Merryana Adriani
Fakultas Kesehatan Masyarakat Universitas Airlangga, Indonesia

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ADMINISTRATION OF RED ROSELLA’S PETALS EXTRACT (Hibiscus sabdariffa) INCREASE LEVEL OF SUPEROXIDE DISMUTASE (SOD) WISTAR RATS WHICH INDUCED BY REPETEADLY HEATED COOKING OIL Herdiani, Novera; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 2 (2015): Edisi Desember 2015
Publisher : Universitas Wijaya Kusuma Surabaya

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Background:  repeatedly heated cooking oil is cooking oil that is used many times, had saturated fatty acids containing free radicals. Red rosella petals extract contains antioxidants to minimize the effects of repeatedly heated cooking oil that can raise the levels of SOD. The aim of this study was to analyzed the effect of red rosella’s petals extract against oxidative stress of Wistar rats were induced by repeatedly heated cooking oil with examine levels of  serum SOD.This research was conducted True Experimental Laboratory with a completely randomized design (CRD) and use the post test. The sample consisted of 24 male rats were divided 4 groups: negative control (fed with standard diet); positive control (fed with standard diet + administered by repeatedly heated cooking oil as much as 2.1 ml / kg bw); treatment group dose I (fed with standard diet + administered by red rosella extract dose 540 mg / kg bw + repeatedly heated cooking oil as much as 2.1 ml / kg bw), and treatment group dose II (fed with standard diet + administered by red rosella extract dose 810 mg / kg bw + repeatedly heated cooking oil as much as 2.1 ml / kg bw). Analysis of data using statistical test One Way ANOVA and Tukey HSD (α = 0.05).Results: There were significant differences (p = 0.000) between groups. Red rosella extract treatment group dose 810 mg / kg bw and 540 mg / kg bw were significantly different from the positive control (p = 0.000). Red rosella extract group dose 540 mg / kg bw was significantly different from the negative control (p = 0.000). Red rosella extract group dosage of 810 mg / kg bw was not differ significantly from the control group (p = 0.171).Conclusion: The red rosella’s petals extract dose of 810 mg / kg bw and dose of 540 mg / kg bw were able to prevent oxidative stress. Optimal deose of red rosella petals extract dose of 810 mg / kg bw was the most effective, because the higher antioxidant activity (67.33%) at dose 810 mg / kg bw dose than 540 mg / kg bw.
EFFECT OF FORTIFIED MILK (CALCIUM AND VITAMIN D) AND OSTEOPOROSIS GYMNASTICS TOWARD BONE DENSITY OF PRE ELDERLY WOMEN IN THE WORKING AREA OF HEALTH CENTER BANYUANYAR IN DISTRICT SAMPANG Prasetya, Desy; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 1 (2015): edisi September 2015
Publisher : Universitas Wijaya Kusuma Surabaya

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Disorders of bone density becomes a major public health problem, especially in women pre elderly. Besides due to low intake of essential nutrients for bone, also because of declining estrogen due to menopause. Low bone density can lead to osteoporosis and impact on risk of bone fracture. Fortified milk is one of strategy to provide the intake of calcium and vitamin D daily. In addition, osteoporosis gymnastics also plays a role to increase the absorption of calcium in the small intestine. The aim of this study was to analyzed the effect of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density in women pre elderly in the working area of health center Banyuanyar Sampang. Research design used Non equivalent Control Group Design. Samples were 45 pre elderly womens (age 50-59 years) which is composed of 15 people (treatment group I) in the form of gymnastics osteoporosis, 15 (treatment group II) in the form of osteoporosis gymnastics and fortified milk, and 15 people in the control group. Statistical test using paired T-test, Wilcoxon and Kolmogorov Smirnov. There was the influence of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density (p = 0.037). While in the first treatment group (p = 0.217) and showed no effect on controls groups (p = 0.157). There was the influence of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density. Some respondents have improvement or increase of T-score.
THE EFFECTS OF CORN FLOUR WITH TEMPEH FLOUR SUPPLEMENTATION FEEDING IN DIABETES MELLITUS WISTAR RATS TOWARD BLOOD GLUCOSE LEVEL Asmarani, Fatifa; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 2 (2015): Edisi Desember 2015
Publisher : Universitas Wijaya Kusuma Surabaya

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Background: Diabetes mellitus (DM) is metabolic disorder syndrome characterized by hyperglycemia due to deficiency of insulin secretion. Patients of diabetic patients increases each year, so it needs proper handling. Corn flour is a source of carbohydrates with a low glycemic index to help reduce the rise in blood sugar levels. In addition, supplementation with tempeh flour containing isoflavones act to protect cells from free radical thereby inhibiting damage cells. Fiber in tempeh affect blood glucose levels because it slows the absorption of glucose.Objective: To determine the effect supplementation of corn flour with tempeh flour on blood sugar levels in diabetes mellitus Wistar rats.Methods: The study was true experimental design with Pre-posttest control group design, samples were 20 male Wistar rats aged 2-3 months were then divided into 4 groups (T0, T1, T2, T3.) T0 was injected with alloxan as 30 mg / 150 grams of BB rats are subsequently treated with standard diet; T1 was dministered by standard diet 50% + 50% corn flour; T2 was administered by standard diet 50% + 30% + corn flour tempeh flour 20%; and T3 was administered by standard diet of corn flour 50% + 15% + 35% tempeh flour for 2 weeks. Blood glucose levels were measured with a glucose kit (GOD FS). Research data were analyzed by One Way ANOVA followed by Tukeys Post Hoc test p-value <0.05.Results: There were significant differences on blood sugar levels in all groups (p = 0.000): control group (only dietary standards), T1 (administered by standard diet 50% + corn flour 50%), T2 (administered by a standard diet 50% + cornstarch 30% tempeh flour + 20%) and T3 (administered by standard diet of corn flour 50% + 15% + 35% tempeh flour).Conclusion: corn flour with tempeh flour supplementation effect on decresing of blood sugar levels.
THE GIVING EFFECTS OF BISCUITS AND TEMPEH-BASED FLOUR CAKES AS SUPPLEMETARY FEEDING TOWARDS IMPROVEMENTS IN BODY WEIGHT AND HEIGHT IN CHILDREN SUFFERING MALNUTRITION 2015 Rizky, Oktovina; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 1 (2015): edisi September 2015
Publisher : Universitas Wijaya Kusuma Surabaya

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Background: Nutritional problem in children is considered as a major issue and one that should receive priority in treatment is concerning to malnutrition. Malnutrition in children occurs due to insufficiency in energy and protein. Energy and protein are required in supporting rapid growth in children.Objective: to learn the giving effects of biscuits and tempeh-based flour cakes as supplementary feeding towards improvements in body weight and height of children under five suffering malnutrition in one of Public Health Center working area, northern region of Kediri Municipality.Methods: This study used a Randomized Control Triall Design, towards groups of children under five by providing tempeh-based flour cakes for supplementary feeding in the treatment group and by providing biscuits for supplementary feeding in control group. Samples were as many as 30 children under five and the data were being analyzed using peason and pre-post differences analysis was done using paired samples T-testResult: There was significant difference between body weight and body height after  provision of providing biscuits and tempeh-based flour cakes for supplementary feeding with  p = 0.001 (p <α) for the treatment group and p = 0.001 (p <α) for the control group.Conclution: Providing and tempeh-based flour cakes in the treatment group for 30-days gave influence on increasing body weight and height.
Cocoa Liquor Increases SOD Activity in Wistar Rats Experiencing Oxidative Stress Dwi Putra, Kartika Wahyu; Wirjatmadi, Bambang; Purwanto, Bambang; Adriani, Merryana
Health Notions Vol 2 No 1 (2018): January, 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Young Khalaal Dates (Phoenix dactylifera) Effect on Blood Glucose in Alloxan-induced Wistar Male Rats Sholikhah, Desty Muzarofatus; Wirjatmadi, Bambang; Adriani, Merryana
Health Notions Vol 2 No 1 (2018): January, 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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Young Khalaal Dates (Phoenix dactylifera) Effect on Blood Glucose in Alloxan-induced Wistar Male Rats
Bee Pollen Effect on Blood Glucose Levels in Alloxan-induced Male Wistar Rats Rahayu, Aprilia Nurcahyaning; Wirjatmadi, Bambang; Adriani, Merryana; M., Soenarnatalina; Winarni, Dwi; Hartiningsih, Sri
Health Notions Vol 2 No 1 (2018): January, 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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The Role Of Zinc Sulphate And Omega 3 On The Improvement Of Weight And Speed Conversion Conversion On Tuberculosis Parent Patients At Surabaya Park Hospital, 2015 Durry, Fara Disa; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, can affect almost all organs of the body with the most locations in the lungs. Immunity and high nutrients such as vitamin C, zinc and other antioxidants have shown good effects for infections, including tuberculosis. One effort to help accelerate sputum conversion of people with pulmonary tuberculosis is by supplementation of Zinc Sulphate and Omega 3.Objective: Analyze the role of Zinc Sulphate and Omega 3 on sputum conversion acceleration in patients with pulmonary tuberculosis at Surabaya Paru Hospital 2015.Method: This research use Randomized Pre Post Test Post Control Group Design design. In patients with pulmonary tuberculosis with Zinc Sulphate and Omega 3 in the treatment and placebo group in the control group. A sample of 20 patients consisting of 10 treatment patients and 10 control patients. Statistical test using paired T-Test, Friedman test and Mann whitney.Results: Friedman test showed that in the treatment group showed significant difference in the number of BTA between before and after supplementation (p=0,001), while in the control group significance of 0.141. Mann-Whitney test  showed no significant difference in the amount of reduction of BTA between the treatment group and the control group (p = 0.080). This means that statistically does not show any significant difference.Conclusions: Zinc Sulphate and Omega 3 play a role in accelerating sputum smear conversion of respondents. The results of smear test in pulmonary TB patients with Zinc Sulphate and Omega 3 supplementation showed positive results
Pengaruh ekstrak melon terhadap kadar HbCO pada tikus Wistar jantan yang dipapar asap rokok Susanti, Yuyun Erlina; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Gizi Klinik Indonesia Vol 13, No 3 (2017): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

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Background: Smoking is something that is usual for most Indonesian society, especially adult males. According to Riskesdas, smoking behavior of the population trends to increase. A previous study suggested that exposure to cigarette smoke produce CO bond to hemoglobin. Melon (Cucumis melo) contains antioxidants that prevent tissue damage.Objective: Analyze differences in levels HbCO Wistar male rats in treated and untreated extracts of melon.Method: The research was a laboratory experiment with the post test control group design and complete random design. The subjects were 25 male Wistar rats aged 3 months. Subjects were divided into 5 groups and each group received treatment for 28 days. Data of level HbCO was collected and analyzed by Anova One Way test at 95% confidence level.Results: The results showed a difference between the average levels of HbCO male Wistar rats (p value=0,000) treated and untreated extracts of melon.Conclusion: Melon extracts effect on decreasing the levels of HbCO due to exposure to cigarette smoke. There were differences in levels of male Wistar rats HbCO on treated and untreated extracts of melon and be given at a dose of 250 IU/day.
Peranan kadar nitrit oksida (NO) darah dan asupan lemak pada pasien hipertensi dan tidak hipertensi Astutik, Pudji; Wirjatmadi, Bambang; Adriani, Merryana
Jurnal Gizi Klinik Indonesia Vol 10, No 2 (2013): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.341 KB) | DOI: 10.22146/ijcn.18847

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Background: Hypertension is closely related to impaired endothelial dependent vasodilation due to decreasing availability of blood nitric oxide (NO) and high fat intake.Objective: To analyze blood NO and fat intake differences in patients with hypertension andnon hypertension.Method: The study was a cross-sectional design and sampling was carried out in Sidoarjo District Hospital. Subjects of the study were 24 patients aged between 40 to 65 years, which consist of 12 cases and 12 controls. Measurement of blood NO and recall of fat intake were performed.Results: Blood NO in hypertension andnon hypertension patients were 72.333 ± 40.511µM and 116.083 ± 46.962 µM respectively. Fat consumption in hypertension andnon hypertension were 51.52 ± 5.99 g and 41.65 ± 8.32 g respectively. Two independent samples t-test showed meaningful differences in the levels of blood NO (p=0.023) as well as fat intake (p=0.004) between the hypertension andnon hypertension patients.Conclusion: There is a difference in the levels of blood NO and fat intake in patients with hypertension andnon hypertension.