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All Journal Pharmacon Journal Syifa Sciences and Clinical Research (JSSCR) Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Borneo Journal Of Pharmascientech Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Nursing and Health (JNH) Akper Yakpermas Banyumas Jurnal Ilmiah Farmasi Akademi Farmasi Jember Jurnal Pengabdian Masyarakat JHeS (Journal of Health Studies) Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT
Rani Prabandari
universitas harapan bangsa
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Jurnal Farmasi dan Sains Indonesia (JFSI)

 1 
UJI AKTIVITAS ANTI INFLAMASI EKSTRAK ETANOL BAWANG MERAH (Allium Cepa L.) VARIETAS BIMA BREBES PADA TIKUS PUTIH JANTAN GALUR WISTAR Abidia Kamil; Adita Silvia; Rani Prabandari
Jurnal Farmasi & Sains Indonesia Vol 5 No 1 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no1p60-64

Abstract

Shallots are one of the leading vegetable commodities in Indonesia. The center for shallot production is Central Java Province, especially in the Brebes Regency area. Shallots (Allium cepa L) can be used as medicine, one of which is as an anti-inflammatory. The purpose of this study was to determine the anti-inflammatory activity and to determine the best dose of ethanolic extract of shallot (Allium cepa L) which has anti-inflammatory activity against male white rats of wistar strain. The method used is the experimental method. Shallot extract (Allium cepa L.) was extracted using 70% ethanol by maceration method. The test animals used were white male rats wistar strain as many as 25 rats weighing 200-250 grams. The test animals were divided into 5 groups, namely the negative control group (Na CMC 0.5%), the positive group (Na Diclofenac), the onion extract dose variation group (25 mg/KgBW, 50 mg/KgBW, and 100 mg/KgBW). . Treatment 1 hour afterthe hind legs of rats was induced by subplantar carrageenin. The measurement of the volume of edema on the soles of the rats' feet was observed once every 1 hour for 6 hours. The results of the study showed that there was antiinflammatory activity at the three doses (25 mg/KgBW, 50 mg/KgBW and 100 mg/KgBW) ethanol extract of shallot (Allium cepa L) Bima Brebes in male white rats of the Wistar strain. The best dose of ethanolic extract of shallot (Allium cepa L) which has anti-inflammatory activity against male white rats of wistar strain is 50 mg/KgBW.
Formulasi Antibakteri Mouthwash Ekstrak Etanol Daun Kirinyuh (Chromolaena odorata (L.) R.M.King & H.Rob.) Pada Bakteri Streptococcus mutans STCC 31987 Esti Erdiyati; Rani Prabandari; Sunarti Sunarti; Desi Nawangsari
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p17-27

Abstract

Kirinyuh leaves (Chromolaeina odorata (L.) R.M.King &; H.Rob.) contain secondary metabolites in the form of flavonoids, saponins, steiroids, tannins that can inhibit the growth of antibacterial growth. Based or its antibacterial properties, kirinyuh leaf extract can be developed into mouthwash to prevent dental plaque. The purpose of this study was to determine the physical stability test of the kirinyuh leaf ethanol extract mouthwash preparation and to determine the antibacterial activity of the kirinyuh leaf ethanol extract against Streptococcus mutans ATCC 31987 bacteria, so that a  formulation of the kirinyuh leaf ethanol extract mouthwash preparation could be made. Mouthwash is an antiseptic preparation that is used to clean the oral cavity and is used by gargling. The extraction used was remaceration method with 70% ethanol solvent, made in various extracts with concentrations of 10%, 20%, 30%. Further evaluation of the preparation includes : organoleptic test, pH test, viscosity test. The results of the One Way ANOVA analysis showed that there was no significant difference in the pH test, viscosity test with a p>0,05 value. Organoleptic test during 6 cycles of storage in a stable state during storage. The results showed that the ethanol extract of kirinyuh leaf mouthwash was able to inhibit the growth of Streptococcus mutans bacteria, namely in F1 the weak category was 2.43±0.81 mm, F2 was 10.21±3.56 mm the strong categori, F3 was 13.38±2.72 mm strong category.   Keywords : Antibacterial, Kirinyuh leaves, Mouthwash
Co-Authors Abidia Kamil Adita Silvia Adita Silvia Fitriana Adriani, Prasanti Anggestia Zakina Anggiani Nuralinda desi nawangsari Desy Nawangsari dina febrina Dwi Novitasari Erni Lovianasari Esti Erdiyati Fina Rudiyanti Galih Samodra Gita Rizki Saputri Ikhwan Yuda Kusuma Indariah Purbasari Khamdiyah Indah Kuurniasih Kukuh Yunianto Sumargo Lina Umami Made Suandika Niken Oktaviani Nisa Nur Fadilah Noor Yunida Triana Nur Rifka Zaneta Peppy Octaviani Peppy Octaviani Peppy Octaviani DM Riska Fitria Ningsih Riska Norma Sarita Riska Setyaningsih Riza Mustofa Sita Nur Faradila Sita Sunarti Sunarti Sunarti Triana Nur Safitri umi sangadah Yulsela Senaen Yustiyani Arifah Zulfa Fadhilah