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All Journal e-Journal Pustaka Kesehatan UNEJ e-Proceeding Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Tropical Pharmacy and Chemistry JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA JURNAL FARMASIMED (JFM) Jurnal Pengabdian kepada Masyarakat
Diana Holidah
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : UNEJ e-Proceeding

 1 
IN VITRO ALFA-GLUCOSIDASE INHIBITORY ACTIVITY OF VARIOUS TEA (Camellia sinensis L.) EXTRACTS Fransiska Maria Christianty; Diana Holidah; Yasmin Yasmin
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Diabetes mellitus is a group of metabolicdiseases characterized by hyperglycemia [1]. DM isclassified based on the pathogenic process that leadsto hyperglycemia as opposed to earlier criteria suchas age of onset or type of therapy. There are twobroad categories of DM, designated type 1 and type2 [2]. There were 10 million cases of diabetes inIndonesia in 2015. The number of these cases ispredicted to continue rising [3].Therapeutic approaches for the treatment oftype 2 diabetes, such as diet, sulphonylurea,metformin and insulin therapy, are all successful indecreasing fasting glucose levels. The importance ofpostprandial hyperglycaemia has led to thedevelopment of new agents to control this importantaspect of diabetes.Thus, α-glucosidase enzyme hasbecome one of important target in the treatment oftype-2 diabetes [4,5].α-glucosidase inhibition will slow thedigestion of carbohydrate and absorbtion ofmonosaccahrides in the proximal jejenum [6].Acarbose is an oligosaccharide which reversiblyinhibits intestinal α-glucosidase enzymes responsiblefor digestion of complex carbohydrates anddisaccharides to absorbable monosaccharides [7].The most common adverse effect of acarbose isabdominal discomfort associated with flatulence anddiarrhoea [8]. The undesirable side effects that existunderlie the emergence of research for alternativetherapy of type 2 diabetes, particularly through themechanism of inhibition enzyme α-glucosidase.Tea (Camellia sinensis L.) is annual plant thatwidely spread in Southest Asia, India, South China,Northwest Laos, Thailand and Burma. Tea is one ofthe most popular beverages consumed worldwide[9]. Various studies have reported beneficial effectof tea extract, including for diabetes mellitustherapy. Previous studies showed that tea extracthave antidiabetic activity in mice induced bystreptozotocin [10]. Antidiabetic activity of teaextract have been reported by Yang and Koh. Theresults showed that black tea extract had higheractivity to inhibit α-glucosidase than green teaextract. The present study was designed to comparein vitro α-glucosidase inhibitory activity of varioustea extracts, such as black tea, green tea, oolong tea,and white tea.
GREEN TEA EXTRACT EFFECT ON BLOOD GLUCOSE LEVEL AND LIVER HISTOPATHOLOGY IN DIABETIC MICE Diana Holidah; Fransiska Maria Christianty; Wilda Zidni Ilma
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Diabetes mellitus is a disorder of hyperglycemia andglucose intolerance due to insulin deficiency,impaired of insulin receptor or both (Unwin et al.,2009). There are generally two types of diabetes aretype 1 diabetes (pancreatic beta cell damage causedabsolute insulin deficiency) and type 2 (acombination of a lack of insulin production andsecretion and sensitivity to insulin receptor) (Dipiroet al, 2008).Diabetes mellitus disease is increasing rapidly inworlwide. The incidences in 2010 were about 285million people and It has been estimated that by theyear 2025, the global incidence of diabetes wouldincrease to 350 million (International diabetesfederation, 2006).In diabetes, activation of hepatic gluconeogenesisenzymes can increase glucose production and thuscontribute to increase blood glucose which coulddeteriorate diabetes (Sundaram et al., 2013). Thestate of diabetes characterized by decreased insulinsensitivity is the major cause of NAFLD (Non -Alcoholic Fatty Liver Disease), because in diabetesstate occurs disorders of glucose metabolism and fatso that could result in fibrosis, infiltration,necroinflamation, to acute liver disease (Marchesiniet al., 2001).Treatment of diabetes mellitus is chronic and longlife, causing undesirable side effects (Unwin et al.,2009). Metformin is an oral hypoglycemic agent,which belongs to the class known as the biguanides.Metformin is now widely used as one of themainstays in the management of type 2 diabetes.Metformin reduces fasting plasma glucoseconcentration by reducing rate of hepatic glucoseproduction via gluconeogenesis and glycogenolysis.Metformin improves glycemic control asmonotherapy and in combination with other oralantidiabetic agents, such as sulfonylureas andthiazolidinediones (Frendell et al. 2003).Several plant extracts are known to have antidiabeticproperties and a large number of compounds fromplant extracts have been reported to have beneficialeffects for treatment of diabetes mellitus (Anhauser,2003). Tea (Camellia sinensis L.) is one of plant thatcan decrease blood glucose. Green tea is producedby enzymatic inactivation of the leaves of Camelliasinensis followed by rolling or comminution anddrying. In the manufacturer of green tea, theenzymatic inactivation achieved by steam or panfiring treatment to preserve natural polyphenolswith respect to the health promoting properties.Green tea derived products are mainly extracts ofgreen tea in liquid or powder form varying in theproportion of polyphenols (45-90%) and caffeinecontent (0.4-10%). The polyphenolic fraction ofgreen tea, has been reported to have multiplepharmacological actions (Sano et al., 1995).Green tea is an excellent source of polyphenolantioxidants, known as green tea catechins. Theimportant catechins of green tea are epicatechin(EC), epicatechin-3-gallate (ECG), epigallocatechin(EGC) and epigallocatechin-3-gallate (EGCG). Thepolyphenolic fractions of green tea have beenreported to have multiple pharmacological actions.They exhibit potent antioxidant activity in vitro andin vivo. Epidemiologic observation and laboratorystudies have indicated that polyphenolic compoundspresent in the tea may reduce the risk of a variety ofillnesses, including cancer and coronary heartdisease (McKay and Blumberg 2002).Some studies suggest that green tea extract loweredcholesterol levels and blood glucose on mice and rat(Yang et al., 2001). Green tea extract at dose of300mg /kg /day can lower blood glucose in diabeticrats and was also able to reduce the lipids in heartdefects (Babu et al., 2006). Blood glucose loweringactivity of green tea was greater and totalpolyphenol content was higher when compared withblack tea and oolong tea (Holidah et al., 2015).
SKINCARE LEARNING YOUTH EDUCATION PROGRAM FOR KNOWLEDGE IMPROVEMENT AT SMA NEGERI 1 SUBOH SITUBONDO Ika Puspita Dewi; Diana Holidah; Mochammad Amrun Hidayat
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

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Teenagers' lack of knowledge of cosmetics causes the risk of using dangerous or illegal products. Students at SMA Negeri 1 Suboh Situbondo have never received special material regarding the selection and use of beauty products. The outcome of this educational program is to increase the knowledge of SMA Negeri 1 Suboh students about how to use and choose the right and safe skincare. This program is carried out by offline method at SMA Negeri 1 Suboh Situbondo and online method with the Zoom Meeting. The materials given to students are various teenage skin problems, introduction to skincare ingredients, and choosing the right skincare. The results of the survey related to the skin characteristics of the participants showed that most of the skin types owned by students of SMA Negeri 1 Suboh were oily (38.09%), with most of them having skin problems (79.37%), and the majority problem was acne (42.68%), while 79.37% of participants had used skincare. The results of the post-test showed that the average score of the participants was 88.57, which indicates most of the participants had understood the materials given. This program has succeeded in providing information about the correct, appropriate, and safe use of skincare to the students of SMA Negeri 1 Suboh Situbondo. Keywords: knowledge, skincare, SMA Negeri 1 Suboh Situbondo, teenager
Co-Authors Andrean Roni Antonius Nugraha Widhi Pratama Ayik Rosita Puspaningtyas1 Brahmansyah Diar Rosiarto Diana Lady Yunita Handoyo Dwi Aftiningsih Ema Rachmawati Evi Umayah Ulfa Fifteen Aprila Fajrin Fifteen Aprila Fajrin Fifteen Aprilia Fajrin Fifteen Aprilia Fajrin, Fifteen Aprilia Fransiska Maria Christianty Gati Dwi Sulistyaningrum Ika Puspita Dewi Ika Puspita Dewi Ika Puspita Dewi Iskandar P. A. Siregar Jihan Ulya Ulinnuha Junaidi Khotib Lesti Eko Pangestuti M Nuril Huda Mochammad Amrun Hidayat Monica Cinuradha Aura Salsabina Mutmainnatus Solihah Ninda Titis Ainorrochma Sendika Widi Saputri Shinta Cholifatu Rohma Siti Muslichah Sri Nur Atiqah Wilda Zidni Ilma Wiratmo Wiratmo Wiratmo Wiratmo Yasmin Yasmin Yasmin Yasmin