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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Pharmasipha Journal of Tropical Pharmacy and Chemistry Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) ad-Dawaa : Journal of Pharmaceutical Sciences Mattawang: Jurnal Pengabdian Masyarakat Journal of Fundamental and Applied Pharmaceutical Science Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Acta Holistica Pharmaciana

Niluh Puspita Dewi

Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu

Author-ID : 4024604

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

Published : 17 Documents Claim Missing Document

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Efek Antihiperkolesterol dan Antihiperglikemik Daun Ceremai (Phyllantus acidus (L.) Skeels) pada Tikus Putih Jantan (Rattus norvegicus) Hiperkolesterol Diabetes: Antihypercholesterol and Antihyperglicemic Effect of Ceremai Leaf (Phyllantus acidus (L.) Skeels) Extract on Hypercholesterolemia Diabetes White Male Mice (Rattus norvegicus) Dermiati tatto; Niluh Puspita Dewi; Feiverin Tibe
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Daun Ceremai (Phyllantus acidus (L.) Skeels) merupakan tanaman yang diyakini memiliki khasiat antihiperglikemik dan antihiperkolesterol serta didukung oleh sejumlah penelitian terdahulu yang menunjukkan bahwa daun ceremai mengandung senyawa kimia yang memiliki efek sebagai antihiperglikemik dan antihiperkolesterol. Penelitian ini merupakan penelitian lanjutan untuk mengetahui efek serta dosis efektif ekstrak daun ceremai dalam menurunkan kadar gula darah dan kolesterol total darah pada hewan uji tikus putih jantan model hiperkolesterolemia diabetes yang diinduksi pakan tinggi lemak dan streptozotocin dosis 30 mg/KgBB. Penelitian dilakukan menggunakan 40 ekor hewan uji yang dikelompokkan dalam 8 kelompok dengan perlakuan yaitu kelompok kontrol normal, kontrol positif simvastatin, kontrol positif metformin, kontrol negatif dan 4 kelompok uji dengan variasi dosis ekstrak masing-masing 50 mg/KgBB, 100mg/KgBB, 200 mg/KgBB dan 400 mg/KgBB. Hasil yang diperoleh menunjukkan bahwa ekstrak daun ceremai memiliki efek antihiperglikemik dan antihiperkolesterol secara bersama-sama terhadap tikus putih jantan model hiperkolesterol diabetes dengan dosis efektif 200 mg/KgBB.

Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) Terhadap Kadar Glukosa Darah Tikus Putih Jantan (Rattus Novergicus) Model Hiperkolesterolemia-Diabetes: Effectiveness of Ethanol Extract of Avocado Seeds (Persea americana mill.) on Blood Glucose Levels of Male White Rat (Rattus novergicus) Hipercolesterolemia-diabetes Model Recky Patala; Niluh Puspita Dewi; Meilinda Handayani Pasaribu
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Diabetes mellitus is a metabolic disorder characterized by increased blood glucose levels due to a deficiency of insulin secretion or when insulin resistance occurs. Herbal medicine is one alternative method that can be used to control blood glucose levels and prevent complications of diabetes mellitus. One of the medicinal plants is avocado seeds (Persea americana Mill.) The active compounds contained in avocado seeds that have antidiabetic activity are flavonoids, alkaloids, tannins and saponins. This study aims to determine the content of secondary metabolites in the extract of avocado seed, the effect of extract of avocado seed and the dose of extract of avocado seed that is effective in lowering blood glucose levels. This research was a laboratory experiment using a modified randomized controlled pretest and posttest group design. Test animals used were 30 rats which were divided into six treatment groups, namely normal control, negative control, positive control, a dose of 250, 300 and 350 mg/kg groups. The results showed that extract of avocado seed contained secondary metabolites: flavonoids, alkaloids, saponins, and tanins;extract of avocado seed gave effect to decrease blood glucose levels; extract of avocado seed with a dose of 350 mg/kg was effective in lowering blood glucose levelswith an avarage decrease of 99,8 mg/dL.

Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes: Ethanol Extract of Some Cowpea (Vigna unguiculata (L.) Walp) Leaves: Morphometry Study of Pancreatic Islet of Diabetic Rat Model Puput Octaviani Solehah; Fikhta Agnesya Tarusu; Joni Tandi; Niluh Puspita Dewi; Gabriella Bamba Ratih Lintin; Yuli Fitriana; David Pakaya
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Diabetes is characterized by an increasing of blood levels and progressive changes in the structure of pancreatic islet of pancreas. Natural ingredients that contain antioxidants such as some cowpea leaves can be an alternative treatment for diabetes. This study aims to examine the effect of ethanol extract of some cowepea leaves (Vigna unguiculata (L.) Walp) on morphometry (perimeter and diameter) of pancreatic islet of diabetic rat models. The type of research is quasi-experimental with posttest group design. Samples were 30 male wistar rats, age 8 weeks, BW 250-300 grams, that induced by single dose of STZ 40 mg/kg BW. Rats were divided into 5 groups. Group A: normal control, Group B: negative control, Group C: positive control, Group D: DM rats with 100mg/Kg BW extract therapy, Group E: DM rats with 200mg/Kg BW extract therapy, Group F: DM rats with extract therapy 300mg/Kg BW. Blood sugar levels were measured on days 7, 14 and 21. Pancreatic tissue was prepared with 5μm thickness and stained with Hematoxylin Eosin. The sample was observed under 400x magnification microscope. The observation uses Image J software to measure the perimeter and diameter of the pancreatic insula. Data were analyzed by non-parametric Kruskal Wallis and post hoct Mann Whitney statistical tests. Blood glucose level was obtained on 21st day with the highest mean in group B (246.8±156.3) and lowest in group A (67.2 ±7.85), perimeter of pancreatic islet was significantly different (p=0.026), the diameter is significantly different (p =0.046). Ethanol extract of some cowpea (Vigna unguiculata (L.) Walp) leaves with dose of 300mg/kgBB helps to restore the blood and morphometry of pancreatic islet model of diabetic rats.

Potensi Rumput Laut (Eucheuma cottonii J.Agardh) Terhadap Nefropati Diabetik Tikus Putih Jantan (Rattus norvegicus): (Potency of Seaweed (Eucheuma cottonii J.Agardh) Against Nephropathy Diabetic Male White Rats (Rattus norvegicus)) Joni Tandi; Niluh Puspita Dewi; Resky Chandra Wirawan; Megawati R. Surat
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15046

ABSTRACT This study aims to determine the effect of a multilevel dose of ethanol extract of seaweed (Eucheuma cottonii J. Agardh) on the decreasing blood glucose levels and kidney tissue regeneration of hypercholesterolemia-diabetic male white rats. 24 rats were divided into 6 groups, namely groups 1-3 (normal control, negative control, and positive control/Glibenclamide, respectively) and groups 3-6 (seaweed extract doses of 100, 200, and 400 mg/kg BW per oral, respectively). Rats were induced by high fat diet and Streptozotocin. Histopathological picture of the kidney was observed by HE staining using 400 magnifications. Data scoring of the level of kidney damage were analyzed by One Way ANOVA at a 95% confidence level and a Least Significant Difference (LSD) test was conducted. Seaweed ethanol extract at a dose of 100 mg/kg BW was effective in reducing blood glucose levels with an average value of 122.25 mg/dL and effective in regenerating the kidney tissue of male white rats with an average value of damage of 1.9. Therefore, seaweed extract has potency to be developed and further investigated as an antidiabetic agent.

The Effect of Ethanol Extract of Guava (Psidium guajava L) Leaf on Hypercholesterolemia-Diabetic White Rats Male Induced by High Fat Feed and Streptozotocin Joni Tandi; Franciska Diana Pratiwi; surisna surisna; Niluh Puspita Dewi; Magfirah Magfirah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15533

This study aims to determine the effect of guava (Psidiium guajava L) leaf extract on hypercholesterolemia-diabetic white rats male and the effective dose for reducing cholesterol and blood glucose levels. This study is a laboratory experimental study using 30 rats divided into 6 test animals. the treatment group, each group consisted of 5 rats. Group I was normal control, group II negative control was given Na-CMC suspension, group III as positive control was given simvastatin group IV dose 150 mg / kg BW, group V dose 250 mg / kg BW and group VI dose 350 mg / kg BW. The results showed that the ethanol extract of guava leaves influenced reducing blood glucose levels of male white rats with an effective dose of 250mg / kg BW with an average reduction of 119 mg/dL and effective reducing the cholesterol levels at a dose of 150 mg /kg BW with an average reduction of 28,33 mg/dL.

Co-Authors Aris Widiastuti Ayu Wulandari David Pakaya Debora Rislianti Lakiu Dermiati tatto DIAN RAHMAWATI Elasari Dwi Pratiwi Febry Grasela Aula Feiverin Tibe Fikhta Agnesya Tarusu Franciska Diana Pratiwi Gabriella Bamba Ratih Lintin Gunawan Pamudji Indah Kurnia Utami Indah Kurnia Utami Joni Tandi, Joni Magfirah - - Megawati R. Surat Meilinda Handayani Pasaribu Muthmainah Tuldjanah Patala, Recky Puput Octaviani Solehah Putri Pratiwi Ramla Allia Resky Chandra Wirawan Rezky Yanuarty Sri Mulyani Sabang surisna surisna Syafika Alaydrus Wayan Wirawan Wayan Wirawan Windi Olivia Kawanga Yuli Fitriana

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