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Paulina yamlean
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Medicine & Pharmacology

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Antibacterial Potential Test of Cream Preparation of Ethanol Extract of Matoa Stem Bark (Pometia pinnata) against Staphylococcus aureus. Violeta Gavelentri Melga Tambingon; Paulina Yamlean; Jainer Siampa
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Skin diseases can be caused by several factors, one of which is a bacterial infection. One of the bacteria that causes infection is Staphylococcus aureus. The results of previous studies showed that the ethanolic extract of the bark of matoa (Pometia pinnata) had antibacterial potential. This study aims to test the quality of cream preparations including homogeneity test, organoleptic test, pH test, adhesion test and dispersibility test, as well as to test the antibacterial activity of cream preparations ethanol extract of matoa stem bark. The matoa bark extract was obtained by maceration method using 95% ethanol as solvent. The antibacterial activity test was carried out using the well method, with a concentration variation of 0.5%, 1.5%, 2.5% and 3.5%. The test results showed that all the parameters of the test preparation, namely homogeneity test, organoleptic test, pH test, adhesion test and spreadability test met the requirements of the quality of the preparation. Antibacterial testing showed cream preparations with a concentration of 3.5% produced the largest inhibition zone of 8.66 mm which was included in the category of moderate inhibition.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI GEL EKSTRAK ETANOL KULIT BUAH ALPUKAT (Persea americana Mill.) MENGGUNAKAN BASIS NA-CMC DAN KARBOPOL TERHADAP BAKTERI Staphylococcus aureus Tasya Mangkey; Paulina Yamlean; Jainer Siampa
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Kulit buah Alpukat (Persea americana Mill.) memiliki kandungan senyawa alkaloid, flavonoid dan saponin yang bersifat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui daya hambat sediaan gel terhadap bakteri Staphylococcus aureus dan untuk mengetahui karakteristik fisik sediaan gel. Penelitian ini menggunakan metode eksperimental laboratorium. Formulasi sediaan gel ekstrak etanol kulit buah Alpukat dibuat dengan menggunakan basis Na-CMC 3%, 4% dan Karbopol 0,5%, 1,5%. Uji antibakteri sediaan gel ekstrak etanol kulit buah Alpukat menggunakan metode sumuran terhadap bakteri Staphylococcus aureus menghasilkan diameter zona hambat pada basis Na-CMC 3% (27,3 mm), Na-CMC 4% (26,3 mm), Karbopol 0,5% (28 mm), dan Karbopol 1,5% (27,1 mm). Gel dengan zona hambat tertinggi dilanjutkan dengan pengujian fisik. Hasil pengujian fisik sediaan gel memenuhi persyaratan organoleptik, homogenitas, pH, daya lekat dan daya sebar. Dapat disimpulkan bahwa sediaan gel ekstrak etanol kulit buah Alpukat menggunakan basis Na-CMC dan Karbopol memiliki aktivitas antibakteri yang sangat kuat dan memenuhi persyaratan karakteristik fisik sediaan.
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF LIQUID SOAP CORN SILK (Zea mays L.) ETHANOL EXTRACT AGAINST Staphylococcus aureus Veren Naftalia Mamangkey; Paulina Yamlean; Karlah Mansauda
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Corn Silk (Zea mays L.) contains flavonoid compounds that can inhibited the growth of bacteria. This study aimed to make a liquid soap formulation of corn silk ethanol extract which is physically good and to test the antibacterial activity against Staphylococcus aureus with variations in the concentration of the extract, that is 6%, 9%, 12%, 15%. This study used the maceration method with 96% ethanol solvent, then the antibacterial activity is tested by the well method. The results of physical testing for the liquid soap of corn silk ethanol extract filled the requirements set by Indonesian national standards. Antibacterial testing showed that the diameter of the inhibition zone at F1 was 4.8 mm (weak), F2 6.6 mm and F3 10.8 mm (moderate), and F4 12.2 mm (strong). From this research, it can be concluded that the ethanolic extract of corn silk can be formulated into liquid soap preparations that are physically good and have strong antibacterial activity in formula 4 with a concentration of 15%, which is 12.2 mm.
Co-Authors Abubakar, Poetry Melinda Adeanne Wullur Apriliani Margaret Marista Lourina Rarung Daimunon, Regita Edwin de Queljoe Falugah, Fathia Fatimawali . Frendsiane Pangalinan Gayatri Citraningtyas Hamidah Sri Supriati Immanuela Irene Mandias Jainer Siampa Jayanto, Imam Jimmy Posangi karlah mansauda Lahagina, Juan Liempepas, Angelika Majid, Nurul Manarisip, Thesya Maureen Regina Satolom Novel Kojong Pratasik, Meyla Risma Meidy Hardina Sitorus Rompis, Ferrna Singal, Ausich Sukandi, Gabrilia Suru, Eunike Surya Sumantri Abdullah Tasya Mangkey Umboh, Defritsevani Veren Naftalia Mamangkey Violeta Gavelentri Melga Tambingon Virginia lasut Walewangko, Marfincy Weny Wiyono Widya Astuty Lolo, Widya Astuty