Diponegoro International Medical Journal (DIMJ)
Diponegoro International Medical Journal (DIMJ) ISSN Number: 2745-5815 welcomes contributions which promote the exchange of ideas and rational discourse between practicing educators and medical researchers all over the world. DIMJ is an international, peer review, electronic, and open access journal. DIMJ is seeking an original and high-quality manuscript. Areas of interest in all aspects of medical and physiology include but are not limited to the following topics: Modelling of diagnose and cure of human diseases The scientific underpinning of medicine and pathophysiology Biochemistry and biology molecular solution Decision support systems Biomedicine Any experimental design and statistical analysis The application of new analytical and study methods (including biomolecular studies)
Articles
43 Documents
<![CDATA[Correlation of Obesity Status with Zinc Serum Levels and Insulin Resistance in Perimenopause Obese Women ]]>
<![CDATA[Heidi Listya]]>;
<![CDATA[Muhammad Sulchan]]>;
<![CDATA[Etisa Adi Murbawani]]>;
<![CDATA[Niken Puruhita]]>;
<![CDATA[Amalia Sukmadianti]]>
<![CDATA[ Diponegoro International Medical Journal Vol 1, No 2 (2020): December ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v1i2.9559
<![CDATA[Background : Obesity is one of the global health problems. The prevalence of obesity in women is higher than men. Various metabolic problems are caused by obesity, such as insulin resistance and deficiency of micronutrients such as zinc. The occurrence of insulin resistance in obesity is also influenced by zinc deficiency.Objectives : To analyse the correlation of obesity status with serum zinc levels and insulin resistance in perimenopause obese women.Methods : Correlational research with 62 perimenopause obese women subject aged 40-50 years old who met the inclusion and exclusion criteria. Serum zinc levels were measurement using AAS and insulin resistance using HOMA IR formula. Serum zinc levels, fasting insulin, fasting blood glucose taken from venous blood. Hypothesis testing uses Pearson correlation.Results : 12.9% had low serum zinc levels and high HOMA IR 9.09%. There was a significant negative correlation between BMI with serum zinc levels (r = -0.402; p = 0.001) and significant positive correlation between BMI with insulin resistance (r = 0.396; p = 0.001). There was a significant negative correlation between WC with serum zinc levels (r = -0.18 , p = 0.161) and significant positive correlation between WC with insulin resistance ( r =0.284 , p =0.025 ). and significant negative correlation between serum zinc levels with insulin resistance (r = -0.404; p = 0.001).Conclusion : There is a correlation between obesity status with serum zinc levels and correlation between obesity status with insulin resistance in perimenopause obese women.]]>
<![CDATA[The Effect of Forward Leaning and Pursed Lips Breathing Exercises on The Value of Oxygen Saturation in Adult Smokers ]]>
<![CDATA[Muhammad Nurul Amin]]>;
<![CDATA[Erna Setiawati]]>;
<![CDATA[Rahmi Isma Asmara Putri]]>;
<![CDATA[Meita Hendrianingtyas]]>
<![CDATA[ Diponegoro International Medical Journal Vol 1, No 1 (2020): July ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v1i1.7940
<![CDATA[Background: Smoking which is a lifestyle trend continues to increase and take its toll each year. Cigarettes have chemical compounds. Which has toxic and carcinogenic effects that can cause respiratory, cardiovascular, and other irritants. This can affect the distribution of oxygen to the body tissues. Forward leaning and PLB exercises can help maximize breathing thereby improving tissue oxygen distribution. Objective: To determine the differences in oxygen saturation of adult smokers before and after practice forward leaning and pursed lips breathing.Methods: This study used a quasi-experimental method with two group pre-post test design. The research subjects were 20 male respondents, the place of implementation at the Faculty of Medicine, Diponegoro University, Semarang. Research procedures included CKD and PLB exercises in the respondent group.Results: Analysis using the Wilcoxon test obtained significant results, with p values <0.05 on acute and chronic effects after CKD and PLB exercises were performed on 20 respondents Conclusion: A significant result in the oxygen saturation value of the group with PLB and CKD treatment with the PLB group before and after exercise on acute and chronic effects in adult smokers]]>
<![CDATA[The Effect of Paracetamol and Codeine Analgesic Combination on Creatinine Levels in Male Wistar Rats ]]>
<![CDATA[Vianney Natasaputra]]>;
<![CDATA[Taufik Eko Nugroho]]>
<![CDATA[ Diponegoro International Medical Journal Vol 1, No 1 (2020): July ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v1i1.7833
<![CDATA[Background : Pain is one of the most common complaint in patients. Combination of paracetamol and codeine is an alternative analgesic combination in chronic pain management. They belong to different group of analgesic and have different mechanism of action. Combination of these drugs give a better potential in pain management. However, these drugs also have potential side effect on the kidney.Methods : An experimental study of post-test only control group design. The sample were 20 Wistar rats, randomized into 4 groups: control group, a group receiving paracetamol 32 mg/kg body weight, a group receiving codeine 1,9 mg/kg body weight, and a group receiving paracetamol 32 mg/kg body weight and codeine 1,9 mg combination, administered 4 times a day orally using gastric instillation for 28 days. At the 29th day, blood is collected from retro orbital vessel to measure the serum creatinine levels. Statistical analysis was conducted using ANOVA TestResult : Obtained from statistical analysis there is no significant difference in serum creatinine levels in Wistar rats given all treatment group (p > 0,05).Conclusion : There is no significant difference in serum creatinine levels between administration of paracetamol and codeine combination compared to the control group. ]]>
<![CDATA[Risk Factors for Mortality among HIV/AIDS Patients ]]>
<![CDATA[Zaki Mita Kusumaadhi]]>;
<![CDATA[Nur Farhanah]]>;
<![CDATA[Muchlis Achsan Udji Sofro]]>
<![CDATA[ Diponegoro International Medical Journal Vol 2, No 1 (2021): July ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v2i1.9667
<![CDATA[Background: Morbidity and mortality of HIV/AIDS infections is still high and as a global health problem particularly in Low-Middle Income Countries (LMICs). Indonesia ranks third in Asia Pacific in increasing HIV infection. A Study on risk factors for mortality in HIV/AIDS patients in Dr. Kariadi General Hospital has never been conducted. This study analyzed the risk factors for mortality among HIV/AIDS patients.Methods: Case control study, data from medical records of inpatients and outpatients in Dr. Kariadi General Hospital from January 2015 to December 2017.Results: Study subject: Two hundred and ten HIV/AIDS patients, were included; 105 (56.75%) as cases and 105 (9.65%) control patients. The significant risk factors for mortality were as follow: male sex (p = 0.030); age ≥ 45 years (p = 0.035); non compliance to treatment (p = 0,000); WHO clinical stage III and IV (p = 0,000); co-infection of pulmonary tuberculosis (p = 0,000); CD4 cell count < 200 cells/mm3 (p = 0,000); eGFR < 60 mL/minute/1.72 m2 (p = 0.001) and Haemoglobin level < 10 g/dL (p = 0.008). The non-significant risk factors for mortality were as follow: level of education (p = 0.650); Hepatitis B co-infection (p = 0.153) and Hepatitis C co-infection (p = 0.506). The most important risk factors for mortality in this study in were non compliance to treatment (p = 0.003; OR = 3.285) and CD4 count < 200 cells/mm3 (p = 0.014; OR = 5.480).Conclusion: In this study, the risk factors for mortality in HIV/AIDS patients were male sex; age ≥ 45 years; non compliance to treatment; WHO clinical stage III and IV; co-infection of pulmonary tuberculosis, CD4 count < 200 cells/mm3; eGFR < 60 mL/minute/1.72 m2 and Hb level < 10 g/dL. The most important risk factors for mortality were non compliance to treatment and CD4 count < 200 cells / mm3.]]>
<![CDATA[Correlation Between Level of Depression and Risk of Suicide in Elderly at Purwodadi, Grobogan ]]>
<![CDATA[Rilla Fiftina Hadi]]>;
<![CDATA[Titis Hadiati]]>;
<![CDATA[Natalia Dewi Wardani]]>
<![CDATA[ Diponegoro International Medical Journal Vol 1, No 2 (2020): December ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v1i2.9585
<![CDATA[Background: According to WHO, the elderly people have physical and mental challenges, including depression. The incidence of depression lead to suicide on elderly is about 12.7%. In Grobogan Regency, Purwodadi, Central Java, there has been an increase of depression in the last 5 years. Purwodadi Subdistrict depends on the number of orders with the highest number of traffic cases and the elderly.Objective: To determine the correlation between depression level and the risk of suicide.Methods: This research is a quantitative study with cross sectional design in which all respondents were observed and variables were measured at one time. Samples were taken from elderly outpatient of primary health care and Posyandu lansia at Purwodadi, who met the inclusion and exclusion criterias. Research samples were selected based on nonprobability sampling method through purposive sampling. This research used the Indonesian version of the GDS (Geriatric Depression Scale) and CSSRS (Columbia Suicide Severity Rating Scale) questionnaire.Results: The prevalence of elderly depression is 63.3%, and a significant correlation was found between severe depression and low risk of suicide (p <0.05)Conclusion: significant correlation was found between severe depression and low risk of suicide.]]>
<![CDATA[Adverse Outcome in a Near Term, High-Risk Twin Pregnancy Complicated by COVID-19: A case report ]]>
<![CDATA[Razmaeda Sarastry]]>;
<![CDATA[Crismanto Layarta]]>;
<![CDATA[Ussisti Aladini]]>;
<![CDATA[Alini Hafiz]]>;
<![CDATA[Besari Adi Pramono]]>
<![CDATA[ Diponegoro International Medical Journal Vol 1, No 2 (2020): December ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v1i2.7937
<![CDATA[Background: COVID-19 affecting the outcome of pregnancy is still under investigation. Here we report a case of primigravida with monochorionic diamniotic twin pregnancy with superimposed preeclampsia who develop symptoms of COVID-19 infection on her near term pregnancy and was confirmed later on as COVID-19 positive after cesarean section. The pregnancy was terminated abdominally due to the intrauterine fetal demise of both twins using COVID-19 standard equipment.Case Presentation: A 29-year-old female, gravida 1, para 0 presented with a twin pregnancy at the gestational age of 36 weeks was referred to our emergency department for further management of intrauterine fetal death of both twins. Six days before admitted to our emergency department, she has been experienced a remittent fever which followed by a mild cough. Four days before admission, she complained of decrease movement of the babies. She went to the Secondary Hospital to check her pregnancy and both fetal heart rates were not found. The patient is obese (BMI 49.2 kg/m2) and had prior uncontrolled hypertension but no other medical history, including epilepsy, allergies, asthma, heart disease as well as Diabetes Mellitus.Conclusion: A research about placental pathology in pregnancy with confirmed case of COVID-19 infection showed no pathognomonic feature in the histopathologic examination but mostly, there were maternal vascular malperfusion (decidual arteriopathy in particular) and intervillous thrombi. In the end, a further examination is suggested to evaluate the course and causal factors pertaining to this case.]]>
<![CDATA[The Association between Serum Malondialdehyde and Nitric Oxide Level of Children Living In Area of Chronic Pesticide Exposure ]]>
<![CDATA[Astra Parahita]]>;
<![CDATA[Galuh Hardaningsih]]>;
<![CDATA[Anindita Soetadji]]>
<![CDATA[ Diponegoro International Medical Journal Vol 1, No 1 (2020): July ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v1i1.7897
<![CDATA[Background: Chronic exposure of organophosphate pesticides is an oxidative stress that causes liver and aortic damage. Malondialdehyde (MDA) is a biological marker of oxidative damage to cell lipids membrane. The liver produces insulin growth factor-1 (IGF-1) which stimulates the enzyme nitric oxide synthase (eNOS) to produce vascular nitric oxide (NO). Children who are living in those area may be exposed to pesticide chronically. Objective: The study aims is to determine the relationship between serum MDA and NO level of children living in an area of chronic pesticide exposure.Method: Cross sectional study was conducted to 50 children aged between 8 – 10 years in agriculture areas of Brebes. Serum MDA and NO level was measured at the same time using ELISA method, data were shown on numerical scale. Statistical analysisby Pearson correlation.Result: Fifty children met the criteria, consisting of 30 males (60%) and 20 females (40%). The mean of serum MDA level in males, females, and total subjects were normal 6.03 (3.86) µg/ mL, 5.18 (2.11) µg/ mL, and 5.69 (2.60) µg/ mL, respectively. The mean of serum NO level in males, females, and total subjects were increased 79.42 (50.78) µmol/ L, 68.11 (50.81) µmol/ L, and 74.90 (50.58) µmol/ L, respectively. There was no association between serum MDA and NO level found.Conclusion: Serum NO level of children living in an area of chronic pesticide exposure was higher than normal value. However, there was no association between serum MDA and NO level found.]]>
<![CDATA[The Effect of Using Blue Light Filter Feature on Smartphones with Asthenopia Occurrence ]]>
<![CDATA[Arnan Victor Wiryawan]]>;
<![CDATA[Maharani Maharani]]>;
<![CDATA[Tanti Ajoe Kesoema]]>;
<![CDATA[Riski Prihatningtias]]>
<![CDATA[ Diponegoro International Medical Journal Vol 2, No 1 (2021): July ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v2i1.9761
<![CDATA[Background: Smartphone users can be found in almost every class society in Indonesia. Excessive use of smartphones and the blue light emitted by smartphones play an important role in causing asthenopia symptoms. Smartphone development companies have developed a blue light filter feature, which is expected to reduce the incidence of Asthenopia symptoms.Objective: To evaluate the Asthenopia questionnaire's comparison results before and after smartphone use with various levels of opacity in the blue light filter.Methods: This study used a quasi-experimental pre-posttest study. The research subjects were students of the Faculty of Medicine, Diponegoro University (n = 30), selected by purposive sampling. In this study, research subjects saw an hour-long smartphone with a predetermined opacity level for the blue light filter, with the same room lighting. Before and after the treatment, the subjects were asked to fill out the Asthenopia questionnaire. Data were analyzed using the Wilcoxon test, Mann Whitney U test, and Kruskal Wallis test.Results: The results of the Asthenopia questionnaire before and after using a smartphone with a blue light filter opacity level of 0% and 100% showed a significant difference in results (p <0.05), and there was no significant difference for the pre-posttest using a smartphone with a blue light filter with 50% opacity level. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 0% and 50% only showed a significant difference in sore/aching eye symptoms. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 50% and 100% only showed a significant difference in sleepy eye symptoms. The comparison results of the Asthenopia questionnaire between smartphone use with the opacity level of the blue light filter 0%, 50%, and 100%, did not show a significant difference.Conclusion: There were no significant differences between the Asthenopia questionnaire results with 0%, 50%, and 100% opacity blue light filters after one hour of smartphone use.]]>
<![CDATA[Differences of Ampicillin and Cefazolin Effects in Reducing hs-CRP Level in Premature Rupture of Membranes ]]>
<![CDATA[Ahmad Bukhoeri]]>;
<![CDATA[Syarief Thaufik Hidayat]]>;
<![CDATA[Ediwibowo Ambari]]>;
<![CDATA[Julian Dewantiningrum]]>;
<![CDATA[Putri Sekar Wiyati]]>;
<![CDATA[Besari Adi Pramono]]>
<![CDATA[ Diponegoro International Medical Journal Vol 2, No 1 (2021): July ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v2i1.8428
<![CDATA[Background: Premature rupture of membranes (PROM) is a rupture of amniotic sac before delivery. PROM is associated with an increased incidence of preterm labor and infection. The use of prophylactic antibiotic may reduce the risks of infection. High-sensitivity C-reactive protein (hs-CRP) is an acute-phase reactant protein that is associated with PROM. How much effect of prophylactic antibiotic to hs-CRP level remains unclear.Objective: To compare the reduction in hs-CRP levels in premature rupture of membranes before and after given ampicillin or cefazolin.Methods: The design of this study was true experimental design (pre and post-test) conducted at Dr. Kariadi General Hospital Medical Center Semarang and Kartini General Hospital Jepara from September 2019 to January 2020. Study samples are pregnant women with premature rupture of membranes that came to the Emergency Department and Maternity Ward Dr. Kariadi General Hospital Medical Center Semarang and Kartini General Hospital Jepara. Samples were divided into two groups, a group treated with ampicillin and the other with cefazolin therapy. All samples were subjected to a hs-CRP examination. Statistical analysis was performed by Mann-Whitney and Wilcoxon.Results: There are no significant differences in the age variable (28.8 ± 6.54 vs 29.1 ± 5.93), gestational age (36.3 ± 2.55 vs 36.3 ± 2.90), and parity (2,2 ± 0.99 vs 2.47 ± 1.19) in the ampicillin and cefazolin groups (p> 0.05). In this study, 37.1% patients have a history of PROM while 62.9%. had no history of PROM. Reduction in hs-CRP levels after administration of ampicillin and cefazolin was significant (4.4 ± 2.65 mg/L vs 6.3 ± 4.43 mg/L, respectively, p = 0.03). The difference in the decrease in hs-CRP levels before and after given ampicillin and cefazolin was significant (p = 0.0001). Conclusion: There is a decrease in hs-CRP levels after the administration of ampicillin or cefazolin in PROM, whereas cefazolin induced higher reduction in hs-CRP levels. Ampicillin can still be used as a first-line prophylactic antibiotic in primary healthcare facilities.]]>
<![CDATA[The Effect of Nigella Sativa on Clinical Improvement of Laryngopharyngeal Reflux Patients ]]>
<![CDATA[Lusia Lusia]]>;
<![CDATA[Farokah Farokah]]>;
<![CDATA[Rery Budiarti]]>
<![CDATA[ Diponegoro International Medical Journal Vol 1, No 2 (2020): December ]]>
Publisher : <![CDATA[Faculty of Medicine, Diponegoro University ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
DOI: 10.14710/dimj.v1i2.8992
<![CDATA[Background : Laryngopharyngeal Reflux (LPR) decribes as retrograde reflux from gaster into the laryngopharynx because of the premature relaxation upper esophageal sphincter. The management of LPR patients includes lifestyle and dietary arrangements, medical therapy and surgical management. Nigella sativa (NS) / black cumin has anti-inflammatory, anti-oxidant and gastroprotective effects that are expected to provide clinical improvement in LPR patients.Objective : The purpose of this study was to determine the effectiveness of NS on the clinical improvement of LPR patients.Methods : This research is an intervention study using pre and post test design methods of 34 LPR patients in Dr. Kariadi, hospital and 2 affiliated hospital from November 2019 - March 2020.Result : 24 patients with complete data while 10 patients were unable to evaluate RFS because of a pandemic. The treatment group (15 patients) were given omeprazole 20 mg / 12 hours plus NS 1000 mg / 12 hours orally and control group (9 patients) were given omeprazole 20 mg / 12 hours orally and placebo. Data were tested by Shapiro Wilk test, followed by the appropriate parametric test, and Fisher's exact test. There were no differences in clinical improvement in LPR based on RSI and RFS values between groups given additional NS and groups without NS, p 0.105.Conclusion : there were no significant differences in clinical improvement between groups given additional NS and groups without NS.]]>
