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Sunarno Sunarno
Biology Laboratory Structure And Function Of Animals, Department Of Biology, Faculty Of Science And Mathematics, Diponegoro University, Jl. Prof. Soedarto, SH, Tembalang, Semarang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Engineering Health Professions Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : International Journal of Science and Engineering (IJSE)

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Potential of Glutathione Antioxidant in the Hippocampus Repair: Preliminary Study on Bioactive Materials Antiaging of Snakehead Fish (Channa striata) in Animal Models of Aging Sunarno Sunarno
International Journal of Science and Engineering Vol 8, No 1 (2015)
Publisher : Chemical Engineering Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.461 KB) | DOI: 10.12777/ijse.8.1.22-25

Abstract

Snakehead fish meat contains active ingredients with anti-aging potential that serves as a precursor of glutathione. The ability of glutathione as an antiaging opportunities in the utilization of fish meat, especially snakehead fish. Snakehead fish meat contains several important amino acids, such as glutamine, cysteine​​, and glycine so the potential to be developed for the production of food that is nutritious and healthy. This study examines the essential amino acid composition of the antioxidant glutathione precursors found in snakehead fish from Rawa Pening Central Java to increase glutathione in the body and brain. The results showed that every 100g of snakehead fish meat from Rawa Pening containing glutamine (32.39%), cysteine ​​(6.61%), and glycine (9.69%). Snakehead fish meat extract given at a dose of 30 ml/kg/day in both types of animal models of aging effect on the increase in the content of glutathione and glutathione precursors, both in blood and hippocampus. Increased glutathione precursor of the most high to low, respectively glutamine, glycine, and cysteine​​. Availability of essential amino acids can support increased glutathione in the brain. This is indicated by an increase in glutathione hippocampus in both animal models, both on chronological aging or aging due to oxidative stress, respectively (0.822 and 0.359) mol/g bb compared to control tissue.
Co-Authors A. P. Nagari Adhitya Yoga Pradana Riyadi Ahmad Edi Darmawan Ahmad Rifai Alfisa Devi Amni Z. Rahman Annisa Widyasari Bayu Pradika Beta Cahyaning Nugraheni Bima Adistya Dara Puspita Jati Windoro Dwi Rahmawati Eko Purnomo Endang Nawarikita Evi Lestari F Pratiwi Falasifah Falasifah Fendy E. Wahyudi Garin F Fairuzzaki Hikmah Putri Pratiwi K. Budiraharjo Kasiyati Kasiati Kencana Ayudya Prabahandari Khunfaya Firnanda Putri Rossida Khunfaya Firnanda Putri Rossida Laili Fitria Zulfa Linda Ayu Mamluatul Lailiyah Maulida Aqlinia Mohammad Farhan Aditya Muhammad Adnan Jafar Alfian Muhammad Alvin Gibran Muhammad Anwar Djaelani Muhammad Fikri Muhammad Fikri Zulfikar Novia Marcelina Rahayu Damayanti Rd Yudhi Tresnadi Kusumah Rully Rahadian Salindri Prawitasari Salsabila Alifah Salsabila Alifah Satwika Paramasatya, Satwika Silvana Tana Siska Hairunnisa Siti Muflichatun Mardiati Siti Murni Mas'adah Siti Murni Mas'adah Solikhin Solikhin SRI ISDADIYANTO Sri Pujiyanto Sri Widodo Agung Suedy Susan Nuraeni Vinsensius M Dhani Widiartanto Widiartanto