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All Journal Jurnal Kesehatan Andalas Syntax Literate : Jurnal Ilmiah Indonesia Journal of Tropical Pharmacy and Chemistry JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Indonesian Journal of Pharmacology and Therapy Jurnal Sains dan Kesehatan JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA

Sjarif Ismail

Fakultas Kedokteran, Universitas Mulawarman, Indonesia

Author-ID : 4251691

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Aktivitas Vasodilatasi Pembuluh Darah secara in vitro dan Uji Toksisitas Akut Minuman Fungsional Herbal Kaltim Sjarif Ismail; Yuniati Yuniati
Journal of Tropical Pharmacy and Chemistry Vol. 3 No. 3 (2016): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Latar belakang: pangan fungsional dapat berupa makanan atau minuman. Pangan fungsional lebih bersifat pencegahan terhadap penyakit, sedangkan obat lebih bersifat menyembuhkan penyakit. Minuman Fungsional Herbal Kaltim (MFHK) yang diracik dari bahan-bahan tumbuhan yang ada di Kaltim telah diketahui memiliki citra rasa yang enak dan memiliki aktivitas antioksidan yang kuat tetapi belum diketahui aktivitas vasodilatasi pada pembuluh darah dan keamanan pada penggunaan akut secara oral. Tujuan: mengeksplorasi MFHK pada kontraktilitas tonus pembuluh darah secara in vitro dan keamanan pada penggunaan akut secara oral. Metode: MFHK dikeringkan lalu diuji kontraktilitas pada pembuluh darah dengan menggunakan organ terpisah aorta tikus dengan endotel, hasil dinyatakan dalam bentuk persen tonus kontraktilitas aorta. Uji toksisitas akut peroral menggunakan tikus Wistar dan mencit Balb/c jenis kelamin jantan dan betina. Hasil: pada uji kontraktilitas aorta didapatkan secara berurutan dalam persen tonus kontraktilitas aorta pada konsentrasi ekstrak MFHK 0,04 mg/mL adalah (1,02 + 1,43) % dan kontrol (3,27 + 1,00) % dengan p>0,05; pada 0,08 mg/mL didapatkan (-1,39 + 1,41) % dan (4,50 + 1,14) % dengan p<0,05; 0,16 mg/mL didapatkan (-5,36 + 1,40) % dan (8,42 + 2,00) % dengan p<0,05. Dosis tunggal ekstrak 2 g/kgBB yang diberikan secara oral tidak didapatkan kematian pada tikus dan mencit jenis kelamin jantan dan betina. Kesimpulan: ekstrak MFHK memiliki aktivitas vasodilatasi pada pembuluh darah secara in vitro dan tidak toksik pada pemberian akut secara oral. Kata kunci: Minuman Fungsional Herbal Kaltim â€“ Vasodilatasi â€“ Toksisitas Akut

Aphrodisiac Activity of Ethanol Extract of Cratoxylum sumatranum (JACK) Blume Stems on Isolated Rat Corpus cavernosum Sjarif Ismail; Meiliati Aminyoto
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Cratoxylum sumatranum (Jack) Blume of the Hypericaceae family is known as â€œBentalengâ€ by Dayak Benuaq. In ethnobotany, Cratoxylum sumatranum stems (CSS) is used as energy drink or aphrodisiac, but its effect has not been scientifically proven. Research objective to study the aphrodisiac activity of CSS extract by screening the aphrodisiac activity in vitro. Method: CSS was collected from Kutai Kertanegara Regency, East Kalimantan Province. Extraction was by maceration with ethanol solvent for three days. Re-maceration was done twice. In vitro screening of aphrodisiac activity used isolated rat corpus cavernosum. The organ was placed into a 10 mL chamber containing Krebs-Henselheit solution at pH 7.4, 37Â°C and aerated with carbogen gas. After acclimation, a contraction test was performed with phenylephrine solution and after reaching the peak of contraction at plateau the Control (solvent extract) or CSS ethanol extract was administerd at cumulatively increased concentration. Vasodilation activity was known if the contraction response was decreased after the extractâ€™s administration and expressed in percent contraction with negative value. Results: CSS ethanol extract induce vasodilatory response on rat Corpus cavernosum blood vessels. Vasodilation activity is increasing with increasing concentration of extract given compared to Control. Conclusion the aphrodisiac activity of CSS ethanol extracts is directly through the vasodilation action mechanism on blood vessels in the rat corpus cavernosum.

Effect of Ethanol Extract of Eleutherine bulbosa (Mill.) URB on Anaerobic Bacterial Prophyromonas gingivalis In Vitro Siti Nur Azizah; Sinar Yani; Sjarif Ismail; Masyudhi Masyudhi; Endang Sawitri
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Periodontitis is an inflamation of supporting tissues on teeth that became the main cause of Prophyromonas gingivalis (P. gingivalis) bacteria. Treatment of periodontitis is by giving antibacterial agent therapy. Plants that have antibacterial effects one are Eleutherine bulbosa (UEB) bulbs from the Iridaceae family. This plant has been used for ethnobotany boils drugs and has been known to have antibacterial activity toward against intestinal pathogen bacteria that is anaerobic Gram Negative, but still unknown its activity against on oral pathogenic bacteria such as P. gingivalis. The purpose of this study was to know the effect of UEB extract on the growth of P. gingivalis bacteria as in vitro. UEB is taken from agriculture center in Samarinda city. UEB Simplisia was tested for antibacterial activity using Kirby-Bauer disc diffusion method on BHI-A media supplemented with vitamin K and hemin. The bacteria which used were P. gingivalis ATCCÂ® 33277. Blank disc 6 mm with nine concentrations attached to BHI-A medium, incubated for 24 hours at 37 Â°C in an anaerobic atmosphere, then sprayed MTT (3-[4,5-Dimethylthiazole-2-yl]-2,5-diphenylttetrazoliumbromide) reagent and read a few moments later. For comparison, then used Chlorhexidine gluconate (CHX) 2 mg/ml. The statistical analysis with t-test and there was significant different if p<0.05. The result showed that the higher concentration of UEB ethanol extract will increase the growth inhibition zone of P. gingivalis bacteria and reach maximum at 10 mg/ml concentration. The result of t-test showed no difference significant of P. gingivalis bacterial inhibition zone in the treatment group of 7.5 mg/ml and 10 mg/ml concentration on CHX group. This study proves UEB ethanol extract can inhibit the growth of P. gingivalis bacteria.

Potensi Ekstrak Etanol Rimpang Jeringau (Acorus calamus L.) Sebagai Spasmolitik Marihot Pasaribu; Nataniel Tandirogang; Sjarif Ismail; Swandari Paramita; Agustina Rahayu Magdaleni; Hary Nugroho
Jurnal Sains dan Kesehatan Vol. 1 No. 7 (2017): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Pain due to smooth muscle stiffness can occur in various circumstances of patients, ranging from normal circumstances such as menstrual pain, to a pathological condition of gastrointestinal infections. To overcome the pain it can be given medication to reduce muscle stiffness as spasmolytics, but there are side effects of the drug. Thus, the need for developing new spasmolytics drugs based on medicinal herbs with fewer side effects. This study was conducted to examine the potential of rhizome extract of jeringau (Acorus calamus L.) that is traditionally used by Dayak tribe to heal upset stomach. Spasmolytic activity of plant extracts tested with isolates organ methods of guinea pig ileum induced by histamine. Result of the study showed 0.3 mg/ml A. calamus rhizomes extract could decrease ileum contraction better than papaverine 0.03 mg/ml (p=0.00). The conclusion of this study is rhizome extract of jeringau (A. calamus) has the potential to be used as spasmolytics in treatment of health problems caused by smooth muscle contraction

Effect of African Leaves Extract (Vernonia amygdalina DEL.) on Wound Healing Velocity after Tooth Extraction in Rattus norvegicus Andre Kusuma Ruslim; Silvia Anitasari; Sjarif Ismail; Eka Marwansyah Oli’I; Sinar Yani
Jurnal Sains dan Kesehatan Vol. 1 No. 8 (2017): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Povidone iodine is an antiseptic that is often used for wounds after tooth extraction, but is often debated because it can cause damage to cells and tissues. African leaf (Vernonia amygdalina Del.) from the family Asteraceae has saponins as anti-microbial, anti-inflammatory and antioxidant flavonoids as that all may be able to accelerate wound healing. To investigate the activity of extracts of Vernonia amygdalina folia (VAF) to accelerate the process of wound healing after tooth extraction in rats. VAF extracted by maceration using methanol. Wistar male rats as much as 6 groups (n = 5 mice each group) performed tooth extractions, and then observed the reduction of gingival socket closure for 21 days after being given povidone iodine, distilled water and methanol extract group VAF by 4 concentration. The closure of the wound after tooth extraction in the group of povidone iodine rats occurred on the 8th day, the group aquadest cover the wound occurred on the 12th day, the extract group 1, 3, 5, 7% sequentially occur wound closure on day 6th, 5th, 4th and 4th. VAF methanol extract of the leaves can accelerate wound healing after tooth extraction of mice

Aktivitas Anti-Inflamasi In Vitro Ekstrak Etanol Daun Vernonia amygdalina DELILE Dengan Pengujian Stabilisasi Membran Muhammad Khairul Nuryanto; Swandari Paramita; Abdillah Iskandar; Sjarif Ismail; Andre Kusuma Ruslim
Jurnal Sains dan Kesehatan Vol. 1 No. 8 (2017): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Inflammation is a normal process in the human body as a response to injury from the healing process. Meanwhile, chronic inflammation will cause new health problems to patients. Anti-inflammatory agents generally used for those conditions, have several side effects to patients. The objective of this research was to find alternative anti-inflammatory agents, especially from natural sources. Vernonia amygdalina Delile knew locally as “Daun Bismillah” belong to family Apiaceae is one of those potential natural sources for alternative anti-inflammatory agents. This plant is known as traditional medicine and used as material in this research. The experimental method of in vitro anti-inflammatory measurement using membrane stabilization activity for ethanol extracts of V. amygdalina leaves. The results showed that significant differences of EC50 (p<0.05) were achieved between indomethacin as the positive control with V. amygdalina leaves extracts for concentration 1% and 10%. EC50 of leaves ethanol extract of V. amygdalina showed the potential anti-inflammatory activities. It could be concluded that V. amygdalina leaves ethanol extracts to have anti-inflammatory activities, which could be further developed as a new natural source of the anti-inflammatory agents.

EFEK HEPATOPROTEKTIF SECARA IN VITRO TERHADAP TANAMAN OBAT (STUDI TERHADAP SKRIPSI MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS MULAWARMAN ANGKATAN 2001- 2009) Desy Merindasari; Swandari Paramita; Sjarif Ismail
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 2 No 2 (2014): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Hepatitis merupakan salah satu masalah kesehatan utama di Indonesia dan kebanyakan terjadi padatahap akut. Tatalaksana utama pada tahap ini ialah pemberian bahan-bahan yang berkhasiathepatoprotektif yang banyak terkandung dalam tanaman obat. Penelitian ini mengumpulkan sembilantanaman obat yang telah diuji efek hepatoprotektif secara in vitro dengan induksi CCl4 oleh mahasiswaFakultas Kedokteran Universitas Mulawarman angkatan 2001-2009, kemudian dilakukan penelitianmeta-analisis untuk mengetahui tanaman obat yang memiliki efek hepatoprotektif terbaik. Hasilpenelitian efek hepatoprotektif tanaman obat diatas dihitung nilai konsentrasi efektif 50% (EC50)dengan regresi linier dan heterogenitas diuji dengan One Way Anova, selanjutnya diaplikasikan dalammeta-analisis. Hasil penelitian meta-analisis pada nilai EC50 Mallotus paniculatus, Koordersiodendronpinnatum, Elaeocarpus stipalaris, Piper crocatum, Omalanthus populneus, Spatolobus ferrugineus,Aristolochia papilifolia dan Coccinia grandis didapatkan nilai p<0.001 terhadap Dracontomelon dao.Hasil meta-analisis disimpulkan Dracontomelon dao memperlihatkan efek hepatoprotektif yang palingefektif.

IMPLEMENTASI TEKNOLOGI DIGITAL DITENGAH PANDEMI COVID-19 SEBAGAI INFORMASI DAN PENDORONG UMKM DI KELURAHAN MARGOMULYO SAMBOJA, KABUPATEN KUTAI KARTANEGARA Sjarif Ismail; Muhammad Tajul; Ngadiman Ngadiman; Viter Pernando Limbong; Gerhana Ferina; Hasdianti Rosma; Khoirunnissa Nabila; Muhammad Rizki Rahman Pratama Juan
JUARA: Jurnal Wahana Abdimas Sejahtera Volume 2, Nomor 2, Juli 2021
Publisher : Universitas Trisakti

Since the Covid-19 pandemic, economic growth, especially Micro, Small and Medium Enterprises (MSMEs) in Margomulyo Samboja Village, has been greatly affected, due to the rules for working at home so that people's incomes have decreased and people have not understood the importance of using digital technology to market the product of MSMEs. The 2020 Extraordinary Events Real Work Lecture at Mulawarman University was carried out by students online due to the policy of the University. The activity was carried out by training setup an official website for Margomulyo Samboja Village to promote local MSME products. In addition, they are also taught how to enter the latest news on websites which are carried out online, and redesign the stickers for MSME products to make them look attractive. The village response to this activity is very good, which is known from the evaluation of the assessment to students is very satisfying. In conclusion, the implementation of digital technology in the Margomulyo Samboja Village can reduce barriers to information dissemination to the public and increase the fighting power of MSMEs in the midst of the Covid-19 pandemic.

The effects of Curcuma xanthorrhiza rhizome simplicia and Camellia sinensis green tea in a patient with chronic hepatitis B infection: a case report Sjarif Ismail; Ika Fikriah; Nataniel Tandirogang; Khemasili Kosala
Indonesian Journal of Pharmacology and Therapy Vol 3 No 3 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

The hepatitis B virus (HBV) causes acute and chronic liver infections which can be treated by using interferon and antiviral. However, the treatment is relatively expensive. We reported here a case of a patient with chronic hepatitis B who had negative seroconversion without interferon (IFN) and antiviral treatment after herbal consumption. A retrospective investigation showed that the patient consumed Curcuma xanthorrhiza rhizome and Camelia sinensis green tea. These herbs were widely both in vitro and in vivo studied for their effects against HBV infection, although the clinical studies are limited. This case reported the effect of C. xanthorrhiza rhizome and C. sinensis green tea consumption in a patient with chronic hepatitis B. A female patient with chronic hepatisis B infection at the age of 32 y.o. had been taking neuro vitamins regularly for a year before infection detected. She was an asymptomatic patient with normal limits liver function, positive HBsAg and negative anti-Hbs. At the age of 45, she started taking C. xanthorrhiza rhizome simplicia equivalent to 5mg of curcumin twice daily and drinking C. sinensis green tea regularly. Six years later, HBsAg was not detected and her liver function remained within normal limits and Anti-HBs were detected 5 years later. In conclusion, the consumption of C. xanthorrhiza rhizome and C. sinensis green tea can against chronic hepatisis B infection by eliminate HBV dan induce anti-HBs.

Uji Efek Antiinflamasi Ekstrak Etanol Mitragyna (Mitragyna Speciosa) Pada Mencit (Mus Musculus) Dengan Metode Induksi Xylene Pada Telinga Mencit Wilman Rante Marampa; Sjarif Ismail; Masyhudi Amir
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Latar Belakang: Daun sapat (Mitragyna speciosa) diketahui mengandung zat aktif flavanoid, dan alkaloid, serta memiliki efek antiinflamasi dengan metode edema kaki yang diinduksi karagenan pada tikus. Namun, efek antiinflamasi ekstrak etanol daun Mitragyna speciosa (MS) dengan metode induksi xylene pada telinga mencit belum pernah dilaporkan. Tujuan: Mengetahui efek antiinflamasi ekstrak Mitragyna speciosa dengan metode induksi xylenepada telinga mencit Metode: Mencit jantan dibagi ke dalam 5 kelompok (n=5): kontrol negatif (CMC 0,5%), kontrol positif (natrium diklofenak 0,013 mg/gr BB), dosis I (ekstrak MS 0,5 mg/gr BB), dosis II (ekstrak MS 1 mg/gr BB), dosis III (ekstrak MS 2 mg/gr BB) diberikan secara oral sebelum induksi xylene pada telinga mencit. Ketebalan telinga diukur dengan digimatic calliper pada menit ke-30,60,90, dan 120 setelah diinduksi xylene. Efek antiinflamasi dinyatakan dengan nilai AUC (Area Under Curve) edema dan disajikan dalam mean ± SD. Uji statistik dengan ANOVA berbeda bermakna jika p<0,05 Hasil: Nilai AUC edema masing-masing kelompok yaitu kontrol negatif (77±11,6), kontrol positif (31,72 ± 6,67), dosis I (46,37 ± 10,04), dosis II (32,33± 11,24), dan dosis III (26,69 ± 6,57). Uji ANOVA (p=0,01), dosis I, dosis II, dan dosis III berbeda bermakna (p<0,05) dengan kontrol negatif Kesimpulan: Ekstrak MS mempunyai efek anti-inflamasi pada telinga mencit yang diinduksi xylene

Co-Authors Abdillah Iskandar Agustina Rahayu Magdaleni Andre Kusuma Ruslim Andre Kusuma Ruslim Desy Merindasari Eka Marwansyah Oli’I Endang Sawitri Fikriah, Ika Gerhana Ferina Hary Nugroho Hasdianti Rosma Khemasili Kosala Khoirunnissa Nabila Marihot Pasaribu Masyhudi Amir Masyudhi Masyudhi Meiliati Aminyoto Muhammad Khairul Nuryanto Muhammad Rizki Rahman Pratama Juan Muhammad Tajul Nataniel Tandirogang Ngadiman Ngadiman Ronny Isnuwardana Silvia Anitasari Sinar Yani Siti Nur Azizah Swandari Paramita Viter Pernando Limbong Wenda Safitri Wilman Rante Marampa Yuniati Yuniati

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