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All Journal JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan AcTion: Aceh Nutrition Journal Jurnal Aplikasi Teknologi Pangan Journal of Tropical Pharmacy and Chemistry
Endang Mahati
Departemen Farmakologi Dan Terapi, Fakultas Kedokteran, Universitas Diponegoro, Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : AcTion: Aceh Nutrition Journal

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Effect of hepatogomax on serum alkaline phosphatase, bilirubin, gamma-glutamyl transferase levels in Sprague Dawley rats cirrhosis Elfrida Sianturi; Hery Djagat Purnomo; Adriyan Pramono; Endang Mahati; Etika R. Noer
AcTion: Aceh Nutrition Journal Vol 8, No 2 (2023): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v8i2.969

Abstract

Cirrhosis is the final stage of all chronic liver diseases. Complications that occur are malnutrition. Administration of Hepatogomax as an enteral formula with adequate nutrients, specifically Branched-Chain Amino Acids (BCAA) and Medium-chain Triglyceride (MCT), can reduce serum ALP, bilirubin, and GG levels. This study aimed to determine the effect of hepatogomax in different doses on serum ALP, bilirubin, and GG levels. The study used the True Experimental post-test group design. Twenty-four male rats were divided into control group K normal and K(-) cirrhotic, treatment groups P1 and P2, given TAA and hepatogomax induction, respectively, at doses of 4,87 g/200gBW/day and 14,6 g/200gBW/day. Intervention for 28 days at the PAU Laboratory, Gadjah Mada University, February 2022 to April 2022. Statistical analysis used the Kruskal Wallis and Mann Whitney Post Hoc tests. The data is the result of examining serum levels after the intervention. The results showed significant differences in ALP, bilirubin, and GGT (p<0,05) in the group of rats induced by TAA intervention with hepatogomax compared to those not given hepatogomax. There was no significant difference in the decrease in serum ALP levels between the K normal (p<0,05) and P2 (p>0,05) groups. Giving hepatogomax at a dose of 14,6 g/200BB/day reduced serum ALP, bilirubin, and GG levels. In conclusion, Hepatogomax decreased ALP, bilirubin, and GGT serum levels in rats with cirrhosis. The most significant decrease in serum ALP, bilirubin, and GGT levels was observed at the P2 dose.  
Co-Authors . Ngatidjan Abdul Khairul Rizki Purba Adriyan Pramono Anjani, Gemala Diana Nur Afifah, Diana Nur Dodik Pramukarso Dwi Pudjonarko Dzaki Edmonda Setyawan Elfrida Sianturi Etika R. Noer Etika Ratna Noer Feriyandi Nauli Fina Alvia Rahma Hery Djagat Purnomo Indwiani Astuti Jarir At Thobari Kartika, Yolanda Dyah Martha Irene Kartasurya Mohammad Zen Rahfiludin Nani Maharani Nurhasanah Nurhasanah Nyoman Kertia Qurrota A&#039;yun Febrina Triwindiyanti R.A. Kisdjamiatun RMD Retnaningsih Retnaningsih Ryan Halleyantoro Stephani Nesya Renamastika Tiffany Nisa Arviyani Udin Bahrudin Viqi Sajidah