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Wartana Putra, I Gusti Ngurah Agung Windra
Universitas Bali Internasional
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGARUH FERMENTASI DENGAN Lactobacilus acidophilus TERHADAP SIFAT FISIK AMILUM BENGKUANG (Pachyrhizus erosus (L.) Urb.) SEBAGAI BAHAN PENGISI TABLET I Gusti Ngurah Agung Windra Wartana Putra
Jurnal Kesmas (Kesehatan Masyarakat) Khatulistiwa Vol 6, No 1 (2019): Jurnal Kesmas (Kesehatan Masyarakat) Khatulistiwa
Publisher : Universitas Muhammadiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.613 KB) | DOI: 10.29406/jkmk.v6i1.1761

Abstract

Tanaman bengkuang (Pachyrhizus erosus (L.) Urb.) merupakan salah satu tanaman legume penghasil amilum. Amilum ini dapat digunakan sebagai bahan tambahan dalam pembuatan tablet karena sifatnya yang inert dan dapat tercampurkan dengan sebagian besar bahan obat. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh dari fermentasi dengan menggunakan Lactobacillus acidophilus terhadap sifat fisik dari amilum bengkuang (Pachyrhizus erosus (L.) Urb.) sebagai bahan pengisi tablet. Pada penelitian dibuat suspensi amilum dengan konsentrasi 10 %. Medium tersebut diinokulasikan dengan 5 ml Lactobacillus acidophilus (3 x 108 CFU/ml) kemudian digoyangkan pada shaker 120 rpm. Fermentasi dilakukan pada waktu 24, 48, 72 jam kemudian diuji sifat fisiknya seperti sifat organoleptis, mikroskopis, kadar air, pH, sifat alir dengan uji kerapatan bulk dan pengetapan, dan kompaktibilitas dengan uji kekerasan tablet. Hasil analisis pada sifat fisik amilum bengkuang menunjukkan nilai koefisien korelasi, adjusted R square, dan persamaan regresi linear secara berturut-turut yaitu pada kadar air nilai r = -0.972; R2 = 0.884; dan y = -0.024x + 12.845;  pada rata-rata ukuran butir amilum nilai r = -0.427; R2 = 0.150; dan y = -0.063x + 17.488; pada pH nilai r = -0.488; R2 = 0.136; dan y = -0.006x + 6.092; pada kerapatan bulk nilai r = -0.696; R2 = 0.624; dan y = 0.0001x + 0.484; pada indeks pengetapan nilai r = 0.821; R2  = 0.653; dan y = 0.051x + 15.733; pada kompaktibilitas pada skala 8 mm nilai r = 0.797; R2  = 0.616; dan y = 0.005x – 0.052; dan skala 9 mm nilai r = 0.839; R2 = 0.707; dan y = 0.006x + 0.096. Dari hasil penelitian dapat disimpulkan bahwa fermentasi dengan menggunakan Lactobacillus acidophilus berpengaruh terhadap  penurunan  kadar  air,  penurunan  rata-rata  ukuran  butir  amilum,  pH, penurunan sifat alir dan peningkatan kompaktibilitas amilum bengkuang (Pachyrhizus erosus (L.) Urb.).
PENGARUH VARIASI CARBOMER DAN GLISERIN TERHADAP KUALITAS HAND SANITIZER EKSTRAK ALOE VERA: THE EFFECT OF VARIATIONS OF CARBOMER AND GLISERIN ON THE QUALITY OF HAND SANITIZER ALOE VERA EXTRACT I Gusti Ngurah Agung Windra Wartana Putra; I Putu Gede Adi Purwa Hita; I Gusti Ayu Agung Septiari; Ida Ayu Manik Partha Sutema
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 6 No 2 (2021)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (534.66 KB) | DOI: 10.37874/ms.v6i2.310

Abstract

Kondisi pandemi COVID-19 membuat penggunaan hand sanitizer dimasyarakat menjadi meningkat. Kepraktisan merupakan salah satu alasan masyarakat lebih mengunakan sediaan antiseptik hand sanitizer dibanding membersihkan tangan dengan sabun dan air mengalir. Tingginya penggunaan hand sanitizer membuat perlu adanya inovasi produk sehingga dapat memberikan kepuasan masyarakat yang lebih maksimal. Inovasi yang sering dilakukan oleh formulator adalah inovasi formula yang terkait pembaharuan bahan bahan dalam sediaan untuk meningkatkan kualitas dari suatu produk. Dalam melakukan inovasi, perlu melewati berbagai  tahapan tahapan pengujian untuk mengetahui sifat fisika dan kimia dari sediaan sehingga didapatkan sediaan  hand sanitizer yang berkualitas. Penelitian ini merupakan tahapan pendahuluan dalam inovasi yang bertujuan untuk mengetahui pengaruh yang dominan dari formula gelling agent carbomer dan humektan gliserin terhadap sifat fisika dan kimia dari hand sanitizer gel ekstrak lidah buaya. Penelitian ini termasuk penelitian eksperimental dimana dibuat 8 formula dengan variasi gelling agent carbomer dan humektan gliserin. Kemudian dilakukan pengukuran sifat fisika dan kimia seperti viskositas, daya sebar dan pH.  Data dari hasil sifat viskositas sediaan gel menghasilkan persamaan polinomial Y = 85148.37(A) + 109.16 (B) – 32936.27 (A)(B).  Dari sifat daya sebar sediaan gel menghasilkan persamaan polinomial Y = -17.63 (A) + 6.69 (B) + 4.60 (A)(B). Dari hasil uji pH ke 8 formula, rata rata nilai pH yang didapat yaitu 6.8. Dari hasil penelitian dapat diperoleh kesimpulan yaitu komponen carbomer memberikan pengaruh yang dominan dibanding komponen gliserin terhadap kenaikan viskositas gel dengan nilai koefisien pengaruh sebesar 85.148.37 dan memberikan pengaruh negatif terhadap nilai daya sebar gel dengan nilai koefisien pengaruh sebesar -17.63.
The relationship of pharmaceutical services toward the use of herbal medicine : Indonesian case Putu Eka Arimbawa; Dewi Puspita Apsari; I Gusti Ngurah Agung Windra Wartana Putra; Muhammad Iqbal Fasa
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 14, No 1 (2020): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v14i1.1677

Abstract

Pharmaceutical services are services provided by a pharmacist in providing health information including the use of herbal medicines. The purpose of this study was to look at the relationship between pharmaceutical services and the use of herbal medicines in the city of Denpasar. The number of samples used was 97. Data were collected from January to February 2020 in the city of Denpasar using a questionnaire. Data were analyzed using the binary logistic test. The results showed that pharmaceutical services did not have a significant relationship with the use of herbal medicines (P> 0.05). Pharmaceutical services such as completeness of the drug, pharmacist's readiness to assist, and the speed of drug preparation services that are less good can affect the physical, mental, and spiritual aspects of herbal medicine.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% DAUN SAMBILOTO (Andrographis paniculata (Burm.f.) Nees TERHADAP Propionibacterium acnes I Putu Gede Adi Purwa Hita; Putu Yudhistira Budhi Setiawan; I Gusti Septiari; I Gusti Ngurah Agung Windra Wartana Putra
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 1 (2022): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v11i1.76

Abstract

Background: Acnes vulgaris is a skin disease that can reduce self-confidence in adolescence and adulthood. This disease can be caused by infection with Propionbacterium acnes bacteria and treatment of this disease using antibiotics causes a lot of resistances. One alternative that can be developed to overcome this problem is the use of herbal medicines. Objective: To determine the antibacterial activity of 96% ethanol extract sambiloto leaf (Androgaphis paniculata (Burm.f.) Nees) in inhibiting the growth of Propionbacterium acnes bacteria. Method: The maceration method was used in the preparation of extracts and a qualitative test of active compounds was carried out. The antibacterial activity test was carried out using the disc diffusion method. Results: Qualitatively identified in the extract contains several active compounds like alkaloids, flavonoids, tannins, triterpenoids and saponins. 96% ethanol extract of sambiloto leaf with concentrations of 25, 50, 75, and 100% w/v had antibacterial activity against Propionibacterium acnes, indicated by the diameter of the inhibition zone at each concentration. Conclusion: 96% ethanol extract of sambiloto leaf (Andrographis panuculata (Burm.f.) Nees) has antibacterial activity against the growth of Propionibacterium acnes bacteria where the category of strong antibacterial activity was found in samples with concentrations of 75 and 100% w/v with the diameter of the inhibition zone formed respectively 11.26±0.44 mm and 16.52 ± 1.33 mm. Keywords: Andrographis paniculata (Bum.f.) Nees, antibacterial, disc diffusion, 96% ethanol extract, Propionibacterium acnes
FORMULASI SEDIAAN SABUN CAIR EKSTRAK LIDAH BUAYA (Aloe vera L.) Made Galih Dwi Mahayuni; I Gusti Ngurah Agung Windra Wartana Putra; Ni Putu Wintariani
Jurnal Riset Kefarmasian Indonesia Vol 5 No 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.309

Abstract

Skin is the external part of body which protects internal organs from external interference, such as bacteria, viruses, cold air, hot sun, exposure to UV radiation, pressure, etc. Maintain clean skin is an important thing to do to prevent skin diseases. The way to keep our skin clean is use a mild soap which is good for the skin. Soap is one of the preparations commonly used in daily life. The ingredients of liquid soap are made up of surfactants, thickeners, preservatives and pH regulators. The presence of surface-active agents in soap is important for cleansing the dirt from the skin. Thickeners are important in the soap to obtain the required viscosity of the formulation. The aim of this study was to determine the characteristics of aloe vera (Aloe Vera L.) liquid soap. This type of research is an experimental study with a completely randomized design. The formula will be tested for physical and chemical properties which include organoleptic tests, viscosity tests, specific gravity tests, foam stability tests, and pH tests. Aloe vera liquid soap in all formulas has physical and chemical characteristics that meet the standards where the viscosity values obtained are 2616-4188 cP, specific gravity 1.067-1.082, foam resistance 61-70%, and pH 6.1-7
Uji Efektivitas Antibakteri Ekstrak Etanol 96% Tanaman Gonda (Sphenoclea zeylanica Gaertn) terhadap Staphylococcus aureus Pande I Ketut Sukadiasa; Ni Putu Wintariani; I Gusti Ngurah Agung Windra Wartana Putra
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.4644

Abstract

Staphylococcus aureus is a gram-positive bacterium that is the leading cause of infections of the skin, soft tissue, respiratory tract, bones, and joints. The use of traditional medicine is generally considered safer than the use of modern medicine. One of the plants in Indonesia that can be used as medicine is the Gonda plant (Sphenoclea zeylanica Gaertn). The phytochemical compounds in the gonda plant are saponins, flavonoids, phenols, alkaloids, and steroids, which have antibacterial activity. This study aims to determine the content of secondary metabolites and the antibacterial activity of 96% ethanol extract of Gonda plants with different concentration variations against Staphylococcus aureus bacteria. This research is quantitative research with an experimental research design. The results showed that the 96% ethanol extract of the gonda plant contained flavonoids, saponins, tannins, steroids, and alkaloids and showed antibacterial activity. The average inhibition zone concentration of the extract was 5%, 10%, 15%, and 20%, respectively, 9.4 ± 0.19 mm, 12.56 ± 0.18 mm, 14.63 ± 0.30 mm, 17.45 ± 0.36 mm in the medium to strong category. There was a significant difference (P<0.05) between the inhibition zone values of each concentration, where the increase in the inhibition zone value was directly proportional to the increase in the extract concentration. The extract with a concentration of 20% had an immense inhibition zone value of 17.45 mm.
Aktivitas Kombinasi Ekstrak Etanol Daun Salam (Syzygium Polyanthum) dan Daun Gambir (Uncaria Gambir) terhadap Penurunan Glukosa Darah Tikus (Rattus Norvegicus) Putu Ayu Nita Pebriyanti; I Gusti Ngurah Agung Windra Wartana Putra; I Dewa Putu Sutjana
Jurnal Dunia Farmasi Vol 7, No 2 (2023): Edisi April
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v7i2.5376

Abstract

Latar Belakang: Tanaman salam (Syzygium polyanthum) dan gambir (Uncaria gambir) merupakan tanaman digunakan sebagai pengobatan hiperglikemia. Metabolit sekunder berupa flavonoid dan tanin pada daun salam dan daun gambir diduga dapat menurunkan glukosa darah. Tujuan: Mengkaji secara terukur penurunan glukosa dalam darah sebelum dan setelah pemberian kombinasi ekstrak etanol 96% daun salam dan daun gambir. Metode: Ekstrak Daun Salam dan daun Gambir dibuat dengan metode maserasi dengan pelarut etanol 96%. Sebanyak 15 ekor tikus di induksi dengan aloksan dengan dosis 150 mg/KgBB. Tikus dibagi menjadi 5 kelompok. Kelompok I (Metformin), kelompok II (kombinasi ekstrak dosis 50/50 mg/gBB), kelompok III (kombinasi ekstrak dosis 100/100 mg/gBB), kelompok IV (kombinasi ekstrak dosis 150/150 mg/gBB), dan kelompok V (aquadest). Pengukuran kadar glukosa dilakukan dengan metode POCT (Point of Care Testing) pada hari hari ke-2, 3, 4 dan 5 yang diuji secara deskriptif. Hasil: Hasil penelitian menunjukkan perbedaan penurunan kadar glukosa darah. Kelompok kontrol positif menunjukan penurunan sebesar 84,5%, kelompok II 38,6%, kelompok III 67,9%, kelompok IV 81,3%, dan kelompok kontrol negatif 3,7%. Kesimpulan: Kombinasi ekstrak etanol 96% daun salam dan daun gambir mampu menurunkan kadar glukosa darah tikus pada dosis 50/50 mg/gBB, 100/100 mg/gBB dan 150/150 mg/gBB.
Penyuluhan Penggunaan Antibiotik yang Bijak di Rumah Tangga Desa Bengkel, Tabanan I Gusti Ayu Rai Widowati; Ida Ayu Manik Partha Sutema; Ni Made Maharianingsih; Ni Putu Aryati Suryaningsih; I Gusti Ngurah Agung Windra Wartana Putra; Ketut Agus Adrianta; Ni Komang Semara Yanti; Ni Nyoman Sri Budayanti
Jurnal Pengabdian kepada Masyarakat Wahana Usada Vol. 5 No. 1 (2023): Juni: Jurnal Pengabdian kepada Masyarakat Wahana Usada
Publisher : Sekolah Tinggi Ilmu Kesehatan KESDAM IX/Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47859/wuj.v5i1.310

Abstract

Background: Using antibiotics for self-medication increases the risk of developing resistance, which raises morbidity and mortality. Communities are crucial in stopping and limiting the spread of antibiotic resistance (AMR). 80% of the residents in Bengkel Village work as farmers. The agrarian community in Bengkel Village has highly magnificent natural potential as well as agricultural and cultural activities that are still well maintained. It also has the largest “subak” land in Kediri Regency. Purpose: This community service is to educate the general population about the importance of limiting the use of antibiotic self-medication, which is essential for combating AMR. Methods: The Clinical Pharmacy Study Program, the Indonesian Pharmacists Association Bali Province, and the One Health Collaborating Center collaborated on this community service. On July 17, 2022, in Bengkel Village-Tabanan, a health counseling intervention was done with housewives who are participants in the Family Welfare Empowerment. Results: Over 50 people from the Chairman, Management, and Family Welfare Empowerment cadres in Bengkel Village made up the community component of this health counseling. The participants' enthusiasm for watching the event and engaging with the resource people is proof that the activity went off without a hitch. By providing more counseling, activities are intended to be sustained (stage 2). Conclusion: Community service in Bengkel Village-Tabanan is expected to provide knowledge about health and the importance of AMR awareness. For the continuation of this activity, it is recommended to conduct outreach to other community groups such as farmers, breeders, and young age groups.
Potential of Frangipani (Plumeria alba) Leaves Extract as Ultra Violet Protection I Gusti Ngurah Agung Windra Wartana Putra; Putu Eka Arimbawa; Ni Putu Rahayu Artini
Borneo Journal of Pharmacy Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i4.1644

Abstract

Sunlight is the source of life and energy. Besides that, sunlight also creates skin challenges such as sunburn, pigmentation, wrinkles, dermatitis, aging, and skin cancer. Natural sunscreen protection is a popular and preferred way among various regions of the world to reduce sunlight's harmful effect. This study aimed to determine the potential of frangipani (Plumeria alba) leaves extract in some concentrations as ultraviolet protection. Plumeria alba extract contained secondary metabolites such as flavonoids, phenolics, and alkaloids that function as impeding ultraviolet radiation. This study used an experimental method consisting of four treatments and six replications. This study shows that the extract with concentration 2500; 5000; 7500; and 10000 ppm consecutively have SPF value of 6.24; 12.00; 18.45; and 22.64. It can be concluded the P. alba leaves extract potential as ultraviolet protection.
Co-Authors Dewi Puspita Apsari I Dewa Putu Sutjana I Gusti Ayu Agung Septiari I Gusti Ayu Rai Widowati I Gusti Septiari I Putu Gede Adi Purwa Hita Ketut Agus Adrianta Made Galih Dwi Mahayuni Muhammad Iqbal Fasa Ni Komang Semara Yanti Ni Made Maharianingsih Ni Nyoman Sri Budayanti Ni Putu Aryati Suryaningsih Ni Putu Rahayu Martini Pande I Ketut Sukadiasa Putu Ayu Nita Pebriyanti Putu Eka Arimbawa Putu Eka Arimbawa Putu Yudhistira Budhi Setiawan Sutema, Ida Ayu Manik Partha Wintariani, Ni Putu