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All Journal Journal of Mathematical and Fundamental Sciences Indonesian Journal of Biotechnology UNEJ e-Proceeding Berkala Kedokteran Panrita Abdi - Jurnal Pengabdian pada Masyarakat Universa Medicina JPSCR : Journal of Pharmaceutical Science and Clinical Research JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Abdi: Media Pengabdian Kepada Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Sains dan Kesehatan Borneo Journal of Pharmacy
Suko Hardjono
Fakultas Farmasi Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Universa Medicina

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Ethyl p-methoxycinnamate from Kaempferia galanga inhibits angiogenesis through tyrosine kinase Juni Ekowati; Suko Hardjono; Iwan Sahrial Hamid
Universa Medicina Vol. 34 No. 1 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.43-51

Abstract

BACKGROUNDMany tumors express on their receptor tyrosine kinases vascular endothelialgrowth factor activity associated with angiogenesis. Inhibition ofangiogenesis through reduction of tyrosine kinase activity is a promisingstrategy for cancer therapy. The present study aimed to determine themechanism and potency of ethyl p-methoxycinnamate (EPMC) isolatedfrom Kaempferia galanga as angiogenesis inhibitor.METHODSA laboratory experimental study was conducted using chorio-allantoicmembranes (CAMs) of nine-day old chicken eggs induced by 60ng basicfibroblast growth factor (bFGF). Ethyl p-methoxycinnamate (EPMC) potencywas determined at dosages of 30, 60, 90 and 120 μg and compared withcelecoxib 60 μg as reference drug and one negative bFGF-induced controlgroup. Neovascularization and endothelial cell count in CAM blood vesselswere evaluated. To predict the antiangiogenic mechanism of EPMC, adocking study was performed with the Molegro Virtual Docker program ontyrosine kinase as receptor (PDB 1XKK).RESULTSAngiogenesis stimulation by bFGF was prevented significantly (p<0.05)by EPMC at dosages of 30, 60, 90 and 120 μg and this activity was dosedependent. Molecular docking showed interaction between EPMC functionalgroups and tyrosine kinase amino acids at Met766, Met793, Thr854, Thr790,Gln791 and Ala743. There was an association between EPMCantiangiogenic activity and docking study results.CONCLUSIONSEthyl p-methoxycinnamate is a potential new angiogenesis inhibitor throughinteraction with tyrosine kinase. EPMC could be a promising therapeuticagent for treatment of angiogenesis-related diseases.
Co-Authors Aguslina Kirtishanti Andayani, Rina Asri Darmawati Bambang Tri Purwanto Burhan Ma’arif Burhan Ma’arif Denis Mery Mirza Dewi Isadiartuti Dian Triwidiandany Diyah, Nuzul Wahyuning Faisal Akhmal Muslikh Herra Studiawan I Gusti Ayu Adhi Aryapatni I NYOMAN WIJAYA Isnaeni isnaeni, isnaeni isnaeni Iwan Sahrial Hamid Juni Ekowati Mangestuti Agil Mangestuti Agil Maria Lucia Ardhani Dwi Lestari Muhammad Yuwono Muhammad Yuwono Muhammad yuwono Muhammad yuwono, Muhammad Yuwono Muhammad Yuwono Noor Erma Nasution Noor Erma Nasution Sugijanto Noorma Rosita Purbosari, Ira Randiman, Sugijanto Sugijanto Reyhan Rahma Samudra Siswandono, Siswandono Sugijanto Sugijanto Sugijanto Sugijanto Randiman Sugijanto, Noor Erma Nasution Noor Erma Nasution Tri Widiandani Tristiana Erawati Virnanda Syafira Hartatiningrum Widji Soeratri Wiwied Ekasari Zulvikar Syambani Ulhaq