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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis JURNAL PHARMASCIENCE Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA JKPK (Jurnal Kimia dan Pendidikan Kimia) Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian

Yandi Syukri

Department Of Pharmacy, Faculty Of Mathemathics And Natural Sciences, Universitas Islam Indonesia

Author-ID : 421676

Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences

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Articles

Title

A Preformulation of a Water Soluble Furosemide Dosage Form Syukri, Yandi; Yuwono, Tedjo; Hakim, Lukman
Indonesian Journal of Pharmacy Vol 13 No 1, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Solid dispersion system of water-insoluble furosemide in polyvinylpirolidon (PVP) was prepared by a solvent method in various ratios of 1 : 1, 1 : 3, 1 : 5, 1 : 7 and 1 : 9 of the drug and PVP, respectively in order to improve furosemide solubility and dissolution. The improvement of furosemide solubility was studied by a solubility method in a shaking waterbath. The solubility test showed that various concentrations of PVP and temperature gave statistically significant increased of furosemida solubility (P < 0,05). The dissolution study of furosemide solid dispersion system was done using a dissolution tester at the rotation rate of 50 rpm. Furosemide concentration released was determined spectrophotometrically using a UV spectrofometer. This test showed a significant increased of furosemida solubility (P < 0,05), but with a prolonged of releasing time.Key Word : solid dispersion, solubility, dissolution, bioavailability.

PHYTOCHEMICAL SCREENING AND ANALYSIS POLYPHENOLIC ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF WHITE DRAGON FRUIT (Hylocereus undatus) VH, Elfi Susanti; Utomo, Suryadi Budi; Syukri, Yandi; Redjeki, Tri
Indonesian Journal of Pharmacy Vol 23 No 1, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

White dragon fruitÂ isÂ a wellÂ knownÂ andÂ widelyÂ usedÂ herbal medicine,Â especiallyÂ inÂ Asia,Â whichÂ containsÂ severalÂ interesting bioactive constituents and possesses health promoting properties. TheÂ aimÂ ofÂ thisÂ studyÂ wasÂ toÂ analyzeÂ forÂ theÂ bioactive compounds,Â evaluateÂ totalÂ phenolicÂ contentsÂ andÂ antioxidant capacitiesÂ ofÂ methanolicÂ extractÂ ofÂ whiteÂ dragonÂ fruit.Â The antioxidantÂ activityÂ wasÂ determinedÂ byÂ theÂ 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. Total phenolicÂ contentÂ wereÂ determinedÂ byÂ Folin-CiocalteuÂ method. PhytochemicalÂ screeningÂ ofÂ theÂ whiteÂ dragonÂ fruitÂ showed theÂ presenceÂ ofÂ triterpenoid,Â alkaloid,Â flavonoidÂ andÂ saponin. TheÂ extractÂ exhibitedÂ strongÂ antioxidantÂ activityÂ withÂ IC50 of 193 Î¼g/mL, and total phenolic content of 246 Î¼g/mL in 1 Kg dry extract.Key words: antioxidant activity, total phenolic, DPPH, white dragon fruit

Formulation, Characterization and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS) Yandi Syukri; Hannie Fitriani; Herianto Pandapotan; Bambang Hernawan Nugroho
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Ibuprofen is a poorly water-soluble drug with analgesic, antipyretic and anti-inflammatory effects. Self-Nano Emulsifying Drug Delivery System (SNEDDS) formulation is a solution to improve the solubility and bioavailability of ibuprofen. This research purposed to perform a formulation, characterization, and stability studies of ibuprofen-loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS). Screening of ibuprofen SNEDDS was prepared by ternary diagrams for the chosen co-surfactants, surfactants, and oil. The following was characterizations of droplet size, zeta potential, and clarity. The solubility test for the determination of co-surfactant, surfactant, and oil obtained Propylene glycol monocaprylate (Capryol-90), Polysorbate 20 (Tween 20) and PEG 400. The screening of SNEDDS showed nine formulas (compositions) in the range concentration of Propylene glycol monocaprylate (1-3 mL), Polysorbate 20 (4-8 mL), and PEG 400 (1-3 mL). The composition of Propylene glycol monocaprylate (1-2 mL), Polysorbate 20 (5-8 mL) and PEG 400 (1-3 mL) passed the thermodynamic stability test. The test of robustness to dilution and stability study indicated that the formula with Propylene glycol monocaprylate, Polysorbate 20 and PEG 400 with the ratio of 1: 8: 1 and 1: 7: 2 was more stable. In conclusion, the stable ibuprofen SNEDDS could be prepared with Propylene glycol monocaprylate, Polysorbate 20, and PEG 400.

The profile of propanolol HCl release from sustained release tablet with floating system used matrix Methocel K15M T. N. Saifullah; Yandi Syukri; Rini Utami
Indonesian Journal of Pharmacy Vol 18 No 1, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The aim of this research was to study the profile of propanolol HCl release from sustained release tablet with a floating system using matrix Methocel K15M. Citric acid and sodium bicarbonate were used as gasgenerating agents. Tablets were made by wet granulation method in four formulations based on the variation concentration of Methocel K15M. The concentrations were 90 mg/tablet (F1), 105 mg/tablet (F2), 120 mg/tablet (F3) and 135 mg/tablet (F4) respectively. The produced tablets were tested for physical characteristics such as uniformity of weight, tablet hardness, drug concentration, floating test and the dissolution. In the dissolution testing used Becker method in HCl pH 3.0 as medium dissolution at 37±0.50 C; with a speed 50 rpm during five hours. The results of dissolution showed that the release profile of propanolol HCl following zero order kinetic that showed amount of propanolol HCl were released linear with time. Mechanisms of propanolol HCl release were combination of diffusion and erosion, however diffusion more dominant. Rate of release (k value) of drugs were 0.174 %/minute (FI); 0.101 %/minute (FII); 0.105 %/minute (FIII); and 0.108 %/minute (FIV).Key words: Propanolol HCl, Floating, Methocel K15M

PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD Yandi Syukri; Laryssa Fernenda; Fissy Rizki Utami; Isna Qiftayati; Aris Perdana Kusuma; Rochmy Istikaharah
Indonesian Journal of Pharmacy Vol 26 No 2, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Glimepiride is an oral antidiabetic drugs which is practically insoluble in water. The formation of β-cyclodextrin inclusion complex was able to increase the solubility of glimepiride. This study aim to prepare, characterize and formulation of inclusion complex tablets in order to meet the requirement in Pharmacopeia. The inclusion complex were prepared in a molar ratio of 1:1 and 1:2 by freeze drying method, afterthat characterized include FTIR spectroscopy and scanning electro microscope (SEM). Further, it was formulated into tablets by direct compression technique using primogel and crospovidone as superdisintegrants. The tablets were evaluated include weight uniformity, hardness, friability, disintegration, and dissolution. The dissolution studies of inclusion complex were performed by using USP II apparatus. The result of FTIR and SEM provided evidence of the formation of complexes after utilizing freeze-drying methods. The tablet evaluation containing inclusion complex glimepiride-β cyclodextrin with primogel and cropovidone as disintegrant showed that increased concentration of disintegrant will increase disintegration time of the tablets. All of formulas meet the requirements in the Pharmacopoeia. The inclusion complex of glimepiride–β cyclodextrin successfully used for enhancing the solubility of glimepiride and the tablets meet the requirement in Pharmacopeia.Keywords: Glimepirid, β-cyclodextrin, primogel, crospovidone

A COMPARATIVE BIOAVAILABILITY OF FUROSEMIDE IN SOLID DISPERSIONS FORMS Yandi Syukri; Lukman Hakim; Tedjo Yuwono
Indonesian Journal of Pharmacy Vol 12 No 1, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Furosemide is a poorly soluble diuretic drug, the solubility of which can be enhanced by solid dispersion with polyvinylpirolidon (PVP). The solid dispersion system was prepared by a solvent method in various ratios of 1 : 5 and 1 : 7 of the drug and PVP, respectively, in order to improve furosemide bioavailability. The bioavailability of furosemide - PVP solid dispersion was compared with pure furosemide (control) and Lasix (reference). The study was done in a cross over design with a single-dose peroral that administered to the white male rabbits (n = 6). Furosemide blood levels were determined spectrofluorometrically by an extraction method. The area under the blood concentration-time curve AUC0 - , peak blood concentration Cmax and time to reach peak blood concentration Tmax were used to compare their bioavailabilities. The solid dispersion systems produced a higher extent of bioavailability than pure furosemide (P < 0,05). On the contrary, no statistically significant difference about the extent of bioavailability between solid dispersion and Lasix (P > 0,05). Finally, furosemide – PVP solid dispersion (1 : 7) was the best formulation with the highest extent of bioavailability and bioequivalence with the Lasix formula.Key Word : Solid dispersion, solubility, dissolution, bioavailability, furosemide.

Characterization and dissolution studies of Furosemide solid dispersions using polyethylene glycol (PEG), talc and PEG-talc as dispersion carriers Yandi Syukri; Diny Rizayulianty; Yuni Darty
Indonesian Journal of Pharmacy Vol 15 No 1, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Solid dispersions of furosemide were prepared by melting and solvent methods using polyethylene glycol (PEG) 6000, talc and PEG – talc as dispersion carrier in order to improve furosemide dissolution. The increase of dissolution and physical properties of its powder was evaluated. Only furosemide solid dispersions with combination of PEG – talc 1 : 3 showed a good physical properties. The assay of the effect of PEG – talc ratio on furosemide dissolution showed that the increase of ratio of PEG – talc increased significantly dissolution rate.Key Word : furosemide, solid dispersion, dissolution

Co-Authors Ade Herlin Aditya Sewanggara Amatyawangsa Wicaksana Aditya Sewanggara Amatyawangsa Wicaksana Agita Dyah Permatasari Agung Endro Nugroho Agung Endro Nugroho Aji Winanta Aldia Dwi Karina Ningrum Aldia Dwi Karina Ningrum Amalia Humairah Amelia Arum Prasetya Anik Ariyani Anisa Nur Fazzri Annisa Fitria Arba Pramundita Ramadani Arifa Caryn Dea Aris Perdana Kusuma, Aris Perdana Asih Lestari Asih Triastuti Bambang Hernawan Nugroho Budy Wijiyanto Denox Asih Pertiwi Diny Rizayulianty Elfi Susanti V. H. Endang Lukitaningsih Endang Lukitaningsih Farida Ulfa Feris Firdaus Fissy Rizki Utami Galuh Annaba Maharani Hakim, Lukman Hannie Fitriani Hannie Fitriani Herianto Pandapotan Iqmal Tahir Isna Qiftayati Isnatin Miladiyah Istanti Istanti Ivan Julio Joko Tri Wibowo Kartika Puspitasari Larysa Fernenda Laryssa Fernenda Lelita Ayu Saputri Lisnawati Tiara Putri Lukman Hakim Lutfi Chabib, Lutfi M. Hatta Wibowo Maulia Ulfa mega octavia Melinda Dewi M Mira Amaliasari Sitorus Muhammad Sulaiman Zubair Muhammad Sulaiman Zubair Muhammad Sulaiman Zubair Mulyanti, Eka Mulyanti, Eka Mutiara Herawati, Mutiara Nadia Hazami Nur Asita Nurul Ainah Octavia, Mega Prima Aulia Putra Primadara Damayanti Ratih Dyah Listianingrum Ratih Lestari Ratih Lestari Redjeki, Tri Rini Utami Rio Fandi Sholehuddin Ririk Purwati Rochmy Istikaharah Rochmy Istikharah Romdhonah Romdhonah Ronny Martien Ronny Martien Saepudin Saepudin Septiani Eka Cahyani Sherina Nabila Putri Hakim Shinta Dewi Sista Werdyani Sista Werdyani Siti Zahliyatu T. N. Saifullah Tamhid, Hady Anshory Tasya Salsabila Tatang Shabur Julianto Tedjo Yuwono Utomo, Suryadi Budi Wintari Taurina Yoga Febriana Yuni Darty Yuwono, Tedjo Ziyyatul Kholidah

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