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UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SENDOK (Plantago major L.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Adiansyah Adiansyah; Hapsah Junita Siregar
Jurnal Farmanesia Vol 5 No 1 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Spoon leaves contain active ingredients, namely tannins, flavonoids, sterols, and polysaccharides. These compounds may be responsible for providing a hypoglycemic effect. This study aims to determine the characterization of the ethanol extract of spoon leaves in male white rats induced by alloxan. Diabetic rats were grouped into five treatment groups, each group consisted of 5 rats. Group I (CMC-Na suspension 0.5% w/v), group II (glibenclamide 0.45 mg/kg BW); Groups II, III, and IV (EEDS doses of 200 mg/kg BW, 400 mg/kg BW, and 600 mg/kg BW) were taken orally for 15 consecutive days. Furthermore, the measurement of glucose levels was observed and measured with a glucometer on days 3, 5, 7, 9, 11, 13, and day 15. The results of the examination of simplicia characteristics showed that the water-soluble extract content was 13.47%, the ethanol-soluble extract content was 12.84%, the total ash content was 3.29%, and the acid insoluble ash content was 0.29%. The results of the analysis of the administration of EEDS showed a significant effect of reducing blood glucose levels in mice compared to the 1% CMC-Na control group. The best decrease in blood glucose levels on the 15th day was shown in the 600 mg/kg BW dose group. Statistical test results (a = 0.05) showed that EEDS at a dose of 400 mg/kg BW and a dose of 600 mg/kg BW were not significantly different from glibenclamide at a dose of 0.45 mg/kg BW.

FORMULASI SEDIAAN MASKER PEEL-OFF EKSTRAK DAUN PAKIS (Diplazium esculentum (Retz.)sw.) SEBAGAI ANTI-AGING Ahmad Ghazali; Jon Kenedy Marpaung; Adiansyah Adiansyah; Carlos Salinas Sitorus
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Tumbuhan pakis memiliki kandungan flavonoid, vitamin C, vitamin A, vitamin B kompleks, kalsium, dan fosfor. Flavonoid merupakan senyawa utama yang digunakan dalam sediaan masker gel peel-off sebagai anti-aging. Flavonoid mempunyai sifat sebagai antioksidan. Tujuan dari penilitian ini adalah memformulasikan dan mengevaluasi kemampuan masker gel peel-off ekstrak etanol daun pakis (Diplazium esculentum (Retz.)sw.) dalam memberikan efek anti-aging pada kulit wajah. Metode penelitian ini dilakukan secara eksperimental. Ekstrak etanol daun pakis diperoleh dengan cara maserasi menggunakan penyari etanol kemudian dipekatkan dengan rotary evaporator pada suhu 40, kemudian diformulasikan dalam sediaan masker gel peel-off dengan konsentrasi 2,5% (formula 1), 5% (formula 2), dan 7,5% (formula 3). Evaluasi terhadap sediaan masker gel peel-off meliputi pemeriksaan organoleptis, homogenitas, pengamatan stabilitas sediaan (perubahan warna, bau, pH dan waktu sediaan mongering dikulit) selama penyimpanan 4 minggu, uji viskositas, uji iritasi, dan uji efektifitas menggunakan alat skin analyzer terhadap kulit wajah. Parameter yang diukur meliputi kadar air, besar pori, jumlah noda, dan keriput. Perawatan dilakukan selama 4 minggu.Hasil penilitian menunjukkan bahwa ekstrak etanol daun pakis dapat diformulasikan sebagai masker gel peel-off. Hasil pemeriksaan kadar air yang terbaik adalah 7,5%, pori yang terbaik adalah 7,5%, penurunan noda yang terbaik pada konsentrasi 7,5%, dan penurunan keriput yang terbaik pada konsentrasi 5% terhadap pemakaian selama empat minggu.

ISOLASI DAN IDENTIFIKASI PEKTIN DARI KULIT PISANG MAS (Musa acuminata Colla) Panal Sitorus; Supartiningsih Supartiningsih; Jon Kenedy Marpaung; Bernadetta R. Munthe
Jurnal Farmanesia Vol 7 No 1 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Pectin is one of the types of carbohydrate from polysacharide compound derivatives found in plan cell walls. pectin can be used in the viscosity, stability, texture and appearance of the food. The use of pectin in pharmacy is used for diarrhea, where pectin works as absordent in the intestine and also used as wound medicine as the hemostatic agent. The purpose of this research is utilize the mas banana peel as the source of pectin. This research was conducted by using the reflux extraction method using 1N hydrochloric acid as a solvent. Pectin isolation at pH 2, temperature 70-80-C for 60 minutes. The result of the precipitate is then added ethanol into the filtrate to precipitate the pectin and the final process is drying to obtain dry pectin which is 2.2975 gr. Dried pectin is obtained in the form of a fine powder, reddish brown in color and practically insoluble in ethanol. From the result of the identification that was carried out positive for the reaction with the addition of 96% ethanol and 2N NaOH, there was a gel which when added with 3N HCI and heated it formed brownish yellow lumps and had a distinctive odor. Physical specific characterization of pectin was also carried out, including moisture content (31.37%) and ash content (38.79%). Pure pectin standard for maximum moisture content of 12%, and maximum ash content of 10%. Pectin from mas banana (Musa acuminataColla) does not meet IPPA (International Pectin Producers Association) quality standards. Keywords: Banana peel, pectin, extraction, Reflux

AKTIVITAS PENGHAMBATAN ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2 OLEH SENYAWA ALKALOID DARI ATTARASA (Litsea cubeba (Lour.)Pers.) SECARA IN-SILICO Jon Kenedy Marpaung; Melisa Rekayana Tambuan
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Attarasa (Litsea cubeba (Lour.) Pers.) is a mountain plant known as "Mountain pepper" or "Mountain Pepper". This plant contains alkaloids, such as Oblongine; Actinodaphine; Isoboldine; Cassameridine; Coclaurine; Corydine; Corytuberine; Dicentrine; Laurotetanine; Lindcarpine; Isocorydine; Isodomesticine; Juziphine; N-Methylcoclaurine; N-Methyllaurotetanine; N-Methyllindcarpine; Norcorydine; Norisoboldine; Norisocorydine; Xanthoplanine. Alkaloids in Attarasa (Litsea cubeba (Lour.) Pers.) have properties such as antimicrobials. This study aimed to determine the inhibition of the protease enzyme 6LU7 of the SARS-CoV-2 virus by an alkaloid compound from Attarasa (Litsea cubeba (Lour.) Pers.) by using the in silico tethering method. The in silico tethering process is carried out using the PLANTS program and visualized using the MOE2008 program. The protease enzyme was downloaded via the Protein Data Bank (PDB) with the code 6LU7. Two- and three-dimensional models are generated using the Marvin Sketch program. The resulting docking value is evaluated as a result of the docking process. The results of this study indicate that the binding of alkaloid compounds from Attarasa (Litsea cubeba (Lour.) Pers.) to 6LU7 expression gave valid results in silico. The compound N-Methylcoclaurine, Coclaurine, and Laurotetanin inhibited the protease enzyme 6LU7 with the best score close to the comparative value of Lopinavir and Remdesivir and produced 7 amino acid residues that were bound to each other, namely val_114, val_13, leu_115, phe_150, gly_140, val_140, and ser_147.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN LEGUNDI (Vitextrifolia L.) TERHADAP PERTUMBUHAN Staphylococcus epidermidis Jon Kenedy Marpaung; Panal Sitorus; Pandapotan Nasution; Roma Devina Yanti
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Legundi leaves (Vitextrifolia L.) contain flavonoid compounds, alkaloids and saponins, tannins, steroids/triterpenoidsthatact as antiseptic substancesandaid in the wound healing process. Staphylococcusepidermidis (Gram positive) is a mild skin infection-causing bacteria that accompanies the formation of abscesses. As for the purpose of this study To know the absence of antibacterial activity from concentrations of 10%, 15%, 20%, 25% legundileaf extractagainst Staphylococcus epidermid is bacteria and know the effective concentration of legunleaf extract in in hibiting the growth of Staphylococcus epidermidis bacteria. This research methoduses experimental methods and legundileaf extract with concentrations of 10%, 15%, 20%, 25%. The resultsshowedthatconcentrationsof 10%, 15%, 20%, 25% of legundileaf ethanol extract had antibacterial activity against the growth of Staphylococcus epidermidisindicated with a blockable zone diameter of 8 mm, 8.84 mm, 9.84 mm, 10.54 mm, respectively. Base dont here search that has beendone can be concluded that legundileaf extractcan inhibit the growth of bacteria Staphylococcus epidermidis, because around the discpaperthere is a clear zone that indicates the absence of bacterial growth.

ANALISA CEMARAN LOGAM MERKURI PADA IKAN AIR LAUT DAN UDANG SECARA SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Yosy Cinthya Eriwaty Silalahi; Jon Kenedy Marpaung; Supartiningsih Supartiningsih
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Mercury is a heavy metal that can have a toxic effect on the body so it can cause death. Mercury metal contamination in food is regulated in SNI number 7387 of 2009 regarding the Maximum Heavy Metal Limit. Some metal waste disposal ends up in rivers, lakes, or sea waters so that metal pollution can occur in the ecosystem. This study aims to determine levels of mercury metal contamination in seawater fish, including shark, mackerel, salmon, tuna, red snapper, and white shrimp. Sample preparation was carried out by wet digestion method using a microwave digestion device. Mercury analysis was carried out using the AAS (Atomic Absorption Spectrophotometry) method. The wavelength used is 253.7 nm. The results showed that mercury in sharks was 0.2045 ± 0.0099 mg/kg, mackerel 0.4184 ± 0.0297 mg/kg, salmon 0.3848 ± 0.0794 mg/kg, tuna fish 0.3706 ± 0.0674 mg/kg, snapper 0.4088 ± 0.0397 mg/kg, and shrimp 0.4289 ± 0.0813 mg/kg. The results of the analysis showed that of the six samples of seawater fish that had been tested, the maximum metal contamination limit determined by SNI 7387 the Year 2009 was 0.5 mg/kg.

PEMANFAATAN LIMBAH CAIR TAHU MENJADI Nata de Soya MENGGUNAKAN BAKTERI Acetobakter xylinum Zuhairiah Zuhairiah; Jon Kenedy Marpaung; Maringan Silitonga
Jurnal Farmanesia Vol 7 No 2 (2020): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Nata de Soya merupakan salah satu jenis pangan yang diperoleh dari pengolahan limbah cair tahu yang berbahan dasar kedelai. Penelitian ini bertujuan untuk memanfaatkan limbah cair tahu yang sering terabaikan dan menjadi penyebab rusaknya lingkungan perairan dekat perindustrian pembuatan tahu. Nata de Soya dibentuk oleh bakteri Acetobacter xylinum yang merupakan bakteria erob. Masing-masing perlakuan difermentasi selama 8-14 hari, parameter yang diamati yaitu berat nata, kadar air, kadar serat dan selulosa Nata de Soya selama 8-14 hari. Pada penelitian ini didapat data ketebalan Nata de Soya dengan perlakuan 1, 2, dan 3 dengan kosentrasi 5, 10, dan 20% starter bakteri yaitu, 2,4503 gr, 2,8922 gr, dan 2,9226. Pada berat nata didapat 0,21 cm, 0,82 cm, dan 1,53 cm. Kandungan kadar air pada Nata de Soya pada perlakuan 1,2 dan 3 dengan kosentrasi masing-masing 5, 10, dan 20% yaitu 82,71, 83,71%, dan 84,17%%. Kandungan kadar serat Nata de Soya pada perlakuan 1, 2, dan 3 dengan kosentrasa bakteri 5, 10 dan 20% didapat 49,90%, 50,74% dan 54,02%. Pada uji kadar selulosa menggunakan FTIR dengan sampel 0,4 g nilai tertinggi didapat sebanyak 3361,12 menunjukan adanya gugus aldehid dari selulosa acetat. Pemanfaatan limbah cair tahu menjadi Nata de Soya menggunakan bakteri acetobacter xylinum dapat menjadi alternative pengolahan limbah cair tahu.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KEMANGI (Ocimumbasilicum L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcusaureus Kesaktian Manurung; Jon Kenedy Marpaung; Mardianis Mardianis
Jurnal Farmanesia Vol 8 No 1 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Basil (Ocimumbasilicum L.) is one of the natural plants that is easily obtained in Asia such as Indonesia which has medicinal properties. Basil leaves contain flavonoid compounds, tannins, saponins, and steroids/triterpenoids. These compounds are known to have antibacterial activity. This study aims to determine the antibacterial activity of the ethanolic extract of basil leaves (Ocimumbasilicum L.) against Staphylococcus aureus bacteria. This research is experimental. The test was carried out through several stages including material collection, preparation of simplicia, making ethanol extract of basil leaves, and testing the inhibitory power of basil leaves against Staphylococcus aureus bacteria. The ethanol extract of basil leaves was made by the maceration method using 96% ethanol and concentrated with a rotary evaporator to obtain a thick extract from basil leaves. Antibacterial activity was tested by the agar diffusion method using disc paper. The results of the antibacterial activity test showed that the ethanolic extract of basil leaves inhibited the growth of Staphylococcus aureus bacteria at concentrations of extracts of 5%, 10%, 15%, 20%, and 25% with inhibition zone diameters of 8. 31 mm, 9. 43 mm, respectively. 9. 73 mm, 9. 91 mm, and 11. 33 mm. The ethanol extract of basil leaves has antibacterial activity against Staphylococcus aureus bacteria.

UJI AKTIVITAS ANTIBAKTERI DARI BLACK GARLIC DENGAN VARIASI WAKTU BERBEDA TERHADAP Streptococcusmutans PENYEBAB KARIES GIGI Vivi Purwandari; Jon Kenedy Marpaung; Suharyanisa Suharyanisa
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Dental cariesand gingivitis are the two mostcommon dental and oral diseases in human society. The main cause of both diseasesis a collection of bacteria bound in anorganicmatrix and firmlyattachedtothe tooth surface known as plaque. Black garlicis garlic that has been processed by fermentationat a certaintemperaturefor a long time, resulting in new compounds that have pharmacological effects showing broad antibiotic properties against gram-positiveand gram-negative bacteria, includingstrains that are multi-bacterial. Antibiotic resistance. The purpose of this study was to determine the antibacterial activity of black garlic against Streptococcus mutans bacteria and to determine the differences in the variation of the antibacterial fermentation time of blackgarlicon the antibacterial activity of Streptococcus mutans bacteria. The methodused in this study isanexperimentalmethod (experimentalresearch) to determine the effect of blackgarlic as anantibacterial against Streptococcusmutans. The resultsobtained fromthis study are blackgarlic extract containsalkal oids, flavonoids, tannins, andsaponins. Black garlic extract from variations of 7 days, 12 days, 15 days, and Chlorhexidine had an inhibitoryzone with a strong category while steriledistilled water had an inhibitionzone in the weakcategory.

FORMULASI SEDIAAN MASKER PEEL-OFF EKSTRAK DAUN PAKIS (Diplazium esculentum (Retz.)sw.) SEBAGAI ANTI-AGING Ahmad Ghazali; Jon Kenedy Marpaung; Adiansyah Adiansyah; Carlos Salinas Sitorus
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2730

Tumbuhan pakis memiliki kandungan flavonoid, vitamin C, vitamin A, vitamin B kompleks, kalsium, dan fosfor. Flavonoid merupakan senyawa utama yang digunakan dalam sediaan masker gel peel-off sebagai anti-aging. Flavonoid mempunyai sifat sebagai antioksidan. Tujuan dari penilitian ini adalah memformulasikan dan mengevaluasi kemampuan masker gel peel-off ekstrak etanol daun pakis (Diplazium esculentum (Retz.)sw.) dalam memberikan efek anti-aging pada kulit wajah. Metode penelitian ini dilakukan secara eksperimental. Ekstrak etanol daun pakis diperoleh dengan cara maserasi menggunakan penyari etanol kemudian dipekatkan dengan rotary evaporator pada suhu 40, kemudian diformulasikan dalam sediaan masker gel peel-off dengan konsentrasi 2,5% (formula 1), 5% (formula 2), dan 7,5% (formula 3). Evaluasi terhadap sediaan masker gel peel-off meliputi pemeriksaan organoleptis, homogenitas, pengamatan stabilitas sediaan (perubahan warna, bau, pH dan waktu sediaan mongering dikulit) selama penyimpanan 4 minggu, uji viskositas, uji iritasi, dan uji efektifitas menggunakan alat skin analyzer terhadap kulit wajah. Parameter yang diukur meliputi kadar air, besar pori, jumlah noda, dan keriput. Perawatan dilakukan selama 4 minggu.Hasil penilitian menunjukkan bahwa ekstrak etanol daun pakis dapat diformulasikan sebagai masker gel peel-off. Hasil pemeriksaan kadar air yang terbaik adalah 7,5%, pori yang terbaik adalah 7,5%, penurunan noda yang terbaik pada konsentrasi 7,5%, dan penurunan keriput yang terbaik pada konsentrasi 5% terhadap pemakaian selama empat minggu.

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