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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease
Linda Astari, Linda
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Berkala Ilmu Kesehatan Kulit dan Kelamin

 1 
Susceptibility test of Griseofulvin, Ketoconazole, Itraconazole, and Terbinafine to Dermatophyte Species Using Microdilution Method Anggarini, Dyah Ratri; Sukanto, Hari; Astari, Linda; Endraswari, Pepy Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (130.616 KB) | DOI: 10.20473/bikkk.V27.1.2015.55-62

Abstract

Backgroud: Dermatophytosis is common disease in tropical countries such as Indonesia. The prevalence of dermatophytosis in general population also high (20%). The dermatophyte fungi are the etiologic agents that cause this disease, some of them had already reported to be resistant to some anti-fungi. Purpose: To determine dermatophyte species causing dermatophytosis and the resistancy of griseofulvin, ketoconazole, itraconazole, dan terbinafine to dermatophyte species. Methods: Isolates of dermatophyte from patient who met the inclusion criteria in outpatient clinic of dermato-venereology Dr. Soetomo Hospital Surabaya during October until December 2014 were analyzed with respect to their susceptibility to four anti-fungal agents (griseofulvin, ketoconazole, itraconazole, and terbinafine) using microdilution methode. Results: Thirthy patients were included in inclusion criteria, with T. mentagrophytes var. Interdigitale was the most common cause of dermatophytoses. According to MIC all 30 isolates were already resistant to all anti-fungal agent, except T. rubrum that still sensitive to ketoconazole and 80,  itraconazole.  Conclusion: According to MIC 16.7% isolates sensitive to griseofulvin, 23.3% to ketoconazole, 16.7% to 80 itraconazole and 20% to terbinafine.Key word: dermatophyte species, susceptibility test of anti-fungal, microdilution.
Cutaneous Aspergilosis Caused by Aspergillus Flavus: A Case Report Sheilaadji, Maria Ulfa; Agusni, Indropo; Astari, Linda; Anggraeni, Sylvia; Widia, Yuri; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.72-77

Abstract

Background: Cutaneous aspergillosis occurs relatively less frequent and therefore remains poorly characterized. Cutaneous aspergillosis can be as primary or secondary infection. Primary cutaneous aspergillosis usually involves sites of skin injury, intravenous catheter, traumatic inoculation, and associated with occlusive dressings. Secondary lesions result from contiguous extension from infected underlying structures or from widespread blood-borne seeding of the skin. Purpose: To know the skin manifestation, efflorence, examination and therapy of cutaneous aspergillosis. Case: A man complaint itchy redness macule and pimples on the right arm since 2 weeks. Initially just felt a little then expands. Patients with post operative brachial injury and uses a cast during one month. On examination there are erythematous macule unsharply marginated with papules. Potassium hydroxide examination, shows conidiophores, dichotomously branching and septate hyphae appropriate description with Aspergillosis Sp. Cultures found grow granular colonies, flat often with radial grooves, yellow at first but quickly becoming bright to dark yellow-green with age, For the identification microscope from the culture specimen there was conidia, phialde, conidiophore and vesicle that suitable with Aspergillus flavus. Patients received itraconazole 2 x 200 mg for 6 weeks and obtained satisfactory results. Discussion: Healthy hosts can develop cutaneous aspergillosis in surgical wounds, by traumatic inoculation, at sites associated with occlusive dressings. In some instances, a presumptive diagnosis of primary cutaneous aspergillosis can be made immediately by examining a potassium hydroxide preparation and culture. Conclusion: Diagnose of cutaneous aspergillosis can establish by potassium hydroxide and culture examination, therapy with itraconazole 2x 200mg give satisfactory results.
A Case Report of Tinea Capitis in Children: Utility of Trichoscopy Harningtyas, Citra Dwi; Ervianti, Evy; Astari, Linda; Anggraeni, Sylvia; Yuri Widia
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.66-72

Abstract

Background: Tinea capitis (TC) is the most prevalent pediatric superficial dermatophyte infection. Scalp dermoscopy or "trichoscopy” represents a valuable, noninvasive technique for the evaluation of patients with hair loss due to TC. Purpose: To characterize trichoscopic findings in children with clinical findings suggestive of TC. Case:  A 13-year-old boy was presented with a scaled plaque on his scalp that had appeared 1 month earlier. A physical examination revealed a scaly, nonerythematous, rounded lesion in the parietal area of the head. Wood's lamp yielded a blue fluorescence. Microscopic morphology from fungal culture found the typical spindle-shaped macroconidia of Microsporum canis. Trichoscopy showed mainly comma hair, corkscrew hair, morse code hair, bent hair, and zig zag hair. The patient was started on oral griseofulvin 20 mg/kg/day and antifungal shampoo for 8 weeks. The patient was cured after two months of treatment and trichoscopy returned to normal. Discussion: Fungal culture remains the gold standard in TC diagnosis, but it needs time. Trichoscopy can be an additional tool to help evaluate the diagnosis, aetiology, and follow up of this disorder. The presence of characteristic trichoscopic features (comma hairs, corkscrew hairs, Morse code-like hairs, zigzag hairs, bent hairs, block hairs, and i-hairs) is predictive of TC. The present analysis confirmed that trichoscopy is a useful method in differentiating between Microsporum and Trichophyton TC, which is important from the perspective of a different therapeutic approach. Conclusion: Trichoscopy is not only of value in the diagnosis of TC but also for the etiologic agent and follow-up after treatment in this case.
Mucocutaneous Manifestations in HIV/AIDS Patients Hidayati, Afif Nurul; Harningtyas, Citra Dwi; Damayanti, Damayanti; Astari, Linda; Indramaya, Diah Mira; Listiawan, M. Yulianto; Utomo, Budi; Budiono, Budiono; Murtiastutik, Dwi; Widyantari, Septiana; Maylita Sari; Astindari, Astindari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.156-161

Abstract

Background: The main target of human immunodeficiency virus (HIV) is cluster of differentiation 4 (CD4) T lymphocytes and several other immune cells that have CD4 receptors. They are also present in skin and mucosa, such as Langerhans cells (LC). Mucocutaneous lesions are one of the first clinical presentations of immunosuppression in HIV seropositive patients that manifest at different stages of the infection and require early diagnosis and prompt treatment. Purpose: To determine the clinical characteristics and the pattern of various mucocutaneous manifestations in Human immunodeficiency virus/Acquired immune deficiency syndrome (HIV/AIDS) patients at Intermediate Care and Infectious Diseases Dr. Soetomo General Academic Hospital Surabaya. Methods: This is a descriptive retrospective study with a cross-sectional design. The study subject was classified as all HIV-AIDS patients with mucocutaneous manifestations treated in Intermediate Care and Infectious Diseases Dr. Soetomo General Academic Hospital Surabaya in 2019. Result: Out of the 614 patients who participated in the study, 72.1% were males. The majority of patients were in the age group 25–49 years (75.4%). The most common risk factor was heterosexuality (41.7%). Based on the distribution of mucocutaneous manifestations, the most common mucocutaneous manifestation was candidiasis mucocutan 387 patients (49.4%) followed by the pruritic papular eruption (PPE) 118 patients (15.1%) and human papillomavirus infection 57 patients (7.3%). Conclusion: Mucocutaneous manifestations occur throughout the course of HIV infection, and they can be considered as good clinical indicators for the progression of the disease and underlying immune status in resource-poor settings.
Clinical and Cure Profile of Tinea Capitis Patients Noviannisa, Farah Ayu; Astari, Linda; Alimsardjono, Lindawati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.86-91

Abstract

Background: Tinea capitis (TC) is a superficial mycoses infection of hair follicles and hair shaft caused by dermatophytes of the genus Trichophyton and Microsporum. Tinea capitis can cause hair loss and scales with varying degrees of inflammatory response. The incidence varies depending on geographical location and factors that affect the incidence rate. It is important to know the incidence also the clinical and cure profile of tinea capitis to provide benefits in the prevention, diagnosis, and treatment. Purpose: To evaluate the clinical and cure profile of TC patients at the Dermatology and Venereology Outpatient Clinic of Dr. Soetomo General Academic Hospital Surabaya from January 2019 to January 2020. Methods: A retrospective descriptive study based on medical records with a total sampling technique. Result: Of the 10 TC patients, who were the research subjects, TC predominantly affected males and at 5–11 years age group. The highest risk factor was a history of contact with cats. Scales were the most common clinical feature. Microsporum canis was the most common causative species, ectothrix arthrospores was revealed during the direct microscopic examination, Wood lamp's fluorescence was mostly yellow-green, and cigarette-shaped hair was the most common dermoscopic finding. Eighty percent of subjects were diagnosed with gray patch type. Conclusion: The diagnosis of TC was established based on the patient's history, clinical examination, and supporting examination.
Pattern of Candida Species Isolated from Patient with Vulvovaginal Candidiasis in Pregnancy Purnamasari, Indah; Ervianti, Evy; Damayanti, Damayanti; Budi Prasetyo; Astari, Linda; Pepy D. Endraswari; Listiawan, M. Yulianto; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.178-183

Abstract

Background: Vulvovaginal candidiasis (VVC) is one of the most prevalent genital tract diseases in women. The identification of the isolated Candida species is critical for guiding empirical antifungal therapy. Purpose: To determine the Candida species that cause vulvovaginal candidiasis in pregnancy at the Obstetrics and Gynecology Outpatient Clinic, Dr. Soetomo General Academic Hospital, thus providing scientific and therapeutic benefits. Methods:  Pregnant woman receiving antenatal care (ANC) at Dr. Soetomo General Academic Hospital Obstetric and Gynecology Outpatient Clinic. Subjects were enrolled in a cross-sectional study during 3 months between March and May 2021. Vaginal swab samples were taken from subjects after informed consent. A specific color change in CHROMagar cultures and VITEK 2 compact were used to identify Candida species. Result: During the study period, 15 pregnant patients were diagnosed with VVC. The majority of the women in the study were pregnant women of sexually active age who complained of a whitish body and genital irritation. There were 18 candida isolates from CHROMagar cultures, with C. non albicans (61.1%) predominating over C. albicans (38.3%). With details, non albicans were C. glabrata (54.4%), C. dubliniensis (36.3%), and C. parapsilosis (18.1%). Conclusion: This study revealed a high prevalence of Candida non-albicans species causing VVC. Culture investigation and identification of Candida are critical to avoid diminished susceptibility to antifungal treatments and recurrence.
The Effects of Hormonal Factor on the Degree of Acne Vulgaris Severity Alarik L., Albertus; Indiastuti, Danti Nur; Astari, Linda; Setyaningrum, Trisniartami
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 2 (2023): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.2.2023.126-129

Abstract

Background: Acne vulgaris is a disease in the form of chronic inflammation of the pilosebaceous follicles with multifactorial causes. Acne vulgaris is a very common skin disease with a prevalence of 85%  in the age range of 18-25 years. There are aggravating factors that can exacerbate acne vulgaris, including hormonal factors. However, the study about how strong the effects of hormonal factors and on acne severity is really limited. Purpose: The objective of this research is to determine how strong hormonal factors contribute on the severity of acne vulgaris. Methods: This was a cross-sectional retrospective study using secondary data obtained from 199 patients at the Dermatology and Venereology Outpatient Unit of RSUD Dr. Soetomo from January- December 2019. The data were analyzed using SPSS with regression analysis.Result: Hormonal factors significantly influenced the degree of acne vulgaris severity (P-value=0.030). Based on the logistic regression model, it can be found that hormonal factors influence the degree of acne vulgaris by 70% Conclusion: The effect of hormonal factors on the severity of acne vulgaris is 70%.
Concordance Test Between Dermoscopic and Histopathological Parameteres in Basal Cell Carcinoma Hartanto, Felix; Kusumaputra, Bagus Haryo; Sari, Maylita; Citrashanty, Irmadita; Mappamasing, Hasnikmah; Astari, Linda; Sandhika, Willy; Hidayati, Afif Nurul; Prakoeswa, Cita Rosita Sigit; Listiawan, Muhammad Yulianto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 1 (2024): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.1.2024.6-11

Abstract

Background: Basal cell carcinoma (BCC) is the most common skin cancer and can cause local tissue damage. BCC can occur in all populations, regardless of skin color. Dermoscopy has compatibility with histopathology in determining the benign or malignant nature of a lesion. Dermoscopy can improve the diagnostic accuracy of BCC by >90%, with 7 parameters that can be found: arborizing vessels, blue-gray ovoid nests, blue-gray dots/globules, maple leaf-like areas, spoke-wheel areas, ulceration, and hiny white areas. Purpose: To assess the compatibility of each dermoscopy parameter with its corresponding histopathological parameters. Methods: Observational analytic study with a cross-sectional approach was performed. Dermoscopy parameters were obtained by reassessing all photographs, while histopathological parameters were obtained from pre-existing slide reviews. Cohen's Kappa test was performed to analyze both variables. Result: A Total of 26 samples met the inclusion criteria. Most BCCs were found in female sex (65.4%), age >50 years (80.8%), and facial location (88.5%). Cohen's Kappa test was significant in 2 out of 7 dermoscopy parameters: "blue-gray ovoid nests" (p = 0.0019; r = 0.458) and "spoke wheel areas" (p = 0.037; r = 0.371). The "shiny white areas” parameter could not be analyzed because there was no negative variation in the examination. The possibility of false positives and negatives could not be ruled out.  Conclusion: Significance between the two variables is found in 28.6% of the 7 parameters analyzed...
Clinical Manifestations and Distribution of Treatment for Pyoderma at a Tertiary Hospital in Surabaya, Indonesia Auliya, Arsya; Astari, Linda; Puspitasari, Dwiyanti; Alinda, Medhi Denisa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 1 (2024): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.1.2024.12-19

Abstract

Background: Pyoderma is a skin disease caused by infection with Gram-positive bacteria. In Indonesia, this disease has a high prevalence due to inadequate sanitation, climate condition, humidity, and high population density. Patients with pyoderma present in diverse range of symptoms, in the form of clinical manifestation or systemic symptoms. Inadequate management of pyoderma can lead to an escalation in morbidity rates. Therefore, it is important to conducting comprehensive research about clinical profile of pyoderma patients. Purpose: To describe the profile of pyoderma patients in Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Acdemic Hospital Surabaya in January 2016 to December 2018. Methods: This study is a retrospective descriptive analysis using secondary data derived from medical records at Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital Surabaya. Result: The analysis of pyoderma patient at Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital Surabaya in January 2016 to December 2018 reveals a total of 407 patients, predominantly male and the most age category were toddlers. Most clinical diagnosis were furuncles and carbuncles. Among the clinical manifestations, macula was the most frequent primary skin lesion, while erosion predominated among secondary lesions. The most commonly administered therapies were systemic and topical antibiotics. Conclusion: In the period from January 2016 to December 2018, clinical manifestations of pyoderma patients at the Dermatology and Venereology Outpatient Unit of Dr. Soeto...
Education and Workshop Improve Healthcare Workers' Knowledge of Laboratory Examination for the Diagnosis of Superficial Dermatomycosis Ervianti, Evy; Astari, Linda; Rahmadewi; Setyaningrum, Trisniartami; Mappamasing, Hasnikmah; Anggraeni, Sylvia; Widia, Yuri; Ngesti Kumalasari, Diah; Axelia, Presstisa Gifta; Hadiwidjaja, Farsha Naufal; Sunarto, Olivia Awwalin; Kathrin Kezia Henry; Sulaksanaswastho Suyoso; Puspowati, Erindah
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 3 (2023): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.3.2023.187-192

Abstract

Background: Superficial dermatomycosis is one of the most prevalent skin diseases worldwide. The diagnosis of  superficial dermatomycosis is established clinically, and supported by several examinations, such as microscopic examination, fungal culture, and Wood's lamp examination for certain species. Purpose: This study is to evaluate the improvement of the knowledge of general practitioners and medical analysts after education and workshop. Methods: This cross-sectional observational study involved 70 subjects, consisting of 35 general practitioners and 35 medical analysts from 35 public health centers in Bojonegoro who were willing to participate in this study. The level of knowledge was assessed before and after the health education on laboratory examination for the diagnosis of superficial dermatomycosis. Result: There was a significant difference in mean scores between the pre-test and post-test after health education (p = <0.001). The mean knowledge score of the pre-test before intervention among general practitioners was 36.57 ± 19.088, which increased to 68.00 ± 13.240, and the mean knowledge score before intervention among analysts was 27.14 ± 13.842, which increased to 62.00 ± 12.078 after health education intervention. Conclusion: Following health education, there was an improvement in the healthcare workers's knowledge of laboratory examinations for the diagnosis of superficial dermatomycosis
Co-Authors Afif Nurul Hidayati, Afif Nurul Alarik L., Albertus Alimsardjono, Lindawati Anggraeni, Sylvia Astindari Astindari, Astindari Aulia, Syifa Auliya, Arsya Axelia, Presstisa Gifta Bagus Haryo Kusumaputra, Bagus Haryo Budi Prasetyo Budi Utomo Budiono Budiono Cita Rosita Sigit Prakoeswa Damayanti Damayanti Diah Mira Indramaya DINAR ADRIATY Dwi Murtiastutik Dwiyanti Puspitasari, Dwiyanti Dyah Ratri Anggarini, Dyah Ratri Evy Ervianti Hadiwidjaja, Farsha Naufal Hari Sukanto, Hari Harningtyas, Citra Dwi Hartanto, Felix Indah Purnamasari Indiastuti, Danti Nur INDROPO AGUSNI Irmadita Citrashanty, Irmadita ISWAHYUDI ISWAHYUDI Kathrin Kezia Henry M. Yulianto Listiawan Mappamasing, Hasnikmah Maylita Sari Maylita Sari, Maylita Medhi Denisa Alinda, Medhi Denisa Meita Ardini Pratamasari, Meita Ardini Ngesti Kumalasari, Diah Noviannisa, Farah Ayu Pepy D. Endraswari Pepy Dwi Endraswari, Pepy Dwi Prakoeswa, Cita Rosita Puspowati, Erindah Rahmadewi Rahmatari, Bandaru RATNA WAHYUNI Sepling Paling Sheilaadji, Maria Ulfa SHINZO IZUMI Siti Kurniawati Sulaksanaswastho Suyoso Sunarto, Olivia Awwalin Trisniartami Setyaningrum Widyantari, Septiana Willy Sandhika Yuri Widia, Yuri