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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Widya Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan Indonesian Journal of Pharmaceutical Education Jurnal Kesehatan Terpadu Benzena Pharmaceutical Scientific Journal
Putu Yudhistira Budhi Setiawan
Universitas Bali Internasional
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : Medfarm: Jurnal Farmasi dan Kesehatan

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% DAUN SAMBILOTO (Andrographis paniculata (Burm.f.) Nees TERHADAP Propionibacterium acnes I Putu Gede Adi Purwa Hita; Putu Yudhistira Budhi Setiawan; I Gusti Septiari; I Gusti Ngurah Agung Windra Wartana Putra
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 1 (2022): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v11i1.76

Abstract

Background: Acnes vulgaris is a skin disease that can reduce self-confidence in adolescence and adulthood. This disease can be caused by infection with Propionbacterium acnes bacteria and treatment of this disease using antibiotics causes a lot of resistances. One alternative that can be developed to overcome this problem is the use of herbal medicines. Objective: To determine the antibacterial activity of 96% ethanol extract sambiloto leaf (Androgaphis paniculata (Burm.f.) Nees) in inhibiting the growth of Propionbacterium acnes bacteria. Method: The maceration method was used in the preparation of extracts and a qualitative test of active compounds was carried out. The antibacterial activity test was carried out using the disc diffusion method. Results: Qualitatively identified in the extract contains several active compounds like alkaloids, flavonoids, tannins, triterpenoids and saponins. 96% ethanol extract of sambiloto leaf with concentrations of 25, 50, 75, and 100% w/v had antibacterial activity against Propionibacterium acnes, indicated by the diameter of the inhibition zone at each concentration. Conclusion: 96% ethanol extract of sambiloto leaf (Andrographis panuculata (Burm.f.) Nees) has antibacterial activity against the growth of Propionibacterium acnes bacteria where the category of strong antibacterial activity was found in samples with concentrations of 75 and 100% w/v with the diameter of the inhibition zone formed respectively 11.26±0.44 mm and 16.52 ± 1.33 mm. Keywords: Andrographis paniculata (Bum.f.) Nees, antibacterial, disc diffusion, 96% ethanol extract, Propionibacterium acnes
Co-Authors Ahmad Fudholi Ahmad Fudholi Darmayanti, Ni Putu Ovy I Gusti Lanang Made Rudiartha I Gusti Ngurah Agung Windra Wartana Putra I Gusti Septiari I Putu Gede Adi Purwa Hita Ni Putu Juli Martasari Ni Putu Rahayu Martini Ni Wayan Yuliasih Putri, Dhiancinantyan Windydaca Brata Satibi Satibi Satibi Satibi Wartana Putra, I Gusti Ngurah Agung Windra