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OVERVIEW CHARACTERISTICS AND P2Y12 REACTIVITY UNIT (PRU) VALUES OF ACUTE CORONARY SYNDROME AGE PRODUCTIVE PATIENTS WITH CLOPIDOGREL THERAPY ., Rahmatini; Aliska, Gestina; Syafri, Masrul
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.612

ABSTRACTBackground: Ischemic heart disease is the leading cause of death and disability in the world with a fairlyhigh portion coming from countries Low- and Middle-Income (LMICs). In Pakistan, 54% patients acutecoronary syndrome (ACS) was resistant to clopidogrel, and no data on clopidogrel resistance on ethnicMinang. This study aims to look at the characteristics and P2Y12 Reactivity Unit (PRU) from ACS patientsin Dr. M. Djamil Hospital, Padang. Methods: This research is a cross sectional study. The effectiveness ofclopidogrel on platelet reactivity identified through examination of PRU value using VerifyNow® with a cutoff point is 208. From the PRU values, it can be classified whether patients resistant or responsive. The studywas conducted in September 2016. Result: From 14 patients with ACS who received clopidogrel, 11 patients(78.57%) are male with 3 female patients (21.43). The mean of age was 53.78 years old. Patients mostlycame from West Sumatra provinces (92,85%) and 7,15% from others. From all of patients head risk factorsof coronary arterial disease. Hipertension was the greatest risk factor. Conclusion: It can be concluded thatmost of the patients were male. From PRU data, 7 patients (50%) were resistant and 7 patients (50%) wereresponse to clopidogrel. Further research is needed with larger numbers of patients and investigatepharmacogenetic profile of CYP2C19 as caused of resistance.

Pengaruh Pemberian Salep Ekstrak Wortel (Daucus carota L.) Terhadap Penyembuhan Luka Bakar Tikus (Rattus novergicus) Pada Fase Proliferasi Kaifa, Anfal; Irrahmah, Miftah; Aliska, Gestina
Archives Pharmacia Vol 3, No 2 (2021): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

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Luka bakar merupakan masalah kesehatan yang serius di dunia. Beberapa tanaman diketahui memiliki potensi untuk menyembuhkan luka, salah satunya adalah wortel (Daucus carota). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak wortel terhadap penyembuhan luka bakar tikus (Rattus novergicus). Jenis penelitian ini dalah penelitian eksperimental dengan rancangan the post test only control group design. Subjek penelitian adalah 18 ekor tikus yang dibagi menjadi tiga kelompok, yaitu kelompok kontrol (K), kelompok perlakuan 1 (P1), dan kelompok perlakuan 2 (P2). Masing-masing kelompok terdiri dari enam (6) ekor tikus. Plat logam (1,5 cm x 1,5 cm) yang dipanaskan digunakan untuk menghasilkan luka bakar pada mencit. Ekstrak wortel 4% diberikan kepada kelompok perlakuan 1 (P1) dan ekstrak wortel 8% diberikan kepada kelompok perlakuan 2 (P2) selama 7 hari. Besar persentase pengerutan diameter luka diukur setiap hari dari hari pertama hingga hari ketujuh. Pada hari ke-7 setelah luka, tikus dieuthanasia untuk diambil jaringan luka, dan dilakukan pemeriksaan secara histopatologi. Hasil penelitian menunjukkan bahwa pemberian salep ekstrak wortel tidak memberikan pengaruh yang signifikan (p > 0,05) terhadap pembentukan jaringan granulasi dan pengerutan diameter luka. Kesimpulan penelitian ini adalah salep ekstrak wortel tidak memberikan pengaruh yang signifikan terhadap penyembuhan luka bakar tikus pada fase proliferasi.

OVERVIEW CHARACTERISTICS AND P2Y12 REACTIVITY UNIT (PRU) VALUES OF ACUTE CORONARY SYNDROME AGE PRODUCTIVE PATIENTS WITH CLOPIDOGREL THERAPY Rahmatini .; Gestina Aliska; Masrul Syafri
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.612

ABSTRACTBackground: Ischemic heart disease is the leading cause of death and disability in the world with a fairlyhigh portion coming from countries Low- and Middle-Income (LMICs). In Pakistan, 54% patients acutecoronary syndrome (ACS) was resistant to clopidogrel, and no data on clopidogrel resistance on ethnicMinang. This study aims to look at the characteristics and P2Y12 Reactivity Unit (PRU) from ACS patientsin Dr. M. Djamil Hospital, Padang. Methods: This research is a cross sectional study. The effectiveness ofclopidogrel on platelet reactivity identified through examination of PRU value using VerifyNow® with a cutoff point is 208. From the PRU values, it can be classified whether patients resistant or responsive. The studywas conducted in September 2016. Result: From 14 patients with ACS who received clopidogrel, 11 patients(78.57%) are male with 3 female patients (21.43). The mean of age was 53.78 years old. Patients mostlycame from West Sumatra provinces (92,85%) and 7,15% from others. From all of patients head risk factorsof coronary arterial disease. Hipertension was the greatest risk factor. Conclusion: It can be concluded thatmost of the patients were male. From PRU data, 7 patients (50%) were resistant and 7 patients (50%) wereresponse to clopidogrel. Further research is needed with larger numbers of patients and investigatepharmacogenetic profile of CYP2C19 as caused of resistance.

Peningkatan Pengetahuan Masyarakat tentang Bahaya Paparan Mikroplastik dan Dampaknya bagi Kesehatan Ilmiawati Ilmiawati; Liganda Endo Mahata; Gestina Aliska; Erlina Rustam; Yusticia Katar; Rahmatini Rahmatini; Julizar Julizar; Elly Usman
Warta Pengabdian Andalas Vol 29 No 3 (2022)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.29.3.305-311.2022

Plastic is a global problem; plastic pollution production reaches 350 million tons annually. This plastic pollution will be degraded into microplastic. This microplastic will pollute the environment and negatively impacted health if exposed too much. Recent research has found microplastics in clothes, toys, and even food. The Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Andalas conducts outreach to the public to enhance the general public's understanding of microplastics and their impact on health. The outreach activity began with filling out a pre-test to assess the public's understanding of microplastics. Followed by education about microplastic exposure, the dangers of microplastics, and education about a healthy lifestyle to reduce sources of microplastic exposure. The event ended with filling out a post-test by participants. Paired t-test analysis on pre-test and post-test data showed an increase in public understanding regarding microplastics, sources of exposure, health impacts and ways to reduce microplastic exposure. Based on these results, it can be concluded that the provision of public service can increase public understanding regarding the sources of microplastics and their impact on health and encourage people to live a healthy lifestyle that minimizes exposure to microplastics.

Edukasi Masyarakat Mengenai Toksikan Abadi (Forever Chemicals) dalam Kosmetik Bersifat Waterproof Ilmiawati Ilmiawati; Liganda Endo Mahata; Gestina Aliska; Rahmatini Rahmatini; Julizar Julizar; Yusticia Katar; Erlina Rustam; Elly Usman
Warta Pengabdian Andalas Vol 30 No 4 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.4.708-714.2023

Per- and poly-fluoroalkyl substances (PFAS) are synthetic chemicals added to cosmetics for their waterproof property to obtain a long-lasting application. PFAS is highly persistent, hence called the forever chemicals. This community outreach was aimed to educate the public on PFAS exposure through waterproof cosmetics and its health implications. Our webinar was attended by 84 people, 50 of whom responded to the pre-and post-test. An expert delivered the presentation of the educational content. There was an increase in attendees’ test scores from 56.4±21.3 to 88.4±19.0 (mean±SD; paired t-test, p<0.05). The webinar improved attendees’ knowledge of PFAS exposure from waterproof cosmetics and its potential effects on health.

Ototoksisitas akibat Penggunaan Cisplatin dan Pendekatan Otoprotektif untuk Pencegahannya Rizki Saputra; Rossy Rosalinda; Sukri Rahman; Gestina Aliska
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 2 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v2i1.36

Latar Belakang: Peningkatan secara statistik angka harapan hidup pasien kanker setelah diterapi membuat pemantauan efek samping jangka panjang kemoterapi sangat dibutuhkan. Cisplatin menjadi agen kemoterapi pilihan pada kanker kepala dan leher karna sifatnya yang sangat poten. Bertentangan dengan manfaat terapiutik tersebut, pemakaian cisplatin memiliki potensi masalah ototksik yang dapat menyebabkan gangguan pendengaran. Tujuan: Untuk mengetahui dan memahami mekanisme ototoksisitas akibat penggunaan cisplatin dan upaya otoprotektif. Tinjauan Pustaka: Sebagai agen kemoterapi, cisplatin memiliki beberapa efek samping salah satunya bersifat ototoksik. Mekanisme ototoksik akibat cisplatin dihubungkan dengan pembentukan radikal bebas yang menyebabkan apoptosis pada sel rambut luar koklea dan jaringan penunjang di organ Corti. Pasien yang menerima pengobatan cisplatin harus dilakukan evaluasi fungsi pendengaran secara berkala. Sampai saat ini belum ada obat-obatan yang menjadi pilihan utama dalam upaya preventif ototoksik akibat cisplatin. Penggunaan obat golongan seperti N-asetilsistein, sodium tiosulfat, vitamin E, amifostin membuka harapan untuk pengembangan terapi preventif ototoksik. Kesimpulan: Efek samping ototoksik yang ditimbulkan merupakan salah satu masalah yang harus ditatalaksana. Monitoring pendengaran dibutuhkan untuk mendeteksi pemasalahan ini. Beberapa agen otoprotektif seperti antioksidan dan kortikosteroid dapat menjadi pilihan tatalaksana dalam upaya preventif. Pemberian agen otoprotektif secara sistemik dan intratimpani memiliki kelebihan dan kekurangan dalam penggunaannya. Kata kunci: ototoksik, cisplatin, preventif, intratimpani

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