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All Journal Jurnal Fitopatologi Indonesia BALI MEDICAL JOURNAL (BMJ) Agrotrop : Journal on Agriculture Science International Journal of Biosciences and Biotechnology Buletin Udayana Mengabdi Journal of Agricultural Science and Biotechnology E-Jurnal Agroekoteknologi Tropika (Journal of Tropical Agroecotechnology) Jurnal Ilmu Lingkungan INTERNATIONAL JOURNAL OF APPLIED CHEMISTRY RESEARCH
Ni Made Puspawati
Program Studi Agroekoteknologi, Fakultas Pertanian, Universitas Udayana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology

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Journal : BALI MEDICAL JOURNAL (BMJ)

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PENTAMETHYLCARBOXYLATE RUTHENOCENE BASED ANTITUMOUR AGENT Wahjuni, Sri; Puspawati, Ni Made; Williams, Michel
BALI MEDICAL JOURNAL Vol 4 No 2 (2015)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Unlike iron ruthenium is not an essential element for life. However, the behavior of ruthenium compounds in biological systems and, in particular their use as antitumour agents has attracted much attention recently. This study aims to determine antitumour properties against human tumour cell line HeLa of pentamethylcarboxylate ruthenocene. Methods: This is an in vitro study by applying an experimental within post only control group design. Cisplatin, a clinical used medicine was applied for control. The human tumour cell line Hela was used for the test. The cells were cultured at 370C in 5% CO2/air in Roswell Park Memorial Institute Medium 1640 and seeded overnight in 96 well microtitre plates. The penthamethylcarboxylate ruthenocene was dissolved in 1,2 dimethoxy ethane and diluted with culture media. The plates were assays by measuring optical density in the range of 490-655 nm. The D37 values were then calculated. Results: The pentamethylcarboxylate ruthenocene compound tested was found to be more cytotoxic than cisplatin (with D37 = 422 nM compare to D37 = 705 nM for cisplatin). Conclusions: The compound tested, pentamethylcarboxylate ruthenocene was found more potent as an antitumor compare to cisplatin a clinical used antitumor for curing testicular carcinoma.
Co-Authors DWI WIDANINGSIH GEDE SUASTIKA Gusti Ngurah Alit Susanta Wirya I Dewa Nyoman Nyana I G. R. M. TEMAJA I Gusti Ngurah Bagus I GUSTI NGURAH BAGUS PRANATA PUTRA I Ketut Siadi I Ketut Suada I MADE SUDARMA I MADE SUDARMA I MADE SUDARMA I MADE SUDARMA I MADE SUDARMA I MADE SUDARMA I NYOMAN WIJAYA IDA BAGUS MADE DWI JAYA KETUT AYU YULIADHI Khairun Nisak Syahdu KHAMDAN KALIMI M SUDANA MADE SRITAMIN Michel Williams, Michel Muhammad Ikhsan Nulzaen NI NENGAH DARMIATI NI NYOMAN ALIT PURWANINGSIH NI NYOMAN ARI MAYADEWI NI PUTU MERRY SENI ANTARI NI WAYAN SUNITI NYOMAN RAI KUNTALINI OCTA FRANSISCA SITORUS ONGKY ARI WIBOWO PANDE MADE INDRAYOGA Putu Sudiarta Sinarsih, Ni Ketut Sri Wahjuni WIWIK SUSANAH RITA