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All Journal International Journal of Public Health Science (IJPHS) Jurnal Ilmiah Farmasi Jurnal Keperawatan Indonesia Jurnal Ilmiah Kesehatan (JIK) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika Jurnal Keperawatan Padjadjaran Jurnal Keperawatan Muhammadiyah Journal of Telenursing (JOTING) Jurnal Aisyah : Jurnal Ilmu Kesehatan Prosiding Seminar Nasional Program Pengabdian Masyarakat Jurnal Kedokteran Hewan
Ikhlas Muhammad Jenie
Bagian Fisiologi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Jurnal Ilmiah Farmasi

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Cytoprotective effect of tangeretin in hydrogen peroxyde-inducedoxydative stress on human umbilical vein endothelial cells (HUVECs) Riris Istighfari Jenie; Irfan Muris Setiawan; Ikhlas Muhammad Jenie; Haruma Anggraini Muflikhasari
Jurnal Ilmiah Farmasi Vol. 11 No. 1 (2015): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol11.iss1.art3

Abstract

Oxydative stress is known as a major trigger in cardiovascular dysfunction that leads to hypertension, atherosclerosis, and chronic heart failure. Polymethoxyflavone such as tangeretin and nobiletin has been reported to have biological activity including reducing cholesterol level and anti inflammation activity. The critical point that mediates atherosclerosis is the formation of stress oxidative which causes endothelial cells dysfunction.This study was conducted to explore the effect of tangeretin in protecting H2O2-induced oxidative stress on HUVEC. Cell viability was determined by using MTT assay. Cells were treated with different concentrations of tangeretin (12.5; 100; and 200 µM) for 24h before exposed to 600 µM H2O2 for 4h. Cells viability analyses showed that at low concentration (12.5 µM), tangeretin inhibited H2O2-induced cytotoxicity. Furthermore, it induced cells proliferation. However, at high concentration, it failed to protect HUVEC from H2O2-induced cytotoxicity and increased the cytotoxicity of H2O2. Based on this result, tangeretin in low concentration has a potential to reduce oxidative stress on HUVECs.  
Co-Authors -, Praseno Adi, Danisworo K. Afrian, Rizki Astuti, Yoni Barii Hafidz Pramono Budi Mulyono Danisworo K. Adi Dian Kartikasari Dian Kartikasari Gindah Ratu Priyasa Purnamasari Haruma Anggraini Muflikhasari Ianah Al Azizah Imaniar Ranti Irfan Muris Setiawan Joni Krismanto Kaslinda Nur Umifa Kusumo, Mahendro Prasetyo Lutfi Putra Perdana Marsetyawan HNE Soesatyo Maya Um Husna Meiryisha, Sisti Muhammad Herjuna Nurliana Achmad, Nurliana Pramono, Barii Hafidz Purnamasari, Gindah Ratu Priyasa Ranti, Imaniar Riris Istighfari Jenie Rizki Afrian Rosefani Intan Indraswari Sisti Meiryisha Slamet Purnomo Soedjono Aswin Sri Kadarsih Soejono Yanuar Primanda Zulkhah Noor Zulkhah Noor