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Hasriana Hasriana, Hasriana
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Journal : Pharmacology and Clinical Pharmacy Research

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The Effect of Anti-Tuberculosis Drugs on the Effectiveness of Anti-Retroviral Therapy in HIV-AIDS Patients Hasriana, Hasriana; Alfian, Sofa D.; Milanda, Tiana; Abdulah, Rizky
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.201 KB) | DOI: 10.15416/pcpr.v2i1.16214

Abstract

patients who infected by Humman Immunodeficiency Virus (HIV) in developing countries. The purpose of this study was to determine the effect of anti-tuberculosis drugs (ATB) on the effectiveness of anti-retroviral (ARV) therapy in HIV–AIDS infected patients.This study was a prospective cohort study conducted at outpatient clinic of Abepura Hospital during April-June 2015. The data were taken from medical records, which include CD4 level, gender, age, education and stage of disease. Statistical analysis was performed using bivariate and multiple regression analysis. A total of 28 subjects was included in this study (7 HIV patients and 21 TB-HIV patients). The results of bivariate analysis showed that there was no significant difference on general characteristics of patients using ARV-ATB and without ATB. Gender, age, occupation, education and the stage of disease did not affect the value of CD4 patients (p>0.005). The result from paired t-test showed that there was no significant difference in the level of CD4 cell, before and after treatment using ARV (p˃0.912), while therapy with ARV-ATB showed significant differences (p˂0.002). In conclusion, this study showed that the combination of ATB and ARV could increase CD4 level up to 72%. Thus, the use of ATB drugs on ARV patients who infected by TB is recommended to reduce disease burden.Keywords: anti-retroviral therapy , HIV- AIDS, tuberculosis
Co-Authors Agustin, Marlinda Akbar Tukan, Ramdya Alfianur Alfianur Anwar, Irawati Armanto, Armanto Batu, Yuliana Damayanti, Ana Darni Darni Febrianti, Selvia Fitria Handayani Handayani, Fitiya Handayani, Fitriya Hidaya, Nurman Indrasari, Neneng Lesmana, Hendy Mulyati Mulyati Najihah, Najihah Nani, Hasni Normawati Normawati, Normawati Nugraha, M. Akbar Ose, Maria Imaculata Paat, Toar Christo Pujianto, Ahmat R. Sapeni, Muhammad Al-Amin Rizky Abdulah Selvia Febrianti Sofa D. Alfian, Sofa D. Tambunan, Santi TIANA MILANDA Ully, Sulidah Warsono Warsono Yuniyanti, Tri Ayu Zulfia, Rahmatuz