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Paediatrica Indonesiana

paediatrica-indonesiana
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Published by Ikatan Dokter Anak Indonesia

ISSN : 00309311 EISSN : 2338476X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.

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Articles 1,955 Documents

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Preoperative intralesional injection of triamcinolone acetonide for a large head and neck lymphangioma in a baby: a case report Julius July; Sophie Peeters
Paediatrica Indonesiana Vol 57 No 5 (2017): September 2017
Publisher : Indonesian Pediatric Society

Lymphangiomas (LMs) are uncommon congenital malformations of the lymphatic system, with an estimated incidence of one in 2,000 to 4,000 live births.1 About half of these lesions are diagnosed at birth, and by two years of age, 90% of those with lesions have been diagnosed.2 Histologically, LMs are benign lesions; however, they can pose a serious threat to the patient due to possible growth into surrounding structures, sometimes causing life-threatening complications. Treatment of large head and neck lymphangiomas in young infants is very challenging, due to the risk of surgical complications. Further challenges include the limited volume of blood loss that infants can tolerate, the lack of the option for radiotherapy or radiosurgery, and the high chance of life-threatening complications if the LM is not treated. Here, we report a case of a two-month-old baby girl presenting with a large head and neck lymphangioma. She was successfully treated with intralesional triamcinolone acetonide injections, followed by surgical resection of the lesion.

Comparison of monotherapy effect of phenytoin, carbamazapine and valproic acid in pediatric general tonic clonic and partial epilepsy Muchamad Budi Nugroho; E. S. Herini; Sunartini Sunartini
Paediatrica Indonesiana Vol 48 No 1 (2008): January 2008
Publisher : Indonesian Pediatric Society

Background Problems on epilepsy do not only depend on thedisease itself but also on management and drug regimens. Drugselection is very important to yield optimal treatment effect andto prevent side effects due to long-term therapy.Objective To determine whether there are any different effectsof monotherapy of phenytoin, carbamazapine, and valproic acidon pediatric general tonic clonic and partial epilepsy.Methods We conducted a historical cohort study on one monthuntil 18-years old children diagnosed as general tonic clonic orparsial epilepsy treated with phenytoin, carbamazapine, or valproicacid routinely for more than two years in Sardjito Hospital fromJanuary 2000 until May 2007. The sample size of each group was41. The main outcome was the time of 12-month remission,whereas the secondary outcomes were withdrawal from treatment,time to remission, side effects and cure rates.Results Valproic acid increased the possibility to achieve 12-monthremission (RR 2.66; 95%CI 1.06;6.65) compared to phenytoin,whereas carbamazapine did not (RR 1.47; 95%CI 0.66;3.28).Survival analysis showed that valproic acid was better thancarbamazapine (P=0.042) and phenytoin (P=0.007). There wereno significant differences among groups in the result of withdrawalfrom treatment, time to remission, and cure variables. The sideeffects of valproic acid seemed less than those of others.Conclusions Valproic acid increases the possibility of 12-monthremission compared to carbamazapine and phenytoin asmonotherapy in pediatric general tonic clonic and partial epilepsywithout increasing side effects. Carbamazapine has similar effectsof therapy to phenytoin.

Effect of intravenous gentamicin on urinary calcium excretion in newborns Kurniawan Tan; Adrian Umboh; Ari Runtunuwu
Paediatrica Indonesiana Vol 55 No 4 (2015): July 2015
Publisher : Indonesian Pediatric Society

Background Studies in newborns and animals have shown that gentamicin increases urinary calcium excretion. New recommendation for gentamicin in newborns is administered intravenously 36-48 hourly. Subsequent to this new recommendation, there have been no further studies on the effects of extended gentamicin dosage on urinary calcium excretion in newborns.Objective To assess the effect of intravenous gentamicin on urinary calcium excretion in newborns.Methods This pretest â€“ posttest study was done in the Neonatology Division of Prof. DR. R. D. Kandou Hospital, Manado, from August to November 2013. Subjects were full-term newborns who received intravenous gentamicin every 36 hours and whose parents provided informed consent. We excluded newborns with asphyxia and cardiovascular shock, also those who received diuretics or steroids. Urine spot collection was done before, after the first dose, and after the second dose of intravenous gentamicin. Urinary calcium and creatinine levels were measuerd. Urine calcium excretion was defined as the ratio of urinary calcium to creatinine level.Results Of 28 newborns, there were 16 males and 12 females. The median of urine calcium creatinine ratio before intravenous gentamicin was 0.021 (range 0.004 to 0.071) mg/mg. After first dose of gentamicin, the median ratio was 0.043 (range 0.009 to 0.156) mg/mg, and after the second dose of gentamicin, the median ratio was 0.144 (range 0.015 to 1.160) mg/mg.Conclusion There is a significant increase in urinary calcium excretion after the first and second doses of intravenous gentamicin. Furthermore, a cumulative effect of gentamicin on urinary calcium excretion is observed after the second dose.Â

Assessment of health-related quality of life in children with cancer using PedsQLâ„¢ (a preliminary study) lvony Yuyu Susanto; Soedjatmiko Soedjatmiko; Sukman Tulus Putra
Paediatrica Indonesiana Vol 49 No 6 (2009): November 2009
Publisher : Indonesian Pediatric Society

Background Cancer in children can adversely affect theirdevelopments and growth. The assessment of health-relatedquality of life (HRQL) will justifY its physical and psychologicaleffects.Methods Seventy-seven subjects who underwent therapy wereassessed using the PedsQLâ„¢, which consisted of parent-proxyreports and or child-self reports. PedsQLâ„¢ is assessments ofphysical, social, emotional and role functions. The controlgroup was students with the same number and age as the sample group.Results Children with cancer had lower HRQL than normalhealthy children (odds ratio 3. 7). Children with cancer who camefrom low socio-economic families had lower social functions andgirls had tendencies to have lower quality oflife. Fathers' education had strong influence in children's quality of life. Leukemic patients had better quality of life than those of lymphoma and solid organ tumor. Group with age of diagnosis at 6-9 year old had lower HRQL compared with younger or older groups. The longer period of illness was, the more emotional function would improved. Despite of a good accordance between parents' and child's reports, parents usually had reports about having lower quality of life.Conclusions Children's HRQL is influenced by clinicalcharacteristics and social-demographic variables differently.Assessment of the children's HRQL is better done with parentsand or child as the source of information.

Multidrug resistance in the neonatal unit and its therapeutic implications Rinawati Rohsiswatmo
Paediatrica Indonesiana Vol 46 No 1 (2006): January 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.1.2006.25-31

Background Neonatal septicemia constitutes an important causeof morbidity and mortality among neonates in Indonesia. The ex-cessive use of antibiotics may cause antibiotic resistant bacteriaand may cause neonatal fungal infection.Objective To investigate the spectrum of organisms which causeneonatal sepsis and assess their sensitivity to various groups ofdrugs in the neonatal unit.Methods A prospective study conducted on newborn babies de-livered in Cipto Mangunkusumo Hospital, Jakarta from July 2004-May 2005 who presented clinical signs of septicemia were sub-jected for blood culture. Those sensitive to antibiotics for 7 daysyet showed no clinical improvement were also cultured for fungi.Results A total of 499 blood cultures were taken, 320 were posi-tive for bacteria (positivity rate was 65.3%). There were 192 samplescultured for fungi, and the positivity rate was 64% (all for Candidasp). Acinetobacter calcoaceticus was the most common bacteriafound (35.7%), followed by Enterobacter sp (7.0%), and Staphylo-coccus sp (6.8%). Most bacteria showed high degrees of resis-tance to commonly used antibiotics (ampicillin and gentamicin).There were also high degrees of resistance to cephalosporins byboth Gram negative and Gram positive organisms. Only 61.7% ofA. calcoaceticus, and 45.7% of Enterobacter sp were sensitive toceftazidime. Gram negative organisms were also highly resistantto amikacin, but Staphylococcus sp was only moderately resis-tant. Resistance to carbapenem (meropenem and imipenem) var-ied from moderate to low. Drugs which were not used for newbornbabies (quinolones/ciprofloxacin and chloramphenicol) varied frommoderate to high resistance.Conclusion Neonatal sepsis remains one of the major causes ofmortality in our neonatal unit. Most organisms have developedmultidrug resistance, and management of patients infected withthese organisms and especially those with fungi infection are be-coming a problem in developing countries

Thiamphenicol in the treatment of cholera in children Haroen Noerasid; Eko Sujanto; Ismoedijanto Ismoedijanto; Djoko Soejono; I. G. G. Djelantik; Surata Surata
Paediatrica Indonesiana Vol 21 No 9-10 (1981): September - October 1981
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi21.9-10.1981.197-204

A study has been performed to measure the efficacy of thiamphenicol by comparing it with tetracycline as a standard drug. Eighty bacteriologically confirmed cholera patients were included in this study.Among them, 41 patients were treated with thiamphenicol while the other39 with tetracycline.Stool volume, duration of diarrhea and duration of hospitalization were higher in the thiamphenicol group. And the volume of intravenous and oral fluid therapy were less in the tetracycline group.Positive bacteriologic examinations of the second samples (taken on the second day of hospitalisation) of the thiamphenicol grollp were 41.46% as compared with 17.94% of the tetracycline group. But almost all o{ the third samples of both groups were negative.Clinical success rate of thiamphellicol was 95.12% and tetracycline was 100%. Thiamphenicol appeared to be effective against cholera in children.

Uses and Limitations of Gammaglobulin Therapy Sumarmo Sumarmo
Paediatrica Indonesiana Vol 14 No 9-10 (1974): September - October 1974
Publisher : Indonesian Pediatric Society

This paper discusses the enormous advances in gammaglobulin therapy, its uses and limitations.

Efficacy of dexamethasone for lung maturity in preterm delivery in association with lamellar bodies count Ni Made Sumiartini; Hendra Santoso; Wayan Retayasa; Made Kardana
Paediatrica Indonesiana Vol 47 No 3 (2007): May 2007
Publisher : Indonesian Pediatric Society

Background Organ immaturities in preterm infants may result inperinatal death. One of the diseases is respiratory distress syndrome(RDS) which is caused by lung immaturity. Dexamethasone is oftenused to accelerate maturity of infant lungs.Objective To determine the efficacy of dexamethasone on lungmaturity measured by lamellar bodies count.Methods A quasi experimental study was done at PerinatologyDivision, Department of Child Health, Medical School, UdayanaUniversity, Sanglah Hospital, Denpasar. We recruited 72 subjects;36 subjects were given four times intramuscular dexamethasone5 mg every twelve hours before delivery. Thirty six subjects whodid not receive dexamethasone belonged to control group. Infantsâ€™lungs maturity assessment was performed using lamellar bodiescount taken from amniontic fluid.Results The gestational age ranged between 28 to 36 weeks, withthe mean gestational age in dexamethasone group was 32.2 (SD1.76) weeks and that in control group was 31.7 (SD 2.65) weeks.The efficacy of dexamethasone therapy on lung maturity wassignificant with Fisherâ€™s exact test P<0.0001, 95%CI 2.546;11.173. Using multivariate logistic regression analysis, there wassignificant correlation between dexamethasone and lung maturitymeasured by lamellar bodies count [OR=239.39; P<0.0001,95%CI 22.12;526.53].Conclusion Administration of dexamethasone in pregnantwomen during preterm delivery significantly improves lungmaturity measured by lamellar bodies count.

Risk factors of bronchiolitis I Gde Doddy Kurnia Indrawan; IB Subanada; Rina Triasih
Paediatrica Indonesiana Vol 53 No 1 (2013): January 2013
Publisher : Indonesian Pediatric Society

Background Bronchiolitis peak incidence is in children aged 2 -6months. History of atopy in parents, non-exclusive breastfeeding,exposure to cigarette smoke, and infants living in crowded areasmay be risk factors for bronchiolitis. Gestational of age at birth isalso influences the mortality oflower respiratory tract infection.Objective To evaluate the following conditions as possiblerisk factors for bronchiolitis: history of atopy, non-exclusivebreastfeeding, preterm infants, exposure to cigarette smoke, and2:: 6 persons residing in the home.Methods A sex-matched case-control study was conductedby collecting data from medical records at Sanglah Hospital,Denpasar. The case group subjects met the diagnostic criteriafor bronchiolitis and were aged 1-24 months. The control groupincluded patients with diagnoses unrelated to the respiratorysystem. Data was analyzed using bivariate (Mc.N emar) andmultivariate methods (logistic regression) with 95% confidenceintervals and statistical significance value of P <0 .05.Results There were 96 subjects in our study, consisted of 48subjects in the case group and 48 in the control group. Thecase and control groups were similar in baseline characteristics.The presence of history of atopy (OR 34.7; 95%CI 3 to 367,P=0.003), non-exclusive breastfeeding (OR 4.3; 95%CI 1.4 to13, P=0.010), exposure to cigarette smoke (OR 3; 95%CI 1 to9.2, P=0.047), and 2:: 6 persons living in the home (OR 7.9;95%CI 2.6 to 24, P<0.0001) were found to be significant riskfactors for bronchiolitis, while the preterm infants seem notsignificant as a risk factor of bronchiolitis (OR3; 95%CI 0.31 to78.99, P=0.625).Conclusion History of atopy, non-exclusive breastfeeding,exposure to cigarette smoke, and 2:: 6 persons living in the homeare found to be risk factors, while preterm infants seem not a riskfactor for bronchiolitis.

Hemolytic anemia in falciparum and vivax malarial patients based on serum bilirubin examination Yoyoh Yusroh; Bidasari Lubis; Syahril Pasaribu; Munar Lubis; Tiangsa Sembiring; Adillida Adillida
Paediatrica Indonesiana Vol 44 No 3 (2004): May 2004
Publisher : Indonesian Pediatric Society

Objective To examine hemolysis in falciparum and vivax malarialpatients based on serum bilirubin examination.Methods A cross sectional study was conducted on childrenyounger than 15 years of age who visited public health center inthe district of Mandailing Natal with complaints of fever, shivering,pale, jaundice, diarrhea, or headache between April 9 th and April19 th 2001. Variables recorded were age, gender, body weight, bodyheight, symptoms and signs, anti malarial drugs, and laboratorytest results. Thin and thick blood smears were done as diagnostictools of malaria. Thin blood smear was also performed to deter-mine the level of malaria parasites in blood (parasitemia) and toexamine the morphology of red blood cells. Hemolysis was deter-mined by bilirubin examination.Results In P. falciparum malaria, there was a moderate correlation(r=0.68, p<0.0001) between parasitemia and indirect bilirubin con-centration. While in P. vivax malaria, there was only a weak corre-lation (r=0.46, p=0.007) between parasitemia and indirect bilirubinconcentration. It was also found that in falciparum malaria, para-sitemia, total and indirect bilirubin concentrations were significantlyhigher than that in vivax malaria, with p values of 0.009, 0.015 and0.003, respectively.Conclusion Hemolysis in falciparum malaria is more severe thanthat in P. vivax malaria, with marked elevation of indirect bilirubin.The elevation of serum bilirubin correlated with parasitemia

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