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Journal : Medula

daun Daun Salam (Syzygium Polyanthum) Sebagai Penurun Kadar Kolesterol Dalam Darah Aditya Ramadhon Islami Sakaganta; Asep Sukohar
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.146

Abstract

Coronary Heart Disease (CHD) is a major health problem in developed or developing countries. CHD is classified as a degenerative disease related to lifestyle, and socio-economic community. In 2008 it was estimated that 17.3 million deaths were caused by cardiovascular disease. The prevalence of hypercholesterolemia in Indonesia according to riset kesehatan dasar (riskesdas) in 2013 was obtained by Indonesians with higher than normal cholesterol levels higher in women by 39.6% when used with men by 30%. The full scientific bay leaf plant has the Latin name Eugenia polyantha Wight and has another scientific name, namely syzygium polyantha wight and eugenia lucidula miq. This plant belongs to the myrtaceae tribe. Bay leaf contains essential oils of 0.17%, citral, eugenol, tannin, flavonoids, and metal cavikol. Substances that are significant in lowering cholesterol are flavonoids and tannins. How flavonoids work in reducing cholesterol occurs when the hydroxyl group on cholesterol is considered with the ketone group on flavonoids forming hemiasetal. The carbonyl group in flavonoids will choose the hydroxyl group in cholesterol to determine the hydrogen bond. Tannins work quickly in binding and shrinking proteins. Tannin works as an antioxidant, astringent, and hypocholesterolemic. Tanninakan with mucous protein and intestinal epithelial cells so it needs to prevent fat.
Hubungan Antara CT Value pada Test RT-PCR Terhadap Parameter Klinis Pasien COVID-19 Josi Jeremia Manurung; Asep Sukohar
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.190

Abstract

Detection of SARS-CoV-2 by reverse transcription-PCR (RT-PCR) test on nasopharyngeal swab specimens is the main diagnostic method for COVID-19, usually reported qualitatively as positive or negative using a defined cut-off, either based on the CT value. or integrated with an automated algorithm that interprets different parameters of the potential amplification. The CT value was inversely related to the number of viruses in the sample. Consequently, the CT value could indirectly indicate the level of viral replication activity, which affects SAR-CoV-2 infectivity in patients, but this does not differentiate between infectious and non-infectious viruses. Several studies stated that there was no correlation between CT values and severity, in the pneumonia and non-pneumonia groups, symptomatic and asymptomatic patients, the presence or absence of olfactory or tasting dysfunction, as well as on leukocytes, neutrophils, lymphocytes, platelets and C-reactive protein. Many factors that influence the CT value such as the timing of sample collection, method of collection of the sample, the kit used, and the skills of the health worker are biased which can affect the CT value. Further research is needed on the correlation of CT values in COVID-19 patients.