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PENGARUH KOMBINASI EKSTRAK JERUK BRASTAGI DAN WORTEL PER ORAL SEBELUM AKTIVITAS FISIK TERHADAP KADAR MALONDIALDEHID PLASMA MENCIT DALAM BERBAGAI DURASI AKTIVITAS FISIK Felix Samuel; Hanna Goenawan; Aziiz Mardanarian Rosdianto; Juliati Juliati
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 1, No 1 (2018)
Publisher : PAIFORI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (606.596 KB) | DOI: 10.51671/jifo.v1i1.72

Abstract

Under specific circumstances such as during aerobic predominant exercise, the production of free radicals increases and creates free radicals-endogen antioxidants imbalance. It causes oxidative stress. The level of oxidative stress can be recognized by measuring the level of plasma malondialdehyde (MDA). But the effect of physical activity and the effect of exogenous antioxidants supplementation is still not clearly known in the literature. Based on the background above, as a preliminary study, the writers conduct a study to investigate the plasma MDA level on mice which is given and not given a combination of Brastagi’s oranges and carrots juice before physical activity using mice’s treadmill for 10,20, and 30 minutes. The research method used in this study is an experimental laboratory study. As objects of this study are 24 mice(mus musculus), white-colored, male, weighting 25-30 grams, which is randomly chosen. The objects are divided into 2 groups, Group A: 12 mice (given a combination of Brastagi’s oranges and carrots juice before physical activity using mice’s treadmill) and group B: 12 mice (not given a combination of Brastagi’s orangesand carrots juice before physical activity using mice’s treadmill). Group A is divided into 3 subgroups: A1 (doing treadmill for 10 minutes), A2 (doing treadmill for 20 minutes), and A3 (doing treadmill for 30 minutes). The same procedure is employed for group B. Plasma MDA level measured after doing a physical activity using mice treadmill. The homogeneity of the result then was tested using Levene’s test and the normality of the result was tested using the Kolmogorov-Smirnov test (p>0.05). Further, the data were analyzed using an independent t-test (p≤0.05), one-way ANOVA (p≤0.05) then Duncan’s test were used. The analyzed data indicated a combination of Brastagi’s oranges and carrots juice supplementation given to mice before physical activity, for 10,20, and 30 minutes caused lower plasma MDA levels than mice not given a combination of Brastagi’s oranges and carrots juice before physical activity. The differences are 38,44% (0,5277 vs 0,8571) (A1-B1); 37,96% (0,5866 vs 0,9455) (A2-B2); dan77,79% (0,8438 vs 1,6161) (A3-B3).The conclusion of the study suggested that a combination of Brastagi’s oranges and carrots juice supplementation given to mice before physical activity for 10,20, and 30 minutes caused lower plasma MDA levels than mice not given a combination of Brastagi’s oranges and carrots juice before physical activity.
ROLE OF RESISTANCE EXERCISE IN CONTROLLING INSULIN-LIKE GROWTH FACTOR 1 (IGF-1) AND IT’S ASSOCIATION WITH METABOLIC DISEASE PREVENTION Fitri Fadhilah; Abdul Hadi Hassan; Hanna Goenawan; Herry Herman; Aziiz Mardanarian Rosdianto; Ronny Lesmana
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 2, No 1 (2019)
Publisher : PAIFORI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.127 KB) | DOI: 10.51671/jifo.v2i1.106

Abstract

Based on data Riset Kesehatan Dasar (Riskesdas) in 2007, the number of people who had no or low physical activity reached 48.2 %. This condition contributes to the increasing number of metabolic disease cases such as hypertension, heart disease, stroke, and diabetes mellitus. Optimizing training approaches especially the aerobic type helps to counter metabolic diseases. Unfortunately, the benefits of resistance training (RT) are less understood. RT improves muscle strength, induces muscle hypertrophy, improvement of local muscular performance, and also helps to strengthen body balance and coordination. There is an interplay between training and hormone in muscle adaptation during resistance training. The hormone plays an important role in the regeneration of muscle after resistance training. The changes in hormone level cause hypertrophy. Regeneration and muscle hypertrophy are mediated by activation, proliferation, and differentiation of satellite cells. It is regulated by mitotic and myogenic activity, namely insulin-like growth factor-1 (IGF-1), which serves as a paracrine or autocrine. A better understanding of homeostasis hormone during training in skeletal muscle and its ultimate purpose to counter metabolic disease will lead us to a better treatment approach for the patient.
Kajian Pustaka: Pemanfaatan Simplisia dan Sediaan Galenik Sebagai Bahan Fitofarmaka dan Herbal Terstandar untuk Kesehatan Promotif dan Preventif Kuda Ziazan Bevina Athallah; Aziiz Mardanarian Rosdianto; Dwi Cipto Budinuryanto
Jurnal Veteriner Vol 23 No 2 (2022)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.186 KB) | DOI: 10.19087/jveteriner.2022.23.2.265

Abstract

Kuda telah lama dikenal sebagai hewan yang memiliki fungsi ekonomi dan nilai budaya. Saat ini, minat dan permintaan terhadap tanaman berkhasiat obat untuk pengobatan etnoveteriner pada kuda semakin meningkat. Penggunaan herbal berpotensi mengobati dan mengatasi masalah kesehatan pada kuda, namun khasiat dan keamanannya belum jelas karena tahapan penelitian yang panjang untuk dikenal sebagai obat standar yang spesifik. Dalam penelitian ini, kami mengumpulkan sejumlah informasi ilmiah dari tinjauan sistematis untuk mengeksplorasi potensi herbal untuk menunjang kesehatan kuda. Ditemukan sejumlah 16 jenis tanaman yang berasal dari beberapa lokasi di dunia yang memiliki khasiat obat pada kuda dengan peran preventif dan promotive. Berbagai bagian dari tanaman Ashwaganda, Kapuk Gurun, Devil’s claw, Ginseng, Jahe, Bawang Putih, Rami, Echinacea, Evening Primrose, Lavender, Rose Hip, Aloe Vera, Kranberi, Sea Buckthorn, Avocado-Soy, Bunga Matahari, dan Temulawak telah digunakan sebagai bahan komplementer dan alternative pengobatan untuk mengatasi beberapa masalah kesehatan pada kuda. Karena adanya keterbatasan dalam sumber informasi, penulis menduga bahwa upaya preventif dan promotif belum menjadi perhatian utama untuk kesehatan kuda. Maka dalam hal ini, penulis mencoba menyampaikan beberapa yang diperoleh terkait dengan pemanfaatan tanaman berkhasiat obat sebagai alternatif dan pelengkap kesehatan kuda secara promotif dan preventif.
NUTMEG EXTRACT POTENTIALLY ALTERS THE CHARACTERISTICS PROFILE OF ADIPOSE TISSUE 3T3-L1 CELL LINES Aziiz Mardanarian Rosdianto; Ronny Lesmana; Iwan Setiawan; Yuni Susanti Pratiwi; Nurul Fadhilah; Ivan Christian Channel; Vita Mutia Tarawan
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 5, No 1 (2022)
Publisher : PAIFORI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51671/jifo.v5i1.125

Abstract

Metabolic syndrome (MS) is currently emerging globally and increases the risk of dangerous chronic diseases. Obesity involving inflammatory mediators secreted by adipocytes appears to be the major cause. While white adipose tissue (WAT) functions as energy storage, brown adipose tissue (BAT) involves in thermogenesis and is known to have the ability to dissipate energy. Currently, researchers are developing BAT through the browning mechanism of adipose tissue to prevent and cure MS. The extract derived from nutmeg, a tropical seed of Myristica fragrans, has a peroxisome proliferator-activated receptor γ (PPARγ) agonistic effect which is known to stimulate brown adipocytes development. PPARγ activation stimulates the expression of uncoupling protein 1 (UCP1), uncoupling protein 2 (UCP2), and uncoupling protein 3 (UCP3). In the present study, we explore nutmeg-induced stimulation of UCP1, UCP2, and UCP3 protein level characterization shift in 3T3- L1 cell lines which indicates the browning mechanism of adipose tissue exerted by nutmeg. Nutmeg was first extracted and 3T3-L1 cell lines taken from ATCC were used which were grown in Dulbecco’s Modified Eagle Medium (DMEM). Cells were treated with nutmeg extract (NuSE) with dose: 0.01; 0.1; 1; and 10 ppm. Western blot and ImageJ software were used for protein analysis and all experimental data were analyzed using SPSS. Results showed that NuSE stimulates the increase of UCP1 and UCP2 protein levels significantly at a 10-ppm dose. This suggests that polyphenol- containing malignant in NuSE has the probability to regulate PPARγ which potentially alters characteristics of white adipose tissue in 3T3-L1 cell lines.
EFFECT OF Archidendron pauciflorum IN DIET ON HEMATOLOGY, GLUCOSE, LIVER FUNCTION, AND WEIGHT INDUCED-RATS WITH HIGH-FAT DIET Hilmi Al Wahid; Aziiz Mardanarian Rosdianto; Ronny Lesmana
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 4, No 2 (2021)
Publisher : PAIFORI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51671/jifo.v4i2.121

Abstract

A. pauciflorum is known to have various pharmacological activities, including antimicrobial, antioxidant, antidiabetic, antidiarrheal, anticancer, and anti-gastric activity. In-vivo studies were conducted to determine the therapeutic and metabolic effects of A. pauciflorum. This research aimed to study the Effect of A. pauciflorum added to the diet in rats. The treatment group was divided into 4 to six mice each. The treatment group consisted of normal control, a negative control, and two test groups. The normal control group was given a normal diet (NCD), and the negative control group was given a high-fat diet (HFD) diet containing palmitic fatty acid to be overweight. Both test groups were given a normal diet and preparations containing A. pauciflorum (NCD-JK), and high-fat diets were fed with A. pauciflorum (HFD-JK). The treatment was carried out for nine weeks. Adding A. pauciflorum to feed can increase hemoglobin, RBC, WBC, glucose, and body weight caused by the content of Se in A. pauciflorum, which can protect cells from free radicals and affect the composition of gut microbiota. However, the administration of A. pauciflorum did not affect the platelets, ALT, and AST levels, which might be due to the lack of Se content in A. pauciflorum.