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All Journal Jurnal Saintika Medika Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Tumbuhan Obat Indonesia Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Indonesian Journal of Biotechnology Caraka Tani: Journal of Sustainable Agriculture Jurnal Biologi Tropis PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM
Siti Rofida
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PHYTOCHEMISTRY PROFILE, EFFICACY, AND SAFETY OF GREEN TEA (Camellia sinensis (L.) Kuntze) FOR BREAST CANCER CHEMOPREVENTION: A SYSTEMATIC REVIEW Dwi Hartanti; Siti Rofida
Jurnal Tumbuhan Obat Indonesia Vol 14 No 2 (2021): Jurnal Tumbuhan Obat Indonesia
Publisher : Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jtoi.v14i2.4994

Abstract

ABSTRACT The consumption of tea (Camellia sinensis (L.) Kuntze), mainly green tea, is famous for various health benefits. This review summarizes the potential use of green tea and epigallocatechin gallate (EGCG) for breast cancer chemoprevention. The data were retrieved from the online publication on the Pubmed database and covered the phytochemistry, preclinical study, and clinical trial of green tea related to its use as a breast cancer chemopreventive agent. Catechins, particularly EGCG, are the chemopreventive bioactive constituents of green tea. Preclinical studies demonstrated that the anti-proliferative and induction of apoptosis potentials of green tea are mediated through several different mechanisms. However, no association between green tea intake and a lowered breast cancer risk in human studies, but it might be favorable for secondary cancer prevention. Keywords: green tea, epigallocatechin gallate, chemopreventive, breast cancer. ABSTRAK Konsumsi teh (Camellia sinensis (L.) Kuntze), terutama teh hijau, terkenal dengan berbagai manfaat kesehatannya. Ulasan ini merangkum potensi penggunaan teh hijau dan epigallocatechin gallate (EGCG) untuk kemoprevensi kanker payudara. Data diambil dari publikasi online di database Pubmed dan mencakup fitokimia, studi praklinis, dan uji klinis teh hijau terkait dengan penggunaannya sebagai agen kemopreventif kanker payudara. Katekin, terutama EGCG, adalah konstituen bioaktif kemopreventif teh hijau. Studi praklinis menunjukkan bahwa anti-proliferatif dan induksi potensi apoptosis teh hijau dimediasi melalui beberapa mekanisme yang berbeda. Namun, tidak ada hubungan antara asupan teh hijau dan penurunan risiko kanker payudara dalam penelitian pada manusia, tetapi mungkin menguntungkan untuk pencegahan kanker sekunder. Kata kunci: teh hijau, epigallocatechin gallate, kemopreventif, kanker payudara.
Screening of Hybrid Jatropha curcas L. Genotypes for Drought Tolerant Abilities as a Source of Superior Variety Characteristics Erfan Dani Septia; Siti Rofidah; Sofyan Arief; Maftuchah Maftuchah
Caraka Tani: Journal of Sustainable Agriculture Vol 36, No 1 (2021): April
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/carakatani.v36i1.38634

Abstract

The scarcity of fuel oil in the future needs to be anticipated by preparing alternative energy. One of the alternative energy sources developed is Jatropha. However, the development of Jatropha should use marginal land as a cultivation area, like a dry land, because the food crops and horticulture use productive land for cultivation. Furthermore, Jatropha development through breeding is an effort to obtain superior varieties as biodiesel producers. This study aimed to determine the best phenotype characteristics of hybrid Jatropha plants as superior candidate trees. This research applied a descriptive qualitative method to determine the characteristics of Jatropha crossing results. The Jatropha characterization was conducted at the experimental garden of Kedung Pengaron Village, Kejayan Sub-district, Pasuruan Regency. The experimental garden was included dry land for Jatropha cultivation. The result showed ten selected genotypes of hybrid Jatropha were found, including 05.01.01, 05.01.02, 05.02.02, 05.02.09, 05.03.17, 05.03.16, 05.04.16, 05.04.15, 06.01.02, 06.01.15. These were based on the two-phase observations, consisting of vegetative and generative observations. The plants’ morphological characters were observed, comprising the stems, leaves, flowers, fruits and seeds. In the vegetative phase, diversity was found in the number of leaves, leaf length and age of flowering, while in the qualitative phase, the shoot colors were more diverse. Moreover, less variations were figured out in the color character of the petiole and the number of shoots. These ten genotypes of hybrid Jatropha are the best genotypes that are resistant to drought with selected agronomic characters.
Curcuma longa as a Natural Immunomodulator for Preventing infection from COVID 19 With an In Silico Approach Lely Mauliana; Ahmad Shobrun Jamil; Siti Rofida
Jurnal Biologi Tropis Vol. 22 No. 2 (2022): April - June
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v22i2.3281

Abstract

SARS-CoV-2 is a Coronaviridae virus with a single-stranded RNA genome. This virus is highly contagious and spreads rapidly, with mutations occurring at a rapid pace. Various preventive actions have been implemented to prevent the spread of Covid-19 instances. The World Health Organization recommended that everyone clean their hands, masks, and other items in their environment on a frequent basis. As a result of these measures, the virus's transmission will be slowed. Furthermore, keeping one's immune system is critical for limiting the spread of Covid-19. As a result of a weakening immune system, our body's defenses will deteriorate, making us more susceptible to sickness and unable to fight diseases caused by viruses or bacteria. If the immune system is strong, it will recognize and kill viral and bacterial compounds when they are exposed. Immunomodulators, such as natural vitamins and herbs, can help maintain and boost immunity. Indonesia is primarily a farming country. In Indonesia, many different varieties of plants can be grown. Turmeric is an Indonesian medicinal plant that may be found all across the country. Turmeric's ability to act as an immunomodulator has also been proven. As a result, the goal of this study is to determine the usefulness of the active chemicals found in the Curcuma longa plant as a natural immunomodulator in order to avoid mutations of the COVID 19 variation by looking at the background of the current situation. The approach employed in this study is an in silico Molecular Docking test, with the goal of determining the active side of the drug and the value of Binding Affinity from the Docking data. Tissue Pharmacology is used to depict the protein network found in turmeric plants, as well as the substances and diseases that are linked to these proteins. According to the findings, the compound quercetin acts as a ligand for the PIK3CG protein and has a high binding affinity of -7.4. As a result, it can be identified as a substance that acts as a natural immunomodulator in turmeric plants.
Antibacterial Activity Of Chromolaena odorata (L) King Leaves With Bioautography Siti Rofida; Nurwahdaniati Nurwahdaniati
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 12 No. 01 Juli 2015
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

ABSTRACT Chromolaena odorata (L) King, commonly referred as kirinyuh, is a traditional medicinal plant from Asteraceae. It has been reported that C. odorata scientifically possessed antimicrobial activity. The aim of this study is to obtain active antibacterial substances from 70% etanolic extract of C. odorata against Staphylococcus aureus. Separation of active substances was carried out by Thin Layer Chromatography (TLC) techniques. The separated substances were tested for their antibacterial activity by bioautography assay using S. aureus. Separation of 70% etanolic extract C. odorata produced six spots with retention factor (Rf) values are 0.9, 0.8, 0.7, 0.6, 0.5, and 0.3. The diameters of inhibition zone of those spots were 35, 27, 27, 20, 31, and 14 mm, respectively. Based on the TLC profiles, the compounds with Rf of 0.9, 0.6, and 0.5 were identified as flavonoids and the compounds with Rf of 0.8, 0.7, and 0.3 were identified as terpenoids. It is concluded that the spot with the most potent antimicrobial activity was flavonoids with of Rf 0.9. Key words: antibacterial, bioautography, Chromolaena odorata.
Screening of Antibacterial Activity of Ethyl Acetate Fraction of Eleutherine palmifolia (L.) Merr Bulbs against Salmonella typhi Siti Rofida; Ahmad Shobrun Jamil; Nurul Amalia Azhari
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.8999

Abstract

Typhoid fever is an infection caused by the bacterium Salmonella typhi, spread through contaminated food or water. Typhoid fever can be treated with antibiotics, but at this time some pathogen microbes have been resistant to the available antibiotics. Antimicrobials derived from natural product might be the alternative to overcome antibiotic resistance. Eleutherine palmifolia (L.) Merr is empirically used to treat infectious diseases. E. palmifolia has chemical compounds of alkaloids, glycosides, flavonoids, phenolics, steroids, and tannins. This study aims to evaluate the antibacterial activity of ethyl acetate fraction against S. typhi. E. palmifolia bulbs were subsequently extracted using n-hexane solvents and followed by ethyl acetate solvents. The ethyl acetate fraction was tested for antibacterial activity using the disc diffusion method. The ethyl acetate fraction of E. palmifolia at the concentrations of 8, 6, and 8 mg/paper disc showed the diameters of the inhibition zone of 15.1±3.6, 15.3±3.3, and 16.9±1.9 mm, respectively. The conclusion of this study was the ethyl acetate fraction of E. palmifolia has a strong antibacterial activity against S. typhi.
Network pharmacology of black cumin (Nigella sativa L.) as a candidate of OMAI in colorectal cancer: in silico study Firzannida Firzannida; Sakti Bagaskara; Savana Sonia Savira; Aufa Fadnurrahim; Siti Rofida
Indonesian Journal of Biotechnology Vol 27, No 2 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.70699

Abstract

Colorectal cancer is the third most common cancer globally and the second leading cause of cancer‐related deaths. The management of colorectal cancer requires consideration of various factors due to the non‐selectivity of drugs, meaning that highly effective treatment with lower side effects is needed. Black cumin (Nigella sativa L.) contains thymoquinone and various other metabolites with potential as anticancer effects. The involvement of various genes and the difficulty of drug development have led to a ashift in the drug development paradigm towards plant‐based medicine that is both multicomponent and synergistic in supporting the resulting pharmacological effects. Network pharmacology can predict the synergistic effect of a multicomponent approach. This study aimed to predict the network pharmacology of black cumin as a candidate for OMAI (“Obat Modern Asli Indonesia”, Indonesian‐origin modern medicine) in colorectal cancer. This research was an in silico study using various ethnobotanical databases and software. The results show that seven metabolites in black cumin are correlated with ten surface receptor proteins, 30 intracellular proteins, and mechanisms involving six colorectal cancer signaling pathways. This result indicates that Nigella sativa L. has potential in OMAI and can be a reference for the development of cancer treatment, especially for colorectal cancer.
Pemberdayaan Dan Pendampingan Kader Binaan Puskesmas Mojolangu Dalam Pembuatan Obat Tradisional Yang Baik Amaliyah Dina Anggraeni; Siti Rofida
JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM) Volume 4 Nomor 3 Juni 2021
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v4i3.3563

Abstract

ABSTRAK Pemanfaatan obat tradisional untuk menunjang kualitas kesehatan, sangat diperlukan keseimbangan dari upaya – upaya dalam peningkatan mutunya. Hal ini berkaitan pula dengan adanya dampak – dampak dari penggunaan obat tradisional pada umumnya. Sehingga untuk melindungi konsumen dari akibat penggunaan obat tradisional yang tidak memenuhi persyaratan, maka produk obat tradisional harus memenuhi persyaratan mutu, keAmanan, dan kemanfaatan untuk dapat diedarkan di Indonesia maupun ekspor ke luar negeri. Puskesmas Mojolangu merupakan fasilitas kesehatan yang memiliki bidang pengembangan dan pemberdayaan masyarakat khususnya departemen kesehatan pengobatan tradisional. Banyaknya masyarakat daerah sekitar mitra yang berprofesi sebagai produsen obat tradisional tetapi belum adanya pemberian informasi terkait cara pembuatan obat tradisional yang baik dan benar. Higenitas dan keamanan jamu atau minuman herbal yang diproduksi oleh produsen jamu di lingkungan puskesmas mojolangu belum terstandarisasi sesuai dengan CPOTB. Sehingga berpotensi dihasilkan produk jamu yang tidak berkhasiat optimal serta keamanan produk tidak tercapai. Kegiatan pengabdian ini menggunakan metode Contextual Teaching and Learning (CTL) untuk mengatasi permasalahan yang dialami oleh masyarakat di kelurahan Mojolangu. Setelah edukasi dan pendampingan produsen jamu atau obat tradisional dapat memproduksi jamu temulawak dan jahe instan yang berkhasiat dan aman untuk dikonsumsi. Kata kunci : Jamu, Obat Tradisional, Kader binaan, produsen jamu, CPOTB  ABSTRACT The use of traditional medicines to support health quality requires a balance of efforts to improve its quality. It is also related to the effects of using traditional medicines in general. It protects consumers from the consequences of using traditional medicines that do not meet the requirements. Traditional medicinal products must meet the quality, safety, and benefit requirements circulated in Indonesia and exported abroad. The Mojolangu Health Center is a health facility with community development and empowerment sector, especially the traditional medicine health department. There are many local communities around the partners who work as producers of traditional medicines, but there is no information regarding how to manufacture traditional medicines correctly and adequately. The hygiene and safety of jamu or herbal drinks produced by herbal medicine producers in the Mojolangu Community Health Center have not standard according to the CPOTB. The potential to produce herbal products that do not have optimal efficacy and product safety does not achieve. This service activity uses the Contextual Teaching and Learning (CTL) method to overcome the community's problems in Mojolangu village. After education and assistance, producers of herbal medicine or traditional medicine can produce herbal ginger and instant ginger, which are efficacious and safe for consumption. Keywords: Jamu, Traditional medicine, construction cadres, herbal medicine manufacturer, CPOTB
Evaluation of sST-2 Role in LVH Regression Obtained in Hypertensive Mice Models After Blocking Renin-Angiotensin System Lilik Yusetyani; Siti Rofida; Dian Yuliartha Lestari; Wawan Kurniawan; Nursela Hijriani; Ilham Niawan Saputra; Setyawati Soeharto; Mohammad Saifur Rahman
Journal of Tropical Life Science Vol. 9 No. 1 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Soluble ST2, is a protein which acts as a decoy receptor for interleukin-33, and served as biomarker associated with left ventricular hypertrophy (LVH).  Few data exist in evaluating the effects of anti-hypertensive agents on the role-played form ST2 on regression of LVH. This study was designed to compare the effects of captopril and valsartan on blood pressures, plasma renin and soluble ST2 levels and regression of LVH in hypertensive mice models. Twenty-four male mice (Mus musculus L), were divided into four groups, namely aquadest/control, L-NAME, L-NAME + captopril and L-NAME + valsartan groups respectively. Mice blood pressures were measured on day 14th after induction with L-NAME extract 1.75 mg/25 g BW/day (pretreatment) and day 14th post treatment. Levels of plasma renin, sST2, and ventricular wall thicknesses reflecting LVHs, were measured on day 14th post treatment. Administration of L-NAME within 14 days resulted in making mice models to be hypertensive paralleled by an increase of Ventricular wall thickness. Treatment with captopril and valsartan lowered the blood pressures to normal level within the next 14 days. Valsartan and captopril treatment induced a significant decrease of plasma renin level. Valsartan, but not for captopril treatment prevented wall thickness increase (p < 0.05), while plasma sST2 was not able to mirroring this effect. Captopril and valsartan had similar effect in lowering plasma renin level and   blood pressure, but sST2 seems to be not involved in LVH regression obtained in hypertensive mice models after blocking renin-angiotensin system.
Co-Authors Ahmad Shobrun Jamil Amaliyah Dina Anggraeni Anak Agung Istri Sri Wiadnyani Aufa Fadnurrahim Dian Yuliartha Lestari Dinda Farida Dwi Hartanti Dwi Retno Nur Syahida Erfan Dani Septia Firdiansyah, Ahmad Firzannida Firzannida Fitriyastuti, Endah Hijriani, Nursela Ilham Niawan Saputra Lely Mauliana Lilik Yusetyani Lilik Yusetyani Maftuchah Maftuchah Mohammad Saifur Rahman Nursela Hijriani Nurul Amalia Azhari Nurwahdaniati Nurwahdaniati Nurwahdaniati Nurwahdaniati, Nurwahdaniati Rahman, Mohammad Saifur Sakti Bagaskara Salahudin Salahudin Saputra, Ilham Niawan Savana Sonia Savira Setyawati Soeharto Setyawati Soeharto, Setyawati Sofyan Arief Trimianti Hidahyatun Nazah Wawan Kurniawan