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All Journal Journal of Mathematical and Fundamental Sciences Indonesian Journal of Biotechnology UNEJ e-Proceeding Berkala Kedokteran Panrita Abdi - Jurnal Pengabdian pada Masyarakat Universa Medicina JPSCR : Journal of Pharmaceutical Science and Clinical Research JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Abdi: Media Pengabdian Kepada Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Sains dan Kesehatan Borneo Journal of Pharmacy

Suko Hardjono

Fakultas Farmasi Universitas Airlangga

Author-ID : 3488477

Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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PELATIHAN CARA PRODUKSI DAN REGISTRASI MAKANAN YANG BAIK, AMAN DAN HALAL BAGI MASYARAKAT KHALAYAK SMK NEGERI 4 BOJONEGORO isnaeni, isnaeni isnaeni; Suko Hardjono, Suko Hardjono Suko Hardjono; Asri Darmawati, Asri Darmawati Asri Darmawati; Sugijanto, Noor Erma Nasution Noor Erma Nasution; Juni Ekowati, Juni Ekowati Juni Ekowati; Randiman, Sugijanto Sugijanto; Muhammad yuwono, Muhammad Yuwono Muhammad Yuwono
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol 6, No 1 (2020)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ja.v6n1.p6-12

Community Service Activities (PENMAS) were held in August 2018 in Kapas, Bojonegoro with a target audience of SMKN 4 communities, totaling 107 people, consisting of students majoring in Cooking, members of Dharma Wanita, Chefs from 2hotels, several UMKM Food and Beverages around the school, teachers and partisipants from other schools. The activity was also attended by the Principal, the Head of the Education Office who witnessed the signing of the MOU between the PENMAS Team and the school. One of the Departments managed by SMK 4 is Tata Boga with thelearning outcome to prepare entrepreneurs or businessmen of food products. As a vocational school that has held the ISO 9001 2008 certificate, the school is obliged to prepare graduates according to the demands of their competence. Based on preliminary studies, information was obtained that there were several problems related to food consumption and production and government regulationin the case of traded food businesses. The training materials provided in this training were: Food business production regulation (1), How to make good food (2),Ingredients additional allowable food (3), Prohibited food additives and substitute alternatives (4), Good packaging methods and techniques for food and beverage (5), Halal Assurance System (SJH) and Halal food product Certification Process (6) and Simple marketing for food business (7). Based on the evaluation of the pre-test and post-test resulted that after the training participants' understanding showed an increasing trend. Three topics that showed a significant increase in understanding were: Requirements for clean and healthy food (1), Introduction of food coloring logos (2), and Examples of halal food ingredients (3). PENMAS activities will be followed up with intensive coaching activities for students of SMKN4 which are included in the group of beginner beverage food businesses.

Evaluation of N-benzoylthiourea derivatives as possible analgesic agents by predicting their physicochemical and pharmacokinetic properties, toxicity, and analgesic activity Suko Hardjono; Siswandono Siswandono; Rina Andayani
Indonesian Journal of Biotechnology Vol 22, No 2 (2017)
Publisher : Universitas Gadjah Mada

This study aimed to predict the physicochemical properties, pharmacokinetic properties (ADME), toxicity, and analgesic activity of 30 compounds of N-benzoylthiourea derivatives that are potential analgesic drugs. One of the mechanisms of action of N-benzoylthiourea derivatives is the inhibition of the cyclooxygenase-2 (COX-2) isoenzyme. An in silico test was performed by docking a compound that would predict its activity with the target COX-2 isoenzyme, PDB ID: 1PXX, using the MVD (Molegro Virtual Docker) program. The result of the docking was a form of energy bond indicated by the value of the rerank score (RS), where compounds that had lower RS values were predicted to have a higher activity. The pkCSM and Protox online tools were used to predict various physicochemical properties. Based on the RS values, the N-benzoylthiourea derivatives can be predicted to have lower analgesic activity than diclofenac, the reference ligand. Three of the N-benzoylthiourea derivatives—N-(2,4-bis-trifluoromethyl)-benzoylthiourea, N-(3,5-bis-trifluoromethyl)benzoylthiourea, and N-(3-trifluoromethoxy)-benzoylthiourea—had RS values of -90.82, -94.73, and -92.76, respectively, suggesting that these compounds were predicted to have analgesic activity relatively similar to diclofenac (RS value = -95.16). Furthermore, the majority of the N-benzoylthiourea derivatives were predicted to have good pharmacokinetic properties (ADME), and cause relatively low toxicity.

The Knowledge of Lombok Praya-Indonesia Regional Community on the Safety Use of Medicinal Plants Wiwied Ekasari; Suko Hardjono; Sugijanto Sugijanto; Juni Ekowati; I Nyoman Wijaya; Tri Widiandani
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: The use of medicinal plants to maintain or overcome health problems has long been carried out by worldwide community. Along with the development of knowledge, data about the existence of undesirable effects or side effects associated with the use of medicinal plants that are not appropriate are obtained. This research is conducted to determine public knowledge about the safety several medicinal plants use. The study was conducted with a questionnaire technique in Lombok Praya, Indonesia. The results show that knowledge about the safety of the use of medicinal plants in breastfeeding mothers obtains the correct answer by 48%, knowledge about the parts of medicinal plants that are dangerous for consumption by 39% and knowledge about medicinal plants that can increase health risks by 21%. Whereas, the knowledges for the use of medicinal plants in pregnant women and the use of medicinal plants that are not right obtains very good results with correct answers of 79% and 81%. Based on further interviews, these good results are obtained because they are supported more by traditional use of the plant that has already existed in the area. Public understanding of the safety of some medicinal plants in Lombok Praya is still lacking. It is necessary to add knowledge about the use of medicinal plants that requires special attention, especially on plants that are often used by people in the area. Local health agencies need to disseminate information on the safety of medicinal plants that is wider and more sustainable. Keywords: Community, medicinal plant, safety, public understanding.

STRUCTURE MODIFICATION AND MOLECULAR MODELING OF 1-(BENZOYLOXY)UREA DERIVATIVES AS ANTICANCER DRUG CANDIDATES Suko Hardjono
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Structure modification made in designing new drugs,by changing the structure of the lead compound.Changes in the structure of a compound would alterthe physicochemical properties including lipophilic,electronic and steric properties of the compound(Korolkovas, 1988; Siswandono, 2014). Changes inphysicochemical properties would lead to changes inthe activity of each compound (Hardjono et al,2016). Molecular modeling through in silico test is atest that is done through computer simulation.Molecular Modeling is used to predict a new drugcandidate compounds to be synthesized. This testwas performed in order to improve efficiency in theoptimization of the activity of the lead compound(Topliss J.G., 1988, Istyastoro 2007; Jenzen 2007,Kumar C.S, 2013, Dyah N.W., 2016).Some derivatives of 1-(Benzoyloxy)urea showedcytotoxic activity and predicted could be used asanti-cancer drugs (Hardjono, 2012; Hardjono 2016).Mechanism of action of urea derivatives including 1-(Benzoyloxy)urea was by inhibiting the action of theenzyme ribonucleotide reductase. This in silico testresearch done by docking the compound whicgactivities to be predicted using MVD (MolegroVirtual Docker) program. The target cell used indocking was 2EUD, a ribonucleotide reductaseenzyme crystal I, which forms a complex with thederivative 1-(Benzoyloxy)urea. 2EUD chosenbecause it was the target cell from Gemsitabin whichwork mechanism similar to urea (Xu H., 2006). Fromin silico test would be obtain Rerank Score (RS)values, which was the bond energy between theligands and target cell. Small RS value indicated thatthe bond energy needed between the compoundwith a target cell was also small. The smaller thebond energy indicated that the bond was morestable. The more stable binding of ligands to thereceptor, it could be predicted activity will be evengreater (Hardjono, 2012).In this research would be done molecular modelingof twenty-four 1-(Benzoyloxy)urea derivatives. Thein silico test result was an image that showed thehydrogen bond, Electrocic and steric interaction aswell as the value of RS from 1-(Benzoyloxy)urea andits derivatives. Of the entire RS values obtainedwould be seen 1-(Benzoyloxy)urea derivates whichhad the smallest RS value or

Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines Bambang Tri Purwanto; Siswandono Siswandono; Suko Hardjono; Dian Triwidiandany
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 2 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.2.3

Urea derivatives are extensively used in the pharmaceutical industry. However, the unsatisfactory level of their membrane penetration requires further modification of the structures with stronger lipophillic properties. Phenylurea has a phenyl group that enables easier membrane penetration as a result of stronger pharmacological activity. Activity prediction was conducted by docking experiments and molecular dynamics, performed with Molegro Virtual Docker 5.5 using checkpoint kinase 1 (CHK1) enzyme with ID PDB: 2YWP. ADMET prediction was applied to collect data using the pkCSM tool. N-(phenyl carbamyol)benzamide compounds, modified by the Schotten Baumann method, were synthesized from benzoil chloride reacting with N-phenylurea. For evaluating anticancer activity, the MTT assay method on HeLa cells was used. Derived from the docking experiments, the compound rerank score of the N-(phenylcarbamoyl)benzamide was 72.0603 kcal/mol, lower than that of hydroxyurea, -32.1514 kcal/mol, causing better inhibitory activities against HeLA cell lines due to higher cytotoxic effects. ADMET Predictor was employed, indicating satisfactory compound distribution with a low, favorable metabolism, possessing good excretion and non-toxicity. The synthesized compound was 82% N-(phenyl carbamoyl)benzamide with 0.8 mM IC80, higher than that of hydroxyurea, 4.3 mM. In conclusion, successfully synthesized N-(phenylcarbamoyl)benzamide was proved to have higher cytotoxic effects. The satisfactory values of these compounds indicate that they are promising anticancer drug candidates.

Ethyl p-methoxycinnamate from Kaempferia galanga inhibits angiogenesis through tyrosine kinase Juni Ekowati; Suko Hardjono; Iwan Sahrial Hamid
Universa Medicina Vol. 34 No. 1 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.43-51

BACKGROUNDMany tumors express on their receptor tyrosine kinases vascular endothelialgrowth factor activity associated with angiogenesis. Inhibition ofangiogenesis through reduction of tyrosine kinase activity is a promisingstrategy for cancer therapy. The present study aimed to determine themechanism and potency of ethyl p-methoxycinnamate (EPMC) isolatedfrom Kaempferia galanga as angiogenesis inhibitor.METHODSA laboratory experimental study was conducted using chorio-allantoicmembranes (CAMs) of nine-day old chicken eggs induced by 60ng basicfibroblast growth factor (bFGF). Ethyl p-methoxycinnamate (EPMC) potencywas determined at dosages of 30, 60, 90 and 120 μg and compared withcelecoxib 60 μg as reference drug and one negative bFGF-induced controlgroup. Neovascularization and endothelial cell count in CAM blood vesselswere evaluated. To predict the antiangiogenic mechanism of EPMC, adocking study was performed with the Molegro Virtual Docker program ontyrosine kinase as receptor (PDB 1XKK).RESULTSAngiogenesis stimulation by bFGF was prevented significantly (p<0.05)by EPMC at dosages of 30, 60, 90 and 120 μg and this activity was dosedependent. Molecular docking showed interaction between EPMC functionalgroups and tyrosine kinase amino acids at Met766, Met793, Thr854, Thr790,Gln791 and Ala743. There was an association between EPMCantiangiogenic activity and docking study results.CONCLUSIONSEthyl p-methoxycinnamate is a potential new angiogenesis inhibitor throughinteraction with tyrosine kinase. EPMC could be a promising therapeuticagent for treatment of angiogenesis-related diseases.

PENINGKATAN PEMBERDAYAAN KELOMPOK WANITA TANI DUSUN WONOREJO KOTA BATU MELALUI PELATIHAN PEMBUATAN PRODUK SUSU PROBIOTIK-SARI BUAH SEBAGAI MINUMAN KESEHATAN Nuzul Wahyuning Diyah; Isnaeni Isnaeni; Asri Darmawati; Suko Hardjono
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 4 No. 1 (2020): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v4i1.2020.128-133

Wonorejo village in Batu city is known as a vegetable and fruit producing area. Another popular product of Batu mostly is fresh dairy milk and only a small amount of processed products while the cow milk collected in KUD Batu has reached 16-17 tons per day. The problem was that the target community had no experiences in processing cow milk using probiotic microbes. The purpose was transfering of science and technology about the production of probiotic milk combined with fruit juice. This program was specifically directed to increase the empowerment of Kelompok Wanita Tani "Wonoasri" in Wonorejo, in developing of fruity- probiotic dairy products to increase the diversification of products with higher economic value. The method included workshop and technical assistance, which were carried out in a serie of steps: 1) exploring the knowledge of target by surveys and pre test, 2) lecturing and discussion, 3) demonstrating how to prepare and characterize the probiotic milk products, 4) training the preparation of product, 5) product characterization and packaging assistance, 6) evaluation. The results of this program were the target community gained increase in knowledge and experience, and they could produce fruity probiotic milk. In addition, we expected that they would increase their understanding and enthusiasm to appreciate the potency of their territory in order to improve the nation's competitiveness. abstrakDesa Wonorejo di kota Batu dikenal sebagai daerah penghasil sayur dan buah. Produk populer lain dari Batu adalah susu segar dan sejumlah kecil produk olahan. Susu sapi dikumpulkan di KUD Batu. Masalahnya adalah bahwa komunitas target tidak memiliki pengalaman dalam memproses susu sapi menggunakan mikroba probiotik. Tujuannya adalah mentransfer ilmu pengetahuan dan teknologi tentang produksi susu probiotik yang dikombinasikan dengan jus buah. Program ini diarahkan untuk pemberdayaan Kelompok Tani Wanita "Wonoasri" di Wonorejo, dalam mengembangkan produk susu buah-probiotik untuk diversifikasi produk dengan nilai ekonomi lebih tinggi. Metode tersebut termasuk lokakarya dan bantuan teknis, dalam serangkaian langkah: 1) mengeksplorasi pengetahuan target dengan survei dan pra-tes, 2) ceramah dan diskusi, 3) menunjukkan bagaimana mempersiapkan dan mengkarakterisasi produk susu probiotik, 4) pelatihan persiapan produk, 5) karakterisasi produk dan bantuan pengemasan, 6) evaluasi. Hasil program ini adalah komunitas sasaran memperoleh peningkatan dalam pengetahuan dan pengalaman, dan mereka dapat menghasilkan susu probiotik buah. Selain itu, kami berharap bahwa mereka akan meningkatkan pemahaman dan antusiasme mereka untuk menghargai potensi wilayah mereka untuk meningkatkan daya saing bangsa.

Prediksi Sifat Farmakokinetik, Toksisitas dan Aktivitas Sitotoksik Turunan N-Benzoil-N’-(4-fluorofenil)tiourea sebagai Calon Obat Antikanker melalui Pemodelan Molekul SUKO HARDJONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2033.055 KB)

Merancang obat baru dapat dilakukan melalui modifikasi struktur yaitu dengan mengubah gugus tersubstitusi yang menyebabkan perubahan sifat fisikokimia, farmakokinetik, toksisitas dan aktivitas masing-masing senyawa. Perubahan tersebut dapat diprediksi melalui uji in silico. Penelitian ini bertujuan untuk memprediksi sifat fisikokimia, proses farmakokinetik (ADME), toksisitas dan aktivitas sitotoksik dari 23 senyawa turunan N-benzoil-N’-(4-fluorofenil)tiourea sebagai calon obat anti kanker. Uji in silico dilakukan dengan cara doking senyawa yang akan diprediksi aktivitasnya dengan enzim target SIRT1 kode pdb. 4I5I. Hasil doking berupa energi ikatan yang digambarkan dengan nilai Rerank Score (RS), dengan menggunakan program Molegro Virtual Docker. Senyawa dengan nilai RS kecil diprediksi mempunyai aktivitas yang besar. Hasil uji in silico menggunakan program pkCSM dan Protox online tool dapat disimpulkan bahwa sebagian besar turunan N-benzoil-N’-(4-fluorofenil)tiourea mempunyai sifat farmakokinetik yang baik, menimbulkan toksisitas yang relatif rendah dan mempunyai aktivitas sitotoksik yang lebih besar dari ligan pembanding 4I5_601, dan senyawa N-(4-fenilazobenzoil)-N’-(4-fluorofenil)tiourea merupakan senyawa yang diprediksi mempunyai aktivitas sitotoksik paling besar.

Pemodelan Molekul, Sintesis dan Penentuan Aktivitas Antineoplastik 1-(4-Trifluorometilbenzoiloksi)Urea SUKO HARDJONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (354.504 KB)

To design new drugs, physical-chemical characteristics of drug molecules can be predicted by in silico test before drugs are synthesized. Ribonucleotide reductase is the main target or receptor of antineoplastic compounds such as hydroxyurea (HU) and its derivatives like 1-(4-trifluoromethylbenzoyloxy)urea or 4-CF3BOU. This compound forms a complex with crystal structure of ribonucleotide reductase I enzyme, which is 2EUD. The hydrogen bond and bond energy in the form of rerank score from both complexes was calculated with Molegro program. Theoretically, compound activity is indicated by rerank score. The compound whose rerank score is small is predicted to have greater activity. The activity of 4-CF3BOU was found to be greater than HU. The reaction mechanism of synthesis 4-CF3BOU was the substitution of nucleophilic hydroxyl group from HU to carbonyl group of 4–trifluoromethylbenzoyl chloride (4-CF3BCl). Purity test was conducted using TLC and melting point. Structure identification was performed based on the spectra of UV-VIS, FT-IR, H/C-NMR and MS. In this study, 4-CF3BOU was discovered to have antineoplastic activity with the IC50 value of 82.37 μg/mL and was tested towards HeLa cells. On the other hand, HU had the IC50 value of 430.21 μg/mL. The antineoplastic activity of 4-CF3BOU was greater than HU.

Uji in silico Aktivitas Sitotoksik dan Toksisitas Senyawa Turunan N-(Benzoil)-N’- feniltiourea Sebagai Calon Obat Antikanker Dini Kesuma; Siswandono Siswandono; Bambang Tri Purwanto; Suko Hardjono
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 3, No 1 (2018)
Publisher : Universitas Sebelas Maret

Senyawa N-(benzoil)-N’-feniltiourea mempunyai gugus farmakofor yang sama dengan turunan urea yang mempunyai aktivitas antikanker, sepertihidroksiurea, sehinggalayakdijadikansenyawaindukuntukdikembangkanlebihlanjutmelaluimodifikasistruktur. Penelitianinibertujuanuntukmemprediksiaktivitas sitotoksik dan toksisitas dari duapuluh tiga senyawa turunanN-(benzoil)-N’-feniltiourea sebagaicalonobatantikanker. Salah satumekanismekerjaturunanN-(benzoil)-N’-feniltiourea sebagaiantikanker adalah menghambat VEGFR2,regulatorpentinguntuk proses angiogenesis, sertasangatberperanuntukpertumbuhan tumor dan metastasis. Aktivitas biologis dapat diprediksi melalui pemodelan molekul yang disebut uji in silico, menggunakan program MVD (Molegro Virtual Docker),sedang toksisitas dapat diprediksi menggunakan program pkCSMdanProtoxonline tool. Uji in silico dilakukan dengan melakukan docking senyawa yang akan diprediksi aktivitasnya dengan target reseptor, VEGFR2, PDB ID. 3WZE.Hasildockingberupaenergiikatandigambarkandengannilai Rerank Score (RS).Senyawa dengan nilai RS kecil berarti mempunyai ikatan ligan-reseptor yang stabil dan diprediksi mempunyai aktivitas yang besar. Dari hasilujiin silicodisimpulkanbahwasemuaturunanN-(benzoil)-N’-feniltiourea diprediksimenimbulkantoksisitas relatifrendah, danmempunyai aktivitas sitotoksik lebihbesardibandinghidroksiurea, tetapimasihlebihrendahdibandingsorafenib.N-(4-propoksibenzoil)-N’-feniltioureadanN-(3,5-di-trifluorometilbenzoil)-N’-feniltioureadiprediksi mempunyai aktivitas sitotoksik paling besar tetapi menimbulkan hepatotoksik, sehingga sebagai senyawa terpilih untuk disintesis dan dikembangkan lebih lanjut adalah N-(3,4-dimetilbenzoil)-N’-feniltiourea.

Co-Authors Aguslina Kirtishanti Andayani, Rina Asri Darmawati Bambang Tri Purwanto Burhan Ma’arif Burhan Ma’arif Denis Mery Mirza Dewi Isadiartuti Dian Triwidiandany Diyah, Nuzul Wahyuning Faisal Akhmal Muslikh Herra Studiawan I Gusti Ayu Adhi Aryapatni I NYOMAN WIJAYA Isnaeni isnaeni, isnaeni isnaeni Iwan Sahrial Hamid Juni Ekowati Mangestuti Agil Mangestuti Agil Maria Lucia Ardhani Dwi Lestari Muhammad Yuwono Muhammad Yuwono Muhammad yuwono Muhammad yuwono, Muhammad Yuwono Muhammad Yuwono Noor Erma Nasution Noor Erma Nasution Sugijanto Noorma Rosita Purbosari, Ira Randiman, Sugijanto Sugijanto Reyhan Rahma Samudra Siswandono, Siswandono Sugijanto Sugijanto Sugijanto Sugijanto Randiman Sugijanto, Noor Erma Nasution Noor Erma Nasution Tri Widiandani Tristiana Erawati Virnanda Syafira Hartatiningrum Widji Soeratri Wiwied Ekasari Zulvikar Syambani Ulhaq

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