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IMPACT OF CISPLATIN BASE CHEMOTERAPY ON QUALITY OF LIFE IN INDONESIAN PATIENTS WITH CERVICAL CANCER Suwendar Suwendar; Achmad Fudholi; Tri Murti Andayani; Herri S. Sastramihardja
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Cervical cancer is the most common malignantcancer of the female reproductive organs and affectsthem for a long period of time. If someone weresuffering from cervical cancer, then the quality of lifewill decline. This have been proven by research incancer patients in Dr. Sardjito Hospital includingcervical cancer [Perwitasari et al, 2011]. Not only theeffect of cervical cancer, the choice of chemotherapyregiment will also affect the quality of life(humanistic outcome) of the patients. There are avariety of chemotherapy regimens for cervicalcancer. Cisplatin-based chemotherapy regimen isrecommended by the NCCN (NationalComprehensive Cancer Network) and the Ministry ofHealth of Republic of Indonesia. Neverthelesshumanistic outcome research of these regimens arestill lacking. This study aims to evaluate the quality oflife of cervical cancer patients in Dr. Hasan SadikinHospital Bandung were treated with cisplatin basechemoterapy using the EQ-5D questionnaire.
Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok Rahimah, Santun Bhekti; Sastramihardja, Herri S.; Sitorus, Trully Detty
Majalah Kedokteran Bandung Vol 42, No 4
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Radikal bebas asap rokok dapat menyebabkan peroksidasi lipid dan perubahan patologis pada sel paru. Hal ini dapat dicegah oleh senyawa yang terkandung dalam jamur tiram putih (Pleurotus ostreatus), antara lain fenol, vitamin C, selenium, dan ergotien. Penelitian bertujuan untuk melihat efek ekstrak jamur tiram putih pada kadar malondialdehid (MDA) dan nilai surface density (S/V) setelah terpapar asap rokok. Metode penelitian menggunakan rancangan acak lengkap dan sebagai pembanding digunakan vitamin E. Dosis ekstrak etanol jamur tiram putih adalah 250 mg/kgBB dan paparan asap rokok diberikan 30 menit/tikus/hari menggunakan smoking pump. Pada hari ke-11 perlakuan, dilakukan pemeriksaan kadar MDA darah dengan metode thiobarbituric acid assay (TBARS) dan perhitungan nilai S/V paru secara mikroskopis. Penelitian dilakukan pada bulan Juli 2009 di Departemen Farmakologi Klinik Rumah Sakit Hasan Sadikin Bandung. Hasil menunjukkan ekstrak etanol jamur tiram putih mencegah kenaikan kadar MDA darah (0,4667+0,22295 nm/mL) dan efeknya sama baik dengan vitamin E (0,7467+0,24089 nm/mL). Ekstrak etanol jamur juga mencegah penurunan nilai S/V (0,62283+0,47939) dan mempunyai efek yang lebih baik dari vitamin E (0,54683+0,39832), p<0,05. Disimpulkan bahwa ekstrak etanol jamur tiram putih merupakan antioksidan kuat yang lebih baik dibandingkan dengan vitamin E dalam mencegah kerusakan oksidatif akibat paparan asap rokok. [MKB. 2010;42(4):195–202].Kata kunci: Asap rokok, jamur tiram putih, malondiadehid, nilai S/V, radikal bebasAntioxidant Effect of Pleurotus ostreatus on Malondialdehyde Level and Surface Density of Rat Lung Cells Exposed to Cigarette SmokeCigarette smoke-free radicals can cause lipid peroxidation and pathological changes in lung cells. This effect could be prevented by highly active metabolite in Pleurotus ostreatus such us fenol, ascorbid acid, selenium, and ergothiene. This study aimed to analyze the effect of the Pleurotus ostreatus extract on the levels of malondialdehyde (MDA) and surface density (S/V) after exposure to cigarette smoke. The research used completed randomized design and á-tocopherol was used as control group. The dose of Pleurotus ostreatus ethanol extract was 250 mg/kg body weight and cigarette smoke exposure was given in 30 minutes/day for 10 days by smoking pump. Malondialdehyde (MDA) level and lung surface density (S/V) were observed on day 11th. This research was done at Clinical Pharmacology Department, Hasan Sadikin Hospital on July 2009.The result showed that ethanol extract of Pleurotus ostreatus can prevent increasing level of MDA (0.4667+ 0.22295 nm/mL), as good as that of á-tocopherol(0,7467+ 0,24089 nm/mL). Ethanol extract also prevented the reduction of lung S/V (0.62283+0.4793) and it's effect was better from á-tocopherol (0.54683±0.39832), p=<0.05. In conclusion, our data shows that etanolic extract of Pleurotus ostreatus is a strong antioxidant that have better effect than á-tocopherol in preventing oxidative damage of cigarette smoke. [MKB. 2010;42(4):195–202].Key words: Cigarette smoke, free radical, Pleurotus ostreatus, malondyaldehyde, S/V DOI: http://dx.doi.org/10.15395/mkb.v42n4.36
Penurunan Nyeri Persalinan Primigravida Kala I Fase Aktif Pascapenghirupan Aromaterapi Lavender Tarsikah, -; Susanto, Herman; Sastramihardja, Herri S.
Majalah Kedokteran Bandung Vol 44, No 1 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Nyeri persalinan merupakan bagian pada proses normal yang tidak jarang menyebabkan stres fisiologis dan psikologis terhadap ibu yang berdampak pada ibu maupun janin. Sebagian besar persalinan (90%) disertai nyeri, bahkan sampai nyeri berat. Penanganan nonfarmakologi merupakan salah satu alternatif untuk mengurangi nyeri persalinan. Penelitian ini bertujuan untuk menganalisis efek analgesik penghirupan aromaterapi lavender pada nyeri persalinan primigravida kala I fase aktif. Rancangan yang digunakan adalah studi praeksperimental, satu kelompok diobservasi sebelum dan sesudah perlakuan terhadap 30 ibu bersalin di Rumah Bersalin (RB) Kasih Ibu Jatirogo kabupaten Tuban provinsi Jawa Timur sebagai sampel yang dipilih secara konsekutif. Pengukuran variabel menggunakan skala nyeri numerik. Dilakukan analisis univariabel kuantitatif untuk mengetahui nyeri sebelum dan sesudah perlakuan. Analisis kuantitatif bivariabel Wilcoxon signed ranks test digunakan untuk mengetahui pengurangan nyeri dengan tingkat kemaknaan p<0,05. Penelitian ini dilakukan periode 14 September–31 Oktober 2009. Hasil analisis univariabel menyatakan bahwa skor nyeri rata-rata sebelum perlakuan 7,3 (SD 1,1) dansesudah perlakuan 5,9 (SD 1,4). Hasil uji Wilcoxon signed ranks test menunjukkan pengurangan nyeri yang bermakna pascapenghirupan aromaterapi lavender (Z=-4,338; p=0,000). Simpulan, terdapat pengurangan nyeri persalinan pascapenghirupan aromaterapi lavender. [MKB. 2012;44(1):19–25].Kata kunci: Nyeri persalinan, penghirupan aromaterapi lavender Labor Pain Reduction in Primigravida Active Phase after Inhalation of Lavender AromatherapyLabor pain is part of a normal process, which often causes physiological and psychological stress to mother. These stress have impact to both mother and fetus. Largely (90%) labor comes with pain and in some cases severe pain. Non-pharmacological approach is one of alternatives to reduce labor pain. This research aims to analyse the analgesic effect of lavender aromatherapy inhalation on labor pain in primigravida in the active phase. The study was pra-experimental by observing one group before and after treatment. The group involved 30 parturients in RB Kasih Ibu Jatirogo district of Tuban, East Java. The sampling method was based on consecutive admission. The variables were measured by using numerical rating scales (NRS). Univariable quantitative analysis was applied to describe the pain before and after treatment. Wilcoxon signed ranks test bivariable quantitative analysis was used to investigate pain relief with significance level of p<0.05. The univariable analysis result revealed that mean pain score before treatment was 7.3 (SD 1.1) and after treatment 5.9 (SD 1.4). Wilcoxon signed ranks test result showed significant pain relief after lavender aromatherapy inhalation (Z=-4.338, p=0.000). The research shows that there is a reduction of labor pain after lavender aromatherapy inhalation. [MKB. 2012;44(1):19–25].Key words: Inhalation lavender aromatherapy, labor pain DOI:  http://dx.doi.org/10.15395/mkb.v44n1.210
Solanumnigrum L. as a Hepatoprotective Agent Nur, Ismet Muchtar; Sastramihardja, Herri S.; Rizky, Muthiana
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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Abstract

  Background: Liver damage may be caused by various factors. SolanumnigrumL.fruit is known to contain flavonoid antioxidant which is responsible for its hepatoprotective effect. A study was conducted to determine the protective effect of Solanumnigrum L. fruit infusion (SNFI) on CCl4-induced hepatic cell damage in rats. Methods: A complete randomized experimental study was conducted on 25 male Wistar strain-white rats (Rattusnorvegicus) which were divided into five groups during the period of September– October 2012. Group I (negative control) was given standardized food and water; group II (positive control) was induced by carbon tetrachloride (CCl4) 10% paraffin intraperitoneally by 8 mL/kg body weight on the 8th day of the study; group III, IV, V (treated) were given Solanumnigrum L. fruit infusion (SNFI) by 22.5g/100mL, 45 g/100mL and 90g/100mL concentrations for 8 days, respectively, prior to CCl4 induction. The calculation of necrotic liver cells was performed in 48 hours after induction. Data were statistically analyzed using Kruskal-Wallis test followed by Mann-Whitney post-hoc test. Results: The percentage of necrosis liver cells in group III, IV, and V was smaller compared to  the positive control group. The protective effect of SNFI against CCl4-induced hepatotoxicity may be related to its ability to elevate the antioxidant agent in the body. There were significant differences in necrotic between Group II and group III, IV, V which were treated with SNFI. Conclusion: Further investigation is required to characterize the active ingredients and the mechanism of SNF action to confirm the hepatoprotective and antioxidant effects.Keywords: CCl4, hepatoprotective, Solanumnigrum L.DOI: 10.15850/amj.v2n1.433  
Soursop Effect in Cervical Cancer Apoptosys Mechanism Yuniarti, Lelly; Sastramihardja, Herri; Purbaningsih, Wida; Tejasari, Maya; Respati, Titik; Hestu, Enggar; Adithya, Agly
Global Medical & Health Communication (GMHC) Vol 2, No 1 (2014)
Publisher : Fakultas Kedokteran Universitas Islam Bandung

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Abstract

Abstract Cervical cancer is the fifth leading cancer cause of women death  in Indonesia.  Acetogenin, flavonoids, and tannins in sour sop leaves have anti-cancer effects through regulated genes which involved in apoptotic process such as in Caspase-3. This study aimed to determine the effect of ethanol extract of sour sop leaves to apoptosis and Caspase-3 gene expression in HeLa cell cultures. This was an in vitro study using HeLa cell culture samples  divided into 4 groups. The first group was HeLa cell cultures without  sour sop leaves ethanol extract. The 2nd ,3rd, and 4th group were HeLa cells cultures which were given sour sop leaves ethanol extract with concentration of 60 μg/mL, 120 mg / mL, and 240 mg / mL respectivelly. Apoptosis in each group was examined using TUNEL method and the expression of the caspase 3 gene by RT-PCR. One Way ANOVA with confidence level of 95% were used as statistical analysis.The result showed the effect of the sour sop leaves ethanol extract increased the apoptosis percentage in HeLa cells culture but did not affect the gene expression of Caspase-3.Key words: apoptosis, caspase-3, sour sop leaves Efek Daun sirsak dalam Mekanisme Apoptosis Kanker Serviks Abstrak Kanker serviks adalah penyebab kematian kelima untuk wanita di Indonesia. Asetogenin, flavonoid, dan tannin dalam daun sirsak terbukti mempunyai pengaruh anti kanker melalui regulasi gen melalui proses apoptosis seperti pada caspase-3. Penelitian ini bertujuan untuk menentukan efek ekstrak etanol daun sirsak untuk apoptosis dan ekspresi gen caspase-3 dalam kultur sel HeLa. Penelitian ini adalah penelitian in vitro menggunakan sel kultur HeLa yang dibagi menjadi 4 kelompok. Grup pertama adalah sel kultur HeLa tanpa ekstrak etanol daun sirsak sedangkan grup dua, tiga dan empat adalah sel kultur HeLa yang mendapat ekstraks etanol daun sirsak dengan konsentrasi  60μg/mL, 120 mg / mL, dan 240 mg / mL secara bertururt turut. Apoptosis dalam setiap kelompok diperiksa dengan menggunakan metode  terminal deoxynucleotidyl transferase-mediated (TUNEL) dan ekspresi gen caspase-3 dengan menggunakan reverse transciptase-polimerase chain reaction (RT-PCR). One Way analysis of varians (ANOVA) dengan tingkat kepercayaan 95% digunakan untuk analisis statistik. Hasil penelitian menunjukkan bahwa ekstrak etanol daun sirsak meningkatkan persentase apoptosis dari kultur sel HeLa tetepi tidak berpengaruh pada ekspresi gen Caspase- 3. Kata kunci: Apoptosis, Caspase-3, ekstrak daun sirsak 
The Effect of Breadfruit Leaves Infusion on Acute Renal Failure Rat model Abstract Hardani, Muhamad Risdan; Sastramihardja, Herri S.; Afiatin, Afiatin
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Abstract

Background : Empirically, breadfruit (Artocarpus altilis) leaf has been used as traditional medicine for several diseases, such as acute renal failure. This research is aimed at finding the effects of breadfruit leaf infusion on blood creatinine levels in rats to model acute renal failure.Methods : This research is an experimental study, using 30 male wistar rats, weighing 150–250 g, divided into 5 groups. The first group is a negative control and the second group is a positive control. Groups 2–5 were induced with Gentamicine and peroxicam for 7 days, and then groups 3–5 given infusion of breadfruit leaf in different doses for 7 days, and then blood creatinine levels were tested at the 15th day. This data was analyzed using a multiple comparison Dunnett T3 test because this data is not homogenous. This research was done in pharmacology laboratorium universitas padjadjaran from Oktober–November 2012.Result : Bases on average creatinine levels of 0.62, 0.87, 0.98, and 0.87 mg/dL observed for the diffetent groups, it was statistically show that significantly different creatinine levels, differing by 0.038 (p < 0.05) were observed for the control group and the group which was given an infusion of breadfruit leaf.Conclusion : It can be concluded that infusions of breadfruit leaf do have an effects on blood creatinine levels in acute renal failure.Key words : acute renal failure, breadfruit leaf, creatinine  DOI: 10.15850/amj.v2n4.527
Hand hygiene, health care workers, methicillin-resistant Staphylococcus aureus, nosocomial infection, Staphylococcus aureus Julius Gunadi; Herri S. Sastramihardja; Nina Susana Dewi
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Background: Hypercholesterolemia is a major risk factor for coronary heart disease. Ear fungus (Auricularia auricula) contains soluble fiber (beta glucan) which is believed to have an effect of reducing cholesterol level. The aim of this study was to determine the effect of fungus infusion in reducing blood cholesterol.Methods: This study used the laboratory experimental method conducted in the pharmacology laboratory of Dr. Hasan Sadikin General Hospital Bandung. The subjects were 25 male Wistar rats which were randomly divided into 5 groups. The first group was given only distilled water as a negative control, the remaining groups were induced to be dyslipidemic and received fungus infusion with different doses of 18%, 36%, 72% and one group received no treatment.Results: The comparison of different doses showed all had the effect of reducing cholesterol levels compared to the positive control group (p<0.05). Each dose showed slight differences in their effectiveness, 18% (p=0.007; p<0.05), 36% (p=0.002; p<0.05), and 72% (p=0.014; p<0.05).Conclusions: ear fungus infusion had the effect of reducing cholesterol with the most effective concentration was 36%. [AMJ.2015;2(1):153–61]
Solanumnigrum L. as a Hepatoprotective Agent Muthiana Rizky; Herri S. Sastramihardja; Ismet Muchtar Nur
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

  Background: Liver damage may be caused by various factors. SolanumnigrumL.fruit is known to contain flavonoid antioxidant which is responsible for its hepatoprotective effect. A study was conducted to determine the protective effect of Solanumnigrum L. fruit infusion (SNFI) on CCl4-induced hepatic cell damage in rats. Methods: A complete randomized experimental study was conducted on 25 male Wistar strain-white rats (Rattusnorvegicus) which were divided into five groups during the period of September– October 2012. Group I (negative control) was given standardized food and water; group II (positive control) was induced by carbon tetrachloride (CCl4) 10% paraffin intraperitoneally by 8 mL/kg body weight on the 8th day of the study; group III, IV, V (treated) were given Solanumnigrum L. fruit infusion (SNFI) by 22.5g/100mL, 45 g/100mL and 90g/100mL concentrations for 8 days, respectively, prior to CCl4 induction. The calculation of necrotic liver cells was performed in 48 hours after induction. Data were statistically analyzed using Kruskal-Wallis test followed by Mann-Whitney post-hoc test. Results: The percentage of necrosis liver cells in group III, IV, and V was smaller compared to  the positive control group. The protective effect of SNFI against CCl4-induced hepatotoxicity may be related to its ability to elevate the antioxidant agent in the body. There were significant differences in necrotic between Group II and group III, IV, V which were treated with SNFI. Conclusion: Further investigation is required to characterize the active ingredients and the mechanism of SNF action to confirm the hepatoprotective and antioxidant effects.Keywords: CCl4, hepatoprotective, Solanumnigrum L.DOI: 10.15850/amj.v2n1.433  
Knowledge and Attitude towards Prevention and Management of Hypertension in Jatinangor Sub-district Supriyadi, Rudi; Malahayati, Kartika; Sastramihardja, Herri S.
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: There is an increase in prevalence of hypertension all over the world as well as Indonesia. Hypertension affects almost all body organs and systems. Hypertension prevention and management are influenced by knowledge and attitude towards the disease. The aim of this study was to assess knowledge and attitude towards prevention and management of hypertension.Methods: This was a descriptive study with cross–sectional approach conducted in Jatinangor sub-district in 2013. Sample sizes were determined based on proportion of the case in population and precision estimates (95% confidence intervals). One hundred twenty respondents aged 18–60 year-old were selected from population using stratified random sampling method. Hypertensions knowledge and attitude were assessed using validated questioner as the scale measurement. Frequency of knowledge level was presented as three ordinal categories; good, moderate, and poor. Attitude of hypertension was presented as frequency in two categories; relatively positive and relatively negative.Results: Out of 120 respondents administered the questioner, 42.50% had good knowledge; 41.67% had moderate knowledge; 15.83% had poor knowledge related to hypertension prevention and 21.67% had good knowledge; 19.17% had moderate knowledge; 59.17% had poor knowledge related to management of hypertension. Hypertension attitude of respondents were 60.83% relatively positive in topics of hypertension prevention and 39.17% in topics of hypertension management.Conclusions: Respondents are knowledgeable about hypertension prevention but are less knowledgeable about its management. Respondents have relatively positive attitudes towards hypertension prevention. In the other hand, respondents have more relatively negative attitudes towards its management. [AMJ.2016;3(2):222–9]DOI: 10.15850/amj.v3n2.801
Polypharmacy Treatment of Hypertensionin Public Health Centers A/P Nayagam, Vasanthi; Afiatin, Afiatin; Sastramihardja, Herri S.
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Hypertension is one of the most prominent global diseases. Despite the availability of effective therapies, hypertension remains poorly controlled in Indonesia. In many cases, patient’s noncompliance may be attributable to the low patients’ knowledge, attitude, and life-style practices such as polypharmacy. Polypharmacy is defined as the administration of many drugs at in one prescription. Polypharmacy increases expenses, possible adverse reaction to a single agent, incidence of drug interactions, and decreases patient’s compliance This study aimed to identify the practice of polypharmacy in hypertension treatment in primary health centers.Methods: A cross-sectional descriptive observational study was carried out on 60 patients from two primary health centers in Jatinangor, West Java, Indonesia in October 2013. Sociodemographic profile, degree of hypertension, types of antihypertensive drugs, concomitant drugs given together with antihypertensive drugs, and treatment compliance data were collected and presented in tables and figures.Results: The incidence of hypertension was more common among male patients compared to female patients. Thirty-three patients (55%) have low compliance to their medication. Twenty-nine patients (48%) received single drug and 31 patients (52%) received more than one drugs.Conclusions: The percentage of polypharmacy practice in treating hypertension in primary health centers is 52%. The most frequently prescribed anti-hypertensive are angiotensin-converting enzyme (ACE) inhibitors and calcium-channel blockers (CCB). Most of hypertensive patients have low compliance to therapy. [AMJ.2016;3(4):633–9] DOI: 10.15850/amj.v3n4.951