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All Journal Jurnal Kedokteran Brawijaya Molecular and Cellular Biomedical Sciences (MCBS) Pendas mahakam : jurnal pendidikan dan pembelajaran Sekolah Dasar Jurnal Keperawatan Padjadjaran Journal of Tropical Pharmacy and Chemistry JIMR - Journal of Islamic Medicine Research Kumawula: Jurnal Pengabdian Kepada Masyarakat Jurnal Kebidanan Mutiara Mahakam Jurnal Kesehatan Pasak Bumi Kalimantan Indonesian Journal of Pharmacology and Therapy Jurnal Sains dan Kesehatan Jurnal Pengabdian Kreativitas Pendidikan Mahakam (JPKPM)
Fikriah, Ika
Department Of Pharmacology, Faculty Of Medicine, Mulawarman University, Samarinda, Indonesia.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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HUBUNGAN PREEKLAMPSIA BERAT DENGAN KOMPLIKASI PADA JANIN DI RSUD ABDUL 2 WAHAB SJAHRANIE SAMARINDA 3 TAHUN 2017-2018 Rifqiya Faiza, Mita Maulida; Fransiska Ngo, Novia; Fikriah, Ika
Jurnal Kebidanan Mutiara Mahakam Vol 7 No 2 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan Mutiara Mahakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (659.912 KB) | DOI: 10.36998/jkmm.v7i2.59

Abstract

Preeclampsia defined as new onset of hypertension and proteinuria after 20 weeks of gestation. Preeclampsia is one of the three main causes of maternal mortality with an incidence of 128,273 each year or around 5.3% in Indonesia. Preeclampsia is classified as preeclampsia without severe features and severe preeclampsia. Severe preeclampsia can be a problem, both in the mother and the fetus due to vascular vasospasm. If uteroplacental blood flow to the fetus is limited, the fetus can be born under low birth weight (LBW), preterm birth, intra uterine fetal death, and low Apgar score. The aim of this research is to determine the correlation of severe preeclampsia with fetal complication, that is intra uterine fetal death (IUFD), preterm labor, neonatal asphyxia, and low birth weight (LBW). The design of this research is case control study with 46 sample for both case and control groups. The data analysis used chi-square for 2x2 table and likelihood ratio for 2x3 table. The results of this this research is showed that there was correlation between severe preeclampsia with preterm labor (p=0,000)and severe preeclampsia with low birth weight (p=0,000), there was no correlation between severe preeclampsia with IUFD (p=0,822) and severe preeclampsia with neonatal asphyxia (p=0,060)
PENGARUH CURCUMIN TERHADAP KADAR KOLESTEROL TOTAL, LDL-KOLESTEROL, JUMLAH F2 -ISOPROSTAN, DAN SEL BUSA (FOAM CELL) DINDING AORTA PADA TIKUS DENGAN DIET ATEROGENIK Fikriah, Ika; Kalim, Handono; Dradjat, Respati Suryanto
Jurnal Kedokteran Brawijaya Vol 21, No 2 (2005)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.016 KB) | DOI: 10.21776/ub.jkb.2005.021.02.1

Abstract

ABSTRACT Death  caused  by  cardiovascular  and  cerebrovascular diseases  are  still  the  highest.  Atherosclerosis  due  to hypercholesterolemia is a predispositioning factor of both diseases. Curcumin has an antioxidant character that can inhibit lipid peroxidase to atherogenesis process. The aim of this study was to observe the effect of curcumin in decreasing total cholesterol level, LDL-cholesterol, the number of  F2-isoprostan and foam cell of aorta’s wall of white rats strain wistar after giving atherogenic diet for 10 weeks. There were 6 groups in this study (n=24): atherogenic diet group (group I as positive control), atherogenic diet group + curcumin 50 mg/kg b.w. per day (group II), atherogenic diet group + curcumin 100 mg/kg b.w. per day (group III), atherogenic diet group + curcumin 200 mg/kg b.w. per day (group IV), atherogenic diet group + curcumin 400 mg/kg b.w. per day (group V), normal diet group (group VI as negative control). After 10th, the level of total cholesterol and LDL-cholesterol were measured by spectrofotometri. Staining F2-isoprostan was done with Avidin Biotin Complex imunohystochemistry method, and staining foam cell with HE-oil Red O. The number of  F2-isoprostan and foam cells were counting semi quantitatively using  light microscope. The highest total cholesterol level was found in group I (275,15 ± 10,01; Mean ± SD), the highest LDL-cholesterol level was found in group I (158,15 ± 12,19). Statistically total cholesterol level and LDL-cholesterol level in group I were significantly higher (p ≤ 0,05) than other
Analysis The Student Perception of Application Clinical Skills Online Learning in The Pandemic Time Covid-19 Anik Puji Rahayu; Sulistiyawati Sulistiyawati; Cicih Bhakti Purnamasari; Endang Sawitri; Ika Fikriah
Jurnal Keperawatan Padjadjaran Vol. 9 No. 2 (2021): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v9i2.1600

Abstract

Background: Government policies that apply social distancing, work from home, and learn from home to prevent the spread of the Covid-19 corona virus have an impact on learning methods. Clinical learning methods in pre-pandemic health education are carried out in campus laboratories and direct clinical services to patients. Thus, in this condition, the provision cannot be implemented. Purpose: For this reason, it is necessary to modify the learning method from offline to online to meet the continuity of the student learning process. Methods: In the first stage, the clinical skills online learning method using online videos is supported by lecturers’ explanations in a 120-minute meeting. In the second stage, students are given the task of making videos of procedural skills that have been taught in 170 minutes, with a video duration of 10-15 minutes. At the next meeting, a review or response is carried out with students on the standard operating procedure and the theory that underlies it. The design in this study is a descriptive analysis with 511 respondents from the medical education study program and the nursing diploma 3 study program at the Faculty of Medicine, Mulawarman University. The research used was 44 items of statement questionnaire that had been tested for validity and reliability, and questionnaire items were sent to respondents via Google Forms. Results: From the results of this study, there is a significant relationship between the perceptions of students who apply clinical skills online learning seen from the effectiveness of learning in the Covid-19 pandemic era with p-value = 0.000, with a very strong relationship with the Spearman value rho of 0.791 in a positive direction. Conclusion: Thus, it can be concluded that the application of online clinical skills learning during the Covid-19 pandemic was effective. As a suggestion, clinical learning methods with various blended learning or hybrid learning methods should be modified.
In vitro Exploration of Vasodilation Activity of the Methanol Extract of the Coptosapelta flavescens Korth stem Khemasili Kosala; Sjarif Ismail; Ika Fikriah; Agustina Rahayu Magdalena
JIMR - Journal of Islamic Medicine Research Vol 1, No 2 (2017)
Publisher : Published by Faculty of Medicine Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (751.843 KB)

Abstract

ABSTRACTIntroduction: Coptosapelta flavescens Korth is a liana plant of the Rubiaceae genus. In East Kalimantan it is known as Akar Tambolekar or Merung. Its stem is ethnobotanically used as herbs to treat high blood pressure but it has not been scientifically proven yet.Method: This study aims to prove the activity of Coptosapelta flavescens stem (BCF) extract as an antihypertensive by using a blood vessels isolated organ model through the action mechanism as a vasodilator. BCF was taken from Paser Regency, East Kalimantan Province. The extraction was macerated using methanol solvent, then concentrated using a vacuum rotavapour at the temperature of 50C. Vasodilator activity was tested using a 3 mm long rat aorta isolated organ with endothel put into Krebs Henselheit solution at 37C, pH 7.4 and fed by carbogen gas. The aorta is contracted using a phenylephrine solution, after the contraction reached its peak and plateaued, the extract solution or the extracts solvent solution (as control) was added cumulatively and the aortic tone activity was observed. The results were expressed in percent of aortic contractility.Results: The results showed that BCF extract caused an increase in the reduction of aortic contractility percentage as extract concentration increase. Conclusion: This proves that BCFs methanol extract can cause vasodilation in blood vessels with endothelium.Keyword: Coptosapelta flavescens, antihypertensive, extract, isolated aorta, vasodilator
Personal Characters Management : Caring Spiritualitas Increased Nursing Practice Implementation in Aji Muhammad Parikesit Hospital Tenggarong Kutai Kartanegara Anik Puji Rahayu; Ika Fikriah; Sholichin Sholichin; Ediyar Miharja; Iwan Samsugito
Jurnal Kesehatan Pasak Bumi Kalimantan Vol 3, No 1 (2020): JKPBK Juni 2020
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (658.094 KB) | DOI: 10.30872/j.kes.pasmi.kal.v3i1.3462

Abstract

Background It is important for nurses to recognize and integrate the dimensions of body, mind, and spirit in their daily clinical practice (Dossey, 2005). If the client's needs are not met in one of the dimensions that can cause health and welfare problems. 94% of patients visiting hospitals in the US believe that spiritual health is as important as physical health. The need to get the attention that understanding caring alone is not enough to make a nurse can provide good service. Based on Maslow's theory that a person will do his work in accordance with the level of his needs. Understanding of a nurse who is at the level 5 stage of self-actualization, actually only wants to provide satisfaction for the achievement of personal self-actualization. If only the understanding of the concept of nurses was already at level 6. The importance of changing the mindset of nurses with the concept of caring spirituality so that nurses are fully aware of the deepest heart to get true blessing and happiness when nurses care for patients and afterward. Result The survey results from the 6-month in-house training process were able to increase the caring spirituality of nurses, which in turn was able to increase the application of services in nursing in hospitals. AM Parikesit Tenggarong. Furthermore, it is expected that nurses must increase their knowledge and understand the true concept of caring spirituality and be able to apply it in providing nursing care services to patients.Keywords: caring, spiritualis, nursing practice,
The Correlation between Internet Addiction and Anxiety Level among Medical Students at Medicine Study Program of Medicine Faculty, Mulawarman University Meilinda Meilinda; Jaya Mualimin; Ika Fikriah
Jurnal Kesehatan Pasak Bumi Kalimantan Vol 5, No 1 (2022): JKPBK Juni 2022
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/j.kes.pasmi.kal.v5i1.7447

Abstract

AbstrakLatar Belakang : Pengguna internet yang terus bertambah berpotensi mendatangkan permasalahan baru bagi penggunanya yaitu suatu fenomena yang disebut adiksi internet. Adiksi internet adalah penggunaan internet yang berlebihan dan bisa berdampak negatif pada kondisi psikologi seseorang salah satunya berupa kecemasan. Tujuan Penelitian : Untuk mengetahui hubungan antara adiksi internet dengan tingkat kecemasan pada mahasiswa Program Studi Kedokteran Fakultas Kedokteran Universitas Mulawarman. Metode : Penelitian ini merupakan penelitian observasional analitik dengan desain cross-sectional. Subjek pada penelitian ini sebanyak 83 orang dipilih dengan metode stratified random sampling. Instrumen yang digunakan adalah  Internet Addiction test (IAT) dan Beck Anxiety Inventory (BAI) disebarkan melalui google form. 83 responden yang terdiri dari 28 mahasiswa laki-laki dan 55 mahasiswa perempuan. Hasil : Didapatkan hasil 15 (18,1%) responden tidak mengalami adiksi internet, 49 (72,1%) responden mengalami adiksi internet tingkat ringan, 18 (26,5%) mengalami adiksi internet tingkat sedang, dan 1 (1,5%) mengalami adiksi internet tingkat berat. Sedangkan untuk kecemasan sebanyak 33 (39,8%) responden tidak mengalami kecemasan, 38 (76%) kecemasan ringan, 11 (22%) kecemasan sedang, dan 1 (2%) kecemasan berat. Hasil analisis bivariat dengan uji Chi Square tidak terdapat hubungan antara adiksi internet dengan tingkat kecemasan pada mahasiswa Program Studi Kedokteran Fakultas Kedokteran Universitas Mulawarman (p value > 0,005; p=  0,077).Kata Kunci: adiksi internet, kecemasan, mahasiswa AbstractBackground: A growing number of internet users may potentially raise a problem called a phenomenon of internet addiction. Internet addiction is generally defined as excessive internet use and gives negative effects on people’s psychological condition, one of which is anxiety. Research Objectives: To know the correlation between internet addiction and anxiety level among medical students at Medicine Study Program of Medicine Faculty, Mulawarman University. Methods: This was an analytical observational research with cross-sectional design. There were 83 research subjects consisting of 28 male and 55 female students selected using stratified random sampling method. Two instruments, Internet Addiction test (IAT) and Beck Anxiety Inventory (BAI), were distributed through Google Form. Result: The findings revealed that 15 (19.1%) respondents experienced the absence of internet addiction, 49 (72,1%) respondents experienced low level of internet addiction, 8 (26,5%) respondents experienced moderate level of internet addiction, and 1 (1.5%) student experienced severe level of internet addiction. In addition, students’ anxiety levels among students were 33 (39,8%) respondents with zero anxiety level, 38 (76%) respondents with low anxiety level, 11 (22%) respondents with moderate anxiety level, and 1 (2%) student with high anxiety level. The result of bivariate analysis using Chi Square test showed that there was no correlation between internet addiction and anxiety level among medical students at Medicine Study Program of Medicine Faculty, Mulawarman University (p value > 0,005; p=  0,077).Keywords: Internet addiction, anxiety, student
Efek Ekstrak Metanol Daun Engkuduk Talun (Fagraea racemosa) pada Peroksidasi Lipid Secara In Vivo Ika Fikriah
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 2 (2011): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (47.131 KB) | DOI: 10.25026/jtpc.v1i2.18

Abstract

ABSTRACT Engkuduk talun plant (Fagraea racemosa) grows in East Kalimantan forest. Stages Extraction research of petroleum eter-cloroform-metanol from leaves, root skin, root, stem skin and Fagraea racemosa’s stem toward radical 2,2-diphenyl-1-picrylhydrazil (DPPH) is proven that the extract of methanol leaves have the strongest scavenger effect, this can be interpreted that the leaves have the strongest antioxidant potency from all plant parts that have been examined. The given single dose 1 gram/kg b.w of the methanol extract from Fagraea racemosa leaves do not caused the death at the female Wistar rats. On the inhibitor test of forming MDA of rat’s liver the very high of absorbance value has accurred on control by CCl4 ( 0.508 ± 0.039 ), significant if compared to CCl4 added with the vitamin E ( 0.224 ± 0.006 ) and CCl4 added with three doses of methanol extract from the Fagraea racemosa’s leaves ( p=0.000 ) Keywords: Fagreae racemosa, lipid peroxidation, CCl4, vitamin E ABSTRAK Tumbuhan engkuduk talun (Fagraea racemosa) banyak terdapat di hutan Kalimantan Timur. Penelitian ekstraksi bertingkat petroleum eter-kloroform-metanol dari daun, kulit akar, akar, kulit batang dan batang Fagraea racemosa terhadap pereaksi radikal 2,2-diphenyl-1-picrylhydrazil (DPPH) terbukti pada ekstrak metanol daun mempunyai efek peredaman paling kuat, ini dapat diartikan daun mempunyai potensi antioksidan yang paling kuat dari semua bagian tumbuhan yang diamati. Pemberian dosis tunggal 1 gram/kgBB ekstrak metanol daun Fagraea racemosa tidak menunjukkan kematian pada hewan coba tikus Wistar betina. Pada uji hambatan pembentukan MDA hepar tikus terjadi peningkatan nilai absorbansi yang sangat tinggi pada kontrol dengan CCl4 (0.508 ± 0,039), berbeda bermakna jika dibandingkan CCl4 yang ditambah dengan vitamin E (0.224 ± 0,006) dan CCl4 yang ditambah dengan tiga dosis ekstrak metanol daun Fagraea racemosa (p=0.000). Kata Kunci: Fagraea racemosa, peroksidasi lipid, CCl4, vitamin E
Aktivitas Hepatoprotektor Batang Fibraure tinctoria Lour Secara In Vivo Ika Fikriah
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (91.031 KB) | DOI: 10.25026/jtpc.v1i4.39

Abstract

Study on Fibraurea tinctoria Lour (FT) stems gives information about its traditional utility as yellow fever treatment. Research of antecedent of FT stem proved that inhibited lipid peroxidation more effective than tocopherol acetate. These study was intended to prove hepatoprotector activity of ethanolic FT stem extract by in vivo. FT stem extract was macerated using absolute ethanol during 5 days that was repeated 3 times . FT stem extract hepatoprotector activity by in vivo was tested using carbon tetrachloride induced hepatotoxicity on Wistar rat. They were given FT stem extract orally once a day at dose 50, 100, and 200 mg/kgBW and Curcumin at dose 50 mg/KgBW as positive control. After 10 days, all groups were examined liver function (SGOT, SGPT, ALP), liver Malonedialdehide (MDA) level by Thiobarbituric acid method, and liver histopathology by Haemotoxylin-Eosin staining. Group that induced by CCl4 showed significant elevation of SGOT, SGPT and ALT also Liver MDA than group control. FT stem extract treatment inhibited elevation of SGOT, SGPT, ALT and Liver MDA significantly.Qualitative histopathological examination on Group 2 showed extensive fibrosis and necrosis, along with periportal PMN and lymphocyte infiltration. FT stem extract treatment inhibited pathological change that was induced by CCl4. Dose elevation showed tendency of stronger inhibition on liver cell tissue destruction and inflammation. Key words: Fibraurea tinctoria, hepatoprotector, in vivo Abstrak Penelusuran secara etnobotani, batang Fibraurea tinctoria Lour (FT) digunakan untuk obat sakit kuning. Penelitian pendahuluan batang FT berkemampuan meredam peningkatan lipid peroksidasi secara in vitro yang lebih kuat dibandingkan dengan tokoferol asetat. Membuktikan khasiat ekstrak etanol batang FT sebagai hepatoprotektor secara in vivo. Batang FT dimaserasi dengan etanol absolut selama 3 x 5 hari. Uji hambatan kerusakan hati secara in vivo digunakan model tikus yang diinduksi karbon tetraklorida (CCL4), ekstrak etanol FT diberikan dengan dosis 50, 100, 200 mg/KgBB sekali sehari dan curcumin dosis 50 mg/KgBB sebagai kontrol positif selama 10 hari lalu diperiksa fungsi hati (serum SGOT, SGPT dan ALP), kadar malondialdehida hati (MDA-hati), serta pemeriksaan patologi anatomi hati dengan pewarnaan Hematoksilin Eosin (HE). Kelompok tikus yang diinduksi CCl4 memperlihatkan peningkatan nilai SGOT, SGPT dan ALT dan MDA-Hati secara bermakna dibandingkan dengan kontrol. Pemberian ekstrak etanol batang FT secara oral dapat melemahkan peningkatkan nilai SGOT, SGPT dan ALT serta dapat menghambat peningkatkan nilai MDA-Hati pada tikus yang diinduksi CCl4 secara bermakna. Hasil pemeriksaan PA menunjukkan fibrosis dan nekrosis yang luas disertai infiltrasi sel-sel PMN dan limfosit di daerah periportal pada kelompok tikus yang diinduksi CCl4 > Curcumin > FT 50 > FT 100 > FT 200 mg/KgBB. Kata Kunci: Fibraurea tinctoria, Hepatoprotektor, in vivo
Mechanism of Vasorelaxation Induced by Coptosapelta flavescens Stems Extract in Rat Thoraric Aorta Sjarif Ismail; Khemasili Kosala; Ika Fikriah; Agustina Rahayu Magdaleni
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.693 KB) | DOI: 10.25026/jtpc.v4i2.146

Abstract

Coptosapelta flavescens Korth. is a liana plant from the Rubiaceae family. In East Kalimantan, it is also known as “Akar Tambolekar” or “Merung”, it is called “akar” or root as its trunk spreads like a root. The plant’s stems are used by ethnic Dayak in East Kalimantan to overcome high blood pressure and it has been proven to induce vasorelaxation on blood vessels, but the its action mechanism in the endothelial or vascular smooth muscle cells (VSMC) are unknown. Vasorelaxation on the blood vessels could be mediated by endothelial or by the VSMC. This research aims to study in vitro which of them is the mechanism of action of Coptosapelta flavescens Stems (CFS) extract. CFS were taken from the secondary forest in Paser Regency, East Kalimantan Province. Its simplicia were macerated with methanol solvent for three days and twice repeated. Vasorelaxation activity of the blood vessels was tested with rats’ isolated thoracic aorta with endothelial and with the endothelial removed (endothelium-denuded). Both aorta of 3 mm length were soaked into Krebs-Henselheit solution at 37°C, pH 7.4 and aerated with carbogen gas. After they have acclimatized, both aortas were contracted with phenylephrine solution, after reaching peak contraction and plateau, the solution of extract or its solvent (Control) was administered in cumulatively increasing doses. The results show that CFS extracts induce vasorelaxation both in the endothelial-intact aorta and in the endothelial-denuded aorta. At high concentrations, the vasorelaxation activity in the endothelial-intact aorta was weaker than that on endothelial-denuded aorta. This study proves that action mechanism of blood vessels’ vasorelaxation induced by the methanol extract of CFS were more dominantly mediated by the blood vessels smooth muscle; and at high concentrations the endothelial actually weakened the VSMC vasorelaxation activity. Further study is necessary on the mechanism of action vasorelaxation through the modulation of intracellular or extracellular calcium ion channels of VSMC Keywords: Coptosapelta flavescens, vasorelaxation, extract, aorta, in vitro
Evaluation of Synergistic Effect of Kaempferia galanga L. Rhizome Extracts on the Antibiotic Activity Antibiotics against Bacterial Pathogens Almira Fahrinda; Sjarif Ismail; Khemasili Kosala; Ika Fikriah; Yuniati Yuniati
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 3 (2018): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (358.004 KB) | DOI: 10.25026/jtpc.v4i3.148

Abstract

Background: aromatic ginger rhizome (Kaempferia galanga L.) is a member of Zingiberaceae family, has been known to have an antibacterial effect is used for everyday cooking spices, but the synergistic effect on broad spectrum antibiotics was unknown. Objective: this research was conducted to find out the synergistic effect of Kaempferia galanga L. Rhizome extract (KGR) on some broad-spectrum antibiotics against gram positive and negative bacterial pathogens in vitro. Method: KGR was taken from farmers in Samarinda City, East Kalimantan Province, Indonesia. Extraction by maceration with ethanol solvent. Antibacterial activity test of KGR ethanol extract, antibiotic and synergistic effect using Mueller-Hinton agar, Kirby-Bauer disc diffusion method on ampicillin, cefuroxime, chloramphenicol, ciprofloxacin, and meropenem antibiotics against Staphylococcus aureus and Escherichia coli. Results were expressed in percentage increase of the inhibition zone. Statistical test with t-test, significantly different if p<0.05. Results: KGR ethanol extract showed increase the percentage of antibiotic inhibition zone, ampicillin being the highest and the weakest of ciprofloxacin in E. coli; meropenem being the highest and the weakest of ciprofloxacin in S. aureus, statistically significant different tests on antibiotic ampicillin (E. coli), meropenem and cefuroxime. Conclusion: KGR ethanol extract showed synergistic effect on antibiotic ampicillin (E. coli), meropenem and cefuroxime in S. aureus and E. coli.
Co-Authors Adheya Putrindashafa Agustina Rahayu Magdalena Agustina Rahayu Magdaleni Almira Fahrinda Anik Puji Rahayu Annin Dya Maina Arfian Deny Prakoso Bilqis Faiqotun Nabilah Dilan Cicih Bhakti Purnamasari Crissty Magglin Denny J. Rotinsulu Ediyar Miharja Endang Sawitri Evi Fitriany Hadi Kuncoro Handono Kalim Handy Wiradharma Imran Irsal Imran Irsyal Iwan Samsugito Jaya Mualimin Khemasili Kosala Khemasili Kosala Krispinus Duma Meiliati Aminyoto Meilinda Meilinda Miftahul Jannah Naina Nataniel Tandirogang Novia Fransisca Novia Fransiska Ngo Nursaci Mardania Pipi Surianti Rahmat Bakhtiar Regina Anastasia Sanjaya Respati Suryanto Dradjat Rifqiya Faiza, Mita Maulida Rochimah Thul Ulyah Rudi Saputra Sapta Rahayuning Ratri Sholichin Sholichin Siti Khotimah Siti Rahmadhani Sjarif Ismail Sulistiawati Sudarso Sulistiawati Sudarso Sulistiyawati Sulistiyawati Yadi Yadi Yuliana Kartika Ningrum Yuniati Yuniati