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All Journal MEDIA MEDIKA INDONESIANA Majalah Obat Tradisional Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Biopendix: Jurnal Biologi, Pendidikan dan Terapan Science Map Journal JSMARTech : Journal of Smart Bioprospecting and Technology Bioscientist : Jurnal Ilmiah Biologi
Theopilus W Watuguly
Program Pendidikan Biologi, Jurusan PMIPA FKIP Dan Program Pendidikan Dokter Universitas Pattimura Ambon, Jl. Dr. Tamaela, Kampus Universitas Pattimura Ambon
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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ETHANOL EXTRACT OF RED DRAGONS (Hylocereus polyrhizus) IN PREVENTING DAMAGE OF THE ALVEOLUS OF MICE (Mus Musculus) EXPOSURE TO KRETEK SMOKE Febi Stevano Rumangun; Theopillus Watuguly; Ine Arini
BIOPENDIX Vol 8 No 2 (2022): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol8issue2page71-79

Abstract

Background: The main toxins in tobacco such as tar, nicotine, and carbon monoxide can trigger the formation of free radicals. Red dragon fruit (Hylocereus polyrhizus) is one of the plants that can be used as a source of protein antioxidants in red dragon fruit that can increase body metabolism and maintain heart health, can lose weight, and vitamin C is able to maintain healthy skin. Based on the description above, it is necessary to conduct research to determine the benefits of red dragon fruit as a source of antioxidants to prevent the formation of free radicals against the risk of oxidative damage in the body by looking at the number of alveolar macrophages. Methods: This research is an experimental laboratory using a qualitative descriptive method. The data obtained from this study will be analyzed using a qualitative descriptive method by observing the histopathology of the alveoli in the lungs of mice. Results: The results showed that the reduction of alveolar damage in mice at each treatment dose (250 mg/g BW, 500 mg/g BW and 750 mg/g BW) ethanol extract of dragon fruit before being exposed to kretek cigarette smoke for 30 days. This is because free radicals contained in kretek cigarette smoke are inhibited by flavonoids from dragon fruit which play a role in stopping chain reactions due to exposure to cigarette smoke, so that neutrophil activity can be balanced by antiproteases. Conclusion: Red dragon fruit has antioxidant potential that plays a role in preventing damage to the alveoli of mice (Mus musculus) exposed to kretek cigarette smoke. Administration of red dragon fruit ethanol extract at a dose of 750 mg/g BW gave a more effective effect in preventing alveolus damage in mice caused by free radicals from kretek cigarette smoke compared to a dose of 250 mg/g BB.
EFEK JUS DAUN MATEL (CLERODENDRUM MINAHASSAE L.) DAN DAUN BAYAM DURI (AMARANTHUS SPINOSUS L.) DALAM MENINGKATKAN KADAR HEMOGLOBIN DAN JUMLAH ERITROSIT PADA MENCIT (MUS MUSCULUS) R Malawat; F Leiwakabessy; Th Watuguly
Science Map Journal Vol 1 No 2 (2019): Science Map Journal
Publisher : Jurusan Pendidikan MIPA FKIP Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (811.317 KB) | DOI: 10.30598/jmsvol1issue2pp105-114

Abstract

Anemia adalah penyebab kedua terkemuka didunia dari kecacatan dan dengan demikian salah satu masalah kesehatan masyarakat paling serius global (WHO, 2014). Tanaman Matel (Clerodendrum minahassae L.) secara empiris merupakan salah satu tanaman yang banyak dimanfaatkan di Indonesia, khususnya di Maluku sebagai sayuran dan obat”. Menurut (Utami et. al., 2017) Kadar abu total dalam simplisia sebesar 27,783 %, sementara itu, Amaranthus spinosus L. mengandung setidaknya 32 mg besi/ 100 gram. Kedua bahan berpotensi menjadi bahan alternatif dalam mengobati anemia. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan jus daun matel dan jus daun bayam duri terhadap kadar hemoglobin dan jumlah eritrosit pada mencit. Hasil pengukuran kadar hemoglobin menunjukkan bahwa kelompok perlakuan 1 Jus Daun Matel memberikan pengaruh yang cukup signifikan (p ≥ 0.05) terhadap kadar hemoglobin rata-rata tertinggi sebesar 14,5 g/dL dan jumlah eritrosit rata-rata sebesar 7.43 x 1012/L, diikuti oleh Kelompok perlakuan 3 Jus Daun Kombinasi (Jus Daun Matel + Jus Daun Bayam Duri) dengan kadar hemoglobin rata-rata sebesar 14,4 g/dL dan jumlah eritrosit rata-rata 6.94 x 1012/L, dan yang terendah adalah pada perlakuan 2 Jus Daun Bayam Duri, dengan kadar hemoglobin rata-rata 10,5 g/dL dan jumlah eritrosit rata-rata 3.61 x 1012/L. Dengan demikian dapat disimpulkan bahwa jus daun matel dan daun bayam duri memberkan efek yang nyata dalam meningkatkan kadar hemoglobin dan jumlah eritrosit
Kepadatan Nyamuk Mansonia dan Anopheles dengan Prevalensi Penyakit Filariasis di Kecamatan Taniwel Kabupaten Seram Bagian Barat Johanis Fritzgal Rehena; Sriyanti Imelda Aksamina Salmanu; Theopilus Wilhelmus Watuguly
Bioscientist : Jurnal Ilmiah Biologi Vol 9, No 1 (2021): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bjib.v9i1.3566

Abstract

Filariasis is an infectious disease caused by filarial worms and transmitted by Mansonia and Anopheles mosquitoes. The prevalence of filariasis is influenced by the density of Mansonia and Anopheles mosquitoes. The purpose of this study was to determine the density of Mansonia, Anopheles mosquitoes, and zoonotic animals, and their relationship to the prevalence of filariasis in Taniwel District, West Seram Regency. This type of research is survey research and case control. The population in this study was the density of Mansonia and Anopheles mosquitoes, and cases of filariasis. While the research sample is people who suffer from filariasis, larval density, Mansonia and Anopheles mosquitoes. Data on the density of larvae/mosquitoes of Mansonia and Anopheles were analyzed descriptively, and analysis of the relationship between density of community habits and prevalence of filariasis was carried out by using the chi square test with SPSS version 20.0 program. The results showed that people used mosquito repellent lotion or brought mosquito rackets before doing activities at night. The density of Mansonia mosquitoes in Sohuwe Village is 4.00-5.85; Lumahlatal Village 5.00-6.60; and Maloang Village 4.00-6.20. Meanwhile, the density of Anopheles mosquitoes in Sohuwe Village is 7.00-9.85; Lumahlatal Village 5.89-6.82; and Maloang Village 5.00-6.50. The prevalence rate of filariasis in Sohuwe Village is 0.66; Lumahlatal Village 0.88; and Maloang Village 1.54; and there is a significant relationship between people's habits and the incidence of filariasis.
Aplikasi Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) Pada Nata De Coco Dalam Menurunkan Kadar Kolesterol Total, LDL, Dan Meningkatkan HDL Pada Mencit (Mus musculus) Theopilus Wilhelmus Watuguly; Anik Uniarti; Maria Nindatu
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2019): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.29 KB) | DOI: 10.33533/jpm.v13i1.691

Abstract

Hypercholesterolemic sufferers generally consume conventional drugs using hypolipidemic drugs to reduce cholesterol levels. But this type of drug also has side effects. In addition to consuming hypolipidemic drugs, increased cholesterol levels can be suppressed by regulating dietary patterns by controlling nutrient intake in a balanced manner as needed. Red dragon fruit skin extract (Hylocereus polyrhizus) applied to nata de coco is believed to reduce cholesterol levels because both contain fiber which can be used for dietary needs, and improve the digestive process. The purpose of this study was to determine the application and determine the dose of red dragon fruit skin extract (Hylocereus polyrhizus) in nata de coco in reducing total cholesterol, LDL and increasing HDL in mice (Mus musculus). The type of research used is experimental research using the Pre-Post Test Only Control Group Design research design that uses 18 mices with different doses of 1: 1 and 1: 2 doses. ANOVA statistical test on the results of the study showed that effective treatment in reducing total cholesterol, LDL, and increasing HDL was treated with extracts of red dragon fruit skin (Hylocereus polyrhizus) in a 1: 2 nata de coco. Thus it can be concluded that the higher the dosage given to mice tested it showed a significant reduction in cholesterol levels.
ANALISIS PENGGUNAAN MODEL PEMBELAJARAN HYPOTHETICAL – DEDUCTIVE LEARNING CYCLES UNTUK MENINGKATKAN HASIL BELAJAR IPA-BIOLOGI SISWA SMP Silvia E Lopulalan; Theopilus W Watuguly; Sintje Liline
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 9 No 1 (2022): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol9issue1page76-81

Abstract

Background: Student learning outcomes of SMP Negeri 22 Ambon on the subject of additive biology learning have not yet fully reached the KKM because the learning process only prioritizes the completeness of the material and the learning strategies applied by the teacher still tend to use the lecture method. The Hypothetical-Deductive Learning Cycles (HDLC) learning model provides opportunities for students to construct their own knowledge and act like scientists. This study aims to determine the improvement of science-biology learning outcomes for junior high school students using the hypothetical-deductive learning cycles model of additive material in class VIII SMP Negeri 22 Ambon. Methods: The type of research used is descriptive research which is used to determine the improvement of student learning outcomes. Results: The results of the study illustrate that the learning outcomes of Biology Sciences for junior high school students before the application of the hypothetical - deductive learning cycles learning model were under the KKM, but after the application of the hypothetical - deductive learning cycles model, the SMP students' learning outcomes of Biology turned out to be increased and fulfilled the KKM. Conclusion: Based on the results of research and discussions that have been carried out, it can be concluded that the final score (NA) obtained by each student shows that using the hypothetical-deductive learning cycles model can help students improve learning outcomes.
POTENSI EKSTRAK DAUN BANDOTAN (Ageratum conyzoides L) SEBAGAI OBAT DIABETES MELITUS Chrismenda Pay; Theopilus W Watuguly; Syahran Wael
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 9 No 1 (2022): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol9issue1page89-99

Abstract

Background: Diabetes mellitus is a chronic disease due to insulin deficiency from pancreatic cells so that blood sugar increases (hyperglycemia) and leads to complications. Bandotan plant (Ageratum Conyzoides L) is an alternative medicine that is safe, affordable and effective because it contains many phytochemicals, especially accumulated in the leaves such as alkaloids and flavonoid compounds that act as antioxidants to ward off free radicals and regenerate pancreatic cells. Methods: This research is a laboratory experiment to determine the antidiabetic activity test of bandotan leaf extract with doses of 75 mg/kg BW, 100 mg/kg BW and 150 mg/kg BW through blood sugar level tests and histopathological observations of Langerhans islet cells in induced diabetic mice. Alloxan monohydrate as much as 150 mg/kg BW intraperitoneally divided into 4 groups, namely 1 control group and 3 treatment groups according to dose. Results: The results showed bandotan leaf extract doses of 75 mg/kg BW, 100 mg/kg BW and 150 mg/kg BW reduced blood sugar levels by an average of 54 mg/dL and there was an improvement in damage as well as regeneration in islet cells. Langernas as the dose increases. With the best results there is a dose of 150 mg/kg BW. Conclusion: It is concluded that bandotan leaf extract can reduce blood sugar levels and repair damage to cells of the islets of Langerhans with the best results at a dose of 150 mg/kg BW, which is 78 mg/kg BW.
Co-Authors Aknes Tahya Alfia Sabban Anik Uniarti Bare, Yohanes Beatrixs Rupilu Chrismenda Pay Didik Wahyudi Dominggus Rumahlatu Edi Dharmana Eldo Dandirwalu F Leiwakabessy Febi Stevano Rumangun H Sinay Hanna Kalorbobir Harfalien Tehubijuluw Haslina Kole Icak Darling Rahakbauw Indahsari, Lilin Ika Nur Indranila KS Ine Arini Jecklyn A Lekal Johanis Fritzgal Rehena M Kaihena Maria Nindatu Martha Kaihena Nia Rusfita Titdoy Nindatu, Maria Nurmila Nurmila Pamela Mercy Papilaya Prelly M Tuapattinaya Prelly M.J Tuapattinaya Prelly Tuapattinaya R Malawat Rezza Julian Patty Sari, Dewi Ratih Tirto Silvia E Lopulalan Sintje Liline Sriyanti Imelda Aksamina Salmanu Syahran Wael Syahran Wael Syahran Wael Tjahjono Tjahjono Uniarti, Anik Viesta Sampe Yosep Matruty Yulviany Latuihamallo