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All Journal Medical Journal of Indonesia Jurnal Kedokteran Indonesia Preventif Journal Jurnal Respirologi Indonesia Respiratory Science Cermin Dunia Kedokteran
Faisal Yunus
Universitas Indonesia
Education Health Professions Medicine & Pharmacology Public Health

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The Proportion of Lung Hyperinflation In Patients With Persistent Asthma In Persahabatan Hospital Jakarta Using Multiple Breath N2-Washout Marisa Afifudin; Faisal Yunus; Triya Damayanti
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.20

Abstract

Background: In asthma, small airway dysfunction and inflammation may induce significant lung hyperinflation. The aim of the study is to discover the proportion of lung hyperinflation in patient with persistent asthma in Persahabatan Hospital Jakarta. Method: A cross sectional study with descriptive analysis was done in Asthma clinic Persahabatan Hospital from September-November 2016. Forty-five subjects were recruited consecutively. Interview, physical examination, chest x-ray (CXR), spirometry and multiple breath N2-washout (MBW) were performed. Lung hyperinflation was defined as a residual volume /total lung capacity (RV/TLC%) above the upper limit of normal. Results: The proportion of lung hyperinflation in patients with persistent asthma was 17,8% (8 of 45 subjects). Median RV in milliliter was 1230 (570-2860). Median functional residual capacity (FRC) in milliliter was 1730 (970-3990). Median TLC in milliliter was 3310 (2490-6350). Mean RV/TLC ratio was 36,39% (SD±8,86). Mean FRC/TLC ratio was 52,86% (SD ±6,85). There was a significant correlation between forced expiratory volume in 1 second (FEV1%) value with lung hyperinflation with the decline of FEV1 <60% increased the risk of lung hyperinflation by 8,46 (95%CI=1,155-61,98; p=0,036). There were no significant correlation between age, gender, smoking habit, body mass index (BMI), ACT score, the severity of persistent asthma, duration of asthma, duration of steroid inhalation use, exacerbation history in the last 12-months and emphysematous in CXR with lung hyperinflation (p>0,05). Conclusions: The proportion of lung hyperinflation in patient with persistent asthma in Persahabatan Hospital Jakarta is 17,8%. Lung hyperinflation in persistent asthma is associated with the degree of airway obstruction.
Neutrophyl – Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) Levels in Stable and Exacerbated Chronic Obstructive Pulmonary Disease (COPD) Patients in Persahabatan Hospital Jakarta Astari Pranindya Sari; Ratnawati Ratnawati; Wahju Aniwidyaningsih; Sita Laksmi Andarini; Faisal Yunus
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.38

Abstract

Background: Although COPD has been believed to be characterized by respiratory disease, there are currently limited study conducted to evaluate inflammation markers and exacerbation rate in COPD by noninvasive methods. We did a prospective cohort study to observe the alteration of Neutrophyl-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in COPD patients to find any possible correlation with COPD exacerbation status. Method: From July to December 2018, a prospective cohort study was performed with blood and spirometry test on 31 COPD patients during exacerbation (AE-COPD) and stable. The mean of NLR and CRP were compared and analyzed. Results: Both NLR and CRP decreased during stable condition (from 7.95±6.8 to 4.6±5.5 and 43.4±71 to 12.2±18.5) with P<0.01 respectively. We also found a significant inverse correlation between NLR and FEV1/FVC in AE-COPD and CRP showed an inverse correlation only with FEV1 in AE-COPD. Another interesting finding was a subject with very high CRP whose value remained above the nomal limit during stable, and died within 2 months after exacerbation. Conclusion: NLR and CRP levels in COPD patients increased during exacerbation, which may reflect lung function and exacerbation status.
Co-Authors . Suradi Adang Bachtiar Adrianison Adrianison Agus D. Susanto Agus Dwi Susanto Agustin, Heidy Allen Widysanto Amira P Tarigan, Amira P Angela BM Tulaar Anita Ratnawati Antalia K.M. Katili Anwar Jusuf Aria Kekalih Arifin Nawas Astari Pranindya Sari Azizman Saad B Setyanto, Darmawan Barmawi Hisyam Budhi Antariksa Bulkis Natsir Cut Yulia Indah Sari Dicky Soehardiman Dwi Handoko Eddy Surjanto Elisna Sjahruddin Erlang Samoedro Fathiyah Isbaniah Flora Ekasari Hadiarto Mangunnegoro Hana Khairina Putri Faisal Helena Turnip Idrus Alwi Indi Esha Isep Supriyana Jamal Zaini Joko Riyadi Kolewora, Yusuf Musafir Lientje S. Maurits, Lientje S. Marisa Afifudin Mariska Pangaribuan Menaldi Rasmin Mohammad Farid Neni Sawitri Nury Nusdwinuringtyas Putri Suci Ramadhany Ratnawati Antaria Ratnawati Ratnawati Ratnawati Ratnawati Ridha Restilla Ririn Astuty Ningsih Risa Febriana Rochsismandoko Rochsismandoko Rochsismandoko Rochsismandoko Sabarina Prasetyo Sita Laksmi Andarini Soerjanto Soerjanto Suradi Suradi Surya Hajar Fitria Dana Syafruddin A.R. Lelosutan Syah Putra Yahya, Wiendo Tamsil Syafiuddin, Tamsil Triya Damayanti Wahju Aniwidyaningsih Widjajalaksmi Widjajalaksmi Wiwien H. Wiyono Yulino Amrie Zulkarnain Barasila