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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

Arjuna Subject : -

Articles 331 Documents

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No Acute Toxicity Tests of Purwoceng (Pimpinella pruatjan Molk.) Ethanolic Extract on Male Albino Rat by Determined Hepatorenal Function Test and Histopathology Fitranto Arjadi; Dhadhang Wahyu Kurniawan; Yudhi Wibowo; Wahyu Siswandari; Lantip Rujito
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Pimpinella pruatjan Molkis a local indegineuos plant speciescommonly used aphrodisiac.This studywas performed to analyze the effect of acute administration of purwoceng (Pimpinella pruatjan Molk.) roots ethanol extract to liver and kidney histological damagein rats. The study used an experimental approachusing post test only with control group design. Rats were randomly divided into five groups; 3 rats in each group. Group A as a control group received aquadest, group B, C, D, and E were given purwoceng roots ethanol extract dose of 5 mg/kgBW, 50 mg/kgBW, 300 mg/kgBW, and 2000 mg/kgBW respectively.Liver histological damage was assessed by a modification of the Roenigk score, whereaskidney damage was by the semiquantitative scoring of proximal tubular necrosis. UV test was used to quantify the AST and ALT levels, the measurement of blood urea levels was using the Urease-GLDH method, and Jaffe methodwas used to access the creatinine levels.Kruskal-Wallis test showed that liver and kidney histologicalparameterswere not significantly affected, as well as theblood urea and creatinine levels (p>0.05).Meanwhile,ALT level wasonly parameters which showed the significant test (p <0.05)among groups. Study concluded that the liver and kidney histological appearance, AST, blood urea, and creatinine levels in the male albino rat were not significantly affected by acute administration of Purwoceng roots in various dosesbut the ALT level was significantly affected

PENGUJIAN DAYA HANTAR LISTRIK AIR TANAH DI SEKITAR TEMPAT PEMBUANGAN AKHIR GUNUNG TUGEL KABUPATEN BANYUMAS MENGGUNAKAN PRINSIP JEMBATAN WHEATSTONE Sehah Sehah; Wahyu Tri Cahyanto
Molekul Vol 4, No 1 (2009)
Publisher : Universitas Jenderal Soedirman

Electrical conductivity of groundwater have been measured in area about the final garbage dismissal place (TPA) of Gunung Tugel, Regency of Banyumas. Groundwater samples have been taken away from 104 point of groundwater sources which distributed around of the research area, consisted of well water, belik water and pump water. Then, water samples are tested in Electronics and Instrumentation laboratory, Faculty of Science and Technique, UNSOED use the Wheatstone bridge principle. Electrical conductivity of groundwater obtained, then mapped pursuant to position of samples points location, so that obtained map of electrical conductivity contour of groundwater in research area. Pursuant to the electrical conductivity contour map, known that the mean electrical conductivity value in research area is 0,0594 kW-1, where highest electrical conductivity value is 0,1449 kW-1 and lowest electrical conductivity value is 0,0209 kW-1. Pursuant to interpretation known that most liquid waste (leacheat) of TPA Gunung Tugel are indicated flow into south and south-west area (Village of Kedungrandu) owning lower topography.

STUDY ON THE FENTON REACTION FOR DEGRADATION OF REMAZOL RED B IN TEXTILE WASTE INDUSTRY Henry Setiyanto
Molekul Vol 11, No 2 (2016)
Publisher : Universitas Jenderal Soedirman

Remazol Red B is a reactive dye that is often used in the textile industry. The dye can cause serious problems in the environmental / water because it is difficult to be degraded by microorganisms. Decolorization of reactive azo dyes (Remazol Red B) before being discharged into the environment is an important aspect in creating technology (method) that are environmentally friendly. The method chosen for this decolorization is Advanced Oxidation Process (AOP) using the Fenton reaction. The optimum conditions for this reaction is 25 mg/L H2O2 and 1.25 mg/L of Fe2+ to Remazol Red B with initial concentration at 83 mg/L ( with ratio [H2O2]/[Fe2+] = 20). The optimum conditions of this reaction were obtained at pH 3 and temperature of 27 0C, with decolorization efficiency up to 100% for a reaction time of 60 minutes. The kinetic model of dye decoloritation follow the second order reaction. Some of the metal ions were added i.e. Cu2+, Pb2+ and Zn2+ , given no significant impact on the degradation performed.

ISOLASI, IDENTIFIKASI KOMPONEN DAN UJI AKTIVITAS ANTIBAKTERI MINYAK ATSIRI RIMPANG LEMPUYANG WANGI (Zingiber aromaticum Val.) Nestri Handayani; Widyo Wartono; Nirub Wijaya
Molekul Vol 7, No 2 (2012)
Publisher : Universitas Jenderal Soedirman

Isolasi, identifikasi dan uji aktivitas antibakteri minyak atsiri rimpang lempuyang wangi (Zingiber aromaticum Val.) telah dilakukan. Minyak atsiri diisolasi dengan metode destilasi Stahl dan dianalisis dengan GC-MS. Kadar minyak atsiri yang dihasilkan 0,6% (v/b). Identifikasi komponen dilakukan dengan membandingkan spektrum massa masing-masing senyawa dengan spektrum massa senyawa standar dari literatur Wiley 7. LIB. Hasil analisis menunjukkan 27 senyawa teridentifikasi yaitu α – pinen (0.36%), Z – β ocimen (2.70%), Champhen (10.91%), Sabinen (0.07%), β – pinen (0.18%), β – myrcen (0.29%),(Z)-α-osimen (0.51)%, allo-osimen (0.08)%, p – cimen (0.50%), 1,8 cineol (2.75%), β – trans ocimen (0.05%), γ – terpinen (0.14%), α – terpinolen (27.19%), champor (2.71%), Isobornyl alcohol (1.51%), Terpinen 4-ol (1.11%), 3-cycloheksan 1 metanol (0.25%), Isobornyl acetat (0.29%), Trans caryophilen (0.47%), α-humulen (7.53%), α-kurkumen (0.13)%, farnesol (0.11%), (-)-kariofilen oksida (2.07%), patchulana (0.25%), Zerumbon (31.05%).Uji aktivitas antibakteri minyak atsiri rimpang lempuyang wangi (Zingiber aromaticum Val.) telah dilakukan terhadap Pseudomonas aeruginosa dan Salmonella typhi dengan metode difusi agar menggunakan metode difusi dengan membuat sumuran. Hasil uji antibakteri menunjukkan bahwa minyak atsiri rimpang lempuyang wangi (Zingiber aromaticum Val) memiliki aktivitas antibakteri terhadap semua bakteri uji dengan Konsentrasi Hambat Minimum (KHM) 0,25% untuk Pseudomonas aeruginosa, dan 0,075% untuk Salmonella typhi. Dibandingkan dengan amoksisilin, potensi antibakteri minyak atsiri rimpang lempuyang wangi (Zingiber aromaticum Val) pada kedua bakteri uji adalah 0,001% dari potensi amoksisilin.

Interactions Between Environmental Factors and Zinc Concentrations in Porewater and Roots of Rhizophora sp. in Ampallas, Mamuju, West Sulawesi, Indonesia Rantih Isyrini; Shinta Werorilangi; Supriadi Mashoreng; Ahmad Faizal; Rastina Rachim; Akbar Tahir
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

The study was to determine the concentrations of Zn in porewater and fine roots of Rhizophora sp., and to examine their interactions with mangrove densities and physico-chemical. Porewater samples, fine roots, and sediments were collected in a 100 m2 plot at each site with different mangrove densities. The average Zn concentrations in mangrove roots in the study area were 0 – 58.21 mg/kg, suggested the capability of mangrove roots in retaining Zn. The average dissolved Zn concentrations in porewater were 0.63 mg/L – 3.50 mg/L, illustrated the amount of Zn bioavailable form and its potential release to the adjacent environment. The Zn concentrations in porewater did not correlate significantly with the densities of mangroves. The concentrations of Zn in roots increased as the densities were higher, which is possibly caused by the absence of mangrove at Site 1. The study discovered the important roles of organic content and silt/clay in Zn sorption thus affect Zn levels in porewater. The concentrations of Zn in mangrove roots increased as the pH of sediment and porewater decreased.

PENGARUH pH LARUTAN DAN UKURAN PARTIKEL ABU SEKAM PADI TERHADAP PENURUNAN KADAR CONGO RED Tien Setyaningtyas; Uyi Sulaeman
Molekul Vol 2, No 1 (2007)
Publisher : Universitas Jenderal Soedirman

Rice husk used as a raw material to produce the rice husk ash. The purpose of this research were to determine the optimum contact time and maximum pH of congo red adsorption by rice husk ash, to find out the influence of particle size to adsorption The rice husk was washed, then soaked in HCl 3.84 M to remove mineral impurities, and it was dried and heated for four hours at the temperature 6000 C. The yield gained from this research is 23.44%. Optimum contact time started at after five minutes and maximum pH is six for the tree mention particle sizes 50, 100 and 140 mesh. Particle size didn’t give any significant effect to adsorption process with percent decreasing of congo red is 84.97 %, 90.39 %, 89.32 % respectively.

PENETAPAN KADAR IBUPROFEN DALAM TABLET SERTA APLIKASINYA PADA PLASMA TIKUS JANTAN WISTAR SECARA IN VITRO DENGAN METODE KCKT Susanti Susanti; Aditya Hanif Evridianto; Ika Diandana Yulia Asmara; Asmiyenti Djaliasrin Djalil
Molekul Vol 9, No 2 (2014)
Publisher : Universitas Jenderal Soedirman

Telah dilakukan penelitian mengenai pengembangan metode KCKT dalam penetapan kadar tablet ibuprofen dalam plasma darah tikus jantan wistar secara in vitro. Metode divalidasi berdasarkan parameter linearitas, akurasi, dan presisi. Kondisi KCKT yang digunakan adalah fase terbalik dengan kolom shim pack CLC ODS dan fase gerak asetonitril:bufer fosfat (35:65 v/v), laju alir 0,8 mL/min. Hasil uji linearitas menunjukan nilai r = 0,993 pada kisaran konsentrasi 0,5-5 μg/mL, presisi 0,93 (%RSD), dan perolehan kembali 92,9%. Penentuan ibuprofen dalam tablet generik dan merek pada matriks plasma tikus jantan wistar menghasilkan persen kadar pada kisaran antara 80-100%. Telah dilakukan penelitian mengenai pengembangan metode KCKT dalam penetapan kadar tablet ibuprofen dalam plasma darah tikus jantan wistar secara in vitro. Metode divalidasi berdasarkan parameter linearitas, akurasi, dan presisi. Kondisi KCKT yang digunakan adalah fase terbalik dengan kolom shim pack CLC ODS dan fase gerak asetonitril:bufer fosfat (35:65 v/v), laju alir 0,8 mL/min. Hasil uji linearitas menunjukan nilai r = 0,993 pada kisaran konsentrasi 0,5-5 μg/mL, presisi 0,93 (%RSD), dan perolehan kembali 92,9%. Penentuan ibuprofen dalam tablet generik dan merek pada matriks plasma tikus jantan wistar menghasilkan persen kadar pada kisaran antara 80-100%

OPTIMASI BIOKRAFT JAMUR Phanerochaete chrysosporium TERHADAP KOMPONEN KIMIA CAMPURAN BATANG DAN LIMBAH CABANG MANGIUM SEBAGAI BAHAN BAKU PULP Devi Silsia; Ridwan Yahya; Mucharomah Mucharomah
Molekul Vol 5, No 2 (2010)
Publisher : Universitas Jenderal Soedirman

Optimation biokraft of fungi P. Chrysosporium through elongated incubation time on mixed stem and branch waste mangium is a solution to solve the environmental pollution problem, low quality of pulp and limited raw material. Effect of P. Chrysosporium 10 % concentration and 45 days incubation time on pre research could not decrease lignin optimally and exstractive degradation had not occured yet. The aims of the study were to observe the effect of incubation time extension, and to determine the best incubation time of P. Chrysosporium applied at 10 % concentration based on the chemical component percentage, 45, 60 and 75 days on mixed stem and branch as raw material for pulp. Results showed that increasing incubation time decreased extractive and lignin content and increased holocelulosa and alpha celulosa content. Mixed stem and branch with 10% amount and 75 day incubation time of P. Chrysosporium gave the best results for raw material of pulp.

Quantitative Analysis of Relationship Structure and Anionic Surfactant Micelle Concentration Critic With Semiempiris AM1 Eva Vaulina Yulistia Delsy; Ponco Iswanto; Sandi Winaryo
Molekul Vol 12, No 1 (2017)
Publisher : Universitas Jenderal Soedirman

This research determines the mathematical equation which calculate the Concentration Micelle Critic theoretical anionic surfactant. The research was conducted the depiction of each surfactant anionic three-dimensional compound models, followed by optimizing the model structure anionic surfactant by using AM1 calculation method. Furthermore the calculation of descriptors (QSPR method), then it was analyzed statistically using Multiple Linear Regression (MLR). The results of statistical calculations showed that to calculate the theoretical CMC anionic surfactant can use the QSPR equation: log CMC = 4.157+0.118qC1+7.698qC2+0.425Î±â0.010Âµ-0.129RDâ0.138 log P+0.021BMâ0.034Avdw, n = 100 ; r = 0.927 ; r2 = 0.860 ; SE = 0.352 ; F= 30.888 ; PRESS = 23.506

PEMANFAATAN KITOSANDAN JAMUR LAPUK PUTIH (Trametes versicolor)UNTUK MENURUNKAN KEKERUHAN DAN WARNA PADA AIR GAMBUT SEBAGAI SUMBER AIR BERSIH ALTERNATIF Karelius Karelius
Molekul Vol 8, No 1 (2013)
Publisher : Universitas Jenderal Soedirman

Telah dilakukan penelitian tentang pemanfaatan kitosan dan jamur lapuk putih (trametes versicolor) untuk menurunkan kekeruhan dan warna pada air gambut sebagai sumber air bersih alternatif dengan tujuan adalah mengetahui perbandingan dosis optimum kitosan dan jamur lapuk serta mempelajari kondisi optimum proses koagulasi dan flokulasi yaitu pengaruh waktu pengadukan dengan kecepatan 40 rpm dan pengendapan terhadap penurunan kekeruhan dan warna pada air gambut.Kitosan yang akan digunakan diisolasi dari limbah kulit udang yang dibuat melalui tiga tahap yakni tahap deproteinasi, demineralisasi dan deasetilasi. Penentuan dosis optimum dilakukan dengan variasi dosis kitosan dan jamur lapuk putih perbandingan 800 : 200; 600 : 400; 400 : 600 ; 500 : 500 dan 200 : 800 (mg/L air gambut). Pengaruh waktu pengadukan lambat terhadap efektifitas koagulasi dan flokulasi dipelajari dengan cara koagulasi dilakukan pada waktu bervariasi yaitu selama 5, 10, 15, 20 dan 25 menit. Pengaruh waktu pengendapan dipelajari dengan suspensi hasil koagulasi diendapkan dengan waktu yang bervariasi selama 15, 30, 45, 60 dan 90 menit. Setelah diketahui dosis dan kondisi optimum koagulasi dan flokulasi selanjutnya diaplikasikan pada 3 (tiga) sampel air gambut yang diperoleh dari 3 (tiga) lokasi yang berbeda.Perbandingan dosis optimum kitosan dan jamur lapuk putih parameter kekeruhan adalah 600 : 400 mg/L air gambut dengan efektifitas sebesar 95,06%, dan parameter warna dengan perbandingan dosis optimum 400 : 600 mg/L air gambut dengan efektifitas 96,20%. Waktu pengadukan dengan kecepatan 40 rpm optimum adalah 10 menit untuk parameter kekeruhan dan warna air gambut, dengan efektifitas masing-masing 96,34 % dan 96,68 %. Waktu pengendapan yang optimum adalah pada waktu 45 menit untuk parameter kekeruhan dan 60 menit untuk parameter warna air gambut, dengan efektifitas masing-masing 96,37 % dan 96,68 %. Aplikasi kitosan dan jamur lapuk putih pada air gambut, KLP 1 dan KLP 2 dapat dikatakan layak untuk digunakan sebagai sumber air bersih, dengan tingkat kekeruhan dan intensitas warna masing-masing adalah 1,27 NTU; 2,90 NTU dan 6,30 Pt-Co ; 18,19 Pt-Co. Sampel air gambut KLP 3 belum dapat dikatakan layak untuk digunakan sebagai sumber air bersih dengan tingkat kekeruhan dan intensitas warna masing-masing adalah 26,29 NTU dan 49,78 Pt-Co.

Page 3 of 34 | Total Record : 331

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Contact Name Amin Fatoni

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Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Abstract

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Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA