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Pengaruh Usia terhadap Cervical Intraepithelial Neoplasia (CIN) pada Wanita dengan Infeksi Saluran Reproduksi Berbasis Pemeriksaan Papsmear Anggraini, Dewi Okta; Dirgahayu, Paramasari; Wasita, Brian
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Cervical Intraepithelial Neoplasia (CIN) is a dysplasia of cervical squamous cells posibbly turn into cervical cancer if not treated immediately. The established cause of CIN is Human Papillomavirus (HPV). Several studies showed correlation between Reproductive Tract Infection (RTI) with CIN. But, it is still controversial. Age is one of predicted factor which can influence CIN. Through some mechanisms, age can change the cervical cells. Methods: This study was cross-sectional approach. Samples were taken from medical record, papsmear’s form result and papsmear preparation in the Pathology Anatomy Laboratory, Faculty of Medicine, Sebelas Maret University from 2009-2012. Total of 410 samples were divided into two groups: control and case group. Control group contain sample without RTI while case group contain sample with RTI. Each group consisted of 205 women who subsequently divided into two subgroup, aged <40 years and ≥ 40 years. In this study, HPV infection is uncontrolled. Data were taken including name, age, clinical symptoms, ISR and CIN. These data are analyzed using Fisher test from SPSS version 19 for windows. Results: Total CIN were found: 5 samples (<40 years) and 3 samples (≥40 years) from positive RTI; 20 samples (<40 years) and 53 samples (≥40 years) from negative RTI. Fisher test results showed that age has correlation with CIN (p=0,001) and there is a significant difference risk between the age distribution with CIN [RD= -12.3%, 95%CI=(-19.8)-(-4798)]. In the negative RTI, there is a significant risk sample aged <40 years and aged ≥40 years to get CIN [RD= -21.28%, 95% CI= (-33.91)- (-8.655)]. RTI does not have correlation with CIN (p = 0.06) Conclusion: Without HPV controlled, age distribution (<40 years and ≥40 years) has an influence to the occurence of CIN and there is no correlation between RTI with CIN. Key words: Age, Cervical Intraepithelial Neoplasia (CIN), Reproduction Tract Infection (RTI)
Hubungan antara Status Gizi dan Infeksi Blastocystis hominis pada Pasien Bangsal Anak RSUD Dr. Moewardi Surakarta Sungkar, Nabila Adib; Dirgahayu, Paramasari; Moelyo, Annang Giri
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background :Blastocystis hominis is one of the most common protozoans found in worldwide human intestinal tract. In Indonesia, its prevalence reached 60%, the highest prevalence found in children less than 6 years old (25%). Epidemiological and clinical researches show that a defect of nutritional status can inhibit immunity response and increase risk of infectional disease. This study aimed to analyze the correlation between nutritional status and Blastocystis hominis infection among children in RSUD Dr. Moewardi Surakarta. Methods :This study was an observational analytical research using cross-sectional approach. The subjects were every pediatric ward patient in RSUD Dr. Moewardi Surakarta period July-August 2013. A total of 50 subjects were selected using total sampling method. Fresh stool samples were examined using Ziehl-Neelsen staining method. Data were analyzed by multiple logistic regression analysis and processed with the Statistical Product and Service Solutions (SPSS) 17.0 for Windows. Results :Blastocystis hominis was found in 36/50 (72%) stool samples. Poor nutritional status patients in pediatric ward of RSUD Dr. Moewardi Surakarta have the same risk to be infected by Blastocystis hominis compared to good nutritional status patients (OR = 1.04 ; p < 0.97). But children aged under 2 years old have lower risk to get infected by Blastocystis hominis compared to children over 2 years old (OR = 29,333 ; p < 0,001) Conclusion :There is not any significant correlation between nutritional status and Blastocystis hominis infection among children in RSUD Dr. Moewardi Surakarta. Keywords :Blastocystis hominis, nutritional status 
Hubungan antara Infeksi Protozoa Cryptosporidium Sp dengan Kejadian Diare Kronis pada Pasien HIV/AIDS di RSUD Dr. Moewardi Surakarta Primawati, Surya Dewi; Dirgahayu, Paramasari; Haryoputro, Dani Redhono
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: Cryptosporidium sp. is apicomplexan parasite that causes chronic diarrhea. This parasite’s infection can cause high mortality in immunocompromais individuals especially who are infected with HIV/AIDS. Although the HIV/AIDS infection is a concern in Indonesia, but there has been no study on the infection of chronic diarrhea in patients with HIV/AIDS. This study aimed to know the correlation between the Protozoan Cryptosporidium sp. infection and chronic diarrhea incident in patients with HIV/AIDS at Dr. Moewardi Hospital Surakarta. Methods: This was an observational analytic study using cross sectional approach conducted on May – September 2013. Thirty six patients with HIV/AIDS at Dr. Moewardi Hospital that were appropriate with the criteria of restriction were taken for samples. The data about chronic diarrhea, age, gender, level of education were obtained from the questionnaire. Identification of Cryptosporidium sp. in stool was examined using modified acid fast stain techniques, while their consistency were obtained through macroscopic examination. Data about the status of patients CD4 were obtained from the medical record. The correlation between chronic diarrhea, sex, level of education, consistency of the stool, CD4 status and Cryptosporidium sp. infection was analyzed by using Fisher Test (a=0.05). Results: Fisher test analysis showed there was no significant correlation between infection of Cryptosporidium sp. and incidence of chronic diarrhea (p = 1). Analysis of correlation between gender, level of education, consistency of the stool, CD4 status and Cryptosporidium sp. infection, the value of p > 0.05 was obtained. Conclusions: There was no significant correlation between Cryptosporidium sp.  infection and chronic diarrhea incident in patients with HIV/AIDS at Dr. Moewardi Hospital Surakarta. Keyword : Cryptosporidium sp, chronic diarrhea, HIV/AIDS  
Faktor sosio ekonomi demografi terhadap kejadian infeksi kecacingan pada anak Sekolah Dasar Mahmudah, Umi; Dirgahayu, Paramasari; Wasita, Brian
Ilmu Gizi Indonesia Vol 1, No 1 (2017): Agustus
Publisher : Program Studi S-1 Ilmu Gizi

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Abstract

Latar belakang: Infeksi kecacingan merupakan masalah kesehatan masyarakat di negara-negara berkembang seperti Indonesia. Anak sekolah dasar merupakan golongan yang paling berisiko terhadap kejadian infeksi kecacingan. Infeksi ini dipengaruhi oleh beberapa faktor yaitu kondisi sanitasi lingkungan, perilaku personal hygiene,  serta kondisi  sosio  ekonomi demograf daerah sekitar. Kondisi sosio demograf yang berbeda di setiap wilayah mengakibatkan terjadinya infeksi kecacingan yang berbeda–beda. Tujuan: Untuk mengetahui hubungan faktor sosio ekonomi demograf  terhadap  kejadian  infeksi  kecacingan  pada  anak  sekolah  dasar. Metode: Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional, pada populasi anak sekolah dasar kelas 1 sampai kelas 5 dengan jumlah 92 siswa, sedangkan besar sampel penelitian berjumlah 74 siswa di SD Barengan Kecamatan Teras Kabupaten Boyolali dengan teknik pengambilan sampel secara purposive. Data kecacingan pada anak diperoleh dengan pengambilan sampel feses dan diperiksa menggunakan metode  formol ether concentration di Laboratorium Parasitologi  Fakultas  Kedokteran  Universitas  Sebelas Maret.  Data  sosio  ekonomi  demograf diperoleh dengan kuisioner dengan metode wawancara. Analisis data diolah menggunakan chi square. Hasil: Prevalensi kejadian infeksi kecacingan pada anak sekolah dasar di SD Barengan Kecamatan Teras Kabupaten Boyolali adalah 40,21%. Pendidikan ayah (p=0,159) dan pendidikan ibu (p=0,352) tidak berhubungan dengan kejadian infeksi kecacingan. Penghasilan ayah (p=0,330) dan penghasilan ibu (p=1,152) tidak berhubungan dengan kejadian infeksi kecacingan. Kesimpulan:  Pendidikan ayah, pendidikan ibu, penghasilan ayah dan penghasilan ibu tidak berhubungan dengan kejadian infeksi kecacingan.Kata kunci: Sosio; ekonomi; demograf; infeksi kecacingan
PENGARUH PEMBERIAN JUS BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP KADAR KOLESTEROL TOTAL TIKUS PUTIH (Rattus norvegicus) JANTAN MODEL HIPERKOLESTEROLEMIA Suryani, Irma; Dirgahayu, Paramasari; Wasita, Brian
Jurnal Gizi dan Kesehatan Vol 1, No 2 (2014)
Publisher : Program Studi Ilmu Gizi Pascasarjana Universitas Sebelas Maret

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Abstract

Abstract Background : Hyperlipidemia is a major cause of cardiovascular disease because it can lead to narrow of the arteries. Prevalence of diseases caused by hyperlipidemia is still quite high in many countries. Some therapeutic agents of modern medicine has been available, but most of these drug give side effects and the cost is quite high. The content of the red dragon fruit has been studied, which consists of fiber and antioxidants.This study was conducted to determine the effectiveness of antihiperlipidemia red dragon fruit juice compared with atorvastatin.Methods : Experimental with pre and post group randomized controlled design. The 36 samples were divided into six groups randomly: negative control group, positive control group (induction high fat diet for 14 days), group 1(induction high fat diet for 14 days and atorvastatin 10 days), 2, 3 and 4 (induction high fat diet for 14 days and red dragon fruit juice with a variety of doses for 10 days). The levels of lipid profiles of samples were measured before and after the intervention is given. Data were analyzed with SPSS 22.0 for windows. Result : After 14 days of margarine induction, group KP, P1, P2, P3, and P4 showed significant increase (p <0,05) on the average of total cholesterol, as well as in P1 with 0,18 mg of atorvastatin. Conclusion Red dragon fruit juice has the potential antihiperlipidemia comparable to atorvastatin Key words: Red Dragon Fruit, Lipid Profile, Atorvastatin
Anthrax Seroprevalence in Central Java, Indonesia Redhono, Dhani; Dirgahayu, Paramasari
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Anthrax is a zoonotic disease that is caused by Bacillus Anthracis is transmitted to humans through infected animal. The transmission to humans occurs when there is a contact to animals or animal products contracting anthrax. Clinical skin manifestations and anthrax serum Ig G antibody can be used to diagnose infected anthrax animals. This study aimed to determine the prevalence of anthrax based on ELISA serum Ig G antibody and clinical skin manifestations occurring in patients with anthrax.Subjects and Method: This was a descriptive study with cross sectional design conducted in Sragen district, Central, Indonesia, in 2015. A sample of 101 patients infected with anthrax was examined based on clinical skin manifestations and anthrax serum Ig G antibody.Results: 39.6% of the sample was 21 to 40 years of age. 57.4% of the sample was female. 74% of the sample completed primary school. 21% worked as farmers. 30.5% of the sample who cooked and consumed meat showed positive Ig G. Test results showed serum Ig G antibody negative 50%, 15.8% and 33.7% borderline positive. Clinical manifestations in the skin as much as 11.9%, which is the eschar on all respondents and 92.8% showed positive Ig  G. While 88.1% did not show any clinical signs of anthrax.Conclusion: The increase in serum antibody titer Ig G anthrax is not all respondents were exposed, in an area that otherwise outbreak of anthrax, which is only a third of all respondents, and when it comes up eschar will be followed by an increase in Ig G antibody titer.Keywords: cutaneous anthrax, Ig G antibody ELISA, escharCorrespondence: Dhani Redhon. Sub Division Tropical Medicine and Infectious Disease, Internal Medicine.Indonesian Journal of Medicine (2016), 1(2): 129-135https://doi.org/10.26911/theijmed.2016.01.02.07
Red dragon fruit juice in reducing ros levels and insulin resistance In rats with type 2 diabetes mellitus model Putri, Mahendri Deayu; Wiboworini, Budiyanti; Dirgahayu, Paramasari
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 10, No 1 (2021): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.10.1.6-14

Abstract

Background: The peel of red dragon fruit (Hylocereus polyrhizus) had been proven to have a total polyphenol content and total flavonoids 2 to 3 times more than its flesh. These components could reduce oxidative stress and maintain the function of pancreatic beta cells, which could affect blood sugar levels.Objectives: This study aimed to test the red dragon fruit juice using peel and flesh to reduce oxidative stress and insulin resistance in T2DM model rats.Materials and Methods: This study was a true experimental study with a randomized controlled trial, with a Matching Pretest Post-test Control Group Design. We used 21 white male rats (Rattus norvegicus) Wistar strain which was divided into three groups: (P1) negative control group (induced Streptozotocin + Nicotinamide induction), (P2) positive control group (given Streptozotocin + Nicotinamide and given Metformin HCl induction 0,9 mg/kg BW, and (P3) Red Dragon fruit group (induced Streptozotocin + Nicotinamide and given Red Dragon Fruit juice 3.6 ml / 200 g BW / day given for 14 days. The data were analyzed using a one-way ANOVA test, paired t-test, and Post Hoc.Results: After 14 days of intervention, the average HOMA-IR levels were as follows: negative control group (Mean=8.32; SD=0.26), positive group (Mean 4.89; SD=0.29), and the Red Dragon Fruit intervention group (Mean=4.65; SD=0.30). The average MDA levels were as follows: control group (Mean = 9.08; SD = 0.68), positive group (Mean=3.34;SD=0.22), and the red dragon fruit intervention group (Mean = 3.05; SD = 0.47). Both the Metformin group and the Red Dragon Fruit group had low HOMA-IR and MDA levels compared to the negative control group.Conclusions: When administered alone, red dragon fruit and metformin effectively reduced HOMA-IR and MDA levels in rats with type 2 DM. Red dragon fruit can be used as an alternative to metformin because of its effectiveness in reducing plasma HOMA-IR and MDA.
Faktor sosio ekonomi demografi terhadap kejadian infeksi kecacingan pada anak Sekolah Dasar Umi Mahmudah; Paramasari Dirgahayu; Brian Wasita
Ilmu Gizi Indonesia Vol 1, No 1 (2017): Agustus
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.538 KB) | DOI: 10.35842/ilgi.v1i1.14

Abstract

Latar belakang: Infeksi kecacingan merupakan masalah kesehatan masyarakat di negara-negara berkembang seperti Indonesia. Anak sekolah dasar merupakan golongan yang paling berisiko terhadap kejadian infeksi kecacingan. Infeksi ini dipengaruhi oleh beberapa faktor yaitu kondisi sanitasi lingkungan, perilaku personal hygiene,  serta kondisi  sosio  ekonomi demograf daerah sekitar. Kondisi sosio demograf yang berbeda di setiap wilayah mengakibatkan terjadinya infeksi kecacingan yang berbeda–beda. Tujuan: Untuk mengetahui hubungan faktor sosio ekonomi demograf  terhadap  kejadian  infeksi  kecacingan  pada  anak  sekolah  dasar. Metode: Penelitian ini merupakan penelitian observasional dengan rancangan cross sectional, pada populasi anak sekolah dasar kelas 1 sampai kelas 5 dengan jumlah 92 siswa, sedangkan besar sampel penelitian berjumlah 74 siswa di SD Barengan Kecamatan Teras Kabupaten Boyolali dengan teknik pengambilan sampel secara purposive. Data kecacingan pada anak diperoleh dengan pengambilan sampel feses dan diperiksa menggunakan metode  formol ether concentration di Laboratorium Parasitologi  Fakultas  Kedokteran  Universitas  Sebelas Maret.  Data  sosio  ekonomi  demograf diperoleh dengan kuisioner dengan metode wawancara. Analisis data diolah menggunakan chi square. Hasil: Prevalensi kejadian infeksi kecacingan pada anak sekolah dasar di SD Barengan Kecamatan Teras Kabupaten Boyolali adalah 40,21%. Pendidikan ayah (p=0,159) dan pendidikan ibu (p=0,352) tidak berhubungan dengan kejadian infeksi kecacingan. Penghasilan ayah (p=0,330) dan penghasilan ibu (p=1,152) tidak berhubungan dengan kejadian infeksi kecacingan. Kesimpulan:  Pendidikan ayah, pendidikan ibu, penghasilan ayah dan penghasilan ibu tidak berhubungan dengan kejadian infeksi kecacingan. 
Pendidikan Kesehatan tentang Personal Hygiene dan Pemeriksaan Kecacingan pada Anak Berkebutuhan Khusus di SLB Anugerah, Colomadu, Karanganyar Betty Saptiwi; Risya Cilmiaty, AR; Widia Susanti; Paramasari Dirgahayu; Adi Prayitno; Sutartinah; Pradipto Subiyantoro
Abdimas Universal Vol. 3 No. 1 (2021): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/abdimasuniversal.v3i1.86

Abstract

Anak Berkebutuhan Khusus (ABK) di SLB Anugerah, Colomadu, Karanganyar Jawa Tengah memiliki personal hygiene yang kurang berdasarkan survey yang dilakukan pada 21 ABK di SLB Anugerah, Colomadu. Dari hasil wawancara dengan guru, belum pernah ada pendidikan kesehatan tentang personal hygiene dan belum pernah ada pemeriksaan kecacingan pada ABK di SLB Anugerah, Colomadu, Karanganyar. Oleh karena itu perlu upaya memperbaikinya. Tujuan dari kegiatan ini adalah melaksanakan salah satu komponen Tri Dharma Perguruan Tinggi yaitu pengabdian kepada masyarakat. Selain itu pengabdian ini juga bermanfaat untuk mencegah gangguan kesehatan umum siswa ABK di SLB Anugerah, Colomadu, Kabupaten Karanganyar. Metode pengabdian yaitu dengan pemeriksaan kesehatan mata, telinga, hidung, kulit, pengambilan sampel anal swab, memberi pemahaman dan contoh kepada tiap siswa setelah diperiksa tentang pemeliharaan kebersihan diri yang benar. Sasaran yang diperiksa berjumlah 21 orang. Hasil pengabdian menunjukkan 21 siswa memiliki hasil negatif pada pemeriksaan kecacingan, 13 siswa (61,9%) memiliki serumen di telinga, 2 siswa (9,5%) tampak adanya hiperemis dan oedem pada hidung. Sementara untuk pemeriksaan lain sudah dalam kondisi baik. Hasil yang negatif pada pemeriksaan kecacingan, masih perlu dilanjutkan dengan pemeriksan sampel feses untuk mendeteksi jenis cacing lain yang tidak bisa dideteksi dengan anal swab dan juga ditambah dengan pengambilan sampel kuku karena pada sampel kuku bisa ditemukan adanya telur cacing.
Hubungan antara Status Gizi dan Infeksi Blastocystis hominis pada Pasien Bangsal Anak RSUD Dr. Moewardi Surakarta Nabila Adib Sungkar; Paramasari Dirgahayu; Annang Giri Moelyo
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background :Blastocystis hominis is one of the most common protozoans found in worldwide human intestinal tract. In Indonesia, its prevalence reached 60%, the highest prevalence found in children less than 6 years old (25%). Epidemiological and clinical researches show that a defect of nutritional status can inhibit immunity response and increase risk of infectional disease. This study aimed to analyze the correlation between nutritional status and Blastocystis hominis infection among children in RSUD Dr. Moewardi Surakarta. Methods :This study was an observational analytical research using cross-sectional approach. The subjects were every pediatric ward patient in RSUD Dr. Moewardi Surakarta period July-August 2013. A total of 50 subjects were selected using total sampling method. Fresh stool samples were examined using Ziehl-Neelsen staining method. Data were analyzed by multiple logistic regression analysis and processed with the Statistical Product and Service Solutions (SPSS) 17.0 for Windows. Results :Blastocystis hominis was found in 36/50 (72%) stool samples. Poor nutritional status patients in pediatric ward of RSUD Dr. Moewardi Surakarta have the same risk to be infected by Blastocystis hominis compared to good nutritional status patients (OR = 1.04 ; p < 0.97). But children aged under 2 years old have lower risk to get infected by Blastocystis hominis compared to children over 2 years old (OR = 29,333 ; p < 0,001) Conclusion :There is not any significant correlation between nutritional status and Blastocystis hominis infection among children in RSUD Dr. Moewardi Surakarta. Keywords :Blastocystis hominis, nutritional status