cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
editor@jpms-stifa.com
Editorial Address
Journal of Pharmaceutical and Medicinal Research Sekolah Tinggi Ilmu Farmasi Makassar Perintis Kemerdekaan Street KM 13.7 90242 Makassar-Indonesia
Location
Kota makassar,
Sulawesi selatan
INDONESIA
Journal of Pharmaceutical and Medicinal Sciences
Published by Sekolah Tinggi Ilmu Farmasi Makassar
ISSN : 25282824     EISSN : 2580328X     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical and Medicinal Sciences (JPMS) pISSN 2528-2824; eISSN 2580-328X dedicated to publish original research papers, original research notes, invited topical reviews, mini-reviews, editorial commentary and news. Medicinal resources about exchange of information and understandings about people's use of plants, fungi, animals, microorganisms, minerals, their biological and pharmacological effects based on the principles established through international conventions. Pharmaceutical including drugs, pharmacokinetics, biopharmaceutics, pharmacodynamics, pro-drug developments, metabolic disposition of bioactive agents, dosage form design, protein-peptide chemistry and biotechnology specifically as these relate to pharmaceutical technology and targeted drug delivery.
Arjuna Subject : -
Articles 90 Documents
 4   5   6   7   8 
Uji Aktivitas Hipoglikemik Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Terhadap Mencit (Mus musculus) Yang Diinduksi Aloksan Zulham Zulham; Wahyu Hendrarti; Nurul Wahyuni
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.70

Abstract

Diabetes mellitus (DM) is a chronic disorder that specifically involves the metabolism of carbohydrates (glucose) in the body, also causes disorders of fat and protein metabolism. The benefits of kersen (Muntingia calabura L.) which are well known, among others, overcome DM. This study was conducted to determine the hypoglycemic activity of ethanol extract of M. calabura leaves in reducing blood sugar levels and effective dose of reducing blood glucose in mice (Mus musculus) induced by alloxan 130 mg/kg BW. Distribution of experimental animals, group I was given a glibenclamide suspension 0.13 mg/kg BW as (positive control), groups II, III and IV were given ethanol extract of M. calabura leaves at a dose of 50, 100 and 150 mg/kg BW and the group V is given a 1% NaCMC suspension (negative control). Giving extracts carried out for 7 days. The results showed blood sugar levels before treatment, after induction, and after treatment, respectively, group I (81.00; 141.00; and 94.75 mg/dL), group II (79.00; 138.50; and 50.00 mg/dL), group III (102.50; 119.25; and 77.75 mg/dL), group IV (88.25; 146.00; and 61.00 mg/dL), and group V (108.00; 131.25; and 114.75 mg/dL). Based on the results of the study showed a decrease in blood sugar levels at all doses of ethanol extract of M. calabura leaves which has the potential as a diabetes drug.
Uji Aktivitas Ekstrak Bunga Brokoli (Brassica oleocera L. var italica), Wortel (Daucus carota L.) dan Cabai Merah (Capsicum annum L.) Sebagai Penghambat Kolagenase Aisyah Fatmawaty; Angriani Angriani
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.71

Abstract

Collagenase is an enzyme family of Matrix Metalloproteinase (MMP) that breaks down collagen and degrade the extracellular matrix resulting in wrinkles and changes in skin thickness. This study was aimed to determine the value of inhibition concentration of flower extracts of broccoli (Brassica oleocera L. var Italica), carrot extract (Daucus Carota L.) and extract of chili pepper (Capsicum annuum L.) as collagenase inhibitor. Collagenase inhibitory activity was determined by measuring the product resulted from the reaction of enzyme and substrate using a microplate reader at λ 345 nm. Results showed that the inhibition of the flowers of broccoli, carrot and chili pepper ekstrak were 88.49%; 53.96% and 89.21% at a concentration of 250 ug / ml.
Isolasi dan Karakterisasi Senyawa Steroid dari Ekstrak Aseton Daun Faloak (Sterculia quadrifida R.Br) Burhanuddin Taebe; Imrawati Imrawati; Cindy Nuradzani Rachman
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.72

Abstract

Faloak leaves (Sterculia qudrifida R.Br) has been used by Aborigine ethnic to treat insect bites, cuts, arrowheads, stinging wounds and injury. This study was aimed to isolate and characterize the steroid compounds from the acetone extract of faloak leaves. Extraction by maceration method use acetone as solvent than acetone extract was partitioned again with n-hexane and ethyl acetate. The steroids positive fraction was separated using preparative thin layer chromatography and thin layer chromatography 2 dimensions for testing the purity. The isolate was characterized using FT-IR. The results of spectroscopic analysis FTIR show that isolates suspected were steroids compounds with functional group C=O, C- O, C=C, C-C, and C-H.
Explorasi Fungi Endofit Dari Tanaman Bunahong (Andredera cordifolia (Ten.) Steenis) Sebagai Penghasil Kandidat Senyawa Antibakteri Ismail Ismail; Megawati Megawati; Nur Fadillah Bakri
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.68

Abstract

Binahong leaves (Andredera cordifolia (Ten.) Steenis) contain triterpenoid saponins, flavonoids and phenyl propanoid which have antibacterial activity. One source of the antibacterial bioactive compounds is endophytic fungi, are symbiotic microorganisms in plant tissues found in A. cordifolia leaves. This study aims to isolate endophytic fungi from A. cordifolia leaves and their activity against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 83125. The stages in this study included isolation of endophytic fungi, purification, test antagonists, metabolite production and active liquid fermentation tests on test bacteria. The results of this study were 9 endophytic fungi isolates with different characteristics. Of the nine isolates, the best isolates were given in isolation, I8 and I9 isolates with an average inhibitory diameter of 10 mm for Escherichia coli and Staphylococcus aureus.
Penetapan Kadar Fenolik Total, Flavonoid Total, dan Uji Aktivitas Antioksidan Ekstrak Daun Benalu Petai (Scurrula atropurpurea Dans.) Beserta Penapisan Fitokimia Wirasti Wirasti
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 1 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.893 KB) | DOI: 10.32814/jpms.v4i1.73

Abstract

Tumbuhan dalam dunia kesehatan dapat digunakan sebagai salah satu pendekatan terapi bahan alam yang ampuh untuk pengobatan berbagai penyakit dikarenakan mengandung antioksidan. Antioksidan yang tinggi umumnya berkorelasi dengan kandungan flavonoid ataupun fenolik yang tinggi pula. Tujuan penelitian ini adalah untuk mengetahui kadar senyawa fenolik total, flavonoid total, dan aktivitas antioksidan ekstrak etanol daun benalu petai (Scurrula atropurpurea Dans.). Fenolik total ditentukan dengan metode folin-ciocalteu, kadar flavonoid total secara kolorimetri menggunakan AlCl3, dan aktivitas antioksidan menggunakan metode penangkapan radikal bebas DPPH. Hasil penelitian menunjukkan bahwa ekstrak daun S. Atropurpurea memiliki aktivitas antioksidan kategori sangat kuat (IC50 = 23.48±0.04 µg/ml). Hal ini juga ditunjang dengan tingginya kandungan fenolik total sebesar 198,08±1,44 mg GAE/g ekstrak, dan flavonoid total sebesar 148,05±4,44 mg QE/g esktrak. Sehingga dapat disimpulkan bahwa daun S. Atropurpurea berpotensi sebagai sumber antioksidan alami.
Uji Difusi dan Iritasi Krim Solid Lipid Microparticle Ekstrak Etanol Daun Kersen (Muntingia calaura L.) Amriani Sapra; Radhia Riski; Nurul Hidayah
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 1 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (646.272 KB) | DOI: 10.32814/jpms.v4i1.74

Abstract

The extract of kersen leaves (Muntingia calabura L) contains flavanoid compounds as polar antioxidants which have difficulty to diffuse through the skin. Solid lipid microparticle is a drug delivery system to improve the availability of water-soluble compounds at site of action. The aim of this study was to determine diffusion profile and irritant effect of solid lipid microparticle cream loaded ethanol extract of kersen leaves. Diffusion of solid lipid microparticle cream loaded ethanol extract of kersen leaves was carried out using Whatman no.1 membrane and circumcision by franz diffusion methods while irritation test was performed on Albino rabbits (Orytoglagus cuniculus). The results of showed profil using Whatman membrane No. 1 are better than circumcision and the irritation test results the cream do not cause irritating effects on the skin.
Ha Uji Aktivitas Antibakteri Fraksi n-Heksan dan Etil Asetat Lichen (Parmotrema tinctoruma) terhadap Staphylococcus aureus dan Escherichia coli Hamdayani L A; Subehan Subehan; Natsir Djide
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 2 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.654 KB) | DOI: 10.32814/jpms.v4i2.79

Abstract

Antibacterial activity of n-hexane and ethyl acetate Lichen (Parmotrema tinctoruma) has been tested on Staphylococcus aureus and Escherichia coli. The fraction was obtained from the liquid-liquid partitioning of Lichen ethanol extract (Parmotrema tinctoruma) which had gone through a maceration stage with 70% ethanol extraction. The liquid partitioning process is carried out using n-hexane and ethyl acetate. Antibacterial activity testing was carried out by agar diffusion method. Chemical components in the most active fractions are identified through phytochemical screening by thin-layer chromatography methods. The antibacterial activity test showed that the fractions of Lichen were able to inhibit the growth of the bacteria Staphylococcus aureus and Escherichia coli. The n-hexane and ethyl acetate fractions each had inhibition zones of 14.50 mm and 11.37 mm. The Identification of compounds in the most active fraction through thin layer chromatography showed the presence of flavonoid compounds.
Asuhan Mandiri Tanaman Obat Keluarga (TOGA) dalam Upaya Peningkatan Kesehatan Masyarakat Kecamatan Banyudono, Boyolali Reni Ariastuti; Vitri Dyah Herawati
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 2 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.456 KB) | DOI: 10.32814/jpms.v4i2.86

Abstract

Abstract Self care utilization of family medicinal plants (“toga”) is one of the government programs to realize the independence of drugs in the family environment in accordance with Minister of Health Regulation No. 9 of 2016. so many people who do not know enough about the “toga” and its use. Therefore this research was conducted with the aim of wanting to see the profile of Asman toga in the community in the Banyudono sub-district of Boyolali Regency. Sampling was carried out using random sampling method with observational descriptive data collection methods using questionnaire aids and interviews directly to respondents as supporting data. Data analysis was evaluated qualitatively based on the results of questionnaire and interview answers. Banyudono people use a part of the yard to plant the toga. The use of toga is generally for preventive, curative, and promotive purposes. Banyudono people tend to use toga to treat minor illnesses such as coughs, flu, diarrhea and headaches for cheap, easy to obtain and natural reasons. Toga is effective enough to overcome the problem of minor ailments and health promotion, and is able to increase the independence of the family for drugs.
Total Flavonoids Contain of Leaves of Sapodilla (Manilkara zapota L.) A Syarifah Hamida Assagaf; Nursamsiar Nursamsiar; Sahibuddin A Gani
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 2 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.93 KB) | DOI: 10.32814/jpms.v4i2.92

Abstract

Sawo manila (Manilkara zapota L.) merupakan salah satu tumbuhan yang secara tradisional berkhasiat untuk mengobati pendarahan, luka, bisul dan demam. Daunnya memiliki kandungan flavonoid dan saponin yang cukup tinggi. Penelitian ini bertujuan untuk menentukan kadar flavonoid total yang terkandung dalam daun sawo manila dengan metode spektrofotometri. Daun yang telah kering diekstraksi secara refluks menggunakan pelarut etanol 70% dan variasi asam (HCl dan CH3COOH). Hasil penelitian menunjukkan kadar rata-rata flavonoid total pada ekstrak daun sawo manila dengan penambahan HCl p adalah sebesar 8,35% lebih rendah dibandingkan dengan penambahan CH3COOH sebesar 14,52%.
Formulasi Sediaan Losio Minyak Biji Mengkudu (Morinda citrifolia L.) Sebagai Repellent Nyamuk Maria ulfa; Achmad Himawan; Sri Astuti Kalni
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 2 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.84 KB) | DOI: 10.32814/jpms.v4i2.90

Abstract

Noni seeds (Morinda citrifolia L) have an odor that is not liked by mosquitoes and contain alkaloid compounds and cardiac glycosides which act as mosquito repellents which have the ability to protect humans from disturbances or mosquito bites. This study aims to obtain a physically stable anti-mosquito lotion formula from noni seed oil which conducted by steam distillation method. Noni seed oil formulated into lotion preparations with variations in oil concentration (2%, 4% and 6%). Physical stability of the lotion then tested based on organoleptic observation, homogeneity test, pH test, emulsion type test, viscosity test, dispersion test, adhesion test, flow test and test on conditions before and after accelerated storage. The results indicate that all preparations with varying concentrations of oil are stable and effective as mosquito repellents. The noni seed oil lotion produced met the physical quality requirements of lotion preparations and effective as mosquito repellent on concentration 6% of noni seed oil. Keywords: Noni seed oil, lotion, physical stability, repellent

Page 6 of 9 | Total Record : 90

 4   5   6   7   8 

Filter by Year

2016 2022


Reset
Filter By Issues
All Issue Vol 7 No 2 (2022): JPMS Vol 7 Issue 2 Vol 7 No 1 (2022): JPMS Volume 7 Issue 1 Vol 6 No 2 (2021): JPMS Volume 6 Issue 2 Vol 6 No 1 (2021) Vol 5 No 2 (2020) Vol 5 No 1 (2020) Vol 4 No 2 (2019) Vol 4 No 1 (2019) Vol 3 No 2 (2018): JPMS Vol 3 No 1 (2018): JPMS Vol 2 No 2 (2017): JPMS Vol 2 No 1 (2017): JPMS Vol 1 No 2 (2016): JPMS Vol 1 No 1 (2016): JPMS More Issue