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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Dentika Dental Journal Althea Medical Journal Global Medical and Health Communication Journal of Medicine and Health Medika Kartika : Jurnal Kedokteran dan Kesehatan
Andri Rezano
Department Of Biomedical Sciences, Division Of Cell Biology, Faculty Of Medicine, Universitas Padjadjaran, Bandung
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : International Journal of Integrated Health Sciences

 1 
Association of Ki-67 Expression and Response of Neoadjuvant Chemotherapy in Invasive Breast Cancer Patients in Bandung Andri Rezano; Chen En Pan; Afrida Aizzatun Istiqomah; Almira Zada
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1663.038 KB) | DOI: 10.15850/1374

Abstract

Objective: To analyze the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer.   Methods: A retrospective observational study on the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer was conducted. This study included twenty-five female patients with invasive breast cancer who met the inclusion criteria. Parameters analyzed were age, tumor size, and immunohistochemical expression of Ki-67. Size of the tumor at pre- and post-neoadjuvant chemotherapy were obtained in cm3 and compared between 3 groups of Ki-67 expression levels. One way ANOVA was used to perform the statistical analysis. Results: A significant difference in changes of tumor size for Ki-67 level >20% compared to <14% and 14–20% was seen. Based on the result, neoadjuvant chemotherapy was proven to have similar effects in patients with Ki-67 expression of <14% and 14–20% but less effective in patients with Ki-67 expression of >20%. Conclusions: Low to modest expression of Ki-67 was a better biomarker to predict the response of neoadjuvant chemotherapy in patients with invasive breast cancer compared to high expression of Ki-67. However, the cut-off value of 20% could be ideal to predict the outcome of neoadjuvant chemotherapy in patients with invasive breast cancer. DOI: 10.15850/ijihs.v6n2.1374
Co-Authors . Vitriana Achadiyani Afrida Aizzatun Istiqomah Agustinus Agustinus Almira Zada Ananda Hanifah Husna Ardella Tri Novianti Asep Wiryasa Chen En Pan Chrestella Odillia Christian Christopher Sunnu Dahlan, Mohamad Rinaldi Diah Dhianawaty Endry Septiadi Eni Maria Sisca Erlangga Ing Geni Bisma Pratama Hansen Wangsa Herman Herry Herman Hesti Lina Wiraswati I'tishom, Reny Irma Ruslina Jefry Albari Tribowo Juanarta, Pieter Kiki A. Rizki Latifah Rahman Nurfazriah Liana Awalia Lutfunnisa Maharani Simanjuntak Maitra Djiang Wen Marhendra Satria Utama Maulida Hayati Melia Juwita Adha Mohamad Rinaldi Dahlan Monica Risnadena Priyas Moniq W. Aryantie Nabila Alifia Ahmad Nadiyah Nadiyah Ninik Darsini Nur Agustina Ningsih Nurul Mufliha Patahuddin Pakpahan, Cennikon Pieter Juanarta Pitaloka, Pritha Praditya Virza Ramadhan Qhonita Anif Febian Ramadhan, Praditya Virza Ria Margiana Ria Margiana Rina Puspasari Herdiawan Riyadi Adrizain Riyadi Adrizain Rizqy D. Monica Savira Ekawardhani Siti Silvia Nur Shofa Shamantri Sudigdo Adi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Supardi Supardi Supardi Supardi Tiara Kirana Veronica Oladitha Siagian Vita Murniati Tarawan Widya Juwita Windi Nurdiawan Wiryawan Permadi Wiryawan Permadi Yenni Zuhairini Yosefa Resti Radinda