yang diresepkan dan dikonsumsi dapat meningkatkan risiko gangguan kesehatan dan berpotensi untuk menyebabkan polifarmasi, sehingga dapat meningkatkan risiko terjadinya interaksi obat, Adverse Drug Reactions (ADRs), dan Medications Error. Penelitian ini bertujuan untuk mengetahui jumlah persentase interaksi obat berdasarkan tingkat keparahannya dan persentase interaksi obat berdasarkan jumlah jenis obat (R/) dari hasil evaluasi resep rawat jalan pada pasien geriatri. Identifikasi interaksi antar obat dilakukan dengan melakukan pengkajian resep pada pasien geriatri rawat jalan selama bulan September 2020 di Rumah Sakit Pemerintah di Kota Sukabumi yang kemudian ditentukan kategori interaksinya. Kemudian ditentukan persentase interaksi obat berdasarkan tingkat keparahannya dan persentase jumlah interaksi berdasarkan jumlah jenis obat (R/). Hasil penelitian menunjukkan persentase jumlah interaksi obat yang diperoleh sebesar 4,63% interaksi minor, 83,33% interaksi moderat, dan 12,03% interaksi mayor. Kemudian, persentase antara jumlah interaksi obat dengan jumlah jenis obat (R/) memiliki persentase sebesar 3,7%, 3,7%, 4,63%, 41,67%, 27,78%, dan 18,52% terhadap jumlah R/ tiga, empat, lima, enam, tujuh, dan delapan obat secara berurutan.ABSTRACT Disease complications generally occur in geriatric patients, namely various chronic diseases such as hypertension, diabetes mellitus, heart problems and other diseases. This causes geriatric patients to get a prescription with an amount of R / more than one. The large number of drugs prescribed and consumed can increase the risk of health problems and have the potential to cause polypharmacy, thereby increasing the risk of drug interactions, Adverse Drug Reactions (ADRs), and Medications Error. This study aims to determine the percentage of potential drug interactions based on their severity and the percentage of potential drug interactions based on the number of types of drugs (R/) from the evaluation of outpatient prescriptions in geriatric patients. The identification of potential interactions between drugs was carried out by conducting a prescription review of outpatient geriatric patients during September 2020 at the Government Hospital in Sukabumi City, which then determined the category of the interaction. The results showed that the percentage of the number of drug interactions that occurred was 4.63% minor category, 83.33% moderate interaction, and 12.03% major interactions. Then, the percentage between the number of drug interactions and the number of types of drugs in one prescription (R/) has a percentage of 3.7%, 3.7%, 4.63%, 41.67%, 27.78%, and 18.52 % of the number of types of drugs as many as three, four, five, six, seven, and eight drugs in one prescription respectively.

KHASIAT KACANG KENARI (Canarium Indicum L.) TERHADAP BERBAGAI MACAM PENYAKIT Nisa Masyitah; Sri Adi Sumiwi; gofarana Wilar
Farmaka Vol 16, No 3 (2018): Farmaka (September)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Herbal Medication of Recurrent Aphthous Stomatitis: A Narrative Review Taufik Septiyan Hidayat; Gofarana Wilar; Nasrul Wathoni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 1 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i1.438

A mouth ulcer or recurrent aphthous stomatitis (RAS) is a mouth mucous tissue inflammation. This disease mainly occurs in patients 10-40 years of age, preferably in women and high socioeconomic backgrounds. The cause of mouth ulcers or RAS could be trauma, infection, digestive problems, or blood disorders. Herbal practitioners widely use herbs, folks, and society to treat various diseases. This research aimed to describe the herbal treatment for RAS. The review results show there are nine plants with the ability to cure RAS, they are Persea americana Mill., Averrhoa bilimbi L., Abrus precatorius Linn., Camellia sinensis (L.) Kuntze., Psidium guajava L., Kaempferia galanga Linn., Aloe vera, Curcuma longa and Citrus hystrix DC. The most parameters used in the studies are clinical trials and in vitro tests.

Herbal Medication of Recurrent Aphthous Stomatitis: A Narrative Review Taufik Septiyan Hidayat; Gofarana Wilar; Nasrul Wathoni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 1 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i1.438

A mouth ulcer or recurrent aphthous stomatitis (RAS) is a mouth mucous tissue inflammation. This disease mainly occurs in patients 10-40 years of age, preferably in women and high socioeconomic backgrounds. The cause of mouth ulcers or RAS could be trauma, infection, digestive problems, or blood disorders. Herbal practitioners widely use herbs, folks, and society to treat various diseases. This research aimed to describe the herbal treatment for RAS. The review results show there are nine plants with the ability to cure RAS, they are Persea americana Mill., Averrhoa bilimbi L., Abrus precatorius Linn., Camellia sinensis (L.) Kuntze., Psidium guajava L., Kaempferia galanga Linn., Aloe vera, Curcuma longa and Citrus hystrix DC. The most parameters used in the studies are clinical trials and in vitro tests.

Edukasi Tentang Diabetes Melitus dan Pemanfaatan Kayu Manis sebagai Tanaman Obat Antidiabetes Kepada Masyarakat Ida Musfiroh; Gofarana Wilar; Eka Rosalianti; Almira Agustini Hadirana; Zahra Siti Hanifah
Journal of Community Development Vol. 3 No. 1 (2022): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v3i1.59

The number of people with diabetes mellitus is increasing every year, even statistics show that in 2020 Indonesia is ranked 7th in the world. Many people still do not know how to understand diabetes mellitus and a healthy lifestyle, as well as the use of medicinal plants as antidiabetic. The use of herbal medicine has many advantages. One type of medicinal plant that is effective as a diabetes treatment therapy in the Indonesian Traditional Medicine Formulary (FROTI) is cinnamon. This activity has the aim of providing socialization and education to the public in the health sector about diabetes mellitus and anti-diabetic medicinal plants, especially cinnamon which is developed in dye bags. The implementation method is carried out virtually, considering the current state of the COVID-19 pandemic, with 3 stages, namely the planning stage, the implementation stage and the follow-up stage. The result of this PPM activity is the implementation of online seminars and education through infographic posters and videos and shows that the public is becoming more educated in their knowledge about diabetes treatment efforts by utilizing various types of medicinal plants and how to process them. The results of this activity can be concluded that the education and information activities carried out can increase public understanding and knowledge about diabetes mellitus, as well as understanding of various types of antidiabetic medicinal plants that can be utilized by the community .This is based on the results of the pre-test and post-test as a measure of the success of this PPM activity.

PENDIDIKAN KESEHATAN DENGAN METODE HYBRID TENTANG COVID-19 DAN PENYAKIT HIPERTENSI PADA KADER PKK DESA CIKIDANG KECAMATAN LEMBANG Jutti Levita; Sri Adi Sumiwi; Mutakin Mutakin; Tiana Milanda; Irma Melyani Puspitasari; Sriwidodo Sriwidodo; Ellin Febrina; Yasmiwar Susilawati; Indah Suasani Wahyuni; Irma Erika Herawati; Renny Amelia; Gofarana Wilar
Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Vol 11, No 2 (2022): Juni. 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v11i2.34927

Kegiatan Pengabdian Kepada Masyarakat (PPM) di Desa Cikidang sudah dilaksanakan selama tiga tahun berturut-turut. Masyarakat berpartisipasi sangat baik dan menginginkan kegiatan dapat dilakukan secara kontinu serta melibatkan masyarakat yang lebih luas. Desa Cikidang belum memiliki sarana kesehatan dan lokasi Puskesmas terdekat adalah di Desa Cikole, berjarak 3,5 km. Berdasarkan data dari Puskesmas Cikole periode tahun 2019, tercatat bahwa penyakit hipertensi memiliki angka kejadian tertinggi yaitu 135 kejadian. Kegiatan PPM ini bertujuan untuk meningkatkan pemahaman kader PKK tentang penyakit hipertensi dan juga tentang COVID-19. Kegiatan dilakukan dengan menerapkan metode hybrid luring dan daring (gabungan sinkronus dan asinkronus menggunakan media leaflet dan video). Dari sejumlah enam puluh undangan yang disebarkan, kegiatan PPM dihadiri oleh tiga puluh lima peserta. Hasil pre-test dan post-test menunjukkan adanya peningkatan pengetahuan peserta, sehingga dapat disimpulkan bahwa pendidikan kesehatan secara hybrid berhasil meningkatkan pengetahuan kader PKK tentang COVID-19 dan Penyakit Hipertensi sebesar 13,56%.Â

PENDAMPINGAN PENERAPAN PROTOKOL KESEHATAN PENYELENGGARAAN KEGIATAN DI SEKOLAH PADA MASA KENORMALAN BARU PANDEMI COVID-19 Rudi Saprudin Darwis; Sri Sulastri; Gofarana Wilar
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 5, No 4 (2022): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v5i4.1408-1416

The Covid-19 pandemic has forced people to change their behavior patterns to suit the situation and conditions during the pandemic, which is called the new normal. One of the things that must change is the pattern of education that must be accompanied by adjustments to the behavior of teachers and students in the learning process. At the time the government implemented Limited Face-to-face Learning (PTMT) there were still many. For this reason, this study aims to support the government's efforts to maintain the sustainability of education by assisting the implementation of health protocols in elementary schools during the new normal period of the Covid-19 pandemic. The study was conducted at SDN Pelangi 1 Sukamukti Village, Majalaya District, Bandung Regency. The method used in mentoring the implementation of health protocols is an extension method accompanied by a simulation of the practice of implementing the 3M health protocol (wearing masks, keeping distance, washing hands) which is attended by half of the students from grades 1 to 6. The results of the mentoring show that the students who initially did not recognize the scope of 3M and how it was implemented correctly, by the end of the activity most of them had applied how to wear masks properly, wash their hands properly, and tend to avoid crowds.

PEMANTAUAN TERAPI PASIEN PENDERITA CKD DAN HIPERTENSI DI SALAH SATU RUMAH SAKIT DI BANDUNG Elsa Daw Cristin; Hasna Shafira Zahra; Gofarana Wilar; Anggi Setiadi
Farmaka Vol 20, No 2 (2022): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i2.39722

CKD (Chronic Kidney Disease) merupakan gangguan yang terjadi pada fungsi ginjal secara progresif dan bersifat ireversible karena ginjal tidak mampu mempertahankan keseimbangan dan metabolisme cairan serta elektrolit yang mengakibatkan terjadi uremia (retensi urin dan penumpukan nitrogen dalam darah). Hipertensi merupakan penyebab yang umum dari gagal ginjal karena terjadinya peningkatan tekanan pada kapiler glomerulus. Penggunaan obat hipertensi juga dapat menyebabkan terjadinya edema. Anemia merupakan salah satu komplikasi yang sangat umum pada penderita CKD. Hal tersebut terjadi akibat penurunan produksi eritropoetin endogen pada ginjal. Pelaksanaan PTO ini dilakukan di salah satu Rumah Sakit di Bandung dengan pasien CKD stage V. Pasien tersebut juga didiagnosa CKD dengan asidosis metabolik, dengan diagnosa tambahan anemia dan trombositopenia dengan riwayat sebelumnya adalah hipertensi. Pemantauan Terapi Obat dilakukan dengan memastikan penggunaan obat yang tepat dan menghindari kejadian yang tidak diinginkan.Kata kunci: CKD, Hipertensi, PTOAbstractCKD (Chronic Kidney Disease) is a progressive and irreversible disorder that occurs in kidney function because the kidneys are unable to maintain fluid and electrolyte balance and metabolism, resulting in uremia (urinary retention and nitrogen accumulation in the blood). Hypertension is a common cause of kidney failure due to increased pressure in the glomerular capillaries. The use of hypertension drugs can also cause edema. Anemia is a very common complication in patients with CKD. This occurs due to decreased production of endogenous erythropoietin in the kidneys. The PTO was carried out at a hospital in Bandung with a stage V CKD patient. The patient was also diagnosed with CKD with metabolic acidosis, with additional diagnoses of anemia and thrombocytopenia with a previous history of hypertension. Drug Therapy Monitoring is done by ensuring the proper use of drugs and avoiding unwanted events.Keywords:CKD, Hypertension, PTO

Edukasi Hidup Sehat Tanpa Diabetes Dengan Pemanfaatan Tanaman Obat Bagi Masyarakat Desa Mekarjaya Banjaran Ida Musfiroh; Sandra Megantara; Holis Abdul Holik; Yasmiwar Susilawati; Gofarana Wilar
Journal of Community Development Vol. 3 No. 3 (2023): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v3i3.113

Diabetes mellitus in Indonesia now ranks 5th with the highest number of diabetes mellitus sufferers in the world. At present, the prevalence has increased from 6.2% compared to 2019. Diabetics need to get effective and safe drugs in order to avoid various complications. In addition to using pharmacological therapy, it is also necessary to carry out non-pharmacological therapy. One type of medicinal plant that is known to be effective in reducing sugar is ginger and cinnamon, but there has not been much reported on its processing other than in the form of a decoction or marinade. The purpose of carrying out this PPM activity is to increase the knowledge and understanding of the people of Mekarjaya Banjaran Village regarding the use of medicinal plants as anti-diabetics, and provide knowledge about making ginger-cinnamon instant powder drinks. The activity method is carried out in 3 stages, namely the planning, implementation, evaluation and follow-up stages. The results of this PPM activity show that the community has a better understanding of efforts to be healthy in preventing diabetes through the use of ginger-cinnamon medicinal plants, and how to process them through instant powders. The evaluation is carried out based on the results of the initial test and the final test as a method for measuring the achievements of this PPM activity.

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