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The Effect of Pagoda Leaves Extracts on the Level of IL-6 of Female Rats Induced by Staphylococcus aureus Ibrahim, Fitriana; Prihantono, Prihantono; Ahmad, Mardiana; Siagian, Nurul Aini
Health Notions Vol 2 No 5 (2018): May 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.333 KB)

Abstract

The extract of Pagoda leaves can play roles as an anti-inflammatory, antioxidant, and antibacteria. Interleukin 6 (IL-6 henceforth) is the primary mediator in responding to the inflammation, while mastitis is caused by bacteria often found in the increased level of IL-6. This research aimed to unveil the effect of giving the extracts of Pagoda leaves on the level of IL-6 of female rats (Sprague dawley therefore) induced by staphylococcus aureus bacteria. This true experimental research employing pre- and post-test control design used eighteen rats chosen randomly. All rats were divided into three groups, namely negative control (placebo), positive control (amoxicillin 9.6 mg/ml/kgBB/hari/oral) and treatment group (amoxicillin 9.6 mg/ml/KgBB + EDP 50 mg/ml/KgBB/hari/oral). All groups were induced by S.aureus 0.2x108 CFU. Treatment was given for five days. Investigating the level of IL-6 was done using ELISA method. The data were anaylized using ANOVA formula followed by post hoc. The empirical findings showed that there was a difference in terms of the level of IL-6 in all of the groups ±24 before and after the induction of S.aureus. The result of investigating the level of IL-6 in the post-test was significant (ρ = 0.00), meaning that there was a significant difference, in which the negative control group, the level of IL-6 was insacalating; while it was dipping in both the positive and treatment groups. However, the treatment group experienced the most significant drop in terms of the level of IL-6. It can be concluded that Pagoda leaves can be used as a complementary therapy for mastitis illness caused by the S.aureus bacteria.
PERBANDINGAN EFEKTIFITAS KOMPRES AIR HANGAT DAN KOMPRES ALOE VERA TERHADAP PENURUNAN SUHU TUBUH PADA ANAK DEMAM DI PUSKESMAS DELI TUA KEC. DELI TUA KAB. DELI SERDANG TAHUN 2020 Siagian, Nurul Aini; Yanti, Mutiara Dwi; Manalu, Andayani Boang; Hikmah, Khairatul
JURNAL ILMIAH DHDT - KEBIDANAN Vol 3 No 2 (2021): Jurnal Penelitian Kebidanan & Kespro
Publisher : Fakultas Kebidanan Institut Kesehatan Deli Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpk2r.v3i2.674

Abstract

Demam adalah kondisi yang sering terjadi di kehidupan sehari-hari, semua orang pernah mengalami demam khususnya anak-anak yang imunitasnya rentan terhadap penyakit. Data di Puskesmas Deli Tua Kecamatan Deli Tua Kabupaten Deli Serdang dari bulan Januari hingga bulan November 2019, terdapat 2.758 penyakit dengan gejala awal demam seperti typoid, Infeksi Saluran Nafas Akut (ISPA), dan Dengue Fever (DH). Penelitian ini bertujuan untuk perbandingan efektifitas kompres air hangat dan aloe vera terhadap penurunan suhu tubuh anak yang menderita demam di Puskesmas Deli Tua. Jenis penelitian kuntitatif dengan metode quasi ekperimen dan dengan desain pre-test dan post-test dua perbandingan perlakuan. Populasi ialah seluruh anak yang mengalami demam di Puskesmas Deli Tua sebanyak 30 orang. Pengambilan sampel menggunakan tenik purposive sampling, dan sampel terbagi menjadi 2 kelompok masing-masing tediri dari 6 anak. Analisis data dengan uji T dependen dan uji T independen. Hasil analisis mengindikasikan bahwa rerata penurunan tubuh suhu dengan kompres air hangat yaitu 36,733ºC dan aloe vera reratanya 37,983ºC (0,001<0,05). Saran untuk pihak pelayanan kesehatan bahwa hasil ini diaplikasikan dalam pengobatan komplementer yang mudah dan bermanfaat untuk mengatasi demam.
The Effect of Pagoda Leaves Extracts on the Level of IL-6 of Female Rats Induced by Staphylococcus Aureus Fitriana Ibrahim; Prihantono Prihantono; Mardiana Ahmad; Nurul Aini Siagian
Health Notions Vol 2, No 5 (2018): May
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.333 KB) | DOI: 10.33846/hn.v2i5.193

Abstract

The extract of Pagoda leaves can play roles as an anti-inflammatory, antioxidant, and antibacteria. Interleukin 6 (IL-6 henceforth) is the primary mediator in responding to the inflammation, while mastitis is caused by bacteria often found in the increased level of IL-6. This research aimed to unveil the effect of giving the extracts of Pagoda leaves on the level of IL-6 of female rats (Sprague dawley therefore) induced by Staphylococcus aureus. This true experimental research employing pre-test and post-test control design used eighteen rats chosen randomly. All rats were divided into three groups, namely negative control (placebo), positive control (amoxicillin 9.6 mg/ml/kgBB/hari/oral) and treatment group (amoxicillin 9.6 mg/ml/KgBB + EDP 50 mg/ml/KgBB/hari/oral). All groups were induced by S.aureus 0.2x108 CFU. Treatment was given for five days. Investigating the level of IL6 was done using ELISA method. The data were anaylized using ANOVA formula followed by post hoc. The empirical findings showed that there was a difference in terms of the level of IL-6 in all of the groups ±24 before and after the induction of S.aureus. The result of investigating the level of IL-6 in the post-test was significant (ρ = 0.00), meaning that there was a significant difference, in which the negative control group, the level of IL-6 was insacalating; while it was dipping in both the positive and treatment groups. However, the treatment group experienced the most significant drop in terms of the level of IL-6. It can be concluded that Pagoda leaves can be used as a complementary therapy for mastitis illness caused by the S.aureus bacteria. Keywords: Interleukin 6, Mastitis, Pagoda leaves, Staphylococcus Aureus
The Effect Of Pagoda Leaf Extract (Clerodendrum Paniculatum L) On The IL-10 Level In Mammae Of Female Rats Strain (Sprague Dawley) Induced With Staphylococcus Aureus Bacteria Israini Suriati; Mardiana Ahmad; Nurul Aini Siagian; Prihantono Prihantono
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 1 (2019)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (127.335 KB) | DOI: 10.30651/jqm.v3i1.1865

Abstract

ABSTRACTMastitis is an infectious disease problems of found in breast feeding usually caused by Staphylococcus aureus. When Staphylococcus aureus bacteria enters the body’s tissues, IL-10 immune will active helped prevent cell broken. The immune system will get worse if there is no treatment. So that it takes complementary therapies like pagoda leaves, The content of the pagoda contains tannins, alkaloids and flavonoids, where is this compound can to improve immune system. This study aims to determine the effect of pagoda leaf extract on IL10 levels in rats induced by Staphylococcus aureus bacteria. The type of research used in this study is true experimental with pre and posttest control design. The use of 15 Sprague Dawley strain rats divided into 3 groups: 5 negative control groups (aqua pro injections 1ml/gramBB) five  tails were all given standard feed,  positive control group (Amoxicilin with 9.6ml / 250gramBB ) five tails were all given standard feed, and treatment group (Amoxicilin 9.6ml / 250gramBB plus pagoda leaf extract 50ml/250gramBB) five tails were all given standard feed. All groups were induced bacteria Staphylococcus aureus  (0,2 mlx108ml/CFU). IL-10 levels were examined using the R & D method of the Enzyme Linked Immonosorbent Assay (ELISA) Rat system. Data analysis used ANOVA + post hoc test, with a significant value ρ ≤ 0, 05. This study showed no difference in levels of IL10 cytokines, before induced Staphylococcus aureus bacteria in all groups with values (ρ> 0.05). Whereas after the treatment was given, the value of ρ <0.05) between all groups showed that there was a difference in IL10 levels after treatment between all groups. In the negative control group, IL10 experienced a decrease (mean ± 10.4 pg / ml). While the increase in IL-10 levels was greater in the treatment group (mean ± 58.4 pg / ml), compared to the positive group (mean ± 41.8 pg / ml). The conclusion in this study is that pagoda leaf extract (Clerodendrum Paniculatum L) has an influence in increasing IL-10 levels as an anti-inflammatory. Pagoda leaf extract can be used as a complementary therapyKeywords                    : Staphylococcus aureus , IL-10, Ekstrak Daun PagodaCorrespondence          : israinisuriati@yahoo.com.AbstrakMastitis adalah masalah penyakit infeksi yang ditemukan pada ibu menyusui yang biasanya disebabkan oleh Staphylococcus aureus. Ketika bakteri Staphylococcus aureus masuk ke jaringan tubuh, kekebalan IL-10 akan aktif membantu mencegah sel- sel rusak. Sistem imun akan memburuk jika tidak ada penanganan. Sehingga dibutuhkan terapi komplementer seperti tanaman daun pagoda, kandungan dari tanaman daun pagoda terdiri dari tannins, alkaloids and flavonoids, di mana senyawa ini dapat meningkatkan sistem kekebalan tubuh. Jenis penelitian yang digunakan dalam penelitian ini adalah true experimental dengan rancangan pre dan posttest control design. Yang menggunakan tikus strain Sprague Dawley sebanyak 15 ekor yang dibagi dalam 3 kelompok yaitu kelompok kontrol negatif (aqua pro injections) sebanyak 5 ekor  semuanya  diberikan  pakan  standar,  kelompok  kontrol  positif (Amoxicilin dengan dosis 9,6ml/250gramBB) sebanyak 5 ekor semuanya  diberikan  pakan standar, dan kelompok perlakuan (Amoxicilin 9,6ml/250gramBB ditambah dengan ekstrak daun pagoda (50ml/250gramBB) 5 ekor semuanya diberikan pakan standar. Semua kelompok diinduksisikan bakteri Staphylococcus aureus 0,2 ml/CFU. Pemeriksaan kadar IL-10 menggunakan metode R & D system Enzyme Linked Immonosorbent Assay (ELISA) Rat. Analisis data menggunakan uji ANOVA + post hoc, dengan nilai signifikan ρ ≤ 0, 05. Penelitian ini menunjukkan tidak ada perbedaan kadar sitokin IL-10, sebelum diinduksikan bakteri Staphylococcus aureus pada semua kelompok dengan nilai (ρ > 0,05).. Sedangkan setelah diinduksikan bakteri Staphylococcus aureus ± 24 jam semua kelompok mengalami penurunan kadar IL10 dengan nilai (ρ > 0,05). Setelah diberikan treatment diperoleh nilai ρ < 0,05) antara semua kelompok hal ini menunjukkan ada perbedaan kadar IL-10 setelah diberikan treatment antara semua kelompok. Pada kelompok kontrol negatif kadari IL-10 mengalami penurunan (rerata ± 10,4 pg/ml). Sedangkan peningkatan kadar IL-10 lebih besar pada kelompok perlakuan (rerata ± 58.4 pg/ml), dibandingkan pada kelompok positif (rerata ± 41.8 pg/ml ). Kesimpulan dalam penelitian ini adalah ekstrak daun pagoda (Clerodendrum Paniculatum L) memiliki pengaruh dalam meningkatkan kadar IL-10 sebagai anti-inflamasi. Ekstrak daun pagoda dapat dijadikan terapi komplementer.Kata kunci        : Staphylococcus aureus, IL-10, Ekstrak Daun PagodaKorespondensi : israinisuriati@yahoo.com.  
PENGARUH RANGSANGAN PUTING SUSU TERHADAP WAKTU KELAHIRAN PLASENTA PADA IBU BERSALIN KALA III DI KLINIK MENTA KECAMATAN PATUMBAK KABUPATEN DELI SERDANG TAHUN 2019 Andayani Boang Manalu; Puspa Niat Putri Halawa; Nurul Aini Siagian
Jurnal Penelitian Kesmasy Vol 2 No 1 (2019): Jurnal Penelitian Kesmasy
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Deli Husada Delitua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpksy.v2i1.174

Abstract

Nipple stimulation is an action or treatment given to the nipples in the form of subtle stimulation in the palmar part of the fingers which are carried out alternately which produce the hormone oxytocin naturally, causing the uterus to contract which can prevent postpartum bleeding and accelerate the process of releasing the placenta. This study aims to determine the effect of nipple stimulation on the time of birth of the placenta in the third maternity period. The method used is a quasi-experimental method with a sample of 20 respondents taken by accidental sampling technique. Data analysis using bivariate analysis with t-test independent test statistic. The results showed that the average birth time of placenta in mothers given nipple stimulation was 5.23 minutes, while those not given nipple stimulation 7.02 minutes. Based on the statistical test, it was found that there was an effect of nipple stimulation on the birth time of the placenta in the third stage of maternity with a value of ρ Value 0.002. Suggestions in this study are expected in the management of active management in the third stage to provide stimulation of the nipples to accelerate the birth process of the placenta.
PERBANDINGAN EFEKTIFITAS KOMPRES AIR HANGAT DAN KOMPRES ALOE VERA TERHADAP PENURUNAN SUHU TUBUH PADA ANAK DEMAM DI PUSKESMAS DELI TUA KEC. DELI TUA KAB. DELI SERDANG TAHUN 2020 Nurul Aini Siagian; Andayani Boang Manalui; Mutiara Dwi Yanti; Khairatul Hikmah
JURNAL ILMIAH DHDT - KEBIDANAN Vol 3 No 2 (2021): Jurnal Penelitian Kebidanan & Kespro
Publisher : Fakultas Kebidanan Institut Kesehatan Deli Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpk2r.v3i2.645

Abstract

Fever is a condition that is often encountered in everyday life, everyone has experienced fever, especially in children whose bodies are still susceptible to disease. Data at Puskesmas Deli Tua Kec. Deli Tua Kab. Deli Serdang from January to November 2019, there were 2,758 diseases with early symptoms of fever such as typoids, Acute Respiratory Infection (ISPA), and Dengue Fever (DH). This study aimed to determine the comparison of the effectiveness of warm water compresses and aloe vera compresses on reducing body temperature of fever children at Deli Tua Health Center. This study is quantitative research with a quasi-experimental method and uses a pre-test-post-test design with two comparison treatments. This study used population of 30 fever children in Deli Tua Health Center. Sample divided in 2 groups of 6 people each, used a purposive sampling method. Data analyzed by dependent T test and independent T test. The results showed that there was a comparison of the effectiveness of decreasing body temperature, the mean of warm compresses was 36.733°C and aloe vera was 37.983°C (0.001<0.05). Suggestions for health services from this research can be used as an easy and beneficial complementary medicine for children with fever.
THE EFFECT OF GIVING TOMATO JUICE IN REDUCING CHOLESTEROL LEVELS ON MENOPAUSE IN BPM NURUL UMAIRA TITI PAPAN, MEDAN DELI DISTRICT Husna Sari; Erlina Hayati; Septa Dwi Insani; Nurul Aini Siagian
JURNAL ILMIAH DHDT - KEBIDANAN Vol 4 No 2 (2022): Jurnal Penelitian Kebidanan & Kespro
Publisher : Fakultas Kebidanan Institut Kesehatan Deli Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpk2r.v4i2.843

Abstract

Cholesterol is a fatty substance in the blood that is needed by the body for the formation of cell walls. Excessive fat can cause coronary heart disease which occurs in the elderly, especially in women who have passed menopause due to a decrease in the activity of the hormones estrogen and progesterone which has an impact on increasing cholesterol levels in the body. One non-pharmacological treatment is to consume tomato juice.This Research Objective To determine the effect of giving tomato juice on reducing cholesterol levels in menopause at BPM Nurul Umaira Titipapan, Medan Deli District. The Research method is a Quasi-experimental design with a pre-post test design. The study was conducted in February-May 2021. The population of this study was menopause who did cholesterol checks at BPM Nurul Umaira Titi papan, Medan Deli District. The sample is 15 people, by Total sampling. The independent variable is menopause, the dependent variable is the cholesterol levels of menopause. The research instrument used an Observation Sheet. Processing of statistical test data Sample T-Test. Research results are showing the difference between pre and post-giving tomato juice obtained an average value of 4.667 with Std. Deviation 41,593 with 95% CI 1,367-28,700. The results of the Independent t-Test to determine the difference in the average value of blood cholesterol levels between the intervention group and the control group obtained a p-value of 0.001 (p<0.05). meaning that there is an effect of giving tomato juice to lower blood cholesterol levels. Conclusion: It can be concluded that tomato juice can help lower blood cholesterol levels in menopause
HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA Nurul Aini Siagian; Syafira Nusaibah; Andayani Boang Manalu
Jurnal Penelitian Keperawatan Medik Vol 2 No 1 (2019): Jurnal Penelitian Keperawatan Medik
Publisher : Fakultas Keperawatan Institut Kesehatan Deli Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpkm.v2i1.128

Abstract

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.
PENGARUH TEKNIK MASSAGE BACK-EFFLEURAGE TERHADAP PENGURANGAN RASA NYERI PERSALINAN KALA I DI KLINIK BERSALIN KURNIA KECAMATAN DELITUA KABUPATEN DELI SERDANG Suriani Suriani; Ela Nuraini; Nurul Aini Siagian
Jurnal Penelitian Keperawatan Medik Vol 2 No 1 (2019): Jurnal Penelitian Keperawatan Medik
Publisher : Fakultas Keperawatan Institut Kesehatan Deli Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpkm.v2i1.130

Abstract

This study aims to determine the effect of Back-Effleurage Massage Technique on Reduction of First-Stage Labor Pain in Kurnia Maternity Clinic, Delitua District, Deli Serdang Regency. This study uses a Quantitative Analytical Method with a Quasy-Experimental research design with the One Group Pretest-Posttest approach. Data collection techniques using observation sheets. This Back-Effleurage Massage Technique is carried out for 20 minutes/hour during a contraction. The population in this study were 25 pregnant women entering Trimester III. The sampling technique used is the Total Sampling Method. Data analysis using Paired Sample T Test. The results of this study were obtained that the administration of Back-Effleurage Massage Technique on the abdomen at the Kurnia Maternity Clinic can reduce labor pain from mothers who experience moderate pain to mild pain and mothers who experience severe pain to moderate pain. It can be concluded that there is a significant effect with the giving of the Back-Effleurage Massage Technique on the reduction of Stage I labor pain.
PENGARUH PEMBERIAN KOMPRES KOL TERHADAP PENURUNAN PEMBENGKAKAN PAYUDARA PADA IBU POST PARTUM DI KLINIK BERSALIN KASIH IBU DELI TUA KABUPATEN DELI SERDANG TAHUN 2019 Putri Ayu Yessy Ariescha; Andayani Boang Manalu; Nurul Aini Siagian; Mutiara Dwi Yanti; Rehulina Tarigan
JURNAL KEBIDANAN KESTRA (JKK) Vol 2 No 2 (2020): Jurnal Kebidanan Kestra (JKK)
Publisher : Fakultas Kebidanan Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.081 KB) | DOI: 10.35451/jkk.v2i2.345

Abstract

One of common problems associated with breastfeeding is breast engorgement. This breast swelling can cause the mother to stop breastfeeding. This study aims to determine the effect of cabbage compresses on reducing breast engorgement in postpartum mothers at Kasih Ibu Primary Clinic in Deli Tua in 2019. The research used quasi-experimental, one-group pretest-posttest method design. The sampling technique used convenience sampling to recruit 30 postpartum mothers who had breast engorgement. The instrument used to measure breast swelling was the breast engorgement assessment scale of Hill and Hummenick which consisting of a scale of 1 to 6. Application of cabbage compresses was done by attaching cabbage to the breast until the cabbage withers. This procedure was repeated four times every 6 hours per day, for 2 days. The results of the study showed that at the time before being compressed all the research subjects had a score of 4. On the 1st day of compressing with cabbage leaves, there were 7 people (23.3%) who had decreased breast swelling and on the 2nd day of compressing, the total postpartum mothers experienced a decreased in breast engorgement was 9 people (30%). Statistical analysis by paired t-test obtained the value of p = 0.001 (p <0.05). Thus, the results of this study concluded that there was a significant influence of cabbage compresses to decrease breast engorgement of the postpartum mothers at Kasih Ibu Primary Clinic in Deli Tua in 2019.