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All Journal Jurnal Sains Dasar Jurnal Harpodon Borneo PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman Molecular and Cellular Biomedical Sciences (MCBS) Indonesian Journal of Chemistry JURNAL ATOMIK
Bohari Yusuf
Jurusan Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Energy Environmental Science Immunology & microbiology Medicine & Pharmacology Neuroscience

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Journal : Molecular and Cellular Biomedical Sciences (MCBS)

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Body Weight, Cholesterol Changes and Sub-Chronic Toxicity of Mice Treated with An Emulsion Product Rich in b-Carotene Bohari Bohari; Fenny Dian Lestari; Anton Rahmadi
Molecular and Cellular Biomedical Sciences Vol 4, No 1 (2020)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1449.083 KB) | DOI: 10.21705/mcbs.v4i1.85

Abstract

Background: One of the conditions for releasing standardized herbal medicines is the presence of pre-clinical testing that can be conducted with mice. Emulsion products with the main composition of pumpkin, red palm oil, and dragon fruit have high levels of β-carotene. The purpose of this study was to observe changes in weight, cholesterol, and sub-chronic toxicity from mice treated with emulsion products.Materials and Methods: Mice observed consisted of 6 groups: (1) untreated control (given standard ration); (2) negative control (given standard ration and 2.8% (v/b) egg yolk); (3) positive control (given standard ration and 0.4% (v/b) β-carotene); (4) standard ration, 0.4% (v/b) β-carotene and 2.8% (v/b) egg yolk; (5) given a standard ration and 2% (v/b) emulsion products; and (6) given a standard ration, 2% (v/b) emulsion products and 2.8% (v/b) egg yolk. Observations of sub-chronic toxicity were done by measuring creatinine levels, kidney weight, and visual observation of kidney swelling.Results: The use of β-carotene-rich emulsions does not cause a decrease in the average weight of mice. In general, β-carotene and emulsion can overcome cholesterol increases on the 7th day, but not for the 15th day as a result of standard food intake. The increase in creatinine levels only occurs in mice treated with egg yolk control. The additional treatment of β-carotene and emulsion successfully prevents the increase in creatinine levels.Conclusion: Emulsion products did not cause changes in weight, were able to reduce cholesterol levels in a limited manner and were not toxic to mice.Keywords: cholesterol changes, sub-chronic toxicity, b-carotene, emulsion
Co-Authors Adhi Surya Pranata Surya Pranata Adhi Surya Pranata Surya Pranata, Adhi Surya Pranata Surya Agustin Pratiwi, Agustin Agustinus Miu Albayssag Faisal Tanjung Alimuddin - Alimuddin - Alimuddin Alimuddin Alimuddin Alimuddin Aman S Panggabean Aman S Panggabean, Aman S Aman Sentosa Panggabean Andi Sahriani Anton Rahmadi Apri Nuranda Arifin Syam Surya Arsyik Ibrahim Chairul Saleh Desy Ridho Rahayu Erwin Erwin Fenny Dian Lestari Finqo Aprianto Firzan Nainu Hamsina Hamsina Herman Herman Indri Ayu Lestari Indri Ayu Lestari, Indri Ayu Islamudin Ahmad Khasanah, Manja’a Laode Rijai Linda Ajang Linda Ajang, Linda Linda Yuniar Astria Marlinawati - Mirhansyah Ardana Mutia Wulandari Rahmat Gunawan RAHMAT GUNAWAN Rahmat GUnawan Rani Novia Ulya Ritson Purba Ritson Purba, Ritson Rudi Kartika, Rudi Selvi Jumiatul Astati Septiana, Rientha Siti Nurliana Siti Nurliana, Siti Tangke Veronika Tri Paus Hasiholan Hutapea, Tri Paus Hasiholan