cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muhammad Miftahussurur
Contact Email
bhsj@journal.unair.ac.id
Phone
-
Journal Mail Official
bhsj@journal.unair.ac.id
Editorial Address
-
Location
Kota surabaya,
Jawa timur
INDONESIA
Biomolecular and Health Science Journal
Published by Universitas Airlangga
ISSN : -     EISSN : 26208636     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.
Arjuna Subject : -
Articles 140 Documents
 10   11   12   13   14 
The Potential Effect Of Sweet Potato (Ipomoea batatas L.) Extract On Total Cholesterol And Low-Density Lipoprotein (LDL) In Hypercholesterol-Model Wistar Rat (Rattus norvegicus) Meddy Setiawan; Dzikrulloh Abdi; S Khanza Zatalini; Kevin Muliawan Soetanto
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.31689

Abstract

Introduction: CHD has high development among 86% in the world with the prevalence in urban (0.6%) than rural (0.4 %) areas. Atherosclerosis is an inflammatory response in blood vessels due to hypercholesterolemia and oxidized LDL. LDL and total cholesterol levels can be reduced by anthocyanins compounds, which are contained in purple sweet potato (Ipomoea batatas L.) This study aimed to determine the effectiveness of purple sweet potato extract in reducing total cholesterol and LDL. Methods: This study was a post-test-only control group experimental design. Twenty-five Wistar rats were divided into five groups: normal control, negative control, and three treatment groups fed by purple sweet potato extract doses of 66.67, 133.33, and 266.67 mg/kg BW/day. Results: Based on the statistical analysis there were significant differences between the treatment group and control groups. The highest dose of purple sweet potato extract (266.67 mg/kg BW/day) has an optimal effect in decreasing total cholesterol and LDL levels. Conclusion: Purple sweet potato extract (266.67 mg/kg BW/day) can reduce total cholesterol and LDL levels of Wistar Rats.
Poor Glycemic Control is Correlated with Reduced Cognitive Function in Type 2 Diabetes Mellitus Patients Archangela Olivia Eugenia; Achmad Firdaus Sani; Hermawan Susanto; Jongky Hendro Prajitno
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.31880

Abstract

Introduction: The prevalence of type 2 Diabetes Mellitus (T2DM) in Indonesia is increasing and is known to cause several complications related to the patient’s glycemic control. A chronic hyperglycemic state will lead to microvascular injury of the brain resulting in cognitive impairment as one of the complications of T2DM. Therefore, our present study observed the correlation between glycemic control and cognitive impairment in patients with T2DM.Methods: This was an observational study with a cross-sectional design of T2DM patients in endocrine outpatient clinics of Dr. Soetomo General Academic Hospital from October 2020 to March 2021. The subjects were recruited consecutively then categorized into groups with controlled (HbA1c < 7%) and uncontrolled (HbA1c ≥ 7%) blood glucose. The cognitive function was evaluated using the AD8 informant-based questionnaire.Results: A total of 43 adult T2DM patients aged < 65 years were recruited. The incidence of cognitive impairment was not significantly different (p=0.127) between controlled and uncontrolled blood glucose groups. However, HbA1c levels were positively and significantly correlated with AD8 scores (p=0.031, R=0.330). Moreover, the duration of T2DM was found to significantly affect cognitive abnormalities in these patients. (p=0.021).Conclusion: Poor glycemic control in T2DM patients increased the risk of developing reduced cognitive function.
The Potential of Cammelia sinensis (Tea Leaves) Active Compound as Alternative Therapy on castrate-resistant prostate cancer (CRPC) with Androgen Receptor Inhibition: In Silico Study Mega Memory Rahasa Putra; Kurnia Penta Seputra
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.32147

Abstract

Introduction: Prostate cancer is a leading global cause of increased mortality and morbidity in men which can be complicated by castrate-resistant prostate cancer (CRPC). Pharmacological therapy by inhibiting the androgen receptor (AR) can inhibit prostate cancer progression. Tea leaves (Camellia sinensis) are believed to inhibit the prostate cancer progression but the mechanism is still unknown. Therefore, research on the mechanism by in silico study is needed with the AR as target protein.Methods: The effectivity of tea leaves’ active compound to inhibit androgen receptor was evaluated by docking server with abiraterone acetate as a control. The tea leaves' active compounds consist of catechin, epicatechin, epigallocatechin gallate, epigallocatechin, gallate epicatechin, gallocatechin gallate, and gallocatechinResults: The result showed that epicatechin, epigallocatechin, and gallocatechin have lower free binding energy (ΔG) and high amino acid residue similarity on AR compared with abiraterone acetate. But, it has lower surface interaction compared with abiraterone acetate. Conclusion: Epicatechin, epigallocatechin, and gallocatechin are predicted to have potential as alternative therapy in CRPC with AR Inhibition.
Diagnostic and Management Problems of a Patient with Severe Life-Threatening Acute Hypocalcemia: A Case Report Arvin Wiranata Lianto; Birgita Maria Ratu Rosari Bas; Robert Dwitama Adiwinoto; Libriansyah Libriansyah
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.34295

Abstract

Hypocalcemia is a common electrolyte disorder. Acute hypocalcemia is a life-threatening condition that needs prompt evaluation and management. We present a case of a 54-year-old woman presented to emergency room with muscle spasm and involuntary movement. Upon physical examination, the patient was disoriented and the Trousseau’s sign was bilaterally positive when the cuff was inflated. Blood test revealed severe hypocalcemia with albumin-corrected serum total calcium levels 1.77 mg/dL. Following extensive diagnostic workups, there were no alternative explanations other than vitamin D deficiency. Despite aggressive intravenous (IV) calcium correction and high-dose vitamin D supplementation the calcium levels gradually decreased and neurological symptoms relapsed. The use of phenytoin to treat neurological symptoms decreased calcium levels further. The patient was eventually discharged with oral calcium and calcitriol supplementation with minimal symptoms. This case highlights the importance of thorough diagnostic workups and judicious use of anticonvulsant drugs in hypocalcemia for optimal treatment outcome.
Correlation Between Early Age Pregnancy with Low Body Weight (LBW) Newborn at Universitas Airlangga Academic Hospital, Surabaya, Indonesia Roy Prasojo Wibowo; Budi Prasetyo; Widati Fatmaningrum; Ahmad Hadi Modi
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.34442

Abstract

Introduction: Birth weight is often used to evaluate a newborn baby’s health. Low birth weight (LBW) is one of the leading causes of neonatal mortality. Mothers under the age of 20 (early pregnancy) are at a greater risk of affecting the weight and nutritional status of the unborn child. This research aimed to determine the relationship between early pregnancy and LBW. Methods: This was a cross-sectional study of women and newborns at Airlangga University academic hospital from January through December of 2017. Data on characteristics such as maternal age and LBW were collected. The correlation between early pregnancy and infant weight was determined using the Chi-square test, with a significance level of p<0.05. Results: We conducted research on 210 pairs of mothers and their infants. 64 (30.48%) of the pregnancies occurred in women under the age of 20; 61 (29.55%) were born LBW (weighing less than 2,500 grams). Early age pregnancy was linked to a higher proportion of LBW infants (p=0.001). Research indicated that the risk of LBW was more significant in the early groups of pregnancy.Conclusion: This research establishes a relationship between early age pregnancy and LBW. The findings may aid in identifying vulnerable mothers in need of further assistance and personalized treatments.
Profile of Dengue Fever Complication in Infant at Tertiary Referral Hospital in East Java, Indonesia Khen Mikhael; Dominicus Husada; Pudji Lestari
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.34827

Abstract

Introduction: Dengue virus infection is caused by the dengue virus and transmitted through the bites of infected Aedes aegypti or Aedes albopictus mosquitoes. The spectrum of clinical manifestations is varied from asymptomatic, undifferentiated fever, dengue fever, dengue hemorrhagic fever, dengue shock syndrome, to expanded dengue syndrome. Data from 2016 in Indonesia revealed that dengue virus infection is common in the population, with a total of 333.821 cases of dengue hemorrhagic fever. Methods: This was a descriptive study with a cross-sectional design. The subjects in this study were children under 1-year-old, diagnosed with dengue virus infection, and had a complication. The number of subjects used is 60 infants. Results: Infection of dengue virus in infants is often found in the 7-9 month age group (36,6%). Clinical manifestations found were fever (100%), vomiting (62%), diarrhea (43%), petechiae (22%), bleeding (12%), and irritable (5%). Thrombocytopenia and leukopenia were found in 93,3% and 26,6% of infants respectively. Complications were found in the form of pleural effusion (66%), hypoalbuminemia (62%), hyponatremia (51%), liver involvement (49%), hypocalcemia (43%), hypokalemia (23%), bleeding (21%), brain involvement (21%), kidney involvement (13%), and ascites (11%).Conclusion: The most common clinical manifestations are fever, diarrhea, and vomiting, while the most common complications are pleural effusion, hypoalbuminemia, hyponatremia, liver involvement, and hypocalcemia.
The Effect and Mechanism of Sucrose Consumption to Liver Disease – A Systematic Literature Review Sim Hellene Anjani Sigma
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.35160

Abstract

Introduction: One liver disease caused by excessive fat in the liver, called non-alcoholic liver disease (NAFLD), commonly occurs with obesity, diabetes, and other disorders. NAFLD is also associated with hepatic insulin resistance, steatosis, non-alcoholic steatohepatitis (NASH), and cirrhosis. Sucrose consumption has increased recently, and known can promotes NAFLD and will accelerate NAFLD development. This study aimed to discuss the effect and mechanism of sucrose intake on liver disease using a systematic literature review. Methods: The author identified the articles from 6 online search engines, including PubMed, Science Direct, Sinta, Garuda, Google Scholar, and EBSCOHost. A total of 2271 retrieved articles were obtained from combined search strings in Indonesian and English from the search through online search engines. Excluded articles include title not relevant, duplicate articles, not open access, secondary study or review articles, research objective not appropriate, abstract not suitable, and the results/findings not relevant to the aims of this paper. Results: A final of twenty-three articles were retrieved using the Mendeley reference manager. Studies included were published studies, types of experimental and observational studies, and their specific findings of sucrose effects on liver disease. Results reveal that most research was primarily conducted experimentally and in case-control study types on male rats. Conclusion: The most common disease related to sucrose is NAFLD, fibrosis/cirrhosis with the indication of NASH, obesity, insulin resistance (IR), triglycerides (TG), hepatic steatosis, hepatocyte ballooning, and weight gain, which we will discuss further in this review.
Breeding Preference and Bionomics of Anopheles spp. at the Malarial Endemic Area, Runut Village, East Nusa Tenggara Province, Indonesia Gery Morsales Munthe; David Nugraha; Gabriel Pedro Mudjianto; Etik Ainun Rohmah; Arnoldina Dolfina Dua Weni; Zukhaila Salma; Lynda Rossyanti; Fitriah; Suhintam Pusarawati; Budi Utomo; ukmawati Basuki; Haruki Uemura
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.35278

Abstract

Introduction: Anopheles mosquito is transmitting malaria, one of the health problems in Indonesia. Understanding Anopheles mosquito behaviour and its breeding preference is one of the crucial keys to prevent malaria transmission. This study aimed to identify the breeding place distribution and bionomics of Anopheles spp. in Runut village, Sikka district, East Nusa Tenggara. Methods: A descriptive observational study was conducted in Runut village, Waigete sub- district, in April 2018. Anopheles spp. larvae were collected in 7 suspected breeding places consisting of 2 rice fields, 3 fish ponds, and 2 puddles. Mosquitos behaviour was observed using bed-net traps located inside and outside the house from 7.15 PM to 1.15 AM after obtaining informed consent. Mosquito collection using bed-net trap were performed for 40 minutes then followed by resting mosquito collection for 10 minutes. Results: Anopheles spp. larvae were found in most of the suspected aquatic habitats, presenting different densities and together with larvae of the other mosquito species. Relatively high number of Anopheles spp. larvae was obtained from a puddle. Only one female mosquito of Anopheles spp. resting on the wall inside house was found around 00.55 – 01.05 AM and resulted in low mosquito density determination. Conclusion: Anopheles spp. larvae were harbouring in most of the aquatic habitats and one puddle contained moderately abundant larvae of Anopheles in Runut village, Sikka district, East Nusa Tenggara, Indonesia. Even only one Anopheles spp. mosquito was detected inside the house, residents in Runut village should regular use insecticide-treated bed nets and continuous observation of mosquito breeding places especially puddles to prevent malaria and other mosquito-borne diseases.
Relationship between Sarcopenia in Abdomen CT Scan Results with C-Reactive Protein Level in Colorectal Cancer Patients at Dr. Soetomo General Academic Hospital Surabaya Erlyta Dian Puspitarini; Prijambodo Prijambodo
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.35279

Abstract

Introduction: Colorectal cancer is the third most malignant and the fourth-largest cause of death in the world, one of which is caused by cachexia cancer. Sarcopenia is the main diagnostic criterion for cachexia. The inflammatory response, one of the markers of which is C-Reactive Protein (CRP), is also involved in the occurrence of sarcopenia associated with cachexia cancer. This study aimed to determine the occurrence of sarcopenia and its relationship with CRP preoperative colorectal cancer patients. Methods: This type of observational retrospective analytic study assessed sarcopenia based on the Psoas muscle index (IOP) on preoperative CT scan images and CRP levels measured by an integrated automatic tool Dimension RxL Max with Flex liquid reagent preoperative CRP range (RCRP). Results: Sarcopenia occurs in male colorectal cancer patients with a p-value of 0.001<0.05 (5%) with an IOP mean value of 26.75 m2, while in female patients the IOP mean value was 21.33 m2, it does not occur sarcopenia with p-value 0.583>0.05 (5%). There was an increase in CRP in 62.5% of colorectal cancer patients, but the relationship between IOP values and CRP values of colorectal cancer patients was still categorized as weak with p value of -0.387 in men and -0.046 in women with α=0.05. Conclusion: There was a nonsignificant relationship between sarcopenia and CRP levels in colorectal cancer patients. Further prospective studies are required to consider the indicators of sarcopenia besides the decrease in IOP and identification of confounding factors known to be associated with CRP, muscle strength, and muscle mass.
Diathesis Hemorrhagic, Coagulation and Fibrinolytic System Rizky Amalia Putri; Muhammad Noor Diansyah; Ami Ashariati Ashariati; Siprianus Ugroseno Yudho Bintoro; Putu Niken Ayu Amrita; Merlyna Savitri Savitri; Pradana Zaky Romadhon
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.35280

Abstract

Bleeding is one of the most common complaints when coming to the hospital which can be mild to life-threatening. The balance of the impaired hemostasis system allows for abnormal bleeding such as hemorrhagic diathesis. Balance between blood clotting and bleeding is always maintained in the body under normal physiology. The coagulation system stops existing bleeding with vasoconstricts of blood vessels and the formation of early platelet plugs, this blockage is strengthened by the presence of a cascade of coagulations to form stable and sturdy blockages. Once bleeding has stopped, the fibrinolytic pathway is initiated to dissolve the blood clot to restore normal blood flow. balance the coagulants, fibrinolytic and inhibitor systems, creating a perfect physiological balance. Hemostatic imbalance is a global problem that can lead to thrombosis or hemorrhage.

Page 14 of 14 | Total Record : 140

 10   11   12   13   14 

Filter by Year

2018 2022


Reset
Filter By Issues
All Issue Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal